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A pro-inflammatory diet is associated with higher body adiposity in kidney transplant recipients

Nutrition Research 2025年 138卷 122-134页

作者： Costa, Mariana Silva da Portugal, Mariana Ribeiro Costa Tibaes, Jenneffer Rayane Braga Bianchi, Larissa Santos Maciel de Azevedo Pontes, Karine Scanci da Silva Menna Barreto, Ana Paula Medeiros Caparelli, Lucas Boechat Barreto Silva, Maria Inês Klein, Márcia Regina Simas Torres Post-Graduate Program in Medical Sciences Rio de Janeiro State University Rio de Janeiro Brazil Department of Applied Nutrition Nutrition Institute State University of Rio de Janeiro (UERJ) Rio de Janeiro Brazil Division of Human Nutrition Department of Agricultural Food and Nutritional Science University of Alberta Edmonton AB Canada Post-Graduate Program in Food Nutrition and Health Rio de Janeiro State University (UERJ) Rio de Janeiro Brazil Post-Graduate Program in Clinical and Experimental Pathophysiology State University of Rio de Janeiro (UERJ) Rio de Janeiro Brazil Nutrition Institute - Federal University of Rio de Janeiro Macaé Brazil Nephrology Division Rio de Janeiro State University Rio de Janeiro Brazil

The dietary inflammatory index (DII) has been associated with obesity and cardiovascular risk factors (CVRF) in the general population. We hypothesized that in kidney transplant recipients (KTR), a positive relationship between DII, body adiposity and CVRF would also be observed. To test this hypothesis, we conducted a cross-sectional study with adult KTR. Body mass index (BMI), body adiposity index (BAI) and waist circumference (WC) were assessed. Total fat mass (FM), trunk FM, and load-capacity index (LCI) were evaluated using dual-energy X-ray absorptiometry. Energy-adjusted DII (E-DII) was estimated based on three 24-h recalls and stratified as anti-inflammatory (E-DII<0) and pro-inflammatory (E-DII>0). CVRF included hypertension, diabetes, dyslipidemia, and metabolic syndrome. A total of 170 KTR, 59% male, with 49.5 (42-57) years and E-DII from -2.89 to 4.78 were evaluated. KTR with E-DII>0, compared to those with E-DII<0, exhibited significantly higher values of BAI, total FM (kg), and LCI. In multiple adjusted linear regression, E-DII was significantly associated with WC, total FM (kg), and trunk FM (kg). Logistic regression analysis indicated that E-DII>0 was significantly associated with obesity, as assessed by BAI. E-DII was not associated with CVRF. The present study suggests that a pro-inflammatory diet is associated with higher total and central body adiposity in KTR. Interventions targeting an anti-inflammatory diet may contribute to reducing excessive body adiposity in this population. © 2025 Elsevier Inc.

关键词： Body fat Cardiovascular disease risk factors Dietary inflammatory index Kidney transplant Obesity

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Effects of multi-strain probiotics supplementation on body adiposity and metabolic profile in individuals with hypertension and overweight following an energy-restricted diet: A randomized clinical trial

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clinical Nutrition 2025年 50卷 117-127页

作者： Karine Scanci da Silva Pontes Marcella Rodrigues Guedes Priscila Guadagno de Souza Mario Fritsch Toros Neves Márcia Regina Simas Torres Klein Post Graduate Program in Clinical and Experimental Pathophysiology Rio de Janeiro State University Rio de Janeiro Brazil Post Graduate Program in Food Nutrition and Health Rio de Janeiro State University Rio de Janeiro Brazil Department of Clinical Medicine Rio de Janeiro State University Rio de Janeiro Brazil Department of Applied Nutrition Nutrition Institute Rio de Janeiro State University Rio de Janeiro Brazil

