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Brain-derived neurotrophic factor in main neurodegenerative diseases

Neural Regeneration Research 2023年第3期18卷 554-555页

作者： Serena Camuso Sonia Canterini Division of Neuroscience Department of PsychologyUniversity La SapienzaRomeItaly PhD Program in Behavioral Neuroscience Sapienza University of RomeRomeItaly

Discovered in pig brains in 1982,the brain-derived neurotrophic factor(BDNF)is one of the most studied and characterized neurotrophins in the central nervous *** recent years,BDNF has received considerable attention for its importance in the development and maintenance of normal brain *** is because BDNF plays an important role in crucial functions of the nervous system,such as the survival,differentiation,and maturation of neurons and glial cells as well as the actions of neuroprotection in adverse conditions,such as glutamatergic overstimulation,cerebral ischemia,hypoglycemia,and neurotoxicity(Kowiański et al.,2018).

关键词： stimulation diseases

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Neural Correlates of Semantic Interference and Phonological Facilitation in Picture Naming: A Systematic Review and Coordinate-Based Meta-analysis

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NEUROPSYCHOLOGY REVIEW 2025年第1期35卷 35-53页

作者： [Anonymous] PhD Program in Neuroscience School of Medicine and Surgery University of Milano-Bicocca Monza Italy Department of Psychology University of Milano-Bicocca Milan Italy Center for Mind/Brain Sciences (CIMeC) Neurocognitive Rehabilitation Center (CeRiN) University of Trento Rovereto Italy

Semantic interference (SI) and phonological facilitation (PF) effects occur when multiple representations are co-activated simultaneously in complex naming paradigms, manipulating the context in which word production is set. Although the behavioral consequences of these psycholinguistic effects are well-known, the involved brain structures are still controversial. This paper aims to provide a systematic review and a coordinate-based meta-analysis of the available functional neuroimaging studies investigating SI and PF in picture naming paradigms. The included studies were fMRI experiments on healthy subjects, employing paradigms in which co-activations of representations were obtained by manipulating the naming context using semantically or phonologically related items. We examined the principal methodological aspects of the included studies, emphasizing the existing commonalities and discrepancies across single investigations. We then performed an exploratory coordinate-based meta-analysis of the reported activation peaks of neural response related to SI and PF. Our results consolidated previous findings regarding the involvement of the left inferior frontal gyrus and the left middle temporal gyrus in SI and brought out the role of bilateral inferior parietal regions in PF.

关键词： Picture naming Semantic interference Phonological facilitation Meta-analysis fMRI

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Estudiar interacciones sociobiológicas para comprender las disparidades regionales en salud mental

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Revista Colombiana de Psiquiatría 2023年第3期52卷 171-172页

作者： Hernando Santamaría-García Director Doctorado de Neurociencias Pontifica Universidad Javeriana de Colombia PhD Program of Neuroscience

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All for one, one for all: Compassionate goal orientation, social support, and work engagement

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International Journal of Applied Positive Psychology 2024年第1期9卷 45-67页

作者： Etzel, Lena McGonagle, Alyssa K. Roos, Lydia G. Mooney, Jan T. Health Psychology PhD Program University of North Carolina at Charlotte 9201 University City Boulevard Charlotte 28223-0001 NC United States Department of Psychological Science University of North Carolina at Charlotte 9201 University City Boulevard Charlotte 28223-0001 NC United States Organizational Science PhD Program University of North Carolina at Charlotte Charlotte NC United States Laboratory for Stress Assessment and Research Semel Institute for Neuroscience and Human Behavior Department of Psychiatry and Biobehavioral Sciences University of California 760 Westwood Plaza Los Angeles 90024 CA United States

Though social support plays a critical role in worker well-being and engagement, its mechanisms of action for motivating work engagement remain unclear. Further, literature to date has primarily examined internally-focused personal resources (e.g., confidence, optimism) as a consequence and predictor of job resources such as perceived social support, yet relationally-focused personal resources (e.g., orientation toward others) may have greater relevance in this social context. Extrapolating from associations posited within an expanded job demands-resources model and the egosystem-ecosystem theory of social motivation, this study used a random-intercepts cross-lagged panel model to examine whether a compassionate goal orientation, a novel personal resource, may be a mechanism through which social support at work facilitates work engagement. Using three waves of survey data from 850 working U.S. adults, we demonstrated a reciprocal relationship between a compassionate goal orientation and perceived co-worker support, providing initial evidence for the importance of interpersonal goal orientation in fostering workplace support among colleagues. Yet, we did not find support for a reciprocal relationship between co-worker or supervisor support and work engagement. Our study provides preliminary evidence supporting the importance of a compassionate goal orientation. Insights gained through this work represent a valuable contribution toward a better understanding of factors that promote effective collaboration in the workplace in service of shared organizational goals. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. corrected publication 2023.

