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Ludwigia octovalvis (Jacq.) P.H. Raven extract improves memory performance in mice with chronic kidney disease

Phytomedicine Plus 2024年第2期4卷 100556-100556页

作者： Wang, Hao-Wei Huang, Yi-Hsuan Tung, Hsiao-Jou Lin, Wei-Sheng Chiu, Hao-Chieh Lin, Shuei-Liong Fan, Shou-Zen Wang, Pei-Yu Hsieh Yu Enterprise Co. Ltd. Taipei Taiwan Graduate Institute of Brain and Mind Sciences College of Medicine National Taiwan University Taipei Taiwan Department of Pediatrics Taipei Veterans General Hospital Taipei Taiwan Department of Clinical Laboratory Sciences and Medical Biotechnology College of Medicine National Taiwan University Taipei Taiwan Graduate Institute of Physiology College of Medicine National Taiwan University Taipei Taiwan Department of Anesthesiology National Taiwan University Hospital National Taiwan University Taipei Taiwan Department of Anesthesiology En Chu Kong Hospital Taipei Taiwan Neurobiology and Cognitive Science Center National Taiwan University Taipei Taiwan PhD. Program in Translational Medicine National Taiwan University and Academia Sinica Taipei Taiwan PhD. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan

Background: Chronic kidney disease (CKD) is a significant global health concern often accompanied by cognitive impairment in affected patients. Ludwigia octovalvis extract (LOE) is a traditional medicine widely used for various conditions, including renal disease and its associated complications. However, the pharmacological effects and underlying mechanisms of LOE on CKD remain unclear. Methods: Adult male mice underwent a 4-week oral adenine-induced CKD model, followed by daily administration of either a vehicle, losartan, or LOE for 1 to 2 months. A battery of behavioral tests was conducted to examine CKD-associated cognitive impairments. Additionally, RNA sequencing, Golgi staining, and immunohistochemistry were performed to decipher the underlying mechanisms. Results: Neither losartan nor LOE supplementation could reverse adenine-induced kidney damage. However, during behavioral tests, both losartan and LOE treatments improved memory performance in mice without affecting emotional status and general locomotor activity. Transcriptome profiling and histological analyses revealed altered dendritic arborization and increased spine density of dentate granule cells, along with augmented adult hippocampal neurogenesis, contributing to the improved memory performance of mice treated with LOE. Conclusion: Our study provides comprehensive neurobehavioral and molecular evidence supporting the potential use of LOE for future CKD-associated memory dysfunction treatment. © 2024 The Author(s)

关键词： Adenine Cognitive dysfunction Neurogenesis

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Emotional Dysregulation in ADHD: Preliminary Insights into Internalizing Symptoms, Parental Factors, and Embodiment

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neuroscience Applied 2025年 4卷

作者： Z.S. Albayrak M. Ballı T. Mutluer G. Kahraman Ş. Eray Çamlı H. Aslan Genç H. Yapıcı Eser Koç University Hospital Child and Adolescent Psychiatry İstanbul Türkiye GSHS- Koç University Neuroscience PhD Program İstanbul Türkiye Uludağ University Child and Adolescent Psychiatry Bursa Türkiye Koç University Hospital Psychiatry İstanbul Türkiye

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Different subjective experiences of the environment are associated to different fluoxetine treatment outcomes

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neuroscience Applied 2022年 1卷

作者： C. Delli Colli S. Poggini G. Matte Bon N. Ciano Albanese E. Castrén I. Branchi Istituto Superiore di Sanità Center for Behavioral Sciences and Mental Health Roma Italy Sapienza University of Rome PhD program in Behavioral Neuroscience Roma Italy Neuroscience Center University of Helsinki Helsinki Finland

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Correction: All for one, one for all: Compassionate goal orientation, social support, and work engagement

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International Journal of Applied Positive Psychology 2023年第1期9卷 69-69页

作者： Etzel, Lena McGonagle, Alyssa K. Roos, Lydia G. Mooney, Jan T. Health Psychology PhD Program University of North Carolina at Charlotte Charlotte USA Department of Psychological Science University of North Carolina at Charlotte Charlotte USA Organizational Science PhD Program University of North Carolina at Charlotte Charlotte USA Laboratory for Stress Assessment and Research Semel Institute for Neuroscience and Human Behavior Department of Psychiatry and Biobehavioral Sciences University of California Los Angeles USA

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Correction to: The Montreal Cognitive Assessment (MoCA): updated norms and psychometric insights into adaptive testing from healthy individuals in Northern Italy

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Aging clinical and experimental research 2023年第11期35卷 2857-2859页

作者： Edoardo Nicolò Aiello Chiara Gramegna Antonella Esposito Valentina Gazzaniga Stefano Zago Teresa Difonzo Ottavia Maddaluno Ildebrando Appollonio Nadia Bolognini School of Medicine and Surgery University of Milano-Bicocca Monza Italy. e.aiello5@campus.unimib.it. PhD Program in Neuroscience University of Milano-Bicocca Monza Italy. e.aiello5@campus.unimib.it. Department of Psychology University of Milano-Bicocca Milan Italy. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico University of Milan Milan Italy. Milan Center for Neuroscience (NeuroMI) Milan Italy. Department of Psychology Sapienza University of Rome Rome Italy. School of Medicine and Surgery University of Milano-Bicocca Monza Italy. Neurology Section School of Medicine and Surgery University of Milano-Bicocca Monza Italy. Neuropsychological Laboratory IRCCS Istituto Auxologico Italiano Milan Italy.