Background & aims Recent evidence suggests that gut microbiota has a potential role in the pathophysiology of obesity and other cardiovascular disease (CVD) risk factors, including hypertension, dyslipidemia, and type 2 diabetes. However, clinical trials evaluating the effects of probiotics supplementation on these outcomes have found inconsistent results, probably due to the wide heterogeneity in trial designs. In addition, there is a lack of studies investigating whether probiotics can enhance the beneficial effects of caloric restriction in individuals with increased risk of CVD as individuals with hypertension and excess body adiposity. Thus, the aim of this study was to evaluate the effects of multi-strain probiotics supplementation on body adiposity, glycemic homeostasis, lipid profile, and serum adipokine levels in individuals with hypertension and excess body weight following an energy restricted diet. Methods A randomized, double-blind, placebo controlled clinical trial was conducted for 12 weeks. Were included 66 individuals aged between 40 and 65 years; both sexes; body mass index (BMI) ≥ 25 and < 40 kg/m 2 and diagnosis of hypertension. Were excluded smokers; individuals using probiotics, prebiotics, symbiotics and antibiotics in the last 3 months; presenting diabetes, chronic kidney disease or liver failure; and pregnant and lactating women. Participants were allocated into 2 groups: group with supplementation of 8 probiotic strains in capsules (3 × 10 10 CFU/day) or control group (placebo capsules). Both groups followed a low-calorie diet. Participants underwent anthropometric, body composition (dual-energy radiological absorptiometry) and biochemical (glucose metabolism, lipid profile, adiponectin, and leptin) evaluation at baseline and at the end of the study. Results After 12 weeks of intervention, the probiotics group presented: a) reduction of body weight, BMI, circumferences of waist, hip and neck and waist-to-height ratio; b) decrease in total f

关键词： Probiotics Gastrointestinal microbiome Obesity Overweight Glucose Adipokines

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Down-regulation of transforming growth factor beta-2 expression is associated with the reduction of cyclosporin induced gingival overgrowth in rats treated with roxithromycin: An experimental study

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BMC Oral Health 2009年第1期9卷 1-9页

作者： Condé, Simone Aparecida Probst Bastos, Marcus Gomes Vieira, Beatriz Julio Aarestrup, Fernando Monteiro Department of Clinical Dental Post-graduate Program in Health Federal University of Juiz de Fora/UFJF Valença Brazil Department of Nephrology NIEPEN Institute Federal University of Juiz de Fora/UFJF Juiz de Fora Brazil Center of Biology Reprodution Laboratory of Immunopathology and Experimental Pathology Federal University of Juiz de Fora Juiz de Fora Brazil Department of Semiology Center of Biology Reprodution Federal University of Juiz de Fora Juiz de Fora Brazil

Abstract. Background. Gingival overgrowth (GO) is a common side effect of the chronic use of cyclosporine (CsA), an immunosuppressant widely used to prevent rejection in transplant patients. Recent studies have reported elevated levels of specific cytokines in gingival overgrowth tissue, particularly TGF-beta, suggesting that this growth factor plays a role in the accumulation of extracellular matrix materials. The effectiveness of azithromycin, a macrolide antibiotic, in the regression of this undesirable side effect has also been demonstrated. Methods. In this study, we created an experimental model for assessing the therapeutic effect of roxithromycin in GO and the expression of transforming growth factor beta (TGF-beta2) through immunohistochemistry. We used four groups of rats totaling 32 individuals. GO was induced during five weeks and drug treatment was given on the 6th week as follows: group 1 received saline;group 2 received CsA and was treated with saline on the 6th week;group 3 received CsA and, on the 6th week, ampicilin;and group 4 received CsA during 5 weeks and, on the 6th week, was treated with roxithromycin. Results. The results demonstrated that roxithromycin treatment was effective in reducing cyclosporine-induced GO in rats. Both epithelial and connective tissue showed a decrease in thickness and a significant reduction in TGF-beta2 expression, with a lower number of fibroblasts, reduction in fibrotic areas and decrease in inflammatory infiltrate. Conclusion. The present data suggest that the down-regulation of TGF-beta2 expression may be an important mechanism of action by which roxithromycin inhibits GO. © 2009 Condé et al;licensee BioMed Central Ltd.

