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Mood-congruent negative thinking styles and cognitive vulnerability in depressed COVID-19 survivors: A comparison with major depressive disorder

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JOURNAL OF AFFECTIVE DISORDERS 2022年第0期308卷 554-561页

作者： Benedetti, Francesco Palladini, Mariagrazia 'Orsi, Greta Furlan, Roberto Ciceri, Fabio Rovere-Querini, Patrizia Mazza, Mario Gennaro Study, The COVID- BioB Outpatient Clinic group Univ Vita Salute San Raffaele Milan Italy IRCCS Sci Inst Osped San Raffaele Div Neuroscience Psychiat Clin Psychobiol Milan Italy IRCCS San Raffaele Sci Inst Div Immunol Transplantat & Infect Dis Milan Italy IRCCS Sci Inst Osped San Raffaele Div Neuroscience Clin Neuroimmunol Milan Italy Univ Vita Salute San Raffaele PhD Program Cognit Neuroscience Milan Italy

Background: COVID-19 is associated with depressive psychopathology in survivors. Negative thinking styles are a core feature of major depression, fostering the experience of negative emotions and affects and hampering recovery. This cognitive vulnerability has been observed in medical conditions associated with depression, but never explored in post-COVID depression. Methods: We studied 729 participants: 362 COVID-19 survivors, 73 inpatients with Major Depressive Disorder (MDD), and 294 healthy participants (HC). Severity of depression was self-rated on the Zung Self-Rating Depression Scale (ZSDS). Neuropsychological bias toward negative emotional stimuli and the negative outlook on the self were tested in a self-description task, yielding latencies and frequencies of attribution of morally tuned elements. Dimensions of negative thinking and depressive cognitive style in evaluation of hypothetical events were measured on the Cognition Questionnaire (CQ). Results: 22.4% COVID survivors self-rated depression above the clinical threshold. Frequencies and latencies of attribution of morally negative elements, and CQ scores, correlated between themselves and predicted ZSDS scores, with post-COVID depressed patients showing intermediate scores between the more severe MDD patients, and non-depressed post-COVID participants and HC. Limitations: Recruitment was in a single center, thus raising the possibility of population stratification. Conclusions: The breadth of self-reproach and depressive cognitive style in evaluating events showed the same association with severity of depression in MDD and in post-COVID depressed patients, distributing along a gradient of severity, thus suggesting that individual features of negative thinking styles are shared in these conditions, and should be addressed as treatment targets in depressed COVID-19 survivors.

关键词： COVID Depression Cognition Neuropsychology Bias Distortion

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Apolipoprotein E genotypes and amyloid burden associated with cognitive decline in non-demented Parkinson's disease patients: A preliminary analysis

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Journal of the Neurological Sciences 2025年 473卷 123510-123510页

作者： Trompeta, Clara Gasca-Salas, Carmen Rodríguez-Rojas, Rafael Fernández-Rodríguez, Beatriz Clarimón, Jordi García-Cañamaque, Lina Guida, Pasqualina Hernández-Fernández, Frida Sánchez-Juan, Pascual Olazarán, Javier Vela-Desojo, Lydia HM CINAC (Centro Integral de Neurociencias Abarca Campal) Hospital Universitario HM Puerta del Sur HM Hospitales Madrid Spain Instituto de Investigación Sanitaria HM Hospitales Spain PhD Program in Health Sciences University of Alcala de Henares Alcala de Henares Spain University CEU-San Pablo Madrid Spain Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED) Instituto Carlos III Madrid Spain Department of Neurology Hospital Regional Universitario de Málaga Málaga Spain H. Lundbeck A/S Valby Denmark Nuclear Medicine Department Hospital Universitario HM Puerta del Sur HM Hospitales Madrid Spain PhD Program in Neuroscience Autonoma de Madrid University-Cajal Institute Madrid Spain Department of Nursing and Nutrition Faculty of Biomedical and Health Sciences Universidad Europea de Madrid Madrid Spain Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII Madrid 28031 Spain Hospital General Universitario Gregorio Marañón Madrid Spain Hospital Universitario Fundación Alcorcón Alcorcón Spain

