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Scientific World Journal 2015年第1期2015卷 209783页

作者： Batista Da Silva Ferreira, Douglas Barreiros De Souza, Everaldo Cavalcanti De Moraes, Bergson Meira Filho, Luiz Gylvan Vale Institute of Technology Boaventura da Silva Street 955 Belém PA 66055-090 Brazil Post-Graduate Program in Environmental Sciences Federal University of Pará Augusto Corrêa Street 1 Belém PA 66075-110 Brazil

Empirical orthogonal functions (EOF) and composites analysis were employed on pentad data in order to investigate the tropical atmospheric-ocean patterns over the Atlantic Ocean and the spatial-temporal characteristics of the rainfall in eastern Amazon during the peak of the rainy season (February to April). The EOF results evidenced that the Intertropical Convergence Zone (ITCZ) is the main rainfall-producing system in eastern Amazon during the rainy season. Conditions associated with the southward SST gradient in the intertropical Atlantic formed the dynamic patterns that favored the position of the ITCZ to south of the equator, thus explaining the predominance of positive precipitation anomalies in eastern Amazon, especially in the state of Maranhão and northeastern Pará during the February and April months. © 2015 Douglas Batista da Silva Ferreira et al.

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Preparation of nut-based milk alternative: evaluation of an Amazonian nut (Bertholletia excelsa) beverage with annatto nanodispersion

Food Chemistry Advances

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Food Chemistry Advances 2023年 3卷

作者： Paiva, Luana C． de M. Guedes, Marcelino C. Ferreira, Diego Q. Rodrigues, Ediglei G. Machado, Francisco Paiva Fernandes, Caio P. Post-Graduate Program in Pharmaceutical Innovation (Network Program) Federal University of Amapá AP Macapá CEP 68903-419 Brazil Laboratory of Phytopharmaceutical Nanobiotechnology Federal University of Amapá AP Macapá CEP 68903-419 Brazil Embrapa Amapá AP Macapá CEP 68903-419 Brazil Post-graduate Program in Environmental Sciences Federal University of Amapá AP Macapá CEP 68903-419 Brazil Laboratory of Technology in Natural Products Fluminense Federal University Niterói RJ Rio de Janeiro CEP 24241-000 Brazil

Plant-based milk alternatives are in the spotlight of novelty and Amazonian nut has a great potential for the preparation of these beverages. In the present study, extraction of Amazonian nut was carried out with water and creaming index was evaluated. Hydroethanolic annatto extract was subjected to spectrophotometric analysis in order to determine bixin content. Annatto nanodispersions were prepared through a low energy method involving stepwise addition of deionized water to organic phase. Dynamic light scattering analysis was performed for particle size distribution and encapsulation efficiency determined by ultracentrifugation. In the present paper, we prepared an Amazonian-nut milk alternative, being the prototype added of annatto nanodispersion. Sensory analysis with untrained panelists was performed. Nanosizing (diameter < 300 nm and polydispersity index < 0.400) of annatto extract was reached and toxicity assay of the nanodispersion prepared with annatto extract, polysorbate 80/sorbitan monooleate (HLB = 13), and propyleneglycol at a 2:1:1 ratio indicated no mortality in both gender of zebrafish. Attributes of color, aroma, flavor texture, overall opinion, and intention of purchasing revealed, together with consumer's acceptance, that a suitable Amazonian nut plant-based milk alternative could be reached, contributing to an integrated approach of using two Amazonian raw materials of economic interest for food purposes. © 2023 The Author(s)

关键词： Amazonian nut-milk alternative Annatto extract Bertholletia excelsa Bixa orellana Colloids

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Mapping of rain water harvesting potential at Keduang Sub-watershed, Central Java, Indonesia

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IOP Conference Series: Earth and environmental Science 2021年第1期824卷

作者： H R Dwiatmojo Komariah A H Ramelan E Priyanto Master Program of Environmental Science Post Graduate School Sebelas Maret University Soil Science Dept. Faculty of Agriculture Sebelas Maret University Environmental Science Post Graduate School Sebelas Maret University Watershed Management Technology Centre Ministry of Environmental and Forestry