关键词： Azithromycin Roxithromycin Bullous Pemphigoid Gingival Tissue Fibrotic Area

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Communication Profiles and their Relationship with Executive Functions after Right Hemisphere Stroke

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Procedia - Social and Behavioral Sciences 2011年 23卷 209-210页

作者： Rochele Paz Fonseca Perrine Ferré Maximiliano A. Wilson Bernadette Ska Yves Joanette Psychology Department Post-Graduate Program in Psychology Human Cognition Pontifical Catholic University of Rio Grande do Sul (PUCRS) Clinical and Experimental Neuropsychology Research Group (GNCE) Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal (CRIUGM) Hôpital de réadaptation Villa Medica Montréal Québec Canada Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal (CRIUGM) Québec Canada Université de Montréal Québec Canada

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Erratum to "Anticoagulation for the Prevention of Thrombotic Events in Nephrotic Syndrome" [ Kidney International Reports Volume 9, Issue 10, October 2024, Pages 3053-3056]

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Kidney international reports 2025年第4期10卷 1301页

作者： David Massicotte-Azarniouch Daniel J Crona Priscilla Karnabi Bhadran Bose Patrick H Nachman Marc Carrier Mark Canney David W Johnson Taewoo Lee Raja Ramachandran Vivekanand Jha Nigel S Key Vimal K Derebail Division of Nephrology Department of Medicine University of Ottawa and the Ottawa Hospital Research Institute Ottawa Ontario Canada. Division of Pharmacotherapy and Experimental Therapeutics Eshelman School of Pharmacy University of North Carolina Chapel Hill North Carolina USA. Clinical Epidemiology Program the Ottawa Hospital Research Institute Ottawa Ontario Canada. Department of Nephrology Nepean Hospital Kingswood New South Wales Australia. Division of Nephrology and Hypertension Department of Medicine University of Minnesota Minneapolis Minnesota USA. Department of Medicine University of Ottawa at The Ottawa Hospital Ottawa Ontario Canada. The Ottawa Hospital Research Institute Ottawa Ontario Canada. Department of Kidney and Transplant Services University of Queensland at Princess Alexandra Hospital Brisbane Queensland Australia. Division of Nephrology Department of Internal Medicine Wake Forest University School of Medicine Winston-Salem North Carolina USA. Department of Nephrology Post Graduate Institute of Medical Education and Research Chandigarh India. George Institute for Global Health University of New South Wales New Delhi India. School of Public Health Imperial College London UK. Prasanna School of Public Health Manipal Academy of Medical Education Manipal India. Division of Hematology Department of Medicine UNC Blood Research Center University of North Carolina at Chapel Hill Chapel Hill North Carolina USA. Division of Nephrology and Hypertension Department of Medicine UNC Kidney Center University of North Carolina at Chapel Hill School of Medicine Chapel Hill North Carolina USA.

[This corrects the article DOI: 10.1016/***.2024.07.013.].

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Corrigendum to "JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats" [Neurotoxicology 87 (2021) 70-85]

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Neurotoxicology 2023年 99卷 10-13页