Background: Cognitive impairment is a common non-motor manifestation in Parkinson's disease (PD). Amyloidosis seems to accelerate the onset of dementia in PD. The Apolipoprotein (APOE) ε4 genotype is linked to amyloid aggregation and has been suggested to be a candidate for development of PD dementia, while other APOE alleles have been less investigated. Methods: Forty-eight non-demented PD patients were included (ε2/ε3 carriers: n = 8;ε3/ε3 carriers: n = 35;and ε3/ε4 carriers: n = 5). Patients underwent APOE genotyping, a neuropsychological exam and a [18F]-Flutemetamol PET. Statistical Parametric Mapping 12 was used to analyze regional amyloid differences by APOE genotypes. Cognitive assessment was re-administered after follow-up. Results: APOE ε3/ε4 carriers showed significant amyloid load in left middle occipital areas in comparison with APOE ε3/ε3, whereas APOE ε3/ε4 exhibited several areas of amyloid accumulation in comparison with APOE ε2/ε3 that disappeared after family-wise error cluster level correction, but which hold in nonparametric analyses. No amyloid load differences were found between APOE ε2/ε3 and APOE ε3/ε3. The frequency of progression of cognitive decline was 80 % in ε3/ε4, 50 % in ε2/ε3, and 22.86 % in ε3/ε3 carriers. Conclusions: This compared regional amyloid deposition and cognitive evolution among APOE genotypes. Our preliminary findings suggest an association between APOE ε4 and amyloid burden in posterior cortical areas in non-demented PD and a tendency to a higher frequency of cognitive decline. Larger studies should explore cognition and amyloid burden in APOE ε2 carriers. © 2025 Elsevier B.V.

关键词： Amyloid Apolipoprotein Cognition Follow-up Parkinson's disease Positron emission tomography

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Estudiar interacciones sociobiológicas para comprender las disparidades regionales en salud mental

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Revista Colombiana de Psiquiatría 2023年第3期52卷 171-172页

作者： Hernando Santamaría-García Director Doctorado de Neurociencias Pontifica Universidad Javeriana de Colombia PhD Program of Neuroscience

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srp54 promotes motor neuron development and is required for motility in zebrafish

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neuroscience 2025年 579卷 24-34页

作者： Nikaela Losievski Pooja Kamath Ashley Fox Natalie M Aloi Megan C Baird Amy Everest Thomas L Gallagher Sharon L Amacher Stephen J Kolb Department of Neurology The Ohio State University Wexner Medical Center Columbus OH USA Neuroscience Graduate Program The Ohio State University Columbus OH USA. Department of Neurology The Ohio State University Wexner Medical Center Columbus OH USA. Department of Biological Chemistry & Pharmacology The Ohio State University Wexner Medical Center Columbus OH USA. English Department PhD Program in Writing Rhetoric and Literacy The Ohio State University Columbus OH USA. Department of Molecular Genetics The Ohio State University Columbus OH USA. Department of Molecular Genetics The Ohio State University Columbus OH USA Center for RNA Biology The Ohio State University Columbus OH USA. Department of Biological Chemistry & Pharmacology The Ohio State University Wexner Medical Center Columbus OH USA Center for RNA Biology The Ohio State University Columbus OH USA Center for Muscle Health and Neuromuscular Disorders The Ohio State University and Nationwide Children's Hospital Columbus OH USA. Center for Muscle Health and Neuromuscular Disorders The Ohio State University and Nationwide Children's Hospital Columbus OH USA. Electronic address: Stephen.Kolb@osumc.edu.

The signal recognition particle (SRP) is a highly conserved ribonucleoprotein (RNP) that translocates a subset of secreted and integral membrane proteins to the endoplasmic reticulum for proper localization. The most conserved SRP protein component, SRP54, has been implicated in the molecular etiology of spinal muscular atrophy (SMA). A key feature of SMA is the selective loss of motor neurons; however, the mechanism underlying this selectivity is unknown. SMA arises from deficient levels of the ubiquitously expressed Survival of Motor Neuron (SMN) protein. SMN is proposed to assemble the SRP, and SMN deficiency in SMA may attenuate SRP function and contribute to motor neuron death in patients. Using zebrafish embryos homozygous for a srp54 nonsense mutation (srp54), we investigated the requirement of Srp54 protein in motor axon development. The first grossly distinguishable phenotype observed in srp54 embryos was reduced motility at 30 h postfertilization (hpf). Additionally, we detected reduced length and branching of caudal primary motor axons in srp54 embryos compared to srp54 and srp54 siblings at 30 hpf, suggesting that defective motor neurons may contribute to the observed immotility. We also examined additional neural, secretory, and migratory cell types at 30 hpf to assess whether motor neurons are especially vulnerable to Srp54 deficiency. Of the cell types evaluated, only the hatching gland had distinct expression pattern alterations in srp54 embryos at this developmental stage. Our findings suggest that Srp54 deficiency results in motor neuron developmental defects and support the hypothesis that SRP54 may influence motor neuron selectivity in SMA.

