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International Conference on Management of Emergent Digital EcoSystems, MEDES 2012

作者： Mesfin, Woldmariam F Ghinea, Gheorghita Atnafu, Solomon IT PhD Program Addis Ababa University Ethiopia School of Information Systems Computing and Mathematics Brunel University United Kingdom School of Computer Science Addis Ababa University Ethiopia

ISBN: (纸本)9781450317559

Previous studies concerned with mobile financial services for the poor have been narrowly conceived, mainly depending on secondary data and focusing on technical design issues without having fully understood individuals' complex relationships and money practices. In order to contribute to this knowledge gap and inform mobile money system design, an exploratory case study investigated social relationships and social payment practices among rural individuals in Ethiopia. Key findings regarding their money exchange practices include: (1) secrecy and disclosure of money exchange practices (2) acceptance and or rejection of money gift for some reasons, (3) personalize money giving and accepting practices, and finally (4) separating and labeling of money based on its purpose and source. A qualitative exploratory research approach with key informant focus group discussions served as the primary means of information gathering. Copyright © 2012 ACM.

关键词： Ecosystems

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Knowledge contribution in social media: Exploring factors influencing social taggers' acceptance towards contributing and sharing tags

Knowledge contribution in social media: Exploring factors in...

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6th International Conference on Information Systems, Management and Technology, ICISTM 2012

作者： Allam, Hesham Blustein, James Bliemel, Michael Spiteri, Louise Interdisciplinary PhD Program Dalhousie University Halifax NS Canada Faculty of Computer Science School of Information Management Dalhousie University Halifax NS Canada School of Business Administration Dalhousie University Halifax NS Canada School of Information Mangement Dalhousie University Halifax NS Canada

ISBN: (纸本)9783642291654

Based on a thorough literature review of social tagging and on technology acceptance models, we developed and empirically validated a motivational model to predict users' acceptance to add and share tagging content. Four factors successfully predicted users' intention to add and share metadata tagging content. Unlike previous studies on virtual communities, Reciprocity was found to be positively related to attitude whereas, in line with previous research, Ease of Use and Personal Productivity were confirmed to have substantial influence on users' attitude, which in turn affects the intention towards creating and sharing tagging content. Our findings are expected to shed light on developing strategies to understand and promote tagging content contribution and sharing which have the potential to increase the collective power and intelligence of the community. © 2012 Springer-Verlag.

关键词： Social networking (online)

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Predictive modelling of stem cell differentiation and apoptosis in C. elegans

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9th International Conference on Information Processing in Cells and Tissues, IPCAT 2012

作者： Beyer, Antje Eberhard, Ralf Piterman, Nir Hengartner, Michael O. Hajnal, Alex Fisher, Jasmin Department of Genetics University of Cambridge Cambridge United Kingdom Institute of Molecular Life Sciences University of Zurich Zurich Switzerland PhD Program in Molecular Life Sciences Life Science Zurich Graduate School University of Zurich Zurich Switzerland Department of Computer Science University of Leicester Leicester United Kingdom Microsoft Research Cambridge United Kingdom

ISBN: (纸本)9783642287916

The nematode Caenorhabditis elegans has been established as a modeling organism in biomedical research for several decades. Its hermaphrodite germ line encompasses key developmental concepts like stem cell differentiation and apoptosis;therefore it provides a good model system for these basic concepts. Here, we have extended and refined our previous computational model, which encompasses developmental landmarks and the resulting movement of germ cells along the gonadal tube. We have used the molecular dynamics (MD) framework to model the physical movement of cells due to the force arising from cell divisions. The model simulation was calibrated with experimental time and it is in accordance with experimental observations. In addition, the model provides means for testing hypotheses regarding the behaviour of mutated germ lines and the potential mechanisms causing physiological apoptosis, which are difficult to assess experimentally. © 2012 Springer-Verlag.

关键词： Molecular dynamics

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A narrative game as an educational entertainment resource to teach words to children with learning deficits: A feasibility study

A narrative game as an educational entertainment resource to...

