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Overcoming Cytosolic Delivery Barriers of Proteins Using Denatured Protein-Conjugated Mesoporous Silica Nanoparticles

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ACS Applied Materials and Interfaces 2023年第1期15卷 432-451页

作者： Dembélé, Julien Liao, Jou-Hsuan Liu, Tsang-Pai Chen, Yi-Ping Graduate Institute of Biomedical Materials & Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Laboratory of Toxicology Environment and Health Doctorate School of Health University Joseph Ki-Zerbo Ouaga03 BP 7021 Burkina Faso Department of Chemistry National Taiwan University Taipei10617 Taiwan Department of Surgery Mackay Memorial Hospital Taipei10449 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei11031 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan

Intracellular delivery of therapeutic proteins has increased advantages over current small-molecule drugs and gene therapies, especially in therapeutic efficacies for a broad spectrum of diseases. Hence, developing the protein therapeutics approach provides a needed alternative. Here, we designed a mesoporous silica nanoparticle (MSN)-mediated protein delivery approach and demonstrated effective intracellular delivery of the denatured superoxide dismutase (SOD) protein, overcoming the delivery challenges and achieving higher enzymatic activity than native SOD-conjugated MSNs. The denatured SOD-conjugated MSN delivery strategy provides benefits of reduced size and steric hindrance, increased protein flexibility without distorting its secondary structure, exposure of the cell-penetrating peptide transactivator of transcription for enhanced efficient delivery, and a change in the corona protein composition, enabling cytosolic delivery. After delivery, SOD displayed a specific activity around threefold higher than in our previous reports. Furthermore, the in vivo biosafety and therapeutic potential for neuron therapy were evaluated, demonstrating the biocompatibility and the effective antioxidant effect in Neuro-2a cells that protected neurite outgrowth from paraquat-induced reactive oxygen species attack. This study offers an opportunity to realize the druggable possibility of cytosolic proteins using MSNs. © 2022 American Chemical Society.

关键词： Peptides

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Heterojunction and co-catalyst engineering of bismuth vanadate by nickel molybdenum oxide and carbon quantum dot decorations for photoelectrochemical water splitting

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International Journal of Hydrogen Energy 2024年 51卷 1099-1108页

作者： Kuo, Tsung-Rong Chiou, Yu-Tai Huang, Hsiao-Wen Kongvarhodom, Chutima Saukani, Muhammad Yougbaré, Sibidou Chen, Hung-Ming Lin, Lu-Yin Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 Ouagadougou03 Burkina Faso Gingen technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan

Improving the charge diffusion length and water oxidation kinetics of bismuth vanadate (BiVO4) is essential to achieve better photoelectrochemical catalytic ability for water oxidation. Establishing heterojunctions and incorporating co-catalysts with BiVO4 create facile charge transfer paths and generate more water oxidation reactions. In this work, nickel molybdenum oxide (NM) and carbon quantum dot (CQD) are firstly deposited on BiVO4 by hydrothermal and soaking processes to design an efficient co-catalyst/photocatalyst system for water oxidation. The depositing amount of CQD is optimized to balance contributions of CQD and NM as the hole sink and the light-to-electron generator, respectively. The highest photocurrent densities of 2.2 and 3.9 mA/cm2 are achieved for BiVO4/NM/CQD in the electrolyte without and with hole scavenger, respectively. The BiVO4 electrode only shows a photocurrent density of 1.2 mA/cm2 in the electrolyte without hole scavenger. The best photoelectrochemical catalytic ability of BiVO4/NM/CQD is approached by the reduced charge-transfer resistance and charge recombination as well as the enhancement on carrier densities. The excellent long-term stability with the photocurrent retention of 90% under illumination for 24 h is also obtained for BiVO4/NM/CQD. This study opens a blueprint on designing efficient catalysts for water oxidation by incorporating heterojunction and co-catalyst materials simultaneously. © 2023 Hydrogen Energy Publications LLC

关键词： Heterojunctions

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Prediction of Weather Patterns Using Linear Angstrom Model

Prediction of Weather Patterns Using Linear Angstrom Model

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2022 Advances in Science and engineering Technology International Conferences, ASET 2022