关键词： Central nervous system Hatching gland Neurodevelopment Signal recognition particle Spinal muscular atrophy

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The Reading the Mind in the Eyes Test, Iowa Gambling Task and Interpersonal Reactivity Index: Normative Data in an Italian Population Sample (Jan, acab100, 2022)

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ARCHIVES OF CLINICAL NEUROPSYCHOLOGY 2022年第6期37卷 1229-1229页

作者： Maddaluno, Ottavia Aiello, Edoardo Nicolo Roncoroni, Camilla Prunas, Antonio Bolognini, Nadia Department of Psychology University of Milano-Bicocca Milano Italy Department of Psychology University of Milano-Bicocca Milano Italy Department of Psychology Sapienza University of Rome Rome Italy PhD Program in Neuroscience School of Medicine and Surgery University of Milano-Bicocca Monza Italy Neuropsychological Laboratory IRCCS Istituto Auxologico Italiano Milano Italy

OBJECTIVE: Social cognition and executive deficits are frequent in neurological and neuropsychiatric disorders. Yet, there is a paucity of standardized domain-specific psychometric tools for the assessment of complex decision-making, social cognition (i.e., Theory of Mind), and empathy. To this aim, this study intended at providing normative data in an Italian population sample for the Iowa Gambling Task, the Reading the Mind in the Eyes Test, and the Interpersonal Reactivity Index. METHOD: The Iowa Gambling Task, the Reading the Mind in the Eyes Test, and the Interpersonal Reactivity Index were administered to 462 healthy Italian participants aged between 18 and 91 years, considering demographic factors. A confirmatory factor analysis was run to test for unidimensionality. Normative values were derived by means of the Equivalent Scores method. RESULTS: Education predicted all tests' scores, age influenced scores at the Interpersonal Reactivity Index and the Reading the Mind in the Eyes Test, gender predicted empathic abilities only. The three tests did not underpin a unidimensional structure. CONCLUSIONS: The present work provides demographically adjusted Italian normative data for a set of tests assessing real-life decision-making, emotion recognition and empathy, filling a gap within II-level, domain-specific, neuropsychological testing. For the first time, the Interpersonal Reactivity Index is proposed as an adjuvant neuropsychological tool, while the standardization of the Iowa Gambling Task offers a new scoring system for advantageous/disadvantageous choices.

关键词： Assessment Dementia Executive functions Norms/normative studies Statistical methods

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Therapeutic termination of pregnancy and women’s mental health:Determinants and consequences

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World Journal of Psychiatry 2021年第11期11卷 937-953页

作者： Ester di Giacomo Rodolfo Pessina Mario Santorelli Daniele Rucco Valeria Placenti Francesca Aliberti Fabrizia Colmegna Massimo Clerici School of Medicine and Surgery University Milan BicoccaMonza 20900LombardyItaly Department of Psychiatric ASST MonzaMonza 20900LombardyItaly Psychiatric Residency Training Program University Milan BicoccaMonza 20900LombardyItaly PhD Program in Psychology Linguistics and Cognitive NeuroscienceUniversity Milan BicoccaMilano 20126LombardyItaly Psychiatric Residency Training Program University of GenovaGenova 16126LiguriaItaly

The therapeutic termination of pregnancy(TToP)is an induced abortion following a diagnosis of medical *** is applied to avoid the risk of substantial harm to the mother or in cases of fetal *** type of induced abortion is provided after the second semester of gestation if fetal illness or the pregnancy cause physical danger or pathological mental distress to the *** and economic determinants could influence the desire for children and family planning in couples,as well as the use of effective contraception and the choice to perform an induced ***,pre-existing mental health problems could affect the decision between carrying on a problematic pregnancy or having ***,the TToP is a reproductive event with an important traumatic burden,but also with an intrinsic therapeutic effect and it can produce different psychological and psychopathological effects on women and *** aim of this review is to evaluate what demographic,reproductive and psychopathological determinants are involved in the choice of undergoing a TToP in ***,we will examine both positive and negative consequences of this procedure on women’s mental health,underlying which factors are related to a worse outcome in order to provide the best clinical support to vulnerable groups.

