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Mitochondria-specific near-infrared photoactivation of peroxynitrite upconversion luminescent nanogenerator for precision cancer gas therapy

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Acta Pharmaceutica Sinica B 2024年第1期14卷 378-391页

作者： Hui Yu Aliya Tiemuer Xufeng Yao Mingyuan Zuo Hai-Yan Wang Yi Liu Xiaoyuan Chen Department of Biomedical Engineering School of EngineeringChina Pharmaceutical UniversityNanjing 211198China School of Mechanical Engineering Southeast UniversityNanjing 211189China Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore 119074Singapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore 117599Singapore Nanomedicine Translational Research Program Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnologyand Research(A*STAR)ProteosSingapore 138673Singapore

Gas therapy is emerging as a highly promising therapeutic strategy for cancer ***,there are limitations,including the lack of targeted subcellular organelle accuracy and spatiotemporal release precision,associated with gas *** this study,we developed a series of photoactivatable nitric oxide(NO)donors NRh-R-NO(R=Me,Et,Bn,iPr,and Ph)based on an N-nitrosated upconversion luminescent rhodamine *** the irradiation of 808 nm light,only NRh-Ph-NO could effectively release NO and NRh-Ph with a significant turn-on frequency upconversion luminescence(FUCL)signal at 740 nm,ascribed to lower N-N bond dissociation *** also investigated the involved multistage near-infrared-controlled cascade release of gas therapy,including the NO released from NRh-Ph-NO along with one NRh-Ph molecule generation,the superoxide anion O_(2)^(⋅−)produced by the photodynamic therapy(PDT)effect of NRh-Ph,and highly toxic peroxynitrite anion(ONOO‒)generated from the co-existence of NO and O_(2)^(⋅−).After mild nano-modification,the nanogenerator(NRh-Ph-NO NPs)empowered with superior biocompatibility could target *** an 808 nm laser irradiation,NRh-Ph-NO NPs could induce NO/ROS to generate RNS,causing a decrease in the mitochondrial membrane potential and initiating apoptosis by caspase-3 activation,which further induced tumor immunogenic cell death(ICD).In vivo therapeutic results of NRh-Ph-NO NPs showed augmented RNS-potentiated gas therapy,demonstrating excellent biocompatibility and effective tumor inhibition guided by real-time FUCL ***,this versatile strategy defines the targeted RNS-mediated cancer therapy.

关键词： Near infrared Photo-triggered Mitochondrion Upconversion luminescent bioimaging Peroxynitrite Nanogenerator Gas therapy In vivo

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Effect of physical and biological pretreatment on sugarcane bagasse waste-based biogas production

Effect of physical and biological pretreatment on sugarcane ...

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3rd International Conference on chemical engineering and Applied sciences, ICChEAS 2022

作者： Sumardiono, Siswo Matin, Hashfi Hawali Abdul Sulistianingtias, Ihdina Nugroho, Tri Yulianto Budiyono, Budiyono Department of Chemical Engineering Faculty of Engineering Universitas Diponegoro Semarang50239 Indonesia Study Program of Environmental Science Faculty of Mathematic and Natural Science Universitas Sebelas Maret Surakarta57126 Indonesia Vocational School Universitas Diponegoro Semarang50239 Indonesia

Sugarcane bagasse is a biomass with very potential, especially in agricultural countries. In this research, a study related to pretreatment and the ratio of C/N to biogas production from sugarcane bagasse was conducted. The study was carried out on a laboratory scale with physical pretreatment by grinding with a size of 6 mesh, then biological pretreatment with the microbial consortium 5 % g/V, and variations in the C/N ratio at 25 and 30. Cow rumen fluid was used in this study as a source of anaerobic bacteria and technical urea is used to adjust the C/N ratio. The solid total is set at 7 %. Based on research that has been carried out for 60 days, it was found that physical pretreatment by grinding with a size of 6 mesh can increase biogas production. Biogas production increased both at C/N ratio conditions of 25 and 30. Furthermore, biological pretreatment with the microbial consortium 5 % g/V was proven to increase biogas production at both C/N ratios of 25 and 30. Further studies on the C/N ratio, it was found that the C/N ratio of 25 was better than the C/N ratio of 30. This is evident in several variables, including raw and fine substrate conditions, as well as on variables with or without a microbial consortium, with the amount of biogas productivity at a C/N 25 ratio of 53-90.5 % higher than the C/N 30 ratio. © 2023 Elsevier Ltd. All rights reserved.