One of the main issues in agriculture in this climate change era is the water crisis. It caused a drought that affected the delay of rice cultivation. A study found that Wonogiri Regency has very critical with a value of 163.1%. Hence, it is necessary to have an alternative solution to overcome it. In this case, utilizing rain by harvesting rainwater (RWH) can be used as an alternative to meet water needs during the dry season and for various other uses. One of the RWH applications is a small-farm reservoir (SFR). To identify the potential locations for RWH is using location suitability modelling based on GIS. The determination of the location depends on biophysical criteria such as rainfall, slope, soil texture, stream order, and land use. The socio-economic attributes consist of the distance to the river, road, settlement, and agriculture. To obtain the suitability location, after all of the maps are generated, next is reclassify the value to 0 and 1. In the end, the maps calculate with a raster calculator to define the suitability location that has value 1. Location and dimension details can find out. This study aims to determine the potential of RWH for agriculture (in specific, SFR) at Keduang Sub-watershed as a consideration for stakeholders' decision. The results showed 226 areas are potential for SFR implementation and will make it easier for stakeholders to decide by comparing the suitability location map and the long-term strategic map.

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AHR is a Zika virus host factor and a candidate target for antiviral therapy (vol 52, pg 941, 2020)

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NATURE NEUROSCIENCE 2020年第10期23卷 1307-1307页

作者： Giovannoni, Federico Bosch, Irene Polonio, Carolina Manganeli Torti, Maria F. Wheeler, Michael A. Li, Zhaorong Romorini, Leonardo Rodriguez Varela, Maria S. Rothhammer, Veit Barroso, Andreia Tjon, Emily C. Sanmarco, Liliana M. Takenaka, Maisa C. Modaresi, Seyed Mohamad Sadegh Gutierrez-Vazquez, Cristina Zanluqui, Nagela Ghabdan dos Santos, Nilton Barreto Munhoz, Carolina Demarchi Wang, Zhongyan Damonte, Elsa B. Sherr, David Gehrke, Lee Peron, Jean Pierre Schatzmann Garcia, Cybele C. Quintana, Francisco J. Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital Harvard Medical School Boston MA USA Laboratorio de Estrategias Antivirales Departamento de Química Biológica Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires. CONICET—Instituto de Química Biológica Buenos Aires Argentina Institute for Medical Engineering and Science Massachusetts Institute of Technology Cambridge MA USA Department of Medicine Mount Sinai School of Medicine New York NY USA Neuroimmune Interactions Laboratory Immunology Department—ICB IV University of São Paulo São Paulo Brazil Scientific Platform Pasteur—USP University of São Paulo São Paulo Brazil Laboratorio de Investigación aplicada a Neurociencias Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia Buenos Aires Argentina Immunopathology and Allergy Post Graduate Program School of Medicine University of São Paulo São Paulo Brazil Department of Pharmacology Institute of Biomedical Science University of São Paulo São Paulo Brazil Dept. of Environmental Health Boston University School of Public Health Boston MA USA Program in Virology Division of Medical Sciences Harvard Medical School Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA

Zika virus (ZIKV) is a flavivirus linked to multiple birth defects including microcephaly, known as congenital ZIKV syndrome. The identification of host factors involved in ZIKV replication may guide efficacious therapeutic interventions. In genome-wide transcriptional studies, we found that ZIKV infection triggers aryl hydrocarbon receptor (AHR) activation. Specifically, ZIKV infection induces kynurenine (Kyn) production, which activates AHR, limiting the production of type I interferons (IFN-I) involved in antiviral immunity. Moreover, ZIKV-triggered AHR activation suppresses intrinsic immunity driven by the promyelocytic leukemia (PML) protein, which limits ZIKV replication. AHR inhibition suppressed the replication of multiple ZIKV strains in vitro and also suppressed replication of the related flavivirus dengue. Finally, AHR inhibition with a nanoparticle-delivered AHR antagonist or an inhibitor developed for human use limited ZIKV replication and ameliorated newborn microcephaly in a murine model. In summary, we identified AHR as a host factor for ZIKV replication and PML protein as a driver of anti-ZIKV intrinsic immunity.