作者： Aljaghoub, Haya Alashkar, Adnan Alami, Abdul Hai Tawalbeh, Muhammad University of Sharjah Department of Industrail Engineering and Engineering Management Sharjah United Arab Emirates American University of Sharjah Materials Science and Engineering PhD Program Sharjah United Arab Emirates University of Sharjah Department of Sustainable and Renewable Energy Engineering Sharjah United Arab Emirates

ISBN: (纸本)9781665418010

The paper investigates the correlation between solar irradiance and sunlit hours for the city of Sharjah, United Arab Emirates. This correlation is a strong function of the weather conditions, and is vital for the design and operation of solar energy systems. The Angstrom Model is a straightforward tool that establishes a linear relationship where the model parameters b and a (slope and y-intercept, respectively) are evaluated through plotting of experimental measurements. Wind speed and relative humidity are collected to interpret their effect on the quality of incident solar radiation. The model takes into consideration winter and summer months of the year 2021, hence it provides a complete weather pattern for the year. With continuous data logging, the model will be developed to predict the weather patterns of the city of Sharjah. © 2022 IEEE.

关键词： Solar energy

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Efficiently catalyzing photo-oxidation of water by surface engineering of bismuth vanadate with nickel molybdenum oxide coverages

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International Journal of Hydrogen Energy 2024年 51卷 613-622页

作者： Kuo, Tsung-Rong Huang, Hsiao-Wen Kongvarhodom, Chutima Saukani, Muhammad Yougbaré, Sibidou Chen, Hung-Ming Lin, Lu-Yin International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 Ouagadougou 03 Burkina Faso Gingen Technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan

Bismuth vanadate with suitable band edges is one of the efficient photocatalysts for water oxidation. Establishing heterojunction can improve electron diffusion lengths and photocatalytic ability of BiVO4. In this work, nickel molybdenum oxide (Ni–Mo–O) and BiVO4 heterojunction is established by the hydrothermal process with different nickel to molybdenum precursor ratios. The Ni–Mo–O/BiVO4 electrode is applied as photoanodes for water oxidation. The growth mechanism of Ni–Mo–O on BiVO4 surface is proposed. The Ni–Mo–O deposition amount is optimized regarding to light absorbance and charger transportation. The largest photocurrent density of 1.72 mA/cm2 at 1.23 VRHE is obtained for the optimal NiMoO4/BiVO4 electrode (NM12) in the electrolyte without hole scavenger, while the pure BiVO4 electrode only shows a photocurrent density of 0.90 mA/cm2. The NM12 electrode even presented an impressive photocurrent density of 5.39 mA/cm2 at 1.23 VRHE in the electrolyte with the hole scavenger, owing to the abundant active sites and higher light absorbance as well as the favorable synergistic effects from its suitable Ni to Mo ratio. The NM12 electrode also shows excellent long-term stability with the photocurrent retention of 83% after illumination for 6500 s. This work opens a blueprint for establishing a novel heterojunction with the adjustable metal ratio and coverage on BiVO4. © 2023 Hydrogen Energy Publications LLC

关键词： Heterojunctions

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Optimized Silicon Nitride-Based Passive Components for 850 nm OCT on Photonic Chips

Optimized Silicon Nitride-Based Passive Components for 850 n...

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2024 Laser Science, LS 2024

作者： Meng, Jiawei Hao, Senyue Adkins, Aaron J. Zhou, Weiyan Zhou, Chao Department of Biomedical Engineering Washington University in St. Louis St. LouisMO63130 United States Department of Electrical & Systems Engineering Washington University in St. Louis St. LouisMO63130 United States Imaging Science PhD Program Washington University in St. Louis St. LouisMO63130 United States

For optical coherence tomography (OCT) on photonic chips, we designed and validated optimized silicon nitride-based passive components for photonic integrated circuits. Centered at 850 nm, these components offer high ... 详细信息

关键词： Silicon nitride

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CONDUCTIVITY STUDIES IN MXENE-PVDF COMPOSITE MEMBRANES FOR PEM FUEL CELLS APPLICATIONS 50

CONDUCTIVITY STUDIES IN MXENE-PVDF COMPOSITE MEMBRANES FOR P...