作者： Maylin Wong-Guerra Yanay Montano-Peguero Jeney Ramírez-Sánchez Javier Jiménez-Martin Luis Arturo Fonseca-Fonseca Daniela Hernández-Enseñat Yasmine Nonose Odalys Valdés Abel Mondelo-Rodriguez Yaquelin Ortiz-Miranda Gretchen Bergado Tania Carmenate Roberto Menéndez Soto Del Valle Gilberto Pardo-Andreu Tiago Fleming Outeiro Alejandro Saúl Padrón-Yaquis Adriano Martimbianco de Assis Diogo O Souza Yanier Nuñez-Figueredo Centro de Investigación y Desarrollo de Medicamentos (CIDEM) Ave 26 No.1605 e/Boyeros y Puentes Grandes CP10600 La Habana Cuba Post-graduate Program in Health and Behavior Health Sciences Centre Universidade Católica de Pelotas Pelotas Brazil. Department of Physiology Otago School of Medical Sciences University of Otago P.O. Box 913 Dunedin 9016 New Zealand Department of Biochemistry Universidade Federal do Rio Grande do Sul-UFRGS Porto Alegre Brazil Centro de Inmunología Molecular Calle 216 esq 15 Atabey Playa PO Box 16040 Havana Cuba Centro de Neurociencias de Cuba Rotonda La Muñeca 15202 Avenida 25 La Habana Cuba Centro de Estudio para las Investigaciones y Evaluaciones Biológicas Instituto de Farmacia y Alimentos Universidad de La Habana Calle 222 No. 2317 e/ 23 y 31 La Coronela La Lisa CP 13600 La Habana Cuba Department of Experimental Neurodegeneration Center for Biostructural Imaging of Neurodegeneration University Medical Center Gottingen Göttingen Germany Max Planck Institute for Experimental Medicine Goettingen Germany Translational and Clinical Research Institute Faculty of Medical Sciences Newcastle UK University Framlington Place Newcastle Upon Tyne NE2 4HH UK Post-graduate Program in Health and Behavior Health Sciences Centre Universidade Católica de Pelotas Pelotas Brazil. Electronic address: yanier.nunez@cidem.cu.

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Extended applications the subcutaneous esketamine for major depression with suicidal ideation in autism traits—Case report

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Psychiatry Research Case Reports 2023年第1期2卷 100097-100097页

作者： Ana Paula Anzolin Victor Hugo Schaly Cordova Jeferson Ferraz Goularte Paulo Silva Belmonte-de-Abreu Keila Maria Cereser Acioly L.T. Lacerda Márcia Kauer-Sant'Anna Post-Graduate Program in Biological Sciences: Biochemistry Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil Laboratory of Molecular Psychiatry Experimental Research Center Clinical Hospital (CPE-HCPA) Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil National Institute for Science and Technology in Translational Medicine (INCT-TM) CNPq FAPESP CAPES Brazil Department of Psychiatry and Legal Medicine School of Medicine Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil Post-Graduation Program in Psychiatry and Behavioral Sciences Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil School of Pharmacy Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil PRODAF – Programa de Transtornos Afetivos da UNIFESP Department of Psychiatry Universidade Federal de São Paulo (Unifesp) São Paulo Brazil BR Trials – Clinical Research São Paulo Brazil

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Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021

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The Lancet Public Health 2025年第3期10卷 e172-e188页