关键词： Immunology Microbiology

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Integrating Chinese Herbal Medicine into Conventional Care Was Related to Lower Risk of Sarcopenia Among Rheumatid Arthritis Patients: A Retrospective, Population-Based Study

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Journal of Multidisciplinary Healthcare 2023年 16卷 3117-3127页

作者： Li, Hsin-Hua Livneh, Hanoch Huang, Hua-Lung Wang, Yu-Han Lu, Ming-Chi Chen, Wei-Jen Tsai, Tzung-Yi Department of Chinese Medicine Dalin Tzu Chi Hospital The Buddhist Tzu Chi Medical Foundation Chiayi 62247 Taiwan Rehabilitation Counseling Program Portland State University Portland 97207-0751 OR United States Department of Rehabilitation Dalin Tzu Chi Hospital The Buddhist Tzu Chi Medical Foundation Chiayi Taiwan Center of Sports Medicine Dalin Tzu Chi Hospital The Buddhist Tzu Chi Medical Foundation Chiayi 62247 Taiwan Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital The Buddhist Tzu Chi Medical Foundation Chiayi 62247 Taiwan School of Medicine Tzu Chi University Hualien 97004 Taiwan School of Post-Baccalaureate Chinese Medicine Tzu Chi University Hualien 97004 Taiwan Graduate Institute of Sports Science National Taiwan Sport University Taoyuan 33301 Taiwan Department of Medical Research Dalin Tzu Chi Hospital The Buddhist Tzu Chi Medical Foundation Chiayi 62247 Taiwan Department of Nursing Tzu Chi University of Science and Technology Hualien 97004 Taiwan Department of Environmental and Occupational Health College of Medicine National Cheng Kung University Tainan 70428 Taiwan

Objective: Sarcopenia is a frequently observed comorbidity of rheumatoid arthritis (RA) due to the chronic activation of the innate immune system. Accumulating evidence has indicated that Chinese herbal medicine (CHM) safely suppresses proinflammatory pathways and controls inflammation-associated disease, but its effect in reducing the risk of developing sarcopenia among RA subjects has not been established. We conducted a population-level cohort study to compare the sarcopenia risk in patients with RA who use or do not use CHM. Methods: Using claims from a nationwide insurance database, we recruited patients with newly diagnosed RA and without sarcopenia between 2002 and 2010. Propensity score matching was applied to randomly select sets of CHM users and non-CHM users to compare the sarcopenia risk until the end of 2013. The risk of new-onset sarcopenia was assessed using the Cox proportional hazards model. Results: As compared to non-CHM users, those receiving CHM treatment had a lower incidence of sarcopenia (7.69 vs 9.83 per 1000 person-years). CHM was correlated with a decreased chance of sarcopenia after controlling for potential covariates. Notably, use of CHM for more than two years may diminish the risk of getting sarcopenia by about 47% when taken as prescribed. Prescriptions of several herbal formulae may benefit the reduction of sarcopenia risk, such as Yan-Hu-Suo, Bei-Mu, Da-Huang, Huang Qin, Ping-Wei-San (PWS), Shu-Jing-Huo-Xue-Tang (SJHXT) and Chuan-Xiong-Cha-Tiao-San (CXCTS). Conclusion: This study produced new evidence as it is the first to show that the longer duration of CHM use was correlated to reduced risk of sarcopenia in a dose-dependent manner, implying that CHM treatment could be embraced as a routine care strategy for preventing sarcopenia. © 2023 Li et al.

关键词： Chinese herbal medicine cohort study rheumatoid arthritis sarcopenia

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Analysis of growth phase regulated KatA and CatE and their physiological roles in determining hydrogen peroxide resistance inAgrobacterium tumefaciens

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FEMS Microbiology Letters 2006年第2期237卷

作者： Benjaphorn Prapagdee Warawan Eiamphungporn Panatda Saenkham Skorn Mongkolsuk Paiboon Vattanaviboon Laboratory of Biotechnology Office of Research Chulabhorn Research Institute (CRI) Viphavadee-Rungsit Highway Lak Si Bangkok 10210 Thailand Post-graduate Education Training and Research Program in Environmental Science Technology and Management Asian Institute of Technology Pathumthani 12120 Thailand Department of Biotechnology Faculty of Science Mahidol University Bangkok 10400 Thailand

Agrobacterium tumefaciens possesses two catalases, a bifunctional catalase-peroxidase, KatA and a homologue of a growth phase regulated monofunctional catalase, CatE. In stationary phase cultures and in cultures entering stationary phase, total catalase activity increased 2-fold while peroxidase activity declined. katA and catE were found to be independently regulated in a growth phase dependent manner. KatA levels were highest during exponential phase and declined as cells entered stationary phase, while CatE was detectable at early exponential phase and increased during stationary phase. Only small increases in H 2 O 2 resistance levels were detected as cells entering stationary phase. The katA mutant was more sensitive to H 2 O 2 than the parental strain during both exponential and stationary phase. Inactivation of catE alone did not significantly change the level of H 2 O 2 resistance. However, the katA catE double mutant was more sensitive to H 2 O 2 during both exponential and stationary phase than either of the single catalase mutants. The data indicated that KatA plays the primary role and CatE acts synergistically in protecting A. tumefaciens from H 2 O 2 toxicity during all phases of growth. Catalase-peroxidase activity (KatA) was required for full H 2 O 2 resistance. The expression patterns of the two catalases in A. tumefaciens reflect their physiological roles in the protection against H 2 O 2 toxicity, which are different from other bacteria.

