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Photons Plus Ultrasound: Imaging and Sensing 2023

作者： Haindl, Richard Bellemo, Valentina Rajendran, Praveenbalaji Tan, Bingyao Liu, Mengyang Leitgeb, Rainer Drexler, Wolfgang Schmetterer, Leopold Pramanik, Manojit School of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University 62 Nanyang Drive Singapore Singapore Centre for Medical Physics and Biomedical Engineering Medical University of Vienna Währinger Gürtel 18-20/4L Vienna Austria Program Nanyang Technological University Singapore Singapore Singapore Eye Research Institute Singapore National Eye Centre Singapore Singapore Department of Electrical and Computer Engineering Iowa State University AmesIA United States

ISBN: (纸本)9781510658639

Photoacoustic ophthalmoscopy in rodents is gaining research momentum, due to advancement in transducer shape and technology. Needle transducers emerged as most valuable tool for photoacoustic retinal imaging and have proven to be sensitive enough to resolve retinal vasculature in-vivo. Nevertheless, placement of the eye and screening of the retina remains challenging, since needle transducers must remain static during image acquisition, while the optical field of view is limited. Such restriction mandates movement of the mouse to rotate the eye and therefore the imaging area on the retina. The needle transducer needs to be temporarily detached during this process to avoid damage to the eye or the transducer. Re-attachment involves additional application of ultrasound gel and doesn’t guarantee ideal placement for optimized imaging performance. Additive manufacturing can help to tackle those challenges and allows to design novel rotational rodent holders for imaging. Hence, we present a fully 3D printable rotatable tip/tilt mouse platform with the eye in the center of rotation, combined with a printable needle transducer holder. Such system guarantees optimal placement of the needle transducer during imaging and rotation of the mouse eye, avoiding detachment of the transducer and effortless screening of the retina. The capabilities for retinal screening are demonstrated by a multimodal optical coherence photoacoustic ophthalmoscopy system employing two separated wavelengths, 1310 nm for optical coherence and 570 nm for photoacoustic ophthalmoscopy. © 2023 SPIE.

关键词： Optical tomography

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Efficient Power Transfer via Induced Virtual Critical Coupling in an Overcoupled Silicon Nitride Microresonator

Efficient Power Transfer via Induced Virtual Critical Coupli...

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2023 Conference on Lasers and Electro-Optics, CLEO 2023

作者： Hinney, Jakob Kim, Seunghwi Flatt, Graydon J.K. Datta, Ipshita Alii, Andrea Lipson, Michal Department of Electrical Engineering Columbia University New YorkNY10027 United States Photonics Advanced Science Research Catm City University of New Yor New YorkNY10031 United States Department of Applied Physics and Applied Mathematics Columbia University New YorkNY10027 United States Physics Program Graduate Center City University of New York New YorkNY10016 United States

We induce virtual critical coupling in an overcoupled photonic microresonator using complex-frequency pulses. We observe efficient cavity storage as an incident pulse of time constant 138 ps suppresses the resonant tr... 详细信息

ISBN: (纸本)9781957171258

关键词： Microresonators

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Dark Current and Noise Characterization of InGaAs/GaAsSb T2SL Photodetectors 22

Dark Current and Noise Characterization of InGaAs/GaAsSb T2S...

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Optical Components and Materials XXII 2025

作者： Gil, Armando Phillips, Jamie Ettenberg, Martin H. Kurdak, Cagliyan Applied Physics Program University of Michigan Ann ArborMI48109 United States Department of Electrical and Computer Engineering University of Delaware NewarkDE19716 United States Princeton Infrared Technologies Inc. 7 Deer Park Dr. Ste. E Monmouth JunctionNJ08852 United States Department of Physics University of Michigan Ann ArborMI48109 United States

ISBN: (纸本)9781510684720

We investigate the dark current and dark current noise spectra of a short-wavelength infrared based blind photodiode as a function of temperature. We designed and built a custom cryogenic system with a slow temperature relaxation time to perform measurements. The measured device uses a type-II superlattice (2.9 nm InGaAs / 2.9 nm GaAsSb) absorption layer with an effective bandgap of 580 meV that is lattice-matched to InP. At temperatures above 150 K the dark current activation energy was found to be 140 meV, which rules out diffusion- or GR-limited currents and explains that large magnitudes of dark current when compared to similar devices. When normalized to current, we find that 1/f noise grows with temperature, reaches a maximum at about 200 K, then reduces as the temperature goes to 300 K. © 2025 SPIE.