作者： Steel, Nicholas Bauer-Staeb, Clarissa Maria Mercedes Ford, John A. Abbafati, Cristiana Abdalla, Mohammed Altigani Abdelkader, Atef Abdi, Parsa Zuñiga, Roberto Ariel Abeldaño Abiodun, Olugbenga Olusola Abolhassani, Hassan Abu-Gharbieh, Eman Abukhadijah, Hana J. Abu-Zaid, Ahmed Addo, Isaac Yeboah Addolorato, Giovanni Adekanmbi, Victor Adetunji, Juliana Bunmi Adeyeoluwa, Temitayo Esther Agardh, Emilie E. Agyemang-Duah, Williams Ahmad, Danish Ahmed, Ayman Ahmed, Syed Anees Akinosoglou, Karolina Akkaif, Mohammed Ahmed Al Awaidy, Salah Al Hasan, Syed Mahfuz Al Zaabi, Omar Ali Mohammed Aldridge, Robert W. Algammal, Abdelazeem M. Al-Gheethi, Adel Ali Saeed Ali, Abid Ali, Mohammed Usman Ali, Syed Shujait Ali, Waad Alicandro, Gianfranco Alif, Sheikh Mohammad Al-Jumaily, Adel Allebeck, Peter Alrawashdeh, Ahmad Al-Rifai, Rami H. Alsabri, Mohammed A. Alshahrani, Najim Z. Aluh, Deborah Oyine Al-Wardat, Mohammad Al-Zyoud, Walid A. Amiri, Sohrab Anderlini, Deanna Andrei, Catalina Liliana Anil, Abhishek Anvari, Saeid Anyasodor, Anayochukwu Edward Appiah, Seth Christopher Yaw Aquilano, Michele Arabloo, Jalal Arafat, Mosab Areda, Demelash Aremu, Abdulfatai Armani, Keivan Armocida, Benedetta Ärnlöv, Johan Asaduzzaman, Muhammad Astell-Burt, Thomas Aujayeb, Avinash Ausloos, Marcel Azadnajafabad, Sina Aziz, Shahkaar Azzam, Ahmed Y. Babu, Giridhara Rathnaiah Badache, Andreea Corina Badiye, Ashish D. Bahramian, Saeed Baig, Atif Amin Baker, Jennifer L. Bansal, Hansi Bärnighausen, Till Winfried Barone, Mark Thomaz Ugliara Barrow, Amadou Barteit, Sandra Bashir, Shahid Bashiru, Hameed Akande Basso, João Diogo Bastan, Mohammad-Mahdi Basu, Sanjay Batra, Kavita Bauckneht, Matteo Baune, Bernhard T. Beghi, Massimiliano Beiranvand, Maryam Béjot, Yannick Bell, Michelle L. Bello, Olorunjuwon Omolaja Belo, Luis Beloukas, Apostolos Beneke, Alice A. Bettencourt, Paulo J.G. Bhagavathula, Akshaya Srikanth Bhala, Neeraj Bhaskar, Sonu Bisulli, Francesca Bjørge, Tone Bodunrin, Aadam Olalekan Carvajal, Alejandro Botero Bouaoud, Souad Brayne, Carol Brenner, H Department of Primary Care and Public Health University of East Anglia Norwich United Kingdom Office for Health Improvement and Disparities Department of Health and Social Care London United Kingdom Department of Legal and Economic Studies La Sapienza University Rome Italy Rome Italy Hull York Medical School University of Hull Hull United Kingdom Department of Mathematics and Sciences Ajman University Ajman United Arab Emirates Department of Medicine Memorial University St. John's NL Canada Postgraduate Department University of Sierra Sur Miahuatlan de Porfirio Diaz Mexico Yhteiskuntadatatieteen keskus (Centre for Social Data Science) Helsinki Finland Department of Internal Medicine Federal Medical Centre Abuja Nigeria Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Medical Biochemistry and Biophysics Karolinska Institutet (Karolinska Institute) Stockholm Sweden Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Department of Biopharmaceutics and Clinical Pharmacy University of Jordan Amman Jordan Medical Research Center Hamad Medical Corporation Doha Qatar Department of Biochemistry and Molecular Medicine Alfaisal University Riyadh Saudi Arabia College of Graduate Health Sciences University of Tennessee Memphis TN United States School of Medicine Sydney NSW Australia Centre for Social Research in Health University of New South Wales Sydney NSW Australia Internal Medicine and Alcohol Related Disease Unit Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Department of Medical and Surgical Sciences Università Cattolica di Roma (Catholic University of Rome) Rome Italy Department of Obstetrics and Gynecology University of Texas Medical Branch Galveston TX United States Department of Biochemistry Osun State University Osogbo Nigeria Department of Pharmacology and Therapeutics University of Medical Sciences Ondo Ondo Nigeria Department of Veteri

Background: Decades of steady improvements in life expectancy in Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes in risk factors and cause-specific death rates in different European countries related to changes in life expectancy in those countries before and during the COVID-19 pandemic. Methods: We used data and methods from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to compare changes in life expectancy at birth, causes of death, and population exposure to risk factors in 16 European Economic Area countries (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, and Sweden) and the four UK nations (England, Northern Ireland, Scotland, and Wales) for three time periods: 1990–2011, 2011–19, and 2019–21. Changes in life expectancy and causes of death were estimated with an established life expectancy cause-specific decomposition method, and compared with summary exposure values of risk factors for the major causes of death influencing life expectancy. Findings: All countries showed mean annual improvements in life expectancy in both 1990–2011 (overall mean 0·23 years [95% uncertainty interval [UI] 0·23 to 0·24]) and 2011–19 (overall mean 0·15 years [0·13 to 0·16]). The rate of improvement was lower in 2011–19 than in 1990–2011 in all countries except for Norway, where the mean annual increase in life expectancy rose from 0·21 years (95% UI 0·20 to 0·22) in 1990–2011 to 0·23 years (0·21 to 0·26) in 2011–19 (difference of 0·03 years). In other countries, the difference in mean annual improvement between these periods ranged from –0·01 years in Iceland (0·19 years [95% UI 0·16 to 0·21] vs 0·18 years [0·09 to 0·26]), to –0·18 years in England (0·25 years [0·24 to 0·25] vs 0·07 years [0·06 to 0·08]). In 2019–21, there was an overall decrease in mean annual life expectancy a