关键词： Grinding (machining)

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Electrolyte dependence for the electrochemical decarboxylation of medium-chain fatty acids (n-octanoic acid) into fuel on Pt electrode

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Materials Reports(Energy) 2024年第2期4卷 64-70页

作者： Zhenmin Zhang Dezhang Ren Dian Zhang Tiantian Hu Congyuan Zeng Nengneng Xu Zhibao Huo Jinli Qiao College of Marine Ecology and Environment Shanghai Ocean UniversityShanghai201306PR China Department of Mechanical Engineering Southern University and A&M CollegeBaton RougeLA70807USA State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Environmental Science and EngineeringDonghua UniversityShanghai201620PR China Shanghai Institute of Pollution Control and Ecological Security Shanghai200092PR China

The deoxygenation of organic acids, important biomass feedstocks and derivatives, to synthesize hydrocarbon products under mild electrochemical conditions, holds significant importance for the production of carbon-neutral biofuels. There is still limited research on the influential factors of the electrochemical decarboxylation reaction of medium-chain fatty acids. In this study, n-octanoic acid (OA) was chosen as the research subject to investigate the electrochemical decarboxylation behavior of OA on a platinum electrode, focusing on the influence of different alkali metal cations (Li^(+), Na^(+), K^(+)), common anions (SO^(4)^(2−), Cl^(−)), and electrolyte pH. It was found that KOH as an electrolyte exhibited the best performance for OA. Possibly, the larger size of K^(+) increased the alkalinity of the electrode surface, facilitating OA deprotonation. LiOH electrolyte reduced the solubility of OA, thereby inhibiting the decarboxylation reaction. SO^(4)^(2−) exhibited a weak promoting effect on the decarboxylation reaction of OA, while Cl^(−) showed no adverse effect although Cl^(−) may adsorb on the electrode surface. Furthermore, unlike short-chain fatty acids, medium-chain OA can only achieve efficient decarboxylation under alkaline conditions due to its solubility properties. This study provides references and foundations for future efforts to enhance the efficiency of electrochemical decarboxylation synthesis of hydrocarbon biofuels from medium-chain fatty acids.

关键词： Fatty acids Kolbe reaction Decarboxylation Hydrocarbon Electrolyte

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Interfacial Diffusion Manipulation by Amphiphilic Cellulose Nanocrystal Having Antibacterial Property for Asymmetric Polyamide Layer

SSRN

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SSRN 2023年

作者： Seo, Huiran Shin, Huiseob Kong, Saerom Jung, Kyung Hwa Kim, Mun Hyeon Kim, Jae Jun Lee, Changha Kim, Hee Joong Lee, Jong-Chan Department of Chemical and Biological Engineering Institute of Chemical Processes Seoul National University 1 Gwanak-ro Seoul08826 Korea Republic of Department of Polymer Science and Engineering & Program in Environmental and Polymer Engineering Inha University Incheon22212 Korea Republic of

Polyamide (PA) thin-film composite (TFC) membranes, fabricated by interfacial polymerization (IP) process, have been widely used for the desalination process due to high water permeability with high water/salt selectivity. A number of advanced PA TFC membranes have been developed as more efficient alternatives to further improve separation performance, scalability, and address the surface contamination problem of commercial membranes. Here, we utilized amphiphilic functionalized cellulose nanocrystal (f-CNC) having antibacterial property as a nanofiller material for the preparation of an advanced PA membrane system, featuring improved water permeability with high salt rejection ability. This strategy is inexpensive, scalable, environmentally friendly, and practically relevant, given that typical IP process with a renewable nanofiller was employed. The amphiphilic f-CNC manipulates interfacial diffusion of monomers upon IP process, thereby decreasing the effective PA layer thickness by 30 % and increasing water permeability by 44 %. In addition, the PA membrane with f-CNC showed improved antibacterial and antifouling properties due to the specific nature of f-CNC. This study provides insights for the development of thin, effective, and antibacterial, yet more green and scalable PA membrane alternatives to the conventional desalination membranes. © 2023, The Authors. All rights reserved.

关键词： Cellulose

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Host-Guest Strategy Enabling Nonhalogenated Solvent Processing for High-Performance All-polymer Hosted Solar Cells

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Chinese Journal of Chemistry 2023年第9期41卷 1066-1074页

作者： Yuting Huang Haiyang Chen Qunping Fan Ziyuan Chen Junyuan Ding Heyi Yang Zhe Sun Rui Zhang Weijie Chen Changduk Yang Feng Gao Yaowen Li Laboratory of Advanced Optoelectronic Materials Suzhou Key Laboratory of Novel Semiconductor-optoelectronics Materials and DevicesCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu 215123China Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow UniversitySuzhouJiangsu 215123China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu 215123China State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong UniversityXi'anShaanxi 710049China Department of Energy Engineering School of Energy and Chemical EngineeringPerovtronics Research CenterLow Dimensional Carbon Materials CenterUlsan National Institute of Science and Technology(UNIST)UlsanRepublic of Korea Department of Physics Chemistry and Biology(IFM)Linkoping UniversityLinkopingSweden

