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Vascular Endothelial Growth Factor‑Recruiting Nanofiber Bandages Promote Multifunctional Skin Regeneration via Improved Angiogenesis and Immunomodulation

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Advanced Fiber Materials 2023年第1期5卷 327-348页

作者： Yi Chen Zhengchao Yuan Weiyan Sun Muhammad Shafiq Jun Zhu Jiafei Chen Hai Tang Ling Hu Weikang Lin Yanxi Zeng Long Wang Lei Zhang Yunlang She Hui Zheng Guofang Zhao Dong Xie Xiumei Mo Chang Chen Department of Thoracic Surgery Shanghai Pulmonary HospitalTongji UniversityShanghai 200092China Shanghai Engineering Research Center of Lung Transplantation Shanghai 200433China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano‑Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620China Center for Life Science Tsinghua UniversityBeijing 100084China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain ScienceFudan UniversityShanghai 200433China Department of Chemical Engineering Faculty of EngineeringGraduate SchoolKyushu UniversityFukuoka 819‑0395Japan Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092China Department of Biotechnology Faculty of Science and TechnologyUniversity of Central Punjab(UCP)Lahore 54000Pakistan Department of Cardiothoracic Surgery Hwa Mei HospitalUniversity of Chinese Academy of SciencesNingbo 315000China Ningbo Institute of Life and Health Industry University of Chinese Academy of SciencesNingbo 315000China

Tissue injury leads to gradients of chemoattractants,which drive multiple processes for tissue repair,including the inflam-matory response as well as endogenous cell ***,a limited time window for the gradients of chemoattract-ants as well as their poor stability at the injury site may not translate into healthy tissue ***,intelligent multifunctional scaffolds with the capability to stabilize injury-induced cytokines and chemokines hold great promise for tissue *** endothelial growth factor(VEGF)plays a significant role in wound healing by promoting *** overarching objective of this research was to develop intelligent multifunctional scaffolds with the capability to endogenously recruit VEGF and promote wound healing via angiogenic and immunomodulatory dual ***-1-derived peptide(PR1P)was encapsulated into electrospun poly(L-lactide-coglycolide)/gelatin(P/G)-based *** sustained release of PR1P recruited VEGF in situ,thereby stabilizing the protein concentration peak in vivo and affording a reparative microenvironment with an adequate angiogenic ability at the wound ***,PR1P-recruited VEGF-induced macrophage reprogramming towards M2-like phenotypes further conferred immunomodulatory functions to the *** dual functions of proangiogenesis and immunomodulation formed a cascade amplification,which regulated matrix metalloproteinases(MMP-9)as well as inflammatory factors(nuclear factor(NF)-κb,tumor necrosis factor(TNF)-α)in the wound microenvironment via the VEGF/macrophages/microenvironment ***,the bandages realized multifunctional regeneration in splinted excisional wounds in rats,with or without diabetes,affording a higher skin append-age neogenesis,sensory function,and collagen ***,our approach encompassing in situ recruitment of VEGF at the injury site with the capability to promote immunomodulation-mediated tissue repair affords a p

关键词： Skin regeneration Angiogenesis Immunomodulation Peptide Wound bandage Electrospun nanofiber

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Heteroheptacene-based acceptors with thieno[3,2-b]pyrrole yield high-performance polymer solar cells

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National science Review 2022年第7期9卷 106-115页

作者： Zhenghui Luo Ruijie Ma Jianwei Yu Heng Liu Tao Liu Fan Ni Jiahao Hu Yang Zou Anping Zeng Chun-Jen Su U-Ser Jeng Xinhui Lu Feng Gao Chuluo Yang He Yan Shenzhen Key Laboratory of Polymer Science and Technology College of Materials Science and EngineeringShenzhen University Department of Chemistry and Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration & Reconstruction Hong Kong University of Science and Technology (HKUST) Hong Kong University of Science and Technology-Shenzhen Research Institute Department of Physics Chemistry and Biology (IFM) Link?ping University Department of Physics Chinese University of Hong Kong Synchrotron Radiation Research Center Hsinchu Science Park Department of Chemical Engineering Tsing Hua University Hong Kong University of Science and Technology (HKUST) Light-Emitting Diode and Flat Panel Display Technology Research & Development Center Hong Kong University of Science and Technology (HKUST) Foshan Research Institute for Smart Manufacturing