关键词： Therapeutic abortion Women’s health Depression PostTraumatic stress disorder Perinatal care Psychiatry

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Differences in bipolar disorder type I and type II exposed to childhood trauma: A retrospective cohort study

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Journal of Affective Disorders Reports 2025年 19卷 100869-100869页

作者： Guillen-Burgos, Hernán F Gálvez-Flórez, Juan F Moreno-Lopez, Sergio Kwan, Angela T.H. Gomez, Oscar González-Haddad, Gerardo McIntyre, Roger S. Universidad Simon Bolivar Centro de Investigaciones en Ciencias de la Vida Center for Clinical and Translational Research Barranquilla Colombia Faculty of Medicine Center for Clinical and Translational Research Universidad El Bosque Bogotá D.C. Colombia Department of Psychiatry and Mental Health PhD Program of Neuroscience Hospital Universitario San Ignacio Pontificia Universidad Javeriana Bogotá D.C. Colombia School of Medicine Universidad de Los Andes Bogotá D.C. Colombia Faculty of Medicine University of Ottawa Ottawa K1H 8L1 ON Canada Division of Alcohol Drugs and Addiction McLean Hospital Harvard Medical School Boston MA United States Department of Psychiatry University of Toronto Toronto M5T 1R8 ON Canada

Background: Childhood trauma (CT) exposure is associated with a more pernicious course in bipolar disorder (BD). However, few studies have reported differences between BD I and BD II regarding CT exposure. We explore the differences in the CT trajectories in bipolar disorders. Methods: A retrospective cohort study of individuals with BD (BD I = 73 vs BD II = 73) was carried out. Early age at onset (EAO) and suicide ideation/behavior were used as severity outcomes. Timespan between EAO and treatment was documented and the associations between CT and comorbid alcohol used disorder (AUD), anxiety disorders (AD), and post-traumatic stress disorder (PTSD) were also described. Univariate, bivariate analyses, and a Poisson regression model with bootstrap resampling were used. Results: Higher scores of CT, physical abuse (PA), and sexual abuse (SA) were statistically significant for BD II than BD I (p < 0.001, p = 0.048, p < 0.001, respectively). Early age at onset, suicide ideation/behavior and treatment delay were associated with CT in both BD I and BD II. However, AUD and PTSD showed association with CT only for BD I. Limitations: Sample size, non-comparison control group, and recall bias. Conclusions: There are differences in CT subtype exposure between BD I and BD II with regards to early age onset, suicide ideation/behavior, delayed time to treatment, and comorbid mental disorders. These results claim for early access to strategies such as CT exposure screening in individuals with BD to detect possible pernicious course and improve the quality of life and clinical outcomes. © 2024

关键词： Bipolar disorder Childhood trauma Early age onset Mental comorbidities Suicide ideation/behavior Treatment delay

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On the role of RNA binding proteins in polyglutamine diseases:from pathogenesis to therapeutics

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Neural Regeneration Research 2023年第12期18卷 2695-2696页

作者： AndréConceição Rebekah Koppenol Clévio Nóbrega Algarve Biomedical Center Research Institute(ABC-RI) FaroPortugalFaculdade de Medicina e Ciências BiomédicasUniversidade do AlgarveFaroPortugal PhD Program in Biomedical Sciences Faculdade de Medicina e Ciências BiomédicasUniversidade do AlgarveFaroPortugalCenter for Neuroscience and Cell BiologyUniversity of CoimbraPortugal

Polyglutamine(polyQ) diseases are a group of different neurodegenerative disorders characterized by an abnormal expansion of the trinucleotide cytosine-adenine-guanine(CAG)within coding regions of each disease-associa... 详细信息

关键词： diseases pathogenesis translate

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Emerging roles of microglia cells in the regulation of adult neural stem cells

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Neuroimmunology and Neuroinflammation 2016年第1期3卷 204-206页