The power conversion efficiencies(PCEs)of all-polymer solar cells(all-PSCs),usually processed from low-boiling-point and toxic sol-vents,have reached high values of 18%.However,poor miscibility and uncontrollable crystallinity in polymer blends lead to a nota-ble drop in the PCEs when using green solvents,limiting the practical development of ***,a third component(guest)BTO was employed to optimize the miscibility and enhance the crystallinity of PM6/PY2Se-F host film processed from green solvent toluene(TL),which can effectively suppress the excessive aggregation of PY2Se-F and facilitate a nano-scale interpenetrating net-work morphology for exciton dissociation and charge *** a result,TL-processed all-polymer hosted solar cells(all-PHSCs)exhibited an impressive PCE of 17.01%.Moreover,the strong molecular interaction between the host and guest molecules also en-hances the thermal stability of the *** host-guest strategy provides a unique approach to developing high-efficiency and stable all-PHSCs processed from green solvents,paving the way for the industrial development of all-PHSCs.

关键词： All-polymer solar cells Host-guest systems Crystal engineering Nonhalogenated green solvent Stability Morphology Miscibility Ternary blend solar cells

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Evaluating a Liquid-Phase Plasma Discharge Process for Ammonia Oxidation in Wastewater

Evaluating a Liquid-Phase Plasma Discharge Process for Ammon...

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2023 American Society of Agricultural and Biological Engineers Annual International Meeting, ASABE 2023

作者： Aka, Robinson Junior Ndeddy Mohotti, Dinithi Nasir, Alia Agyekum-Oduro, Ekow Wu, Sarah Environmental Science Program University of Idaho MoscowID83844 United States Department of Chemical and Biological Engineering University of Idaho MoscowID83844 United States

ISBN: (纸本)9781713885887

In this study, a novel continuous flow liquid-phase plasma process was evaluated to remove NH3-N from synthetic wastewater. The process was optimized and modelled using response surface methodology (RSM). The Box-Behnken experimental design was used to determine the effects and optimal conditions of key operating parameters, including the initial NH3-N concentration (50-200 mg/L), power input (150-300 W), and gas-flow rate (1.5-2.5 L/min) for efficient NH3-N removal from wastewater samples. The gas-flow rate and power input were found to be the most significant factors affecting the removal efficiency of NH3-N, whereas the initial concentration of NH3-N played a crucial role in determining the energy efficiency of the process. Under optimal conditions of an initial NH3-N concentration of 200 mg/L, applied power of 223 W, and gas-flow rate of 2.4 L/min, 98.91% of NH3-N could be removed with N2 selectivity of 92.91%, and the corresponding energy efficiency was 0.527g/kWh after 2 hrs of treatment. A small fraction of undesirable NO3 (35.03 mg/L) and NO2 (6.5 mg/L) were also produced. Optical emission spectroscopy (OES) has revealed the presence of several highly oxidative radicals, including ‧OH, ‧O, and ‧O2+. These results demonstrate the potential of liquid phase plasma discharge as a highly efficient technology for removing ammonia from aqueous solutions. © 2023 ASABE Annual International Meeting. All Rights Reserved.

关键词： Flow of gases

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Synthesis and evaluation of the antifungal activity of 5-hydroxy-3-phenyl-1H-pyrazole-1-carbothioamide for use in the oral environment

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Journal of Oral Biology and Craniofacial Research 2024年第2期14卷 211-215页

作者： Amin Zadeh, Hossein Zomorodkia, Ali Asghar Hadi, Saeid Mohammad Zadeh, Iman Sabetghadam, Seyed Abd Alreza Hadi, Vahid Department of Chemistry Shahid Bahonar University of Kerman 76169 Iran Department of Chemical Engineering South Tehran Branch Islamic Azad University Tehran Iran Department of Health and Nutriotion Faculty of Medicine AJA University of Medical Science Tehran Iran Oral and Dental Disease Research Center Kerman University of Medical Sciences Kerman Iran Department of Polymer Engineering Science and Research Branch Islamic Azad University Tehran Iran