Rationally utilizing and developing synthetic units is of particular significance for the design of high-performance non-fullerene small-mole cule acceptors(SMAs).Here,a thieno[3,2-b]pyrrole synthetic unit was employed to develop a set of SMAs(ThPy1,ThPy2,ThPy3 and ThPy4) by changing the number or the position of the pyrrole ring in the central core based on a standard SMA of IT-4 Cl,compared to which the four thieno[3,2-b] pyrrole-based acceptors exhibit bathochromic absorption and upshifted frontier orbital energy level due to the strong ele ctron-donating ability of *** a result,the polymer solar cells(PSCs) of the four thieno[3,2-b] pyrrole-based acceptors yield higher open-circuit voltage and lower energy loss relative to those of the IT-4 Cl-based *** is more,the ThPy3-based device achieves a power conversion efficiency(PCE)(15.3%) and an outstanding fill factor(FF)(0.771) that are superior to the IT-4 Cl-based device(PCE=12.6%,FF=0.758).The ThPy4-based device realizes the lowest energy loss and the smallest optical band gap,and the ternary PSC device based on PM6:BTP-eC9:ThPy4 exhibits a PCE of 18.43% and a FF of ***,this work sheds light on the great potential of thieno[3,2-b]pyrrole-based SMAs in realizing low energy loss and high PCE.

关键词： thieno[3,2-b]pyrrole small-molecule acceptors energy loss intramolecular non-covalent interactions polymer solar cells

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Fabrication Techniques and Sensing Mechanisms of Textile‑Based Strain Sensors:From Spatial 1D and 2D Perspectives

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Advanced Fiber Materials 2024年第1期6卷 36-67页

作者： Shilin Liu Wenting Zhang Jingzong He Yonggen Lu Qilin Wu Malcolm Xing State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China Department of Mechanical Engineering University of ManitobaWinnipegMB R3T 2N2Canada

The intelligent textile sensors based on fiber(1D)and fabric(2D)are the ideal candidates for wearable *** flexible weaving and unique structure endow them with flexibility,lightweight,good air permeability,and feasible integration with *** view of the spring-up of novel textile-based strain sensors,the novel materials and fabrication approaches were elaborated from spatial perspectives,i.e.,1D fibers/yarn and 2D *** intrinsic sensing mechanism is the primary fac-tor affecting sensor sensitivity,and the variation trend of the sensing signal is closely related to *** existing studies have involved various sensing mechanisms,there is still lacking systematic classification and ***,the sensing mechanisms of textile-based sensors were elaborated from spatial *** that strain sensors were mostly based on resistance variation,the sensing mechanisms of resistive textile-based strain sensors were mainly focused,mainly including fiber deformation,tunneling effect,crack propagation,fabric deformation,electrical contact and bridge ***,the corresponding resistance prediction models,usually used as important data fitting methodology,were also comprehensively discussed,which can reproduce the resistance trend and provide guidance for the sensor ***,the multifunctionality of textile-based strain sensors was summarized,namely multi-mode signal detection,visual interaction,energy collection,thermal management and medical treatment were *** was expected to provide research insights into the multifunctional integration of textile sensors.

关键词： Textile sensors Fabrication approaches Sensing mechanism Prediction model Multifunctionality

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Antioxidants activities of Backhousia citriodora leaf extract by ultrasonic assisted extraction

Antioxidants activities of Backhousia citriodora leaf extrac...

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Sustainable & Integrated engineering International Conference, SIE 2022

作者： Adenan, Nur Syuhaida Zahir, Norhidayu Mat Daud, Nurizzati Mohd Sulaiman, Wan Rosli Wan Hasham, Rosnani Ya'akob, Harisun Hamid, Mariani Abdul Department of Bioprocess and Polymer Engineering Faculty of Chemical and Energy Engineering Universiti Teknologi Malaysia Johor Johor Bahru81310 Malaysia Department of Biomedical Engineering and Health Science Faculty of Electrical Engineering Universiti Teknologi Malaysia Johor Johor Bahru81310 Malaysia Department of Petroleum Engineering Faculty of Chemical and Energy Engineering Universiti Teknologi Malaysia Johor Johor Bahru81310 Malaysia

