检索结果-内蒙古大学图书馆

Downsizing and soft X-ray tomography for cellular uptake of interpenetrated metal-organic frameworks

Journal of Materials Chemistry B 2024年第25期12卷 6079-6090页

作者： Yu, Yu-Sheng Liang, Yung-Yi Hsieh, Chia-Chun Lin, Zi-Jing Cheng, Po-Hsiu Cheng, Chih-Chan Chen, Shu-Ping Lai, Lee-Jene Wu, Kevin C.-W. National Taiwan University Department of Chemical Engineering Taipei Taiwan National Health Research Institute Institute of Biomedical Engineering and Nanomedicine Miaoli Taiwan Hsinchu Taiwan International Graduate Program of Molecular Science and Technology Taiwan International Graduate Program Academia Sinica Taipei Taiwan National Taiwan University Taipei Taiwan

Metal-organic frameworks (MOFs) are porous materials with potential in biomedical applications such as sensing, drug delivery, and radiosensitization. However, how to tune the properties of the MOFs for such applications remains challenging. Herein, we synthesized two MOFs, Zr-PEB and Hf-PEB. Zr-PEB can be classified as porous interpenetrated zirconium frameworks (PIZOFs) and Hf-PEB is its analogue. We controlled their sizes while maintaining their crystal structure by employing a coordination modulation strategy. They were designed to serve as sensitizer for X-ray therapy and as potential drug carriers. Comprehensive characterizations of the MOFs' properties have been conducted, and the in vitro biological impacts have been studied. Since viability assay showed that Hf-PEB was more biocompatible compared to Zr-PEB, the cellular uptake of Hf-PEB by cells was evaluated using both fluorescence microscopy and soft X-ray tomography (SXT), and the three-dimensional structure of Hf-PEB in cells was observed. The results revealed the potential of Zr-PEB and Hf-PEB as nanomaterials for biomedical applications and demonstrated that SXT is an effective tool to assist the development of such materials. © 2024 The Royal Society of Chemistry.

关键词： Organometallics

来源：评论

学校读者我要写书评

暂无评论

engineering of hollow polymeric nanosphere-supported imidazolium-based ionic liquids with enhanced antimicrobial activities

引用

Nano Research 2022年第6期15卷 5556-5568页

作者： Yu Zhang Shuwei Li Yixin Xu Xinyun Shi Mingxin Zhang Yingning Huang Ying Liang Yaqiong Chen Wanli Ji Jung Rae Kim Wenliang Song Deng-Guang Yu Il Kim School of Pharmacy Shanghai University of Medicine&Health SciencesShanghai 201318China School of Materials Science&Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Polymer Science and Engineering Pusan National UniversityBusan 46241Republic of Korea School of Chemical and Biomolecular Engineering Pusan National UniversityBusan 46241Republic of Korea

The design of stable,efficient and processable bactericidal materials represents a significant challenge for combating multidrugresistant bacteria in a variety of engineering ***,we report a facile strategy for the preparation of hollow polymeric nanosphere(HPN)-supported imidazolium-based ionic liquids(denoted as HPN-ILs)with superior antimicrobial *** were tailored by moderate Friedel−Crafts polymerization followed by the sequential covalent bonding of imidazole and *** resultant HPN-ILs have uniform hollow spherical morphology,an adequate surface area,and excellent physicochemical ***,they are highly active against both Gram-positive and Gram-negative bacteria and exhibit typical time/dosage-dependent antibacterial *** rational combination of porous HPNs and antibacterial ILs to generate an all-in-one entity may open new avenues for the design and fabrication of efficient bacteriostatic ***,HPN-ILs have good biocompatibility and can also be loaded onto diverse matrices,and thus could extend their practical bactericidal application in the potential biomedical-active field.

关键词： antibacterial materials bioactive materials hollow nanospheres ionic liquids porous polymers

来源：评论

学校读者我要写书评

暂无评论

The influence of latex level and pigment type on the penetration of hot melt adhesive into coated paperboard

The influence of latex level and pigment type on the penetra...

引用

TAPPICon 2023 - Rock the Roll: Unleashing the Harmonies of the Paper Industry

作者： Khlewee, Mubarak DeSisto, William Bousfield, Douglas University of Maine Paper Surface Science Program Department of Chemical and Biomedical Engineering OronoME04469 United States

The penetration of hot melt adhesive into coated paperboard influences the efficient use of adhesive and the final bond strength in the production of boxes and other structures. However, little systematic work is reported on this topic and no fundamental modeling of the penetration event. Here, the penetration of a hot melt adhesive is characterized with a silicone oil method, for a range of latex levels and pigment types in the coating layer. The results are compared to a model of the process. © 2023 TAPPICon 2023 - "Rock the Roll: Unleashing the Harmonies of the Paper Industry". All rights reserved.