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10th International Conference on Entertainment Computing, ICEC 2011

作者： Silva, Marcos Alexandre Rose De Lima, Débora Corrêa Anacleto, Junia Coutinho De Souza, Deisy Das Graças Martinez, Claudia Maria Simões Phd Program on Computer Science Federal University of São Carlos Brazil Phd Program on Special Education Federal University of São Carlos Brazil Department of Computer Science Federal University of São Carlos Brazil Department of Psycologist Federal University of São Carlos Brazil Department of Occupational Therapy Federal University of São Carlos Brazil

ISBN: (纸本)9783642244995

We describe the use of an entertainment computer narrative game to teach words to a child in a special education process. In order to observe the potential of this kind of game, we chosen a child who has difficult to learn some words using a basic computer tool at writing learning special education environment. The results showed that narrative games and its entertainment resources can be a good way to allow child reads and writes words considering different sentences and contexts, as well as, resources of the game can be a useful strategy to engage child on the storytelling. © 2011 Springer-Verlag.

关键词： computer games

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Design Management Review 2014年第3期25卷

作者： John Maeda Steven Heller Tim Hoover Has been a design partner at Kleiner Perkins Caufield & Byers since January 2014 helping entrepreneurs and portfolio companies to build design into their company cultures. He served as the president of Rhode Island School of Design for six years through 2013 and also served as an associate director of research at the MIT Media Lab. Maeda has been a practicing designer since 1990 and his work is in the permanent collections of the Museum of Modern Art San Francisco Museum of Modern Art and the Cartier Foundation. He serves on the boards of several corporations including Sonos and Wieden + Kennedy and is chair of eBay's Design Advisory Board. His four published books include The Laws of Simplicity and Redesigning Leadership. Maeda is the recipient of a variety of international awards for his creative work including induction into the Art Director's Club Hall of Fame. In 2001 he received the White House National Design Award in 2002 he received the Mainichi Design Prize in Japan and in 2005 he was awarded the Raymond Loewy Foundation Prize in Germany. Maeda earned a BS and an MS from MIT in computer science and electrical engineering. He received a PhD in design science from the University of Tsukuba Institute of Art and Design in Japan as well as an MBA from Arizona State University. Co‐chair and co‐founder of the MFA Designer as Author and Entrepreneur program at the School of Visual Arts in New York. He was the art director of The New York Times Book Review and now writes the VISUALS column for the NYTBR. He also writes “The Daily Heller” at *** a weekly online design column for Atlantic magazine. He is author co‐author and editor of more than 165 books on the history and practice of graphic design illustration and satiric art. His forthcoming books include 100 Classic Graphic Design Magazines (Laurence King Publishers) and Raw Data: The Process Behind Information Graphics (Thames + Hudson). Heller was the 2011 recipient of the Smithsonian National Design Award for Design Mind. He has also writ

John Maeda is a past president of Rhode Island School of Design and an internationally known designer. He's now involved in helping entrepreneurs build design into their company cultures. Writer and educator Steven Heller pairs up with Tim Hoover, head of product and design at Canary, to talk about designer CEOs, start‐ups, and cutting out the middleman.

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Simultaneous identification for synergistic transcription factors and their transcription factor binding sites

Simultaneous identification for synergistic transcription fa...

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5th International Conference on Complex, Intelligent and Software Intensive Systems, CISIS 2011

作者： Tsai, Zing Tsung-Yeh Huang, Grace Tzu-Wei Tsai, Huai-Kuang Institute of Information Science Academia Sinica Taipei 115 Taiwan Bioinformatics Program Taiwan International Graduate Program Taiwan Institute of Biomedical Informatics National Yang-Ming University Taiwan Joint CMU-Pitt PhD Program in Computational Biology University of Pittsburgh Carnegie Mellon University Pittsburgh PA United States Research Center for Information Technology Innovation Taipei 115 Taiwan Computer Science and Engineering National Taiwan Ocean University Keelung 202 Taiwan

ISBN: (纸本)9780769543734

Identifying transcription factor binding sites (TFBSs) is crucial for understanding the mechanism of transcriptional regulation. It is known that transcription factors (TFs) often cooperate to regulate genes. While traditional approaches can be used to discover binding motifs of a group of co-regulated genes, they often fail to accurately assign motifs to the corresponding TFs. Here, we consider two TFs together to infer their TFBSs and their synergistic relationship simultaneously. The basic idea is that if two TFs interact, their TFBSs, if distinct, would be conserved across species and coincided in the promoter regions of the genes they co-regulated. Applying our method to Saccharomyces cerevisiae chromatin immunoprecipitation data, we predicted 110 TF pairs with statistically significant motif assignments. A majority of these TF pairs have literature support to be synergistic, and the designated motifs to TFs match well with their known consensus. We further examined the synergism of predicted TF pairs in seven experimental conditions using ANOVA, and identified significant interactions. © 2011 IEEE.