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WAO International Scientific Conference (WISC 2016) Abstracts

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WORLD ALLERGY ORGANIZATION JOURNAL 2017年第SUPPL 1期10卷 25-25页

作者： [Anonymous] Xin Hua Hospital Shanghai Jiao Tong University School of Medicine Pediatric Respirology Shanghai China Cincinnati Childrens Hospital Medical Center Division of Allergy and Immunology Cincinnati OH USA Cincinnati Childrens Hospital Medical Center Division of Asthma Research Cincinnati OH USA Cincinnati Childrens Hospital Medical Center Division of Human Genetics Cincinnati OH USA Universidad La Salle Facultad Mexicana de Medicina Mexico City Mexico Hospital Infantil de Mexico Federico Gomez Pediatric Allergy & Clinical Immunology Mexico City Mexico Beijing TongRen Hospital Department of Otolaryngology Head and Neck Surgery Beijing China Beijing Institute of Otolaryngology Beijing Key Laboratory of Nasal Diseases Beijing China Beijing TongRen Hospital Department of Allergy Beijing China Ghent University Hospital Upper Airways Research Laboratory Ghent Belgium University of Manitoba Section of Allergy and Immunology Department of Paediatrics and Child Health Winnipeg Canada India Department of Pharmacology Pune Poona College of Pharmacy Bharati Vidyapeeth Deemed University Department of Pharmacology Erandwane Paud Road Pune 411038 Maharashtra India Brigham and Women Pulmonary Critical Care Boston MA USA Harvard University Harvard Clinical Research Institute Boston MA USA Harvard TH Chan School of Public Health Environmental Health Boston MA USA Brigham and Women’s Hospital Pulmonary Critical Care Boston MA USA National Jewish Health Pulmonary Critical Care Denver CO USA American Academy of Family Physicians Family Medicine Denver CO USA University of Minnesota Family and Community Health Minneapolis Minnesota MN USA Soonchynhyang University Respiratory-Allergy Bucheon South Korea Utah University Biology Salt Lake City UT USA Sydney University Mathematics Sydney Australia Kaohsiung Veterans General Hospital Pediatrics Kaohsiung Taiwan Kaohsiung Veterans General Hospital Cardiac Surgery Kaohsiung Taiwan Kaohsiung Veterans General Hospital Patho

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Global survey of stigma among physicians and patients with nonalcoholic fatty liver disease

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Journal of hepatology 2024年第3期80卷 419-430页