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Multi-site investigation of gut microbiota in CDKL5 deficiency disorder mouse models: Targeting dysbiosis to improve neurological outcomes

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Cell Reports 2025年第4期44卷 115546页

作者： Damiani, Francesca Giuliano, Maria Grazia Cornuti, Sara Putignano, Elena Tognozzi, Andrea Suckow, Vanessa Kalscheuer, Vera M. Pizzorusso, Tommaso Tognini, Paola Laboratory of Biology BIO@SNS Scuola Normale Superiore Piazza dei Cavalieri 7 Pisa 56126 Italy Health Science Interdisciplinary Center Sant'Anna School of Advanced Studies Piazza Martiri della Libertà 33 Pisa 56127 Italy Institute of Neuroscience National Research Council Via G. Moruzzi 1 Pisa 56124 Italy PhD Program in Clinical and Translational Science University of Pisa Via Savi 10 Pisa 56126 Italy Max Planck Institute for Molecular Genetics Ihnestraße 63 Berlin 14195 Germany

Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a rare neurodevelopmental disorder often associated with gastrointestinal (GI) issues and subclinical immune dysregulation, suggesting a link to the gut microbiota. We analyze the fecal microbiota composition in two CDKL5 knockout (KO) mouse models at postnatal days (P) 25, 32 (youth), and 70 (adulthood), revealing significant microbial imbalances, particularly during juvenile stages. To investigate the role of the intestinal microbiota in CDD and assess causality, we administer antibiotics, which lead to improved visual cortical responses and reduce hyperactivity. Additionally, microglia morphology changes, indicative of altered surveillance and activation states, are reversed. Strikingly, fecal transplantation from CDKL5 KO to wild-type (WT) recipient mice successfully transfers both visual response deficits and hyperactive behavior. These findings show that gut microbiota alterations contribute to the severity of neurological symptoms in CDD, shedding light on the interplay between microbiota, microglia, and neurodevelopmental outcomes. © 2025

关键词： antibiotics CDKL5 CP: Microbiology CP: neuroscience dysbiosis fecal transplantation gut microbiota gut-brain axis microglia neurodevelopmental disorder

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06O NLRP3 inflammasome activation and altered mitophagy are key pathways in inclusion body myositis

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Neuromuscular Disorders 2024年 43卷 104441.10-104441.10页

作者： Naddaf, E. Nguyen, T. Watzlawik, J. Gao, H. Hou, X. Fiesel, F. Mandrekar, J. Kokesh, E. Harmsen, W. Lanza, I. Springer, W. Trushina, E. Department of Neurology Mayo Clinic Rochester USA Department of Neuroscience Mayo Clinic Jacksonville USA Department of Molecular Pharmacology and Experimental Therapeutics Mayo Clinic Rochester USA Neuroscience PhD Program Mayo Clinic Graduate School of Biomedical Sciences Jacksonville USA Department of Quantitative Health Sciences Mayo Clinic Rochester USA Division of Endocrinology and Metabolism Mayo Clinic Rochester USA

Inclusion body myositis (IBM) is the most prevalent muscle disease in adults for which no current treatment exists. The pathogenesis of IBM remains poorly defined. Inflammation and mitochondrial dysfunction are the most common histopathological findings. In this study, we aimed to explore the interplay between inflammation and mitochondrial dysfunction in IBM patients. We included 38 IBM patients and 22 age- and sex-matched controls without myopathy. Bulk RNA sequencing, Meso Scale Discovery ELISA, western blotting, histochemistry and immunohistochemistry were performed on frozen muscle samples from the study participants. We demonstrated activation of the NLRP3 inflammasome in IBM muscle samples, with the NLRP3 inflammasome pathway being the most upregulated pathway. On muscle histopathology, there was increased NRLP3 immunoreactivity in both inflammatory cells and muscle fibers. Mitophagy is critical for removing damaged mitochondria and preventing the formation of a vicious cycle of mitochondrial dysfunction—NLRP3 activation. In the IBM muscle samples, we showed altered mitophagy with elevated levels of p-S65-Ubiquitin, a mitophagy marker. Furthermore, p-S65-Ubiquitin aggregates accumulated in muscle fibers that were mostly type 2 and devoid of cytochrome-c-oxidase reactivity. Type 2 muscle fibers are known to be more prone to mitochondrial dysfunction. NLRP3 RNA levels correlated with p-S65-Ubiquitin levels. NLRP3 inflammasome is activated in IBM, along with altered mitophagy, potentially forming a self-sustaining vicious cycle. These findings could have potential therapeutic significance.

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Autonomic Dysfunction in REM Sleep Disorder: The Role of Respiration in HRV Analysis*

Autonomic Dysfunction in REM Sleep Disorder: The Role of Res...