关键词： Yeast

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Graph-based approach for gene markers and applications in next-generation sequencing data analysis 11

Graph-based approach for gene markers and applications in ne...

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2011 ACM Conference on Bioinformatics, Computational Biology and Biomedicine, ACM-BCB 2011

作者： Johnson, Daniel Wang, Kun Cramer, Carole L. Huang, Xiuzhen Molecular Bioscience PhD Program Arkansas State University Jonesboro AR United States Department of Computer Science Arkansas State University P.O. Box 9 Jonesboro AR United States Arkansas Bioscience Institute Dept. of Biology Arkansas State University Jonesboro AR United States

ISBN: (纸本)9781450307963

With the tremendous large data sets from next-generation sequencing technology, there is the big challenging task of how to transform the large amount of sequencing data to information meaningful for biologists and life scientists. The initial step is to align these data sets to the known reference genomes, which is essential for further data analysis. However next-generation sequencing read alignment is very time consuming. To address this challenge, we developed a general framework to build genome-wide unique gene markers. This framework includes a novel graph theoretical model for extracting robust gene markers and effective methods for evaluating the sets of gene markers. The genome-wide unique gene markers will help accelerating the next-generation sequencing read alignment process. We use the E. Coli genome as a model genome to illustrate our approach and demonstrate its significance in time saving for read alignment. Further testing on using the sets of gene markers for read coverage analysis is being conducted. Copyright © 2011 ACM.

关键词： Genes

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Simultaneous Identification for Synergistic Transcription Factors and their Transcription Factor Binding Sites

Simultaneous Identification for Synergistic Transcription Fa...

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International Conference on Complex, Intelligent and Software Intensive Systems, CISIS

作者： Zing Tsung-Yeh Tsai Grace Tzu-Wei Huang Huai-Kuang Tsai Institute of Information Science Academia Sinica Taipei Taiwan Institute of Biomedical Informatics National Yang-Ming University Taiwan Joint CMU-Pitt PhD Program in Computational Biology University of Pittsburgh Carnegie Mellon University Pittsburgh USA Computer Science and Engineering National Taiwan Ocean University Keelung Taiwan

关键词： Bioinformatics Analysis of variance DNA Databases Gene expression Proteins Stress

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Learning by collaboration in intelligent autonomous systems

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作者： Ierache, Jorge García-Martínez, Ramón De Giusti, Armando Computer Science PhD Program La Plata National University Buenos Aires University Argentina

ISBN: (纸本)3642152856

Very few learning systems applied to problem solving have focused on learning operator definitions from the interaction with a completely unknown environment. Autonomous Intelligent Systems (AIS) deal with that issue by means of architectures where learning is achieved by establishing plans, executing those plans in the environment, analyzing the results of the execution, and combining new evidence with prior evidence. This paper proposes a selective mechanism of learning allowing an AIS to learn new operators by receiving them from another AIS in a higher stage in the Learning Life Cycle (LLC) with more cycles of interaction in the environment. The proposed collaboration mechanism also considers how to deal with theory ponderation (operators ponderation) and how to include the new operators (provided for) in the set of theories of the receiver AIS. The experimental results show how using collaboration-based learning among AIS provides a better percentage of successful plans, plus an improved convergence rate, than the individual AIS alone. © 2010 IFIP.

关键词： Problem solving

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A proposal for consistency checking in dynamic software product line models using OCL

A proposal for consistency checking in dynamic software prod...

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International Conference on Software Engineering (ICSE)

作者： Fabiana G. Marinho Master and PhD Program in Computer Science Federal University of Ceará Fortaleza Ceara Brazil

Ubiquitous applications use context information to provide services and relevant information for their users. On the other hand, in Software Product Line approaches, commonality and variability of a system family should be identified and documented through variability modeling. Thus, one of the challenges to build Context-Aware Product Lines, called Dynamic Software Product Lines, is the consistent representation of context information that influences the variability model. This work proposes the use of UML profiles and OCL to formalize and represent variability and context concepts in a consistent manner.

关键词： Unified modeling language Context modeling Context Software Adaptation models Computational modeling Prototypes

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