关键词： Silicones

来源：评论

学校读者我要写书评

暂无评论

A sustainable thermochemical conversion of animal biomass to N-heterocycles

引用

Collagen and Leather 2023年第2期5卷 108-118页

作者： Yang Tang Xiao Xiao Chaojun Zhang Xiaoling Wang Junling Guo Xuepin Liao BMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and EngineeringSichuan UniversityChengdu 610065SichuanChina National Engineering Laboratory of Clean Technology of Leather Manufacture Sichuan UniversityChengdu 610065SichuanChina Bioproducts Institute Department of Chemical and Biological EngineeringDepartment of Chemistryand Department of Wood ScienceThe University of British ColumbiaVancouverBCCanada State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065SichuanChina

The production of high-valued organonitrogen chemicals,especially N-heterocycles,requires artificial N_(2)fixation accompanied by the consumption of fossil *** avoid the use of these energy-and resource-intensive processes,we develop a sustainable strategy to convert nitrogen-rich animal biomass into N-heterocycles through a thermochemical conversion process(TCP)under atmospheric pressure.A high percentage of N-heterocycles(87.51%)were obtained after the TCP of bovine skin due to the abundance of nitrogen-containing amino acids(e.g.,glycine,proline,and L-hydroxyproline).Animal biomass with more diverse amino acid composition(e.g.,muscles)yielded higher concentrations of amines/amides and nitriles after *** addition,by introducing catalysts(KOH for pyrrole and Al_(2)O_(3)for cyclo-Gly-Pro)to TCP,the production quantities of pyrrole and cyclo-Gly-Pro increased to 30.79 mg g^(-1)and 38.88 mg g^(-1),*** approach can be used to convert the significant animal biomass waste generated annually from animal culls into valued organonitrogen chemicals while circumventing NH3-dependent and petro-chemical-dependent synthesis routes.

关键词： Animal biomass N-heterocycles Nitrogen fixation Nitrogenous chemicals Thermochemical conversion

来源：评论

学校读者我要写书评

暂无评论

A master-slave generalized predictive synchronization control for preheating process of multi-cavity hot runner system

引用

Chinese Journal of chemical engineering 2023年第10期62卷 270-280页

作者： Hongyi Qu Shengyong Mo Ke Yao Zhao-Xia Huang Zhihao Xu Furong Gao Institute of Intelligent Manufacturing Guangdong Academy of SciencesGuangdong Key Laboratory of Modern Control TechnologyGuangzhou 510070China Fok Ying Tung Graduate School The Hong Kong University of Science and TechnologyGuangzhou 511442China Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyHong Kong 999077China National Engineering Research Center of Novel Equipment for Polymer Processing Department of Mechanical and Automotive EngineeringSouth China University of TechnologyGuangzhou 510641China

As a key component of injection molding,multi-cavity hot runner(MCHR)system faces the crucial problem of polymer melt filling imbalance among the *** thermal imbalance in the system has been considered as the leading ***,the solution may rest with the synchronization of those heating processes in MCHR *** paper proposes a’Master-Slave’generalized predictive synchronization control(MS-GPSC)method with’***’strategy for preheating stage of MCHR *** core of the proposed method is choosing the heating process with slowest dynamics as the’Master’to track the setpoint,while the other heating processes are treated as‘Slaves’tracking the output of’Master’.This proposed method is shown to have the good ability of temperature *** corresponding analysis is conducted on parameters tuning and stability,simulations and experiments show the strategy is effective.

关键词： Process control Thermodynamics process Model-predictive control Multi-cavity hot runner system Master-Slave synchronization Mr.Slowest

来源：评论

学校读者我要写书评

暂无评论

Intense Intramolecular Charge Transfer Endows Cyanated polymer with Broad Absorption,Intensified Light-Harvesting,Long-Lived Exciton,and Superior Photovoltaic Property

引用

CCS Chemistry 2024年第9期6卷 2318-2332页

作者： Jinming Chen Huijuan Wang Songmin Mo Hui Chen Xinyu He Mingbin Su Dongyan Li Yonghong Xiao Zhiqi Wang Fanwei Ye Mingde Li Li Dang Xiao-Chun Huang Chang-Zhi Li Feng He Qinghe Wu Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Department of ChemistryShantou UniversityShantou 515063 Department of Chemistry Shenzhen Grubbs InstituteSouthern University of Science and TechnologyShenzhen 518055 Department of Polymer Science and Engineering Zhejiang UniversityHangzhou 310027 Chemistry and Chemical Engineering Guangdong Laboratory Shantou 515063 Guangdong Provincial Key Laboratory of Catalysis Southern University of Science and TechnologyShenzhen 518055