关键词： Agrobacterium tumefaciens Catalase Growth phase H2O2 Peroxidase

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Physical Characteristics of Modified Cassava Flour Wastewater at Room Temperature

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IOP Conference Series: Earth and environmental Science 2019年第1期292卷

作者： N Yaqin A N Al-Baarri A M Legowo Widayat M A Budihardjo Program of Environmental Science School of Post Graduate Studies Diponegoro University Semarang Indonesia Center of Research and Services-Diponegoro University Semarang Indonesia Food Technology Department Faculty of Animal and Agricultural Sciences Diponegoro University Semarang Indonesia Chemical Engineering Department Faculty of Engineering Diponegoro University Semarang Indonesia Department of Environmental Engineering Faculty of Engineering Diponegoro University Indonesia

Cassava is an agricultural material that is considered as important raw resources in the industrial sector. The benefits are even greater after being modified using lactic acid bacteria. However, the mocaf industry often causes water and air pollution. environmental problems arise after the fermentation process. Determination problems with lightness, TDS (Total Dissolved Solid), conductivity and pH analysis are required to measure the impact to the environment. This research was used waste water from mocaf during 3 days fermentation. The wastewater had the highest color level (Lightness) on initial day of fermentation at 83.7±3.73 and then decrease along the day of fermentation at the averages of 65.2±2.0. The highest TDS was resulted from the mocaf wastewater at a value of 1218 ± 4.6 ppm which continued to decline until day 4. The conductivity and pH showed a decrease along the day of fermentation. As conclusion, physical characteristic of wastewater from mocaf production could be analyzed specifically and determined through color, TDS, conductivity, and pH.

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Self-Compassion Around the World: Measurement Invariance of the Short Form of the Self-Compassion Scale (SCS-SF) Across 65 Nations, 40 Languages, Gender Identities, and Age Groups