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50th International Conference on Computers and Industrial engineering: Sustainable Digital Transformation, CIE 2023

作者： Shaikh, Ryan Al Al-Othman, Amani Nancarrow, Paul Tawalbeh, Muhammad Shamayleh, Abdulrahim Engineering Systems and Management PhD Program American University of Sharjah Sharjah United Arab Emirates Department of Chemical and Biological Engineering American University of Sharjah Sharjah United Arab Emirates University of Sharjah P. O. Box Sharjah27272 United Arab Emirates Department of Industrial Engineering American University of Sharjah Sharjah United Arab Emirates

ISBN: (纸本)9781713886952

Energy supply and demand are at the core of one of the pressing problems worldwide as the present energy production is still dominated by non-renewable resources. The need to meet the goals for the climate has motivated the energy sector to embrace cleaner and greener electro-energy systems. Proton exchange membrane (PEM) fuel cells, also known as polymer-electrolyte membrane fuel cells, have lately attracted more attention from various sectors due to their exceptional advantages, including high theoretical efficiency, low operating temperatures, and low-to-zero emissions. Therefore, they can be successfully used in a variety of applications. Hence, a novel membrane that possesses adequate proton conductivity is required. Therefore, in this work, MXene was investigated as a potential proton conductor. MXene/PVDF based membrane was synthesized with different concentrations 3, 5, 8, 10, 13 and 15 wt.% respectively, and evaluated for their proton conduction using electrochemical impedance spectroscopy (EIS). The values of the conductivity obtained were:3.22× x10- 3, 6.2× x10-3, 0.025, 0.041, 3.77×10-3 and 4.2 ×10-3 S/cm, respectively. The results of this study show that the synthesized membranes in this work appear to be promising for PEM fuel cells applications. © 2023 Computers and Industrial engineering. All rights reserved.

关键词： Proton conductivity

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Preparation of Graphene Aerogel for Application in Solar Energy Harvesting

Preparation of Graphene Aerogel for Application in Solar Ene...

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2022 Advances in Science and engineering Technology International Conferences, ASET 2022

作者： Alhammadi, Alya Alnaqbi, Amna Almarashda, Meera Alasad, Shamma Alashkar, Adnan Inayat, Abrar Abdelkareem, Mohammad Alami, Abdul Hai University of Sharjah Sustainable and Renewable Energy Engineering Department Sharjah United Arab Emirates American University of Sharjah Mechanical Engineering Department Sharjah United Arab Emirates American University of Sharjah Materials Science and Engineering PhD Program Sharjah United Arab Emirates

ISBN: (纸本)9781665418010

In this paper, Graphene Aerogel (GA) is prepared and investigated for its potential employment for solar energy harvesting applications. GA can be applied in solar cells applications as an absorption material and as a catalyst for fuel cells. GA is characterized by its extraordinary electrical conductivity and mechanical strength, in addition to a large surface and a low density. The electrical, mechanical, thermal, and absorption characteristics of GA can be tuned depending on the manufacturing process. Hence, GA is utilized in a multitude of applications such as: supercapacitors, air purification, oil and dye absorption from water, and water waste treatment. GA is also an excellent candidate for superior electrodes. In addition, GA are environmentally friendly materials since they are 100% recyclable and do not produce any ozone-depleting compounds. In this paper, GA is synthesized, characterized, and assessed for solar energy harvesting applications with the aid of absorption and Cyclic voltammetry (CV) tests. Results show that GA has immense potential in solar application due to its low band gap and outstanding optical and electrochemical properties. © 2022 IEEE.

关键词： Cyclic voltammetry

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MIRROR: MiRNA regulation-level differential network to study sex and ethnic disparities in cancer 46

MIRROR: MiRNA regulation-level differential network to study...