Antioxidants are critical for protecting the body from the oxidative stress caused by free radicals. These chemicals, which scavenge radicals and are frequently obtained from foods such as fruits, vegetables, and herbs, are extremely important for overall health. Backhousia citriodora produces an essential oil that is notable for its abundance of bioactive components, which greatly add to its advantageous qualities. The purpose of this study was to investigate the chemical composition of the essential oil extracted from B. citriodora leaves, with an emphasis on the oil's potential as an antioxidant. Employing ultrasonic-assisted extraction, this research identified geranial (23.2 %) and neral (19.7 %) as the predominant bioactive constituents through gas chromatography-mass spectrometry analysis. These compounds exhibited notable antioxidant capabilities, as evidenced by the extract's substantial TPC of 134.72 mg GAE/g, underscoring its abundance in phenolic compounds. Evaluation of DPPH and ABTS radical scavenging activities further highlighted B. citriodora leaf extract robust antioxidant efficacy, demonstrating compelling IC50 values of 2.59 ± 0.532 µg/mL and 34.53 ± 1.14 mg/ mL, respectively. These findings underscore the potential of B. citriodora as a natural antioxidant resource with promising applications in pharmaceuticals, cosmeceuticals, and food industries. © 2024 Elsevier Ltd. All rights reserved.

关键词： Medicinal chemistry

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Head-to-tail cyclization for the synthesis of naturally occurring cyclic peptides on organophosphorus small-molecular supports

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Organic Chemistry Frontiers 2022年第4期9卷 946-952页

作者： Haidi Li Junyou Li Jie Chao Zixin Zhang Chuanguang Qin MIIT Key Laboratory of Special Functional&Intelligent Polymer materials MOE Key Laboratory of Supernormal Material Physics&ChemistryShaanxi Key Laboratory of Polymer Science&TechnologyDepartment of ChemistrySchool of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an710072P.R.China

To achieve head-to-tail cyclic peptides via the liquid-phase on-support cyclization and synergistic self-cleavage strategy,4,4’-bis(diphenylphosphinyloxyl)diphenyl ketoxime(BDKO)and 4-diphenyl phospho-loxy benzyl alcohol(DPBA)were designed and prepared as small-molecular supports of greener peptide *** the process of the BDKO(or DPBA)support assisted Boc strategy for liquid-phase peptide chain extension,the last amino acid at the N-terminus of the peptide chain ends with a Fmoc protected amino acid.

关键词： synthesis cyclization synthesis

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Synthesis and Characterization of Gelatin Fibers as Filter Media for Bio-Separation Applications

SSRN

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SSRN 2024年

作者： Wali, Ashwini Khairnar, Ajay Torris, Arun Badiger, Manohar V. Department of Chemical Engineering Ramaiah Institute of Technology MSR Nagar MSRIT Post Karnataka Bangalore India Department of Polymer Science and Engineering CSIR-National Chemical Laboratory Maharashtra Pune India

The bio-polymer based electrospun fibers have tremendous applications in bio-separations. In order to explore further, for the separation of impurities from blood like uremic toxins and smaller sized molecules, we designed a novel filter media from gelatin which is a cost effective and biodegradable resource. The gelatin fibers obtained from electrospinning process were incorporated with the Halloysite nanoclay (HNT) and crosslinked with glutaraldehyde for improvement in the mechanical properties. The morphology was studied by SEM and fiber diameter ranged from 1 to 3 µm. The porosity and pore size distribution, pressure drop were studied using the 3D-Microtomography experiments. The in-vitro MTT assay for cell viability of the L929 fibroblast cells showed no toxicity and the same was confirmed by the haemolysis study which showed that the gelatin filter media could be used as filtration/purification system. This filter media could possibly find a replacement for synthetic membranes which are used in the dialysis treatment for patients with kidney failures and disorders. © 2024, The Authors. All rights reserved.