The donor–acceptor(D–A)copolymers,which exhibit wide broad absorption and intensified light-harvesting,are highly captivating for applications in solar conversion and ***,designing a polymer structure that can achieve these photophysical properties simultaneously remains a ***,we report two novel cyanated units 4-cyanobenzo[1,2-b:6,5-b′:3,4-c″]trithiophene(CBT)and 4,6-dicyanobenzo[1,2-b:6,5-b′:3,4-c″]trithiophene(C2BT)and their corresponding polymers,PCBT and *** interestingly,the PC2BT exhibited a broad absorption band with full width at half maxima(FWHM)of its absorption spectra,almost twice wider than PCBT and benchmark polymers PM6 and ***,the PC2BT demonstrated intensified light-harvesting and long-lived *** in-depth investigation unveiled that the presence of dicyano substitutions induced a strong intramolecular charge transfer(ICT),which,in turn,resulted in the formation of favorable photophysical ***,PC2BT-based polymer solar cells(PSCs)exhibited an efficiency of 18.06%,which was a record-setting efficiency for cyanated *** study suggests an efficient strategy for enhancing ICT to design polymers toward favorable photophysical properties and excellent photovoltaic performance.

关键词： intramolecular charge transfer broad absorption band dicyanobenzotrithiophene cyanated polymer polymer solar cell

来源：评论

学校读者我要写书评

暂无评论

Boost photothermal theranostics via self-assembly-induced crystallization(SAIC)

Aggregate

引用

Aggregate 2022年第5期3卷 194-204页

作者： Xueluer Mu Fapu Wu Ying Tang Rui Wang Yajie Li Kaixuan Li Chunfeng Li Yingxi Lu Xianfeng Zhou Zhibo Li Key Lab of Biobased Polymer Materials of Shandong Provincial Education Department College of Polymer Science and EngineeringQingdao University of Science and TechnologyQingdaoP.R.China College of Material Science and Engineering Qingdao University of Science and TechnologyQingdaoP.R.China College of Chemical Engineering Qingdao University of Science and TechnologyQingdaoP.R.China

Owing to the intrinsic advantages of spatiotemporal selectivity,photothermal theranostics have become the advancing edge of precision medicine for *** photothermal transduction agents(PTAs)with near-infrared(NIR)absorption,high photothermal conversion efficiency,robust photothermal stability,and good accumulation in tumors,is particularly ***,we report a new concept,self-assembly-induced crystallization(SAIC),which can serve as a mechanism that dramatically boosts photothermal behaviors of PTA in NIR *** a proof of concept,three heptamethine cyanine molecules with internal degrees of freedom(geometry and intramolecular interaction)are designed to fine-tune their ***,Cy7-TCF-EMBI molecules with rigid and planar skeletons self-assemble into a crystalline state to maximize their packing density and improve the charge transfer,both of which contribute to nonradiative decay for energy dissipation as *** high packing density also renders an ideal scaffold for controlling intermolecular interactions to exhibit better photothermal stability,and endows an anisotropic three-dimensional architecture for passive tumor ***“SAIC”strategy may offer a conceptually novel,practically simple but effective approach to unveil the structure–property relationship that could provide some general rules in rational design of PTAs,and paves the way for a next generation of supramolecular medicine for photothermal theranostics.

关键词： crystallization photothermal theranostic self-assembly small molecule supramolecular medicine

来源：评论

学校读者我要写书评

暂无评论

Emerging Designs of Aggregation-Induced Emission Agents for Enhanced Phototherapy Applications

引用

CCS Chemistry 2022年第2期4卷 401-419页

作者： Rui Qu Xu Zhen Xiqun Jiang MOE Key Laboratory of High Performance Polymer Materials and Technology Department of Polymer Science&EngineeringCollege of Chemistry&Chemical EngineeringNanjing UniversityNanjing 210093

Phototherapy,including photodynamic therapy(PDT)and photothermal therapy(PTT),that employs phototherapeutic agents to generate cytotoxic reactive oxygen species(ROS)or hyperthermia,is a promising approach for disease ***,conventional organic phototherapeutic agents suffer poor photostability and aggregation-caused quenching(ACQ)in the aggregate state,restricting their therapeutic ***-induced emission(AIE)agents can solve these issues with strong emission in the aggregate state and reverse designation to generate *** review summarizes the recent advances in the development of AIE phototherapy agents for enhanced PDT and PTT performances in biomedical ***,design strategies of AIE agents that adjust the intersystem crossing process or intramolecular charge transfer to boost ROS generation or regulate ROS types are *** AIE agents with ROS generation ability for biomedical applications including antitumor and antibacterial performances are then ***,designs and examples of AIE agents that enhance PTT performances through molecular motions are ***,the current challenges and perspectives of AIE agents in the phototherapy field are discussed.