Background and aim: Candida albicans and Candida tropicalis, can cause superﬁcial infections of the oral mucosa as well as disseminated bloodstream and deep-tissue infections. The most frequently employed class of antifungals used for Candida infection treatment are the azole antifungals. Their low price, low toxic qualities, and availability for oral use make ﬂuconazole and similar azole antifungals the preferred treatment for various infections caused by Candida. Nevertheless, developed and intrinsic resistance to antifungals of the azole family has been widely documented in association with various species of Candida. Candida infection management requires synthesizing new compounds to improve azole class antifungals, as Candida isolates resistant to azole are increasingly encountered in the clinical setting. This study aimed to synthesize a new azole compound and investigate its antifungal activity. Methods: In this experimental study, 5-hydroxy-3-phenyl-1H-pyrazole-1-carbothioamide was synthesized by the reaction between thiosemecarbazide and ethylbezoylacetate. The structure of the synthesized compound was characterized by different techniques such as Fourier transform infrared (FT-IR) and nuclear magnetic resonance (NMR) spectra and its antifungal activity against Candida albicans and Candida tropicalis was investigated by the Spread Plat method to determine its minimum fungicidal concentration (MFC) and minimum inhibitory concentration (MIC). Results and discussion: The Spread Plat test demonstrated that with the increase in 5-hydroxy-3-phenyl-1H-pyrazole-1-carbothioamide concentration, colonies of fungi were increasingly eliminated at a significant level(p < 0.001). At a concentration of 1000 ppm, all Candida albicans and Candida tropicalis colonies were destroyed. Conclusions: The results indicate that the synthesized compound showed a promising antifungal effect. On the other hand, it had a suitable spectrum of effect, because it showed antifungal effects

关键词： Antifungal Candida albicans Candida tropicalis fluconazole Oral health Pyrazole

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3D bioprinting of engineered exosomes secreted from M2-polarized macrophages through immunomodulatory biomaterial promotes in vivo wound healing and angiogenesis

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Bioactive Materials 2025年第3期45卷 345-362页

作者： Sayan Deb Dutta Jeong Man An Jin Hexiu Aayushi Randhawa Keya Ganguly Tejal V.Patil Thavasyappan Thambi Jangho Kim Yong-kyu Lee Ki-Taek Lim Department of Biosystems Engineering Kangwon National University24341ChuncheonRepublic of Korea Institute of Forest Science Kangwon National University24341ChuncheonRepublic of Korea School of Medicine University of California Davis95817SacramentoUnited States Department of Bioengineering College of EngineeringHanyang University04763SeoulRepublic of Korea Department of Plastic and Traumatic Surgery Capital Medical University100069BeijingChina Interdisciplinary Program in Smart Agriculture Kangwon National University24341ChuncheonRepublic of Korea Graduate School of Biotechnology College of Life SciencesKyung Hee University17104YonginRepublic of Korea Department of Convergence Biosystems Engineering Chonnam National University61186GwangjuRepublic of Korea Department of Chemical and Biological Engineering Korea National University of Transportation27470ChungjuRepublic of Korea

Biomaterial composition and surface charge play a critical role in macrophage polarization,providing a mo-lecular cue for immunomodulation and tissue *** this study,we developed bifunctional hydrogel inks for accelerating M2 macrophage polarization and exosome(Exo)cultivation for wound healing *** this,we first fabricated polyamine-modified three-dimensional(3D)printable hydrogels consisting of algi-nate/gelatin/polydopamine nanospheres(AG/NSPs)to boost M2-exosome(M2-Exo)*** cultivated M2-Exo were finally encapsulated into a biocompatible collagen/decellularized extracellular matrix(COL@d-ECM)bioink for studying angiogenesis and in vivo wound healing *** findings show that 3D-printed AGP hydrogel promoted M2 macrophage polarization by Janus kinase/signal transducer of activation(JAK/STAT),peroxisome proliferator-activated receptor(PPAR)signaling pathways and facilitated the M2-Exo ***,the COL@d-ECM/M2-Exo was found to be biocompatible with skin ***(RNA-Seq)and real-time PCR(qRT-PCR)study revealed that co-culture of fibroblast/keratinocyte/stem cells/endothelial cells in a 3D bioprinted COL@d-ECM/M2-Exo hydrogel upregulated the skin-associated signature biomarkers through various regulatory pathways during epidermis remodeling and downregulated the mitogen-activated protein kinase(MAPK)signaling pathway after 7 *** a subcutaneous wound model,the 3D bioprinted COL@d-ECM/M2-Exo hydrogel displayed robust wound remodeling and hair follicle(HF)induction while reducing canonical pro-inflammatory activation after 14 days,presenting a viable therapeutic strategy for skin-related disorders.