关键词： Indium arsenide

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Mechanical plasticity of cell membranes enhances epithelial wound closure

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Physical Review Research 2024年第1期6卷 L012036-L012036页

作者： Andrew T. Ton Arthur K. MacKeith Mark D. Shattuck Corey S. O'Hern Department of Physics Yale University New Haven Connecticut 06520 USA Integrated Graduate Program in Physical and Engineering Biology Yale University New Haven Connecticut 06520 USA Department of Mechanical Engineering & Materials Science Yale University New Haven Connecticut 06520 USA Benjamin Levich Institute and Physics Department City College of New York New York New York 10031 USA Department of Applied Physics Yale University New Haven Connecticut 06520 USA

During epithelial wound healing, cell morphology near the healed wound and the healing rate vary strongly among different developmental stages even for a single species like Drosophila. We develop deformable particle (DP) model simulations to understand how variations in cell mechanics give rise to distinct wound closure phenotypes in the Drosophila embryonic ectoderm and larval wing disc epithelium. We find that plastic deformation of the cell membrane can generate large changes in cell shape consistent with wound closure in the embryonic ectoderm. Our results show that the embryonic ectoderm is best described by cell membranes with an elasto-plastic response, whereas the larval wing disc is best described by cell membranes with an exclusively elastic response. By varying the mechanical response of cell membranes in DP simulations, we recapitulate the wound closure behavior of both the embryonic ectoderm and the larval wing disc.

关键词： Cell mechanics Jamming Cell membrane Epithelial cells

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Development and study on mechanical properties of small diameter artificial blood vessel by using electrospinning and 3d printing 16

Development and study on mechanical properties of small diam...

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16th Siam physics Congress, SPC 2021

作者： Sukchanta, A. Kummanee, P. Nuansing, W. School of Biomedical Innovation Engineering Institute of Engineering Suranaree University of Technology Muang Nakhon Rachasima Nakhon Ratchasima30000 Thailand Medical Physics Program Faculty of Medicine and Public Health HRH Princess Chulabhorn College of Medical Science Lak Si Bangkok10210 Thailand School of Physics Institute of Science Suranaree University of Technology Muang Nakhon Rachasima Nakhon Ratchasima30000 Thailand

The small diameter artificial blood vessel is synthesized with a diameter less than or equal to 6 millimetres. This technique has been used in coronary artery bypass grafting to treat coronary artery disease. Currently, the problem of coronary artery disease is still common, in addition to aortic aneurysm caused by the incompatibility of mechanical properties between the artificial blood vessel and the local blood vessel in the patient's body. This research aims to solve the aforementioned problems using electrospinning and 3D printing technologies, as many types of materials are supported, all parameters are easy to change, and the cost is low. In this report, we describe a design for a small diameter polylactic acid (PLA) vascular graft fabricated by electrospinning with solutions of PLA in AC/DMF (1:1) 10, 12 and 15% w/v at 4 mm. The electrospun PLA nanofibers are tested for their morphology, contact angle, and seam strength. As the results, the fibres are still no same direction alignment due to insufficient rotation speed. The filament holding force is in the range of 1.90-2.71 N and the contact angles are greater than 90° because the samples are not wettable and have hydrophobic property. Further on, we will investigate other required properties, such as cell culture and other mechanical properties. Furthermore, we will compare the results with 3D printed artificial blood vessels with small diameter. © 2022 Institute of physics Publishing. All rights reserved.

关键词： Diseases

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Revisiting the Temperature Dependence of Protein Diffusion inside Bacteria: Validity of the Stokes-Einstein Equation

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Physical Review Letters 2022年第1期129卷 018101-018101页

作者： Asmaa A. Sadoon William F. Oliver Yong Wang Department of Physics University of Arkansas Fayetteville Arkansas 72701 USA Materials Science and Engineering Program University of Arkansas Fayetteville Arkansas 72701 USA Department of Physics University of Thi-Qar Nassiriya 64001 Iraq Cell and Molecular Biology Program University of Arkansas Fayetteville Arkansas 72701 USA