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46th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBC 2024

作者： Alfano, Caterina Filetti, Marco Farina, Lorenzo Petti, Manuela Sapienza University of Rome Dept. of Experimental Medicine Rome Italy Fondazione Policlinico Universitario A. Gemelli Irccs Phase 1 Unit Rome Italy Sapienza University of Rome Dept. of Computer Control and Management Engineering PhD Program in Network Oncology and Precision Medicine Rome Italy Sapienza University of Rome Dept. of Computer Control and Management Engineering Rome Italy

ISBN: (纸本)9798350371499

Cancer disparities are adverse differences in cancer measures that exist among certain population groups. Given that the role they play not only in the disease prognosis but also in therapy response, there is an urgent need to understand what causes them. Most studies investigate these disparities by analyzing transcriptomic data and in particular miRNAs for their regulatory role, but only focusing on expression levels. To face this challenge we propose MIRROR, a new method which analyzes a differential co-expression network of miRNAs between patients' cohorts, to study the role they play at the target genes' level. Doing so, we can study the altered molecular mechanism that are linked to cancer disparities. The application of MIRROR to two different cases of cancer disparities has demonstrated its efficacy in identifying molecular players involved in the considered disparity, presenting itself as a viable option to approach this challenge. © 2024 IEEE.

关键词： differential network modeling disparities in cancer graph theory miRNA-target association transcriptomics

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What Role Do Aggregators Play in Power System Security and Resilience?

What Role Do Aggregators Play in Power System Security and R...

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2023 Resilience Week, RWS 2023

作者： Matsuda-Dunn, Reiko Leddy, Laura Hotchkiss, Eliza Gautam, Mukesh Abdelmalak, Michael National Renewable Energy Laboratory GoldenCO80401 United States Colorado School of Mines Advanced Energy Systems PhD Program GoldenCO80401 United States University of Nevada at Reno Department of Electrical and Biomedical Engineering RenoNV89557 United States

ISBN: (纸本)9798350347470

Barriers to the participation of distributed energy resources (DERs) in wholesale electricity markets have limited the use of DERs for power system security and resilience. In September 2020, the Federal Energy Regulatory Commission (FERC) approved an order to reduce these barriers. FERC Order No. 2222 enables the participation of DER aggregators in wholesale electricity markets. DERs include renewable generation and technologies that support the integration of renewable generation by increasing grid flexibility and resilience. Requiring wholesale energy markets to allow DER aggregator participation provides a path for DERs to become competitive in these markets. As the contribution from aggregated DERs continues to increase, the aggregator's role in supporting grid security and resilience will become more critical. This paper reviews work that demonstrates how DER aggregators can provide resilience support through technical capabilities, operational strategies, and secure communication architectures. Socioeconomic influences and impacts of aggregators, including implications for social resilience, are presented. In surveying the current state-of-the-art across different but interconnected topics, we illustrate how aggregators can be power system participants that enhance grid security. There is no one-size-fits-all approach to enhancing resilience in a power grid that includes a growing cohort of DER aggregators, but there are many options for aggregators to contribute to a more resilient and secure power grid. © 2023 IEEE.

关键词： Power markets

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Stratification of metastatic melanoma patients based on mutational signatures

Stratification of metastatic melanoma patients based on muta...

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IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

作者： Caterina Alfano Lorenzo Farina Manuela Petti PhD Program in Network Oncology and Precision Medicine Sapienza University of Rome Rome Italy Dept. of Computer Control and Management Engineering PhD Program in Network Oncology and Precision Medicine Sapienza University of Rome Rome Italy Dept. of Computer Control and Management Engineering Sapienza University of Rome Rome Italy

Genetic instability is one of the hallmarks of cancer, however mutations can occur for different causes and induce different effects. Mutational signatures are characteristic patterns of somatic mutations in cancer genomes, reflecting the underlying mutational processes. A mutational signature can be determined by studying the kind of mutations a patient has acquired during their life: patient stratification based on mutational signatures has become more and more useful in genomic studies, given its possible clinical implications. In this work we focused on Single Base Substitution (SBS) signatures to study a cohort of 115 metastatic melanoma patients. We inferred and identified two mutational signatures characterizing the patients. Based on these signatures we divided patients into two group: the bigger group was characterized by a signature associated with exposure to ultraviolet light, while the smaller group resulted to be mostly composed of patients which did not respond to immunotherapy (anti-PD1) and that presented a low mutational count. More importantly this second group showed a significantly worse survival outcome. The use of mutational signatures is clearly a powerful tool to identify disease sub-types that have a clinical relevance, however we believe that this topic needs further investigation focused on the characterization of patient subtypes with a multi-omics based approach.

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