关键词： Co-worker support Compassionate goal orientation RI-CLPM Supervisor support Work engagement

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Mood-congruent negative thinking styles and cognitive vulnerability in depressed COVID-19 survivors: A comparison with major depressive disorder

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JOURNAL OF AFFECTIVE DISORDERS 2022年第0期308卷 554-561页

作者： Benedetti, Francesco Palladini, Mariagrazia 'Orsi, Greta Furlan, Roberto Ciceri, Fabio Rovere-Querini, Patrizia Mazza, Mario Gennaro Study, The COVID- BioB Outpatient Clinic group Univ Vita Salute San Raffaele Milan Italy IRCCS Sci Inst Osped San Raffaele Div Neuroscience Psychiat Clin Psychobiol Milan Italy IRCCS San Raffaele Sci Inst Div Immunol Transplantat & Infect Dis Milan Italy IRCCS Sci Inst Osped San Raffaele Div Neuroscience Clin Neuroimmunol Milan Italy Univ Vita Salute San Raffaele PhD Program Cognit Neuroscience Milan Italy

Background: COVID-19 is associated with depressive psychopathology in survivors. Negative thinking styles are a core feature of major depression, fostering the experience of negative emotions and affects and hampering recovery. This cognitive vulnerability has been observed in medical conditions associated with depression, but never explored in post-COVID depression. Methods: We studied 729 participants: 362 COVID-19 survivors, 73 inpatients with Major Depressive Disorder (MDD), and 294 healthy participants (HC). Severity of depression was self-rated on the Zung Self-Rating Depression Scale (ZSDS). Neuropsychological bias toward negative emotional stimuli and the negative outlook on the self were tested in a self-description task, yielding latencies and frequencies of attribution of morally tuned elements. Dimensions of negative thinking and depressive cognitive style in evaluation of hypothetical events were measured on the Cognition Questionnaire (CQ). Results: 22.4% COVID survivors self-rated depression above the clinical threshold. Frequencies and latencies of attribution of morally negative elements, and CQ scores, correlated between themselves and predicted ZSDS scores, with post-COVID depressed patients showing intermediate scores between the more severe MDD patients, and non-depressed post-COVID participants and HC. Limitations: Recruitment was in a single center, thus raising the possibility of population stratification. Conclusions: The breadth of self-reproach and depressive cognitive style in evaluating events showed the same association with severity of depression in MDD and in post-COVID depressed patients, distributing along a gradient of severity, thus suggesting that individual features of negative thinking styles are shared in these conditions, and should be addressed as treatment targets in depressed COVID-19 survivors.

关键词： COVID Depression Cognition Neuropsychology Bias Distortion

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On the role of RNA binding proteins in polyglutamine diseases:from pathogenesis to therapeutics

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Neural Regeneration Research 2023年第12期18卷 2695-2696页

作者： AndréConceição Rebekah Koppenol Clévio Nóbrega Algarve Biomedical Center Research Institute(ABC-RI) FaroPortugalFaculdade de Medicina e Ciências BiomédicasUniversidade do AlgarveFaroPortugal PhD Program in Biomedical Sciences Faculdade de Medicina e Ciências BiomédicasUniversidade do AlgarveFaroPortugalCenter for Neuroscience and Cell BiologyUniversity of CoimbraPortugal

Polyglutamine(polyQ) diseases are a group of different neurodegenerative disorders characterized by an abnormal expansion of the trinucleotide cytosine-adenine-guanine(CAG)within coding regions of each disease-associa... 详细信息

关键词： diseases pathogenesis translate

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Circadian rhythm disruption and retinal dysfunction:a bidirectional link in Alzheimer’s disease?