作者： Eduardo Lira-Diaz Oscar Gonzalez-Perez Laboratory of Neuroscience School of PsychologyUniversity of ColimaColima 28040Mexico Medical Sciences PhD Program School of MedicineUniversity of ColimaColima 28040Mexico

MICROGLIA CELLS Microglia cells are antigen presenting cells with myeloid origin that constituted approximately 10%of all glial cells of the adult mouse brain.^([1])In the early embryo,the microglial precursors are located in the yolk sac and progressively migrate throughout the primitive brain.^([2])In the adult brain,some of microglial cells derive from the bone marrow,but this process only takes place when the brain is lesioned.^([1])Microglial cells can display 4 morphological and functional stages:(1)resting microglia;(2)active microglia;(3)phagocytic microglia;and(4)senescent microglia.

关键词： neural migrate adult

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Major Depressive Disorder in Long COVID and Exposure to Pro-Inflammatory Cytokines During Infection by SARS-CoV-2

Psychiatric Research and Clinical Practice

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Psychiatric Research and Clinical Practice 2025年第0期

作者： Guillen-Burgos, Hernan F. Gálvez-Flórez, Juan F. Moreno-López, Sergio Wong, Sabrina Kwan, Angela T. H. Ramirez-Posada, Mariana Anaya, Juan-Manuel McIntyre, Roger S. Centro de Investigaciones en Ciencias de la Vida Universidad Simón Bolívar Center for Clinical and Translational Research Barranquilla Colombia Faculty of Medicine Universidad El Bosque Center for Clinical and Translational Research Bogotá Colombia Department of Psychiatry and Mental Health Pontificia Universidad Javeriana PhD Program in Neuroscience Hospital Universitario San Ignacio Bogota Colombia Universidad El Bosque Bogotá Colombia Zerenia Clinic. Consultation - Liaison Psychiatric Unit Bogotá Colombia Faculty of Medicine Universidad de Los Andes Bogotá Colombia Mood Disorders Psychopharmacology Unit University Health Network Toronto ON Canada Department of Pharmacology and Toxicology University of Toronto Toronto ON Canada Brain and Cognition Discovery Foundation Toronto ON Canada Faculty of Medicine University of Ottawa Ottawa ON Canada Coosalud IPS Research and Innovation Center and Universidad de la Costa Barranquilla Colombia Department of Psychiatry and Pharmacology University of Toronto Toronto ON Canada

Objective: Major Depressive Disorder (MDD) is common in long COVID syndrome;however, the neurobiological mechanisms are unclear. An immune activation response has been associated with COVID-19 severity as well as in MDD. We hypothesize that high levels of pro-inflammatory cytokines during SARS-CoV-2 infection may be associated with new-onset MDD and severe outcomes such as treatment-resistant depression (TRD) and risk of suicide ideation and behavior (SI/SB). Methods: A case-control nested to a cohort study was carried out on a total of 678 COVID-19 survivors (MDD = 184 vs. non-MDD = 494). A pro-inflammatory panel of serum levels of cytokines (IL-1β, IL-4, IL-6, IL-8, IL-13, IL-17α, TNF-α) was evaluated during COVID-19 hospitalization and severe outcomes such as TRD and SI/SB were assessed in individuals with new onset of MDD after hospital discharge compared to non-MDD COVID-19 survivors. Results: High levels of pro-inflammatory cytokines during SARS-CoV-2 infection were identified in MDD participants compared to non-MDD subgroups during long COVID. These differences were sustained also for TRD and SI/SB severity outcomes. There is a mild association of high levels of pro-inflammatory cytokines and MDD, TRD, and SI/SB. Conclusion: High levels of pro-inflammatory cytokines during severe or critical COVID-19 exposure may explain long COVID associated MDD and thus severe outcomes such as TRD and SI/SB. Relevance to clinical practice: Identifying elevated pro-inflammatory cytokines during COVID-19 as a risk factor for MDD and severe outcomes underscores the need for early screening and targeted treatments in long COVID. Monitoring cytokine levels may help clinicians predict and manage TRD and SI/SB in this population, improving long-term psychiatric outcomes. © 2025 The Author(s). Psychiatric Research and Clinical Practice published by Wiley Periodicals LLC on behalf of American Psychiatric Association.

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