关键词： Pore size

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Alloyed nanostructures integrated metal-phenolic nanoplatform for synergistic wound disinfection and revascularization

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Bioactive Materials 2022年第10期7卷 95-106页

作者： Yi Xie Shengqiu Chen Xu Peng Xiaoling Wang Zhiwei Wei Joseph J.Richardson Kang Liang Hirotaka Ejima Junling Guo Changsheng Zhao College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengduSichuan610065China BMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and EngineeringSichuan UniverisityChengduSichuan610065China Laboratory Animal Center Sichuan UniversityChengduSichuan610065China School of Chemical Engineering Graduate School of Biomedical Engineeringand Australian Centre for NanoMedicineUniversity of New South WalesSydneyNSW2052Australia Department of Materials Engineering School of EngineeringThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo113􀀀8656Japan Bioproducts Institute Departments of Chemical and Biological EngineeringThe University of British ColumbiaVancouverBCV6T 1Z4Canada School of Chemical Engineering Sichuan UniversityChengduSichuan610065China

New materials for combating bacteria-caused infection and promoting the formation of microvascular networks during wound healing are of vital *** antibiotics can be used to prevent infection,treatments that can disinfect and accelerate wound healing are ***,we engineer a coating that is both highly compatible with current wound dressing substrates and capable of simultaneously disinfecting and revascularizing wounds using a metal-phenolic nanoplatform containing an alloyed nanostructured architecture(Ag@Cu-MPNNC).The alloyed nanostructure is formed by the spontaneous co-reduction and catalytic disproportionation reaction of multiple metal ions on a foundation metal-phenolic supramolecular *** synergistic presence of metals greatly improves the antibacterial activity against both Gram-negative and Gram-positive pathogenic bacteria,while demonstrating negligible cytotoxicity to normal *** infected rat models,the Ag@Cu-MPNNC could kill bacteria efficiently,promoting revascularization and accelerate wound closure with no adverse side effects in infected in vivo *** other words,this material acts as a combination therapy by inhibiting bacterial invasion and modulating bio-nano interactions in the wound.

关键词： Metal-phenolic network Wound healing Antibacterial activity Revascularization

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Fabricating 3-dimensional human brown adipose microtissues for transplantation studies

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Bioactive Materials 2023年第4期22卷 518-534页

作者： Ou Wang Li Han Haishuang Lin Mingmei Tian Shuyang Zhang Bin Duan Soonkyu Chung Chi Zhang Xiaojun Lian Yong Wang Yuguo Lei Department of Chemical and Biomolecular Engineering University of Nebraska-LincolnNEUSA Biomedical Engineering Program University of Nebraska-LincolnNEUSA Department of Biomedical Engineering Pennsylvania State UniversityPAUSA China Novartis Institutes for BioMedical Research Co. Ltd.BeijingChina Department of Chemistry University of Nebraska-LincolnNEUSA Mary&Dick Holland Regenerative Medicine Program and Division of Cardiology Department of Internal MedicineUniversity of Nebraska Medical CenterOmahaNEUSA Department of Nutrition University of MassachusettsAmherstMAUSA School of Biological Science University of Nebraska-LincolnNEUSA Huck Institutes of the Life Sciences Pennsylvania State UniversityPAUSA

Transplanting cell cultured brown adipocytes(BAs)represents a promising approach to prevent and treat obesity(OB)and its associated metabolic disorders,including type 2 diabetes mellitus(T2DM).However,transplanted BAs have a very low survival rate in *** enzymatic dissociation during the harvest of fully differentiated BAs also loses significant *** is a critical need for novel methods that can avoid cell death during cell preparation,transplantation,and in ***,we reported that preparing BAs as injectable microtissues could overcome the *** found that 3D culture promoted BA differentiation and UCP-1 expression,and the optimal initial cell aggregate size was 100μ*** microtissues could be produced at large scales via 3D suspension assisted with a PEG hydrogel and could be *** microtissues could survive in vivo for long *** alleviated body weight and fat gain and improved glucose tolerance and insulin sensitivity in high-fat diet(HFD)-induced OB and T2DM *** microtissues impacted multiple organs,secreted protein factors,and influenced the secretion of endogenous *** our best knowledge,this is the first report on fabricating human BA microtissues and showing their safety and efficacy in T2DM *** proposal of transplanting fabricated BA microtissues,the microtissue fabrication method,and the demonstration of efficacy in T2DM mice are all *** results show that engineered 3D human BA microtissues have considerable advantages in product scalability,storage,purity,safety,dosage,survival,and efficacy.