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Neural Regeneration Research 2024年第9期19卷 1967-1972页

作者： Laura Carrero DesireéAntequera Cristina Municio Eva Carro Group of Neurodegenerative Diseases Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpainNetwork Center for Biomedical Research in Neurodegenerative Diseases(CIBERNED)ISCIIIMadridSpain PhD Program in Neuroscience Autonoma de Madrid UniversityMadridSpain Neurobiology of Alzheimer’s Disease Unit Functional Unit for Research into Chronic DiseasesInstituto de Salud Carlos IIIMadridSpainNetwork Centre for Biomedical Research in Neurodegenerative Diseases(CIBERNED)ISCIIIMadridSpain

Dysfunction in circadian rhythms is a common occurrence in patients with Alzheimer’s disease.A predominant function of the retina is circadian synchronization,carrying information to the brain through the retinohypothalamic tract,which projects to the suprachiasmatic ***,Alzheimer’s disease hallmarks,including amyloid-β,are present in the retinas of Alzheimer’s disease patients,followed/associated by structural and functional ***,the mechanistic link between circadian dysfunction and the pathological changes affecting the retina in Alzheimer’s disease is not fully understood,although some studies point to the possibility that retinal dysfunction could be considered an early pathological process that directly modulates the circadian rhythm.

关键词： Alzheimer’s disease amyloid circadian rhythm neurodegeneration retina

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Potential protective role of ACE-inhibitors and AT1 receptor blockers against levodopa-induced dyskinesias:a retrospective case-control study

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Neural Regeneration Research 2021年第12期16卷 2475-2478页

作者： Elena Contaldi Luca Magistrelli Anna VMilner Marco Cosentino Franca Marino Cristoforo Comi Movement Disorders Centre Neurology UnitDepartment of Translational MedicineUniversity of Piemonte OrientaleNovaraItaly PhD Program in Medical Sciences and Biotechnology University of Piemonte OrientaleNovaraItaly PhD Program in Clinical and Experimental Medicine and Medical Humanities University of InsubriaVareseItaly Center of Research in Medical Pharmacology University of InsubriaVareseItaly Center for Research in Neuroscience University of InsubriaVareseItaly

Growing evidence has highlighted that angiotensin-converting enzyme(ACE)-inhibitors(ACEi)/AT1 receptor blockers(ARBs)may influence the complex interplay between dopamine and the renin-angiotensin system in the nigrostriatal pathway,thus affecting the development of levodopa-induced dyskinesia in Parkinson’s disease(PD).In the present study,we analyzed whether the use of this class of medication was associated with a reduced occurrence of levodopa-induced dyskinesia,using electronically-stored information of idiopathic PD patients enrolled at Novara University Hospital“Maggiore della Carità”.We conducted a retrospective case-control study identifying PD patients with dyskinesias(PwD;n=47)as *** each PwD we selected a non-dyskinetic control(NoD),nearly perfectly matched according to sex,Unified Parkinson’s Disease Rating Scale(UPDRS)part III score,and duration of antiparkinsonian *** logistic regression was used to evaluate whether dyskinesias were associated with ACEi/ARBs ***-four PD patients were included,aged 72.18±9 years,with an average disease duration of 10.20±4.8 years and 9.04±4.9 years of antiparkinsonian *** mean UPDRS part III score was 18.87±7.6 and the median HY stage was *** the NoD group,25(53.2%)were users and 22(46.8%)non-users of ACEi/***,in the PwD group,11(23.4%)were users and 36 non-users(76.6%)of this drug class(Pearson chi-square=8.824,P=0.003).Concerning general medication,there were no other statistically significant differences between *** controlling for tremor dominant phenotype,levodopa equivalent daily dose,HY 3-4,and disease duration,ACEi/ARBs use was a significant predictor of a lower occurrence of dyskinesia(OR=0.226,95%CI:0.080-0.636,P=0.005).Therefore,our study suggests that ACEi/ARBs may reduce levodopa-induced dyskinesia occurrence and,thanks to good tolerability and easy management,represent a feasible choice when dealing with the treatment of hypertension in PD patients.

