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Emotional Dysregulation in ADHD: Preliminary Insights into Internalizing Symptoms, Parental Factors, and Embodiment

neuroscience Applied 2025年 4卷

作者： Z.S. Albayrak M. Ballı T. Mutluer G. Kahraman Ş. Eray Çamlı H. Aslan Genç H. Yapıcı Eser Koç University Hospital Child and Adolescent Psychiatry İstanbul Türkiye GSHS- Koç University Neuroscience PhD Program İstanbul Türkiye Uludağ University Child and Adolescent Psychiatry Bursa Türkiye Koç University Hospital Psychiatry İstanbul Türkiye

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Potential protective role of ACE-inhibitors and AT1 receptor blockers against levodopa-induced dyskinesias:a retrospective case-control study

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Neural Regeneration Research 2021年第12期16卷 2475-2478页

作者： Elena Contaldi Luca Magistrelli Anna VMilner Marco Cosentino Franca Marino Cristoforo Comi Movement Disorders Centre Neurology UnitDepartment of Translational MedicineUniversity of Piemonte OrientaleNovaraItaly PhD Program in Medical Sciences and Biotechnology University of Piemonte OrientaleNovaraItaly PhD Program in Clinical and Experimental Medicine and Medical Humanities University of InsubriaVareseItaly Center of Research in Medical Pharmacology University of InsubriaVareseItaly Center for Research in Neuroscience University of InsubriaVareseItaly

Growing evidence has highlighted that angiotensin-converting enzyme(ACE)-inhibitors(ACEi)/AT1 receptor blockers(ARBs)may influence the complex interplay between dopamine and the renin-angiotensin system in the nigrostriatal pathway,thus affecting the development of levodopa-induced dyskinesia in Parkinson’s disease(PD).In the present study,we analyzed whether the use of this class of medication was associated with a reduced occurrence of levodopa-induced dyskinesia,using electronically-stored information of idiopathic PD patients enrolled at Novara University Hospital“Maggiore della Carità”.We conducted a retrospective case-control study identifying PD patients with dyskinesias(PwD;n=47)as *** each PwD we selected a non-dyskinetic control(NoD),nearly perfectly matched according to sex,Unified Parkinson’s Disease Rating Scale(UPDRS)part III score,and duration of antiparkinsonian *** logistic regression was used to evaluate whether dyskinesias were associated with ACEi/ARBs ***-four PD patients were included,aged 72.18±9 years,with an average disease duration of 10.20±4.8 years and 9.04±4.9 years of antiparkinsonian *** mean UPDRS part III score was 18.87±7.6 and the median HY stage was *** the NoD group,25(53.2%)were users and 22(46.8%)non-users of ACEi/***,in the PwD group,11(23.4%)were users and 36 non-users(76.6%)of this drug class(Pearson chi-square=8.824,P=0.003).Concerning general medication,there were no other statistically significant differences between *** controlling for tremor dominant phenotype,levodopa equivalent daily dose,HY 3-4,and disease duration,ACEi/ARBs use was a significant predictor of a lower occurrence of dyskinesia(OR=0.226,95%CI:0.080-0.636,P=0.005).Therefore,our study suggests that ACEi/ARBs may reduce levodopa-induced dyskinesia occurrence and,thanks to good tolerability and easy management,represent a feasible choice when dealing with the treatment of hypertension in PD patients.

关键词： angiotensin-converting enzyme inhibitors AT1 receptor blockers dyskinesias hypertension levodopa motor complications neuroinflammation Parkinson’s disease renin-angiotensin system

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Multi-site investigation of gut microbiota in CDKL5 deficiency disorder mouse models: Targeting dysbiosis to improve neurological outcomes

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Cell Reports 2025年第4期44卷 115546页

作者： Damiani, Francesca Giuliano, Maria Grazia Cornuti, Sara Putignano, Elena Tognozzi, Andrea Suckow, Vanessa Kalscheuer, Vera M. Pizzorusso, Tommaso Tognini, Paola Laboratory of Biology BIO@SNS Scuola Normale Superiore Piazza dei Cavalieri 7 Pisa 56126 Italy Health Science Interdisciplinary Center Sant'Anna School of Advanced Studies Piazza Martiri della Libertà 33 Pisa 56127 Italy Institute of Neuroscience National Research Council Via G. Moruzzi 1 Pisa 56124 Italy PhD Program in Clinical and Translational Science University of Pisa Via Savi 10 Pisa 56126 Italy Max Planck Institute for Molecular Genetics Ihnestraße 63 Berlin 14195 Germany

Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a rare neurodevelopmental disorder often associated with gastrointestinal (GI) issues and subclinical immune dysregulation, suggesting a link to the gut microbiota. We analyze the fecal microbiota composition in two CDKL5 knockout (KO) mouse models at postnatal days (P) 25, 32 (youth), and 70 (adulthood), revealing significant microbial imbalances, particularly during juvenile stages. To investigate the role of the intestinal microbiota in CDD and assess causality, we administer antibiotics, which lead to improved visual cortical responses and reduce hyperactivity. Additionally, microglia morphology changes, indicative of altered surveillance and activation states, are reversed. Strikingly, fecal transplantation from CDKL5 KO to wild-type (WT) recipient mice successfully transfers both visual response deficits and hyperactive behavior. These findings show that gut microbiota alterations contribute to the severity of neurological symptoms in CDD, shedding light on the interplay between microbiota, microglia, and neurodevelopmental outcomes. © 2025

关键词： antibiotics CDKL5 CP: Microbiology CP: neuroscience dysbiosis fecal transplantation gut microbiota gut-brain axis microglia neurodevelopmental disorder

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“Transcranial Direct Current Stimulation and Dual-Task activity in Parkinson's disease" -A pilot study-

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Parkinsonism & Related Disorders 2025年 134卷 107566-107566页

作者： P. Antoniotti E. Arrigoni G. Gilardone M. Ranzani L. Chiveri M. Filareti F. Pesce E. Judica M. Ranieri L. Veronelli M. Feligioni M. Corbo A. Pisoni L. Pantoni Department of Neurorehabilitation Sciences Casa di Cura IGEA via Dezza 48 20144 Milano Italy PhD program in Neuroscience School of Medicine and Surgery University of Milano-Bicocca Via Cadore 48 20900 Monza Italy Department of Psychology University of Milano-Bicocca Piazza dell’Ateneo Nuovo 1 20126 Milano Italy

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Exploring genes that control microglial heterogeneity and transition

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Neural Regeneration Research 2021年第12期16卷 2397-2398页

作者： Tomomi Okajima Fuminori Tsuruta Graduate School of Life and Environmental Sciences University of TsukubaTsukubaIbarakiJapan Master’s and Doctoral Programs in Biology Faculty of Life and Environmental SciencesUniversity of TsukubaTsukubaIbarakiJapan Master’s and Doctoral Program in Neuroscience Graduate School of Comprehensive Human SciencesUniversity of TsukubaTsukubaIbarakiJapan PhD Program in Human Biology School of Integrative and Global MajorsUniversity of TsukubaTsukubaIbarakiJapan PhD Program in Humanics School of Integrative and Global MajorsUniversity of TsukubaTsukubaIbarakiJapan

Microglia,which comprise approximately 10%of total cells in the brain,are the resident immune cells in the central nervous system and contribute to maintaining the brain homeostasis through monitoring their microenvironment(Kettenmann et al.,2011).Recent studies have reported that microglia also regulate neural circuit formation after *** functional transition in microglia has been considered to correlate with their morphological changes over time.

关键词： al. homeostasis transition

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Mood-congruent negative thinking styles and cognitive vulnerability in depressed COVID-19 survivors: A comparison with major depressive disorder

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JOURNAL OF AFFECTIVE DISORDERS 2022年第0期308卷 554-561页

作者： Benedetti, Francesco Palladini, Mariagrazia 'Orsi, Greta Furlan, Roberto Ciceri, Fabio Rovere-Querini, Patrizia Mazza, Mario Gennaro Study, The COVID- BioB Outpatient Clinic group Univ Vita Salute San Raffaele Milan Italy IRCCS Sci Inst Osped San Raffaele Div Neuroscience Psychiat Clin Psychobiol Milan Italy IRCCS San Raffaele Sci Inst Div Immunol Transplantat & Infect Dis Milan Italy IRCCS Sci Inst Osped San Raffaele Div Neuroscience Clin Neuroimmunol Milan Italy Univ Vita Salute San Raffaele PhD Program Cognit Neuroscience Milan Italy

Background: COVID-19 is associated with depressive psychopathology in survivors. Negative thinking styles are a core feature of major depression, fostering the experience of negative emotions and affects and hampering recovery. This cognitive vulnerability has been observed in medical conditions associated with depression, but never explored in post-COVID depression. Methods: We studied 729 participants: 362 COVID-19 survivors, 73 inpatients with Major Depressive Disorder (MDD), and 294 healthy participants (HC). Severity of depression was self-rated on the Zung Self-Rating Depression Scale (ZSDS). Neuropsychological bias toward negative emotional stimuli and the negative outlook on the self were tested in a self-description task, yielding latencies and frequencies of attribution of morally tuned elements. Dimensions of negative thinking and depressive cognitive style in evaluation of hypothetical events were measured on the Cognition Questionnaire (CQ). Results: 22.4% COVID survivors self-rated depression above the clinical threshold. Frequencies and latencies of attribution of morally negative elements, and CQ scores, correlated between themselves and predicted ZSDS scores, with post-COVID depressed patients showing intermediate scores between the more severe MDD patients, and non-depressed post-COVID participants and HC. Limitations: Recruitment was in a single center, thus raising the possibility of population stratification. Conclusions: The breadth of self-reproach and depressive cognitive style in evaluating events showed the same association with severity of depression in MDD and in post-COVID depressed patients, distributing along a gradient of severity, thus suggesting that individual features of negative thinking styles are shared in these conditions, and should be addressed as treatment targets in depressed COVID-19 survivors.