关键词： Brown adipocyte Microtissue Transplantation Obesity Type 2 diabetes

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Regulating microstructure and composition by carbonizing in-situ grown metal-organic frameworks on cotton fabrics for boosting electromagnetic wave absorption

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Nano Research 2024年第8期17卷 7290-7300页

作者： Jie Jin Hongsen Long Hu Liu Yan Guo Tiantian Bai Ben Bin Xu Mohammed A.Amin Hua Qiu Mohamed H.Helal Chuntai Liu Changyu Shen Zeinhom M.El-Bahy Zhanhu Guo State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentNational Engineering Research Center for Advanced Polymer Processing TechnologyZhengzhou UniversityZhengzhou 450002China China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410000China School of Electronic Engineering North China University of Water Resources and Electric PowerZhengzhou 450046China Complex Conditions of High-end Tire Technology Innovation Center Shuguang Rubber Industry Research&Design Institute Co.LtdGuilin 541004China Integrated Composites Lab Department of Mechanical and Civil EngineeringNorthumbria UniversityNewcastle Upon TyneNE18STUK Department of Chemistry College of ScienceTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Department of Chemistry Faculty of Arts and ScienceNorthern Border UniversityRafha 73213Saudi Arabia Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr City 11884CairoEgypt

High-temperature carbonized metal-organic frameworks(MOFs)derivatives have demonstrated their superiority for promising electromagnetic wave(EMW)absorbers,but they still suffer from limited EMW absorption capacity and narrow *** the advantage of microstructure and chemical composition regulation for the design of EMW absorber,hierarchical heterostructured MoS_(2)/CoS_(2)-Co_(3)O_(4)@cabonized cotton fabric(CF)(MCC@CCF)is prepared by growing ZIF-67 MOFs onto CF surface,chemical etching,and *** from the dual loss mechanism of magnetic-dielectric multicomponent carbonized MOFs,chemical etching and carbonization process can effectively introduce abundant micro-gap structure that can result in better impedance matching and stronger absorption capacity via internal reflection,doped heteroatoms(Mo,N,S)to supply additional dipolar polarization loss,and numerous heterointerfaces among MoS_(2),CoS_(2),Co_(3)O_(4),and CCF that produce promoted conduction loss and interfacial polarization ***,a minimal reflection loss of−52.87 dB and a broadest effective absorption bandwidth of 6.88 GHz were achieved via tunning the sample thickness and filler loading,showing excellent EMW absorption *** research is of great value for guiding the research on MOFs derivatives based EMW absorbing materials.

关键词： metal-organic frameworks hierarchical structure chemical etching sulfurization electromagnetic wave absorption

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In situ interphase engineering for all-solid-state Li batteries: a case study on the LiNi0.5Mn1.5O4/Li0.33La0.55TiO3 composite cathode guided by ab initio calculations

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Journal of Materials Chemistry A 2024年第16期12卷 9438-9453页

作者： Lin, Che-An Ihrig, Martin Kung, Kuan-Chen Chen, Hsiang-Ching Finsterbusch, Martin Guillon, Olivier Lin, Shih-Kang Department of Materials Science and Engineering National Cheng Kung University Tainan70101 Taiwan Department of Chemical Engineering National Taiwan University of Science and Technology Taipei106 Taiwan Forschungszentrum Jülich GmbH Jülich52425 Germany Research Center National Cheng Kung University Tainan70101 Taiwan Program on Smart and Sustainable Manufacturing Academy of Innovative Semiconductor and Sustainable Manufacturing National Cheng Kung University Tainan70101 Taiwan Core Facility Center National Cheng Kung University Tainan70101 Taiwan

The sinterability and interfacial stability issues in the composite cathode have been the main bottlenecks of oxide-based all-solid-state Li battery development. The interfacial reaction between the electrode and electrolyte plays an important role in the sinterability and interfacial stability of a composite cathode. A suitable interfacial reaction can not only improve the sinterability by providing an additional driving force for chemical bond formation, but it can also stabilize the electrode/electrolyte interface by forming interfacial reaction products which remain stable during operation of the cell. In this work, a suitable dopant that can induce the formation of the desired interphase between the LiNi0.5Mn1.5O4 cathode and Li0.33La0.55TiO3 electrolyte was obtained through ab inito computational screening. Experimental verification was carried out by field-assisted sintering technology/spark plasma sintering (FAST/SPS) for obtaining mechanically stable composite cathode pellets and heat treatment for inducing the interfacial reaction. The dopant identified by computation was proven to induce the in situ formation of a stable protective layer. A successful method of simultaneously improving sinterability and interfacial stability in an oxide-based composite cathode is demonstrated in this work. © 2024 The Royal Society of Chemistry.

关键词： Spark plasma sintering

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