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Genetic mutation patterns among glioblastoma patients in the Taiwanese population – insights from a single institution retrospective study

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Cancer Gene Therapy 2024年第6期31卷 894-903页

作者： Huang, Yu-Fen Chiao, Ming-Tsang Hsiao, Tzu-Hung Zhan, Yong-Xiang Chen, Tse-Yu Lee, Chung-Hsin Liu, Szu-Yuan