关键词： Exosome Immunomodulation Decellularized extracellular matrix Skin bioprinting Angiogenesis Wound healing

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Spider Silk Supercontraction‑Inspired Cotton‑Hydrogel Self‑Adapting Textiles

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Advanced Fiber Materials 2022年第6期4卷 1572-1583页

作者： Abdul Qadeer Khan Kaiqing Yu Jiatian Li Xueqi Leng Meilin Wang Xuesong Zhang Baigang An Bin Fei Wei Wei Huichuan Zhuang Muhammad Shafiq Lili Bao Zunfeng Liu Xiang Zhou Department of Science China Pharmaceutical UniversityNanjing 211198China State Key Laboratory of Medicinal Chemical Biology College of Pharmacyand College of ChemistryKey Laboratory of Functional Polymer MaterialsFrontiers Science Center for New Organic MatterNankai UniversityTianjin 300071China School of Chemical Engineering University of Science and Technology LiaoningAnshan 114051China Institute of Textiles and Clothing The Hong Kong Polytechnic UniversityHong Kong 999077China Department of Cardiothoracic Surgery Jinling HospitalNanjing 210002China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano‑Biomaterials and Regenerative MedicineCollege of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620PR China

Smart textiles are able to self-adapt to an irregular ***,they found new applications in intelligent clothes and equipments,where the properties and functionality of traditional polymeric fibers are insufficient,and hard to be *** by the supercontraction behavior of the spider silk,we prepared a spinnable hydrogel to form a sheath-core-like composite yarn,after being coated on cotton *** strong hydrogen bonding between the cotton yarn and the polar groups of the hydrogel provides an outstanding mechanical stability,and the twists insertion forms a spiral-like architecture,which exhibited moisture-responsive super contraction *** structural tailoring the chirality of the fiber twists and coiling extends into homo-chiral and heterochiral architectures,as displays contraction and expansion when is exposed to the *** the relative humidity is increased from 60 to 90%,a homochiral yarn exhibits 90%contraction,while a heterochiral yarn shows 450% expansion,and the maximum work capacity reached up to 6.1 J/*** super contracted yarn can be re-stretched to its original length manifesting cyclability,which can be exploited to build a smart textile,selfadaptive to irregular *** a strategy may be further extended to a wide variety of materials to achieve intelligent textiles from common fiber or yarns.

关键词： Supercontraction Yarns Actuator Moisture sensitive Biomimetic

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Macrophage metabolism reprogramming EGCG-Cu coordination capsules delivered in polyzwitterionic hydrogel for burn wound healing and regeneration

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Bioactive Materials 2023年第11期29卷 251-264页

作者： Qinghua Li Huijuan Song Shuangyang Li Pengbo Hu Chuangnian Zhang Ju Zhang Zujian Feng Deling Kong Weiwei Wang Pingsheng Huang Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical EngineeringChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin300192China Institute of Radiation Medicine Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin300192China Department of Polymer Science and Engineering Key Laboratory of Systems BioengineeringSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin300072China Emergency Department of Binzhou Medical University Hospital BinzhouShandong Province256600China State Key Laboratory of Medicinal Chemical Biology College of Life SciencesNankai UniversityTianjin300071China

Excessive reactive oxygen species(ROS)at severe burn injury sites may promote metabolic reprogramming of macrophages to induce a deteriorative and uncontrolled inflammation cycle,leading to delayed wound healing and ***,a novel bioactive,anti-fouling,flexible polyzwitterionic hydrogel encapsulated with epigallocatechin gallate(EGCG)-copper(Cu)capsules(termed as EGCG-Cu@CBgel)is engineered for burn wound management,which is dedicated to synergistically exerting ROS-scavenging,immune metabolic regulation and pro-angiogenic ***-Cu@CBgel can scavenge ROS to normalize intracellular redox homeostasis,effectively relieving oxidative damages and blocking proinflammatory signal ***,EGCG-Cu can inhibit the activity of hexokinase and phosphofructokinase,alleviate accumulation of pyruvate and convert it to acetyl coenzyme A(CoA),whereby inhibits glycolysis and normalizes tricarboxylic acid(TCA)***,metabolic reprogramming of macrophages by EGCG-Cu downregulates M1-type polarization and the expression of proinflammatory cytokines both in vitro and in ***,copper ions(Cu^(2+))released from the hydrogel facilitate ***-Cu@CBgel significantly accelerates the healing of severe burn wound via promoting wound closure,weakening tissue-damaging inflammatory responses and enhancing the remodeling of pathological ***,this study demonstrates the great potential of bioactive hydrogel dressing in treating burn wounds without unnecessary secondary damage to newly formed skin,and highlights the importance of immunometabolism modulation in tissue repair and regeneration.

关键词： ROS scavenging Hydrogel dressing EGCG-Cu capsule Metabolic reprogramming Burn wound healing

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