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

作者： Parisa Sattar Nicla Mandas Giulia Baldazzi Elisa Facchini Elisa Casaglia Michela Figorilli Laura Giorgetti Pietro Mattioli Francesco Calizzano Francesco Fama Dario Arnaldi Monica Puligheddu Danilo Pani Pablo Laguna Raquel Bailon Department of Biomedical Sciences Neuroscience PhD Program University of Cagliari Cagliari Italy Department of Electrical and Electronic Engineering MeDSP Lab University of Cagliari Cagliari Italy The Hadron Academy Istituto Universitario di Studi Superiori IUSS Pavia Italy Interdepartmental Sleep Disorder Research Center University of Cagliari Cagliari Italy SC Neurology AziendaOspedaliero-Universitaria Cagliari Italy Department of Neuroscience Rehabilitation Ophthalmology Genetics Maternal and Child Health (DINOGMI) Clinical Neurology University of Genoa Genoa Italy Neurophysiopathology Unit IRCCS Ospedale Policlinico San Martino Genoa Italy Biomedical Signal Interpretation and Computational Simulation (BSICoS) Aragón Institute for Engineering Research (I3A) IIS Aragón University of Zaragoza Spain Zaragoza Spain Centro de Investigacion Biomedica en Red en Bioingeniería Biomateriales y Nanomedicina (CIBER-BBN) Madrid Spain

ISBN: (数字)9798350371499

ISBN: (纸本)9798350371505

Autonomic nervous system (ANS) has been suggested often associated with the isolated rapid eye movement (REM) sleep behavior disorder (iRBD), with iRBD, and heart rate variability (HRV) is a commonly used tool to assess it. However, the accuracy of HRV is heavily influenced by respiratory rate (RespR), potentially causing misinterpretation of frequency domain HRV indices. This study compares sleep-related ANS function between iRBD patients and a control group (CG) using respiratory-adjusted HRV spectral analysis. It involves 20 iRBD and 20 CG participants in each group, from which five-minute ECG signal epochs during N2, N3, and REM sleep phases are analyzed. RespR were estimated from ECG-derived respiratory signals. Both low and high frequency bands definition for HRV analysis were redefined using the RespR. The results indicate significant differences in HRV parameters between iRBD and CG subjects during REM sleep, highlighting disrupted autonomic regulation in iRBD. This finding is also evident in non-REM phases, thus emphasizing the need to incorporate RespR in HRV analysis, especially in sleep-related studies, for a comprehensive understanding of autonomic dysfunction.

关键词： Phase modulation Frequency-domain analysis Electrocardiography Regulation Rapid eye movement sleep High frequency Heart rate variability Engineering in medicine and biology Spectral analysis Parasympathetic nervous system

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The need for complexity models in psychiatry: enactive approaches are knocking on the door of traditional psychiatry

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Revista Colombiana de psiquiatria (English ed.) 2023年第4期52卷 269页

作者： Hernando Santamaría-García Director Doctorado de Neurociencias Pontifica Universidad Javeriana de Colombia PhD Program of Neuroscience Editor general de la Revista Colombiana de Psiquiatría. Electronic address: hernando.santamaria@javeriana.edu.c.

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Simulations Approaching Data: Cortical Slow Waves in Inferred Models of the Whole Hemisphere of Mouse

arXiv

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arXiv 2021年

作者： Capone, Cristiano De Luca, Chiara De Bonis, Giulia Gutzen, Robin Bernava, Irene Pastorelli, Elena Simula, Francesco Lupo, Cosimo Tonielli, Leonardo Resta, Francesco Mascaro, Anna Letizia Allegra Pavone, Francesco Denker, Michael Paolucci, Pier Stanislao INFN Sezione di Roma Italy European Laboratory for Non-Linear Spectroscopy Sesto Fiorentino Italy Neuroscience Institute National Research Council Pisa Italy University of Florence Physics and Astronomy Department Sesto Fiorentino Italy Jülich Research Centre Jülich Germany Theoretical Systems Neurobiology RWTH Aachen University Aachen Germany PhD Program in Behavioural Neuroscience "Sapienza" University of Rome Italy

The development of novel techniques to record wide-field brain activity enables estimation of data-driven models from thousands of recording channels and hence across large regions of cortex. These in turn improve our understanding of the modulation of brain states and the richness of traveling waves dynamics. Here, we infer data-driven models from high-resolution in-vivo recordings of mouse brain obtained from wide-field calcium imaging. We then assimilate experimental and simulated data through the characterization of the spatio-temporal features of cortical waves in experimental recordings. Inference is built in two steps: an inner loop that optimizes a mean-field model by likelihood maximization, and an outer loop that optimizes a periodic neuro-modulation via direct comparison of observables that characterize cortical slow waves. The model reproduces most of the features of the non-stationary and non-linear dynamics present in the high-resolution in-vivo recordings of the mouse brain. The proposed approach offers new methods of characterizing and understanding cortical waves for experimental and computational neuroscientists. Copyright © 2021, The Authors. All rights reserved.

关键词： Brain

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