关键词： COVID Depression Cognition Neuropsychology Bias Distortion

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Apolipoprotein E genotypes and amyloid burden associated with cognitive decline in non-demented Parkinson's disease patients: A preliminary analysis

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Journal of the Neurological Sciences 2025年 473卷 123510-123510页

作者： Trompeta, Clara Gasca-Salas, Carmen Rodríguez-Rojas, Rafael Fernández-Rodríguez, Beatriz Clarimón, Jordi García-Cañamaque, Lina Guida, Pasqualina Hernández-Fernández, Frida Sánchez-Juan, Pascual Olazarán, Javier Vela-Desojo, Lydia HM CINAC (Centro Integral de Neurociencias Abarca Campal) Hospital Universitario HM Puerta del Sur HM Hospitales Madrid Spain Instituto de Investigación Sanitaria HM Hospitales Spain PhD Program in Health Sciences University of Alcala de Henares Alcala de Henares Spain University CEU-San Pablo Madrid Spain Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED) Instituto Carlos III Madrid Spain Department of Neurology Hospital Regional Universitario de Málaga Málaga Spain H. Lundbeck A/S Valby Denmark Nuclear Medicine Department Hospital Universitario HM Puerta del Sur HM Hospitales Madrid Spain PhD Program in Neuroscience Autonoma de Madrid University-Cajal Institute Madrid Spain Department of Nursing and Nutrition Faculty of Biomedical and Health Sciences Universidad Europea de Madrid Madrid Spain Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII Madrid 28031 Spain Hospital General Universitario Gregorio Marañón Madrid Spain Hospital Universitario Fundación Alcorcón Alcorcón Spain

Background: Cognitive impairment is a common non-motor manifestation in Parkinson's disease (PD). Amyloidosis seems to accelerate the onset of dementia in PD. The Apolipoprotein (APOE) ε4 genotype is linked to amyloid aggregation and has been suggested to be a candidate for development of PD dementia, while other APOE alleles have been less investigated. Methods: Forty-eight non-demented PD patients were included (ε2/ε3 carriers: n = 8;ε3/ε3 carriers: n = 35;and ε3/ε4 carriers: n = 5). Patients underwent APOE genotyping, a neuropsychological exam and a [18F]-Flutemetamol PET. Statistical Parametric Mapping 12 was used to analyze regional amyloid differences by APOE genotypes. Cognitive assessment was re-administered after follow-up. Results: APOE ε3/ε4 carriers showed significant amyloid load in left middle occipital areas in comparison with APOE ε3/ε3, whereas APOE ε3/ε4 exhibited several areas of amyloid accumulation in comparison with APOE ε2/ε3 that disappeared after family-wise error cluster level correction, but which hold in nonparametric analyses. No amyloid load differences were found between APOE ε2/ε3 and APOE ε3/ε3. The frequency of progression of cognitive decline was 80 % in ε3/ε4, 50 % in ε2/ε3, and 22.86 % in ε3/ε3 carriers. Conclusions: This compared regional amyloid deposition and cognitive evolution among APOE genotypes. Our preliminary findings suggest an association between APOE ε4 and amyloid burden in posterior cortical areas in non-demented PD and a tendency to a higher frequency of cognitive decline. Larger studies should explore cognition and amyloid burden in APOE ε2 carriers. © 2025 Elsevier B.V.

关键词： Amyloid Apolipoprotein Cognition Follow-up Parkinson's disease Positron emission tomography

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Estudiar interacciones sociobiológicas para comprender las disparidades regionales en salud mental

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Revista Colombiana de Psiquiatría 2023年第3期52卷 171-172页

作者： Hernando Santamaría-García Director Doctorado de Neurociencias Pontifica Universidad Javeriana de Colombia PhD Program of Neuroscience

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Hericium erinaceus extracts promote neuronal differentiation and excitability through nootropic metabolite activity

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Biomedicine & Pharmacotherapy 2025年 188卷 118204-118204页