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Mindfulness 2025年 1-28页

作者： Swami, Viren Tran, Ulrich S. Voracek, Martin Aavik, Toivo Ranjbar, Hamed Abdollahpour Adebayo, Sulaiman Olanrewaju Afhami, Reza Ahmed, Oli Aimé, Annie Akel, Marwan Al Halbusi, Hussam Alexias, George Ali, Khawla F. Alp-Dal, Nursel Alsalhani, Anas B. Álvarez-Solas, Sara Amaral, Ana Carolina Soares Andrianto, Sonny Aspden, Trefor Argyrides, Marios Aruta, John Jamir Benzon R. Atkin, Stephen Ayandele, Olusola Baceviciene, Migle Bahbouh, Radvan Ballesio, Andrea Barron, David Bellard, Ashleigh Bender, Sóley Sesselja Beydaǧ, Kerime Derya Birovljević, Gorana Blackburn, Marie-Ève Borja-Alvarez, Teresita Borowiec, Joanna Bozogáňová, Miroslava Bratland-Sanda, Solfrid Browning, Matthew H. E. M. Brytek-Matera, Anna Burakova, Marina Çakır-Koçak, Yeliz Camacho, Pablo Camilleri, Vittorio Emanuele Cazzato, Valentina Cerea, Silvia Chaiwutikornwanich, Apitchaya Chaleeraktrakoon, Trawin Chambers, Tim Chen, Qing-Wei Chen, Xin Chien, Chin-Lung Chobthamkit, Phatthanakit Choompunuch, Bovornpot Compte, Emilio J. Corrigan, Jennifer Cosmas, Getrude Cowden, Richard G. Czepczor-Bernat, Kamila Czub, Marcin da Silva, Wanderson Roberto Dadfar, Mahboubeh Dalley, Simon E. Dany, Lionel Datu, Jesus Alfonso D. de Carvalho, Pedro Henrique Berbert de Holanda Coelho, Gabriel Lins De Jesus, Avila Odia S. Debbabi, Sonia Harzallah Dhakal, Sandesh Di Bernardo, Francesca Dimitrova, Donka D. Dion, Jacinthe Dixson, Barnaby Donofrio, Stacey M. Drysch, Marius Du, Hongfei Dzhambov, Angel M. El-Jor, Claire Enea, Violeta Eskin, Mehmet Farbod, Farinaz Farrugia, Lorleen Fian, Leonie Fisher, Maryanne L. Folwarczny, Michał Frederick, David A. Fuller-Tyszkiewicz, Matthew Furnham, Adrian García, Antonio Alías Geller, Shulamit Ghisi, Marta Ghorbani, Alireza Martinez, Maria Angeles Gomez Gradidge, Sarah Graf, Sylvie Grano, Caterina Gyene, Gyöngyvér Hallit, Souheil Hamdan, Motasem Handelzalts, Jonathan E. Hanel, Paul H. P. Hawks, Steven R. Hekmati, Issa Helmy, Mai Hill, Tetiana Hina, Farah Holenweger, Geraldine Hřebíčková, Martina Ijabadeniyi, Olasupo Augustine Imam, Asma İ School of Psychology and Sport Science Anglia Ruskin University Cambridge United Kingdom Centre for Psychological Medicine Perdana University Kuala Lumpur Malaysia Department of Cognition Emotion and Methods in Psychology Faculty of Psychology University of Vienna Vienna Austria Institute of Psychology University of Tartu Tartu Estonia Department of Psychology Istinye University Istanbul Turkey Department of Psychology and Behavioural Studies Ekiti State University Ado-Ekiti Nigeria Department of Art Studies Tarbiat Modares University Tehran Iran Department of Psychology University of Chittagong Chattogram Bangladesh Department of Psychoeducation and Psychology Université du Québec en Outaouais Saint-Jérôme Canada INSPECT-LB: National Institute of Public Health Clinical Epidemiology and Toxicology Beirut Lebanon School of Pharmacy Lebanese International University Beirut Lebanon Department of Management Ahmed Bin Mohammad Military College Doha Qatar Faculty of Psychology Panteion University of Social and Political Sciences Athens Greece Royal College of Surgeons Ireland-Bahrain Adliya Bahrain Department of Midwifery Faculty of Health Sciences Munzur University Tunceli Turkey Department of Oral Medicine and Diagnostic Sciences Vision College of Dentistry and Nursing Vision Colleges Riyadh Saudi Arabia Facultad de Salud Universidad Internacional de La Rioja Logroño Spain Science and Technology of Southeast Minas Gerais Federal Institute of Education Barbacena Brazil Department of Psychology Universitas Islam Indonesia Yogyakarta Indonesia Department of Psychology Aberystwyth University Ceredigion United Kingdom Department of Psychology Neapolis University Pafos Paphos Cyprus Department of Psychology De La Salle University Manila Philippines Department of General Studies The Polytechnic Ibadan Nigeria Department of Psychology University of Ibadan Ibadan Nigeria Health Research and Innovation Science Centre Faculty of Health Sciences Klai

Objectives: The 12-item Self-Compassion Scale–Short Form (SCS–SF) is a widely used instrument for the assessment of self-compassion. To date, there have been few examinations of this instrument’s psychometric properties, particularly across nations and languages. Therefore, we used data from the Body Image in Nature Survey (BINS) to assess measurement invariance of the SCS–SF across nations, languages, gender identities, and age groups. Methods: Participants (N = 56,968) from 65 nations completed the SCS–SF in 40 languages. Using these data, we tested various hypothesised models of the SCS–SF in the total sample and, using multi-group confirmatory factor analysis, tested for invariance of the optimal model across national groups, languages, gender identities, and age groups. Results: In the total dataset, we found that an 11-item, 2-factor model (i.e., SCS-11) provided best fit to the data, with the two factors tapping distinct constructs of compassionate and uncompassionate self-responding. The SCS-11 was found to be partially scalar invariant across national groups and languages, and fully scalar invariant across gender identities and age groups. There was wide variation in latent means for the two factors, particularly across national groups and languages. Further analyses showed negligible associations between the two factors and sociodemographic variables, including marital status, financial security, and urbanicity. Conclusions: Our results suggest that it may be possible to derive a stable 2-factor model of the SCS–SF for use in cross-cultural research, but also highlight the likelihood of cross-national and cross-linguistic variations in the way that self-compassion is understood. © The Author(s) 2025.