作者： Zobair M Younossi Saleh A Alqahtani Khalid Alswat Yusuf Yilmaz Caglayan Keklikkiran Jesús Funuyet-Salas Manuel Romero-Gómez Jian-Gao Fan Ming-Hua Zheng Mohamed El-Kassas Laurent Castera Chun-Jen Liu Vincent Wai-Sun Wong Shira Zelber-Sagi Alina M Allen Brian Lam Sombat Treeprasertsuk Saeed Hameed Hirokazu Takahashi Takumi Kawaguchi Jörn M Schattenberg Ajay Duseja Phil N Newsome Sven Francque C Wendy Spearman Marlen I Castellanos Fernández Patrizia Burra Stuart K Roberts Wah-Kheong Chan Marco Arrese Marcelo Silva Mary Rinella Ashwani K Singal Stuart Gordon Michael Fuchs Naim Alkhouri Kenneth Cusi Rohit Loomba Jane Ranagan Wayne Eskridge Achim Kautz Janus P Ong Marcelo Kugelmas Yuichiro Eguchi Moises Diago Ming-Lung Yu Lynn Gerber Lisa Fornaresio Fatema Nader Linda Henry Andrei Racila Pegah Golabi Maria Stepanova Patrizia Carrieri Jeffrey V Lazarus Beatty Liver and Obesity Research Program Inova Health System Falls Church VA USA Center for Liver Disease Department of Medicine Inova Fairfax Medical Campus Falls Church VA USA The Global NASH Council Washington DC USA. Electronic address: zobair.younossi@***. The Global NASH Council Washington DC USA Division of Gastroenterology and Hepatology Johns Hopkins University Baltimore MD USA Alfaisal University King Faisal Specialist Hospital & Research Centre Riyadh Saudi Arabia. Liver Disease Research Center College of Medicine King Saud University Riyadh Saudi Arabia. Department of Gastroenterology School of Medicine Recep Tayyip Erdoğan University Rize Turkey. Department of Personality Assessment and Psychological Treatment Faculty of Psychology University of Seville Seville Spain. UCM Digestive Diseases and ciberehd Virgen del Rocío University Hospital Instituto de Biomedicina de Sevilla (HUVR/CSIC/US) Department of Medicine University of Seville Seville Spain. Department of Gastroenterology Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai China. MAFLD Research Center Department of Hepatology the First Affiliated Hospital of Wenzhou Medical University China. Infectious Diseases and Hepatology Department Faculty of Medicine Helwan University Cairo Egypt. Department of Hepatology Beaujon Hospital AP-HP Université Paris Cité Inserm UMR1149 Clichy France. Hepatitis Research Center Department of Internal Medicine and Graduate Institute of Clinical Medicine National Taiwan University College of Medicine and Hospital Taipei Taiwan. Department of Medicine and Therapeutics Faculty of Medicine The Chinese University of Hong Kong Hong Kong China. School of Public Health University of Haifa Haifa Israel. Department of Medicine Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA. The Global NASH Council Washington DC USA. Division of Gastroenterology Chulalongkorn University Bangkok Thailand. Department

BACKGROUND & AIMS:Patients with fatty liver disease may experience stigma from the disease or comorbidities. In this cross-sectional study, we aimed to understand stigma among patients with nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) and healthcare providers. METHODS:Members of the Global NASH Council created two surveys about experiences/attitudes toward NAFLD and related diagnostic terms: a 68-item patient and a 41-item provider survey. RESULTS:Surveys were completed by 1,976 patients with NAFLD across 23 countries (51% Middle East/North Africa [MENA], 19% Europe, 17% USA, 8% Southeast Asia, 5% South Asia) and 825 healthcare providers (67% gastroenterologists/hepatologists) across 25 countries (39% MENA, 28% Southeast Asia, 22% USA, 6% South Asia, 3% Europe). Of all patients, 48% ever disclosed having NAFLD/NASH to family/friends; the most commonly used term was "fatty liver" (88% at least sometimes); "metabolic disease" or "MAFLD" were rarely used (never by >84%). Regarding various perceptions of diagnostic terms by patients, there were no substantial differences between "NAFLD", "fatty liver disease (FLD)", "NASH", or "MAFLD". The most popular response was being neither comfortable nor uncomfortable with either term (56%-71%), with slightly greater discomfort with "FLD" among the US and South Asian patients (47-52% uncomfortable). Although 26% of patients reported stigma related to overweight/obesity, only 8% reported a history of stigmatization or discrimination due to NAFLD. Among providers, 38% believed that the term "fatty" was stigmatizing, while 34% believed that "nonalcoholic" was stigmatizing, more commonly in MENA (43%); 42% providers (gastroenterologists/hepatologists 45% vs. 37% other specialties, p = 0.03) believed that the name change to metabolic dysfunction-associated steatotic liver disease (or MASLD) might reduce stigma. Regarding the new nomenclature, the percentage of providers reporting "steatotic liver diseas

关键词： MASH MASLD SLD communication discrimination fatty liver metabolic patient-reported outcomes

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