作者： Brandalise, Federico Priori, Erica Cecilia Giammello, Francesca Venuti, MariaTeresa Ratto, Daniela Goppa, Lorenzo Locatelli, Carlo Alessandro Savino, Elena Roda, Elisa Rossi, Paola Department of Biomedical Sciences Division of Neuroscience and Clinical Pharmacology University of Cagliari Cittadella Universitaria di Monserrato Monserrato 09042 Italy Department of Biology and Biotechnology “L. Spallanzani” University of Pavia Pavia 27100 Italy PhD Program in Genetics Molecular and Cellular Biology University of Pavia Italy Department of Earth and Environmental Sciences (DSTA) University of Pavia Pavia 27100 Italy PhD Program in Earth and Environmental Sciences University of Pavia Italy Laboratory of Clinical & Experimental Toxicology Pavia Poison Centre National Toxicology Information Centre Toxicology Unit Istituti Clinici Scientifici Maugeri IRCCS Pavia Pavia 27100 Italy

AbstractThis study investigates the effects of a blend of Hericium erinaceus (lion's mane mushroom) extract on the differentiation of SH-SY5Y cells, a human neuroblastoma cell line, revealing potential therapeutic implications for neuroblastoma management. Treatment with this blend induced cells differentiation towards a neuron-like profile, as evidenced by enhanced neuronal excitability and upregulation of neuronal markers, such as βIII-tubulin and synaptotagmin. Additionally, the treatment significantly reduced PCNA, a key regulator of proliferation, alongside a decrease in stemness markers, indicating a shift toward a more mature and less proliferative phenotype. These findings demonstrate the ability of Hericium erinaceus to promote neuronal differentiation and inhibit proliferation in neuroblastoma cells, highlighting its therapeutic potential for managing neuroblastoma and potentially other neurological disorders. The results suggest that Hericium erinaceus may serve as a promising candidate for the development of novel neuroregenerative therapies.

关键词： TPA 12-O tetradecanoylphorbol-13-acetate He Hericium erinaceus MTT assay 3 4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide assay Cm Membrane capacitance Rm Membrane resistance Vm Resting membrane potential TTX Tetrodotoxin VGSC Voltage-gated sodium channel I-V plots Current-voltage plots SNARE Soluble N-ethylmaleimide-sensitive factor Attachment protein REceptor PCNA Proliferating Cell Nuclear Antigen Neuroblastoma SH-SY5Y Hericium erinaceus Neuronal differentiation Patch clamp Voltage-gated sodium currents Cell proliferation Action potential Erinacines Hericenones Voltage-Gated Sodium Channel

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The Reading the Mind in the Eyes Test, Iowa Gambling Task and Interpersonal Reactivity Index: Normative Data in an Italian Population Sample (Jan, acab100, 2022)

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ARCHIVES OF CLINICAL NEUROPSYCHOLOGY 2022年第6期37卷 1229-1229页

作者： Maddaluno, Ottavia Aiello, Edoardo Nicolo Roncoroni, Camilla Prunas, Antonio Bolognini, Nadia Department of Psychology University of Milano-Bicocca Milano Italy Department of Psychology University of Milano-Bicocca Milano Italy Department of Psychology Sapienza University of Rome Rome Italy PhD Program in Neuroscience School of Medicine and Surgery University of Milano-Bicocca Monza Italy Neuropsychological Laboratory IRCCS Istituto Auxologico Italiano Milano Italy

OBJECTIVE: Social cognition and executive deficits are frequent in neurological and neuropsychiatric disorders. Yet, there is a paucity of standardized domain-specific psychometric tools for the assessment of complex decision-making, social cognition (i.e., Theory of Mind), and empathy. To this aim, this study intended at providing normative data in an Italian population sample for the Iowa Gambling Task, the Reading the Mind in the Eyes Test, and the Interpersonal Reactivity Index. METHOD: The Iowa Gambling Task, the Reading the Mind in the Eyes Test, and the Interpersonal Reactivity Index were administered to 462 healthy Italian participants aged between 18 and 91 years, considering demographic factors. A confirmatory factor analysis was run to test for unidimensionality. Normative values were derived by means of the Equivalent Scores method. RESULTS: Education predicted all tests' scores, age influenced scores at the Interpersonal Reactivity Index and the Reading the Mind in the Eyes Test, gender predicted empathic abilities only. The three tests did not underpin a unidimensional structure. CONCLUSIONS: The present work provides demographically adjusted Italian normative data for a set of tests assessing real-life decision-making, emotion recognition and empathy, filling a gap within II-level, domain-specific, neuropsychological testing. For the first time, the Interpersonal Reactivity Index is proposed as an adjuvant neuropsychological tool, while the standardization of the Iowa Gambling Task offers a new scoring system for advantageous/disadvantageous choices.

关键词： Assessment Dementia Executive functions Norms/normative studies Statistical methods

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