关键词： angiotensin-converting enzyme inhibitors AT1 receptor blockers dyskinesias hypertension levodopa motor complications neuroinflammation Parkinson’s disease renin-angiotensin system

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The Reading the Mind in the Eyes Test, Iowa Gambling Task and Interpersonal Reactivity Index: Normative Data in an Italian Population Sample (Jan, acab100, 2022)

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ARCHIVES OF CLINICAL NEUROPSYCHOLOGY 2022年第6期37卷 1229-1229页

作者： Maddaluno, Ottavia Aiello, Edoardo Nicolo Roncoroni, Camilla Prunas, Antonio Bolognini, Nadia Department of Psychology University of Milano-Bicocca Milano Italy Department of Psychology University of Milano-Bicocca Milano Italy Department of Psychology Sapienza University of Rome Rome Italy PhD Program in Neuroscience School of Medicine and Surgery University of Milano-Bicocca Monza Italy Neuropsychological Laboratory IRCCS Istituto Auxologico Italiano Milano Italy

OBJECTIVE: Social cognition and executive deficits are frequent in neurological and neuropsychiatric disorders. Yet, there is a paucity of standardized domain-specific psychometric tools for the assessment of complex decision-making, social cognition (i.e., Theory of Mind), and empathy. To this aim, this study intended at providing normative data in an Italian population sample for the Iowa Gambling Task, the Reading the Mind in the Eyes Test, and the Interpersonal Reactivity Index. METHOD: The Iowa Gambling Task, the Reading the Mind in the Eyes Test, and the Interpersonal Reactivity Index were administered to 462 healthy Italian participants aged between 18 and 91 years, considering demographic factors. A confirmatory factor analysis was run to test for unidimensionality. Normative values were derived by means of the Equivalent Scores method. RESULTS: Education predicted all tests' scores, age influenced scores at the Interpersonal Reactivity Index and the Reading the Mind in the Eyes Test, gender predicted empathic abilities only. The three tests did not underpin a unidimensional structure. CONCLUSIONS: The present work provides demographically adjusted Italian normative data for a set of tests assessing real-life decision-making, emotion recognition and empathy, filling a gap within II-level, domain-specific, neuropsychological testing. For the first time, the Interpersonal Reactivity Index is proposed as an adjuvant neuropsychological tool, while the standardization of the Iowa Gambling Task offers a new scoring system for advantageous/disadvantageous choices.

关键词： Assessment Dementia Executive functions Norms/normative studies Statistical methods

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Transparent neural interfaces:challenges and solutions of microengineered multimodal implants designed to measure intact neuronal populations using high-resolution electrophysiology and microscopy simultaneously

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Microsystems & Nanoengineering 2023年第3期9卷 1-30页

作者： Z.Fekete A.Zátonyi A.Kaszás M.Madarász A.Slézia Research Group for Implantable Microsystems Faculty of Information Technology&BionicsPázmány Péter Catholic UniversityBudapestHungary Institute of Cognitive Neuroscience&Psychology Eotvos Lorand Research NetworkBudapestHungary Mines Saint-Etienne Centre CMPDépartement BELF-13541 GardanneFrance Institut de Neurosciences de la Timone CNRS UMR 7289&Aix-Marseille Université13005 MarseilleFrance János Szentágothai PhD Program of Semmelweis University BudapestHungary BrainVision Center BudapestHungary

The aim of this review is to present a comprehensive overview of the feasibility of using transparent neural interfaces in multimodal in vivo experiments on the central nervous *** electrophysiological and neuroimaging approaches hold great potential for revealing the anatomical and functional connectivity of neuronal ensembles in the intact *** approaches are less time-consuming and require fewer experimental animals as researchers obtain denser,complex data during the combined *** devices that provide high-resolution,artifactfree neural recordings while facilitating the interrogation or stimulation of underlying anatomical features is currently one of the greatest challenges in the field of *** are numerous articles highlighting the trade-offs between the design and development of transparent neural interfaces;however,a comprehensive overview of the efforts in material science and technology has not been *** present work fills this gap in knowledge by introducing the latest micro-and nanoengineered solutions for fabricating substrate and conductive ***,the limitations and improvements in electrical,optical,and mechanical properties,the stability and longevity of the integrated features,and biocompatibility during in vivo use are discussed.

关键词： modal resolution transparent

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