关键词： Cross-cultural Measurement invariance Multi-group confirmatory factor analysis (MG-CFA) Self-Compassion Scale Short Form

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Landscape Character of Pongkor Mining Ecotourism Area

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IOP Conference Series: Earth and environmental Science 2017年第1期91卷

作者： A Kusumoarto A Gunawan Machfud A Hikmat Doctoral Student Program Natural Resource and Environmental Management Science School of Post-Graduate Bogor Agricultural University Jl. Raya Pajajaran Bogor Indonesia 16143 Lecturer in Landscape Architecture Department Bogor Agriculture University Jl. Raya Darmaga Bogor Indonesia 16680 Lecturer in AgroIndustrial Technology Department Bogor Agriculture University Jl. Raya Darmaga Bogor Indonesia 16680. Lecturer in Conservation of Forest and Ecotourism Department Bogor Agriculture University Jl. Raya Darmaga Bogor Indonesia 16680

Pongkor Mining Ecotourism Area has a diverse landscape character as a potential landscape resources for the development of ecotourism destination. This area is part of the Mount of Botol Resort, Halimun Salak National Park (HSNP). This area also has a fairly high biodiversity. This study aims to identify and analysis the category of landscape character in the Pongkor Mining Ecotourism Area for the development of ecotourism destination. This study used a descriptive approach through field surveys and interviews, was carried out through two steps : 1) identify the landscape character, and 2) analysis of the landscape character. The results showed that in areas set aside for ecotourism destination in Pongkor Mining, landscape character category scattered forests, tailing ponds, river, plain, and the built environment. The Category of landscape character most dominant scattered in the area is forest, here is the river, plain, tailing ponds, the built environment, and plain. The landscape character in a natural environment most preferred for ecotourism activities. The landscape character that spread in the natural environment and the built environment is a potential that must be protected and modified such as elimination of incongruous element, accentuation of natural form, alteration of the natural form, intensification and enhanced visual quality intensively to be developed as a ecotourism destination area.

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Attitude and knowledge towards the effectiveness of nucleic acid-based vaccines among healthcare workers and medical students in the Jordanian population

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Cogent Public Health 2022年第1期9卷 Article: 2145756页

作者： M. Emad Al Madadha Rama Rayyan Khalid E. Ahmed Nancy Al-Sanouri Saddam Al Demour Muayyad Ahmad 1 Department of Pathology Microbiology and Forensic Medicine School of Medicine the University of Jordan Amman Jordan2 University of Maryland Baltimore Institute of Marine and Environmental Technology Department of Microbiology and Immunology University of Maryland School of Medicine Baltimore Maryland USA 3 Medical Student Jordan University Faculty of Medicine Amman Jordan 4 Department of Medical Laboratory Sciences Post Graduate Program in Laboratory Sciences the University of JordanAmman Jordan 5 Department of Special Surgery School of Medicine The University of Jordan Amman Jordan 6 Clinical Nursing Department School of Nursing The University of Jordan Amman Jordan

Since the beginning of the COVID-19 pandemic, catastrophic mortality and morbidity rates and unknown long-term ramifications were caused, leading to focused efforts on implementing effective vaccination. Nucleic acid-based vaccines (NBVs), an emergent advance in vaccine development, presented high efficacy rates but controversy regarding this approach soon spread. This study assesses healthcare workers (HCWs) knowledge and attitude towards NBVs’ effectiveness. This cross-sectional study was conducted in Jordan from November 2020 to January 2021 through a web-based questionnaire. 320 participants were split into educated and uneducated groups, with the former being exposed to educational material on NBVs before survey completion. The educated group expressed increased concern towards NBVs’ side effects. Specifically, the risk of developing cancer due to genetic modification(40.8%), fever(69.4%), skin rash(58.0%), and amyloid deposition(40.8%) showed a significant difference. The educated group preferred RNA-based NBVs over DNA-based ones(43.9%), had double the response rate, provided more scientifically accurate answers, and showed a more positive attitude towards the ability of NBVs to induce cellular immunity (57.3%) and prevent chronic forms of COVID-19(57.3%) (p < 0.05). Because HCWs are the most integral players in shaping public opinion about NBVs, thorough educational material on NBVs needs to be integrated within the curricula of health-related programs to bridge the gap present. This could prove vital in ensuring the success of the current and future vaccination campaigns.

关键词： COVID-19 nucleic acid vaccine healthcare workers vaccination effectiveness

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