Although the transport and mixing of proteins and other molecules inside bacteria rely on the diffusion of molecules, many aspects of the molecular diffusion in bacterial cytoplasm remain unclear or controversial, including how the diffusion-temperature relation follows the Stokes-Einstein equation. In this study, we applied single-particle tracking photoactivated localization microscopy to investigate the diffusion of histonelike nucleoid structuring (HNS) proteins and free dyes in bacterial cytoplasm at different temperatures. Although the diffusion of HNS proteins in both live and dead bacteria increased at higher temperatures and appeared to follow the Arrhenius equation, the diffusion of free dyes decreased at higher temperatures, questioning the previously proposed theories based on superthermal fluctuations. To understand the measured diffusion-temperature relations, we developed an alternative model, in which the bacterial cytoplasm is considered as a polymeric network or mesh. In our model, the Stokes-Einstein equation remains valid, while the polymeric network contributes a significant term to the viscosity experienced by the molecules diffusing in bacterial cytoplasm. Our model was successful in predicting the diffusion-temperature relations for both HNS proteins and free dyes in bacteria. In addition, we systematically examined the predicted diffusion-temperature relations with different parameters in the model, and predicted the possible existence of phase transitions.

关键词： Anomalous diffusion Diffusion Intracellular transport Network diffusion Proteins

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Entanglement-Enhanced Neyman-Pearson Target Detection

arXiv

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arXiv 2024年

作者： Ward, William Hariri, Abdulkarim Zhang, Zheshen Applied Physics Program University of Michigan Ann ArborMI48104 United States Department of Electrical Engineering and Computer Science University of Michigan Ann ArborMI48104 United States

Quantum illumination (QI) provides entanglement-enabled target-detection enhancement, despite operating in an entanglement-breaking environment. Existing experimental studies of QI have utilized a Bayesian approach, assuming that the target is equally likely to be present or absent before detection, to demonstrate an advantage over classical target detection. However, such a premise breaks down in practical operational scenarios in which the prior probability is unknown, thereby hindering QI's applicability to real-world target-detection scenarios. In this work, we adopt the Neyman-Pearson criterion in lieu of the error probability for equally likely target absence or presence as our figure of merit for QI. We demonstrate an unconditional quantum advantage over the optimal classical-illumination protocol as benchmarked by the receiver operating characteristic, which examines detection probability versus false-alarm probability without resorting to known prior probabilities. Our work represents a critical advancement in adapting quantum-enhanced sensing to practical operational settings. © 2024, CC BY.

关键词： Quantum entanglement

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UV-VIs Spectrophotometry Study of Escherichia Coli Bacteria and Microfluidic Channel Chip Fabrication For Optical Biosensing Application

UV-VIs Spectrophotometry Study of Escherichia Coli Bacteria ...

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National Conference on Radio Science (NSRC)

作者： Sara Mohamed Amira A.M. Ahmed Ahmed Kreta Amany Khalifa Mai Mostafa Shaimaa Ahmed Heba Refaat A. M. Faramawy Ahmed Moustafa Mohamed A. Swillam Department of Physics School of Science and Engineering The American University in Cairo New Cairo Egypt Faculty of Engineering May University in Cairo Cairo Egypt Biotechnology Graduate Program Department of Biology The American University in Cairo New Cairo Egypt Department of Physics Faculty of Science Ain Shams University (ASU) Cairo Abbassia Egypt

One of the most significant foodborne organisms that cause serious foodborne illnesses is Escherichia coli (E. coli). In this work, we demonstrated that the characterization of E. coli suspensions can be facilitated using conventional absorption spectroscopy in the ultraviolet and visible spectral ranges. With increasing concentrations of E. coli, a red shift in the UV-Vis spectra along with an obvious rise in intensity were observed. The results showed that the calculated cell count of E. coli was found in Luria-Bertani (LB) broth in the range of $4.08 \times 10^{8}$ to $1.41 \times 10^{9}$ $\mathrm{CFU} / \mathrm{mL}$. Besides, the optical density was theoretically calculated to be in the range of 1.22 to 3.18. An E. coli suspension in a minute volume needed to be employed, so a microfluidic channel chip was fabricated. To evaluate the suitability and validity of the microfluidic channel for the optical-based measurements, various solutions with different flow rates, including water, acetone, and ethanol, were pumped through the tubes and into the microfluidic channels.