关键词： aggregation-induced emission structural designing phototherapy photodynamic therapy photothermal therapy

来源：评论

学校读者我要写书评

暂无评论

Effect of Ultrasound and Mixing of Folate and Trastuzumab Liposomes on DOX Release and Cellular Uptake 17

Effect of Ultrasound and Mixing of Folate and Trastuzumab Li...

引用

17th IEEE International Conference on Nano/Molecular Medicine and engineering, NANOMED 2024

作者： Alsawaftah, Nour M. Pitt, Willian G. Husseini, Ghaleb A. American University of Sharjah Materials Science and Engineering Program College of Arts and Sciences PO Box 26666 Sharjah United Arab Emirates Brigham Young University Chemical Engineering Department ProvoUT United States American University of Sharjah College of Engineering Chemical and Biological Engineering Department PO Box 26666 Sharjah United Arab Emirates

ISBN: (纸本)9798331516994

This study explores the potential of physically mixing individually targeted Doxorubicin (DOX)-loaded liposomes functionalized with folic acid (FA) and trastuzumab (TRA), combined with ultrasound (US) triggering, to enhance targeted breast cancer therapy. This research focused on synthesizing, characterizing, and evaluating DOX release, cellular uptake, and cytotoxicity of FA-PEG and TRA-PEG-modified liposomes mixed at different volume fractions. Low-frequency ultrasound (LFUS) and high-frequency ultrasound (HFUS) were employed to trigger DOX release. The study demonstrated that the sonicated-physically-mixed liposomes showed superior release performance (specifically the M75 group) and increased cellular uptake (specifically the M25 group) compared to individually targeted liposomes, highlighting their combined potential in breast cancer treatment. © 2024 IEEE.

关键词： Breast cancer Folic acid Liposomes Trastuzumab Ultrasound

来源：评论

学校读者我要写书评

暂无评论

Design and development of an integrated enset processing machine suitable for central highland farmers of west shewa zone Ethiopia

引用

Discover Agriculture 2025年第1期3卷 1-26页

作者： Jima, Beka Adugna Kolhe, Kishor Purushottam Jiru, Moera Gutu Agricultural Machinery Engineering Program Department of Mechanical Engineering School of Mechanical Chemical and Materials Engineering at Adama Science and Technology University Adama Ethiopia Department of Mechanical Engineering School of Mechanical Chemical and Materials Engineering at Adama Science and Technology University Adama Ethiopia

The development of Integrated Enset processing technology is significant for the easy availability of stable food in the current condition for fulfilling the pangs of hunger in Ethiopia, currently; individual manual technologies such as decortication, corm granting, bulla extraction, and fermenting techniques eventually contribute to utilizing food security such as Kocho, which is not affordable for the marginal farmers of Ethiopia. However, there is a lack of integrated compromise of the all-function process of corm granting, decortication, and pulverization in one machine wholesome of the product such as Kocho, and bulla within consuming time and labor. Therefore, it is decided to design and develop an integrated enset processing machine for central high land of Ethiopian farmers with high-quality production. The physical and mechanical properties of the enset is studied to get an efficient and robust design of the various components. The overall design and development of proposed machine components were carried out at Adama science and Technology University, Ethiopia by using ANSYS 2023 R1 software by considering the engineering economics and material specifications as per ASTM standards. The process parameters of the proposed machine are identified as feed rate, drum speed, concave to drum clearance, power requirement, etc. Also, the enset characteristics were considered as decorticating and granting, fiber cutting resistance, fiber length, dimension, shape, and weight. The overall developed enset integrated machine assembles are analyzed for granting and decorticating with drum clearance and bulla extraction throughput capacity, reliability, simplicity, safety, and overall cost. The machine's safety from a Design Perspective is checked and validated by a simulation study on the critical parts subjected to higher stresses. The cost of available individual decorticators, granting, pulverized, and bulla squeezer machines is costly to the farmer’s community. Theref

关键词：

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：