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Electrochemical Performance of a Water-Based LiFePO4 Cathode for Li-Ion Batteries

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Defect and Diffusion Forum 2022年 417卷 163-168页

作者： Chanhaew, Araya Aranmala, Komsak Darmawan, Luthfi Mursid Nisa, Shofirul Sholikhatun Nurohmah, Anisa Raditya Meethong, Nonglak Materials Science and Nanotechnology Program Department of Physics Faculty of Science Khon Kaen University Muang District Khon Kaen40002 Thailand Department of Chemical Engineering Faculty of Engineering Universitas Sebelas Maret Central Java Surakarta57126 Indonesia Centre of Excellence for Electrical Energy Storage Technology Universitas Sebelas Maret Central Java Surakarta57146 Indonesia Khon Kaen University Muang District Khon Kaen40002 Thailand

Lithium iron phosphate (LiFePO4) has received much attention because it can provide high power density, abundant raw materials, safety, low toxicity, and high thermal stability. In general, the production of LiFePO4 cathode uses Polyvinylidene fluoride (PVDF) as a binder and N-Methyl-2-Pyrrolidone (NMP) as a solvent. These components are expensive, toxic, and can affect the environment. Therefore, to cover this shortcoming, the solvent and binder were replaced in this study. The solvent is replaced with water, which is more environmentally friendly and abundant, while the binder is replaced with water soluble binders. Suitable electrode formulations were investigated to obtain high performance cylindrical typed Li-ion batteries. As a result, Formula B (ratio of LiFePO4: AB: KS6: SBR: CMC = 90: 3: 3: 2.677: 1.333) has the highest specific discharge capacity of 120 mAh/g. The NMP-based cathode can give about 145 mAh/g. Therefore, the water-based cathode LiFePO4 gives a value that is slightly lower the NMP-based formular. © 2022 Trans Tech Publications Ltd, Switzerland.

关键词： Lithium compounds

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New insight into pyrrolic-N site effect towards the first NIR window absorption of pyrrolic-N-rich carbon dots

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Nano Research 2023年第4期16卷 6001-6009页

作者： Fitri Aulia Permatasari Reza Umami Citra Deliana Dewi Sundari Tirta Rona Mayangsari Atthar Luqman Ivansyah Fahdzi Muttaqien Takashi Ogi Ferry Iskandar Department of Physics Faculty Mathematics and Natural SciencesInstitut Teknologi BandungJalan Ganesha 10BandungWest Java 40132Indonesia Collaboration Research Center for Advanced Energy Materials National Research and Innovation Agency-Institut Teknologi BandungJalan Ganesha 10BandungWest Java 40132Indonesia Department of Chemistry Faculty of Mathematics and Natural SciencesInstitut Teknologi BandungJl.Ganesha 10BandungWest Java 40132Indonesia Department of Chemistry Education UIN Sunan Gunung Djati BandungJl.CimincrangBandungWest Java 40292Indonesia Department of Chemistry Universitas PertaminaJakarta 12220Indonesia Master Program in Computational Science Faculty of Mathematics and Natural SciencesInstitut Teknologi BandungJl.Ganesha 10BandungWest Java 40132Indonesia Instrumentation and Computational Physics Research Group Faculty of Mathematics and Natural SciencesInstitut Teknologi BandungJl.Ganesha 10Bandung 40132Indonesia Research Center for Nanoscience and Nanotechnology Institut Teknologi BandungJalan Ganesha 10BandungWest Java 40132Indonesia Chemical Engineering Program Department of Advanced Science and EngineeringGraduate School of Advanced Science and EngineeringHiroshima UniversityHigashi-Hiroshima 739-8527Japan

Controlled C-N configurations,i.e.,pyrrolic-N,pyridinic-N,and graphitic-N,are promising strategies to tailor the carbon dots’(CDs)optical properties into the first near infrared(NIR)window(650-900 nm),a responsive range for biomedical ***,a deep understanding of the role of the C-N configuration in the CDs’properties is still challenging and thoughtprovoking owing to their complex ***,an underlying pyrrolic-N concentration and position effect on the pyrrolic-N-rich CDs’absorption was comprehensively elucidated based on the integrated experimental and computational *** assynthesized pyrrolic-N-rich CDs exhibit a first NIR window absorption centered at 650 nm with high photothermal ***-N concentrations from 1.4%to 11.3%and positions(edge and mid-site)were systematically investigated.A mid-site pyrrolic-N was subsequently generated after the pyrrolic-N concentration more than 10%.Edge-site pyrrolic-N induces a frontier orbital hybridization,reducing bandgap energy,while mid-site pyrrolic-N plays a critical role in inducing a first NIR window absorption owing to their high charge ***,pyrrolic-N-rich CDs inherit a bowl-like topological feature,elevating the CDs’layer thickness as much as 0.71 *** study shed light on the design and optimization of pyrrolic-N on CDs for the first NIR window responsive materials in any biomedical application.

关键词： absorption carbon dots charge transfer first near infrared(NIR)window frontier orbital hybridization mid-site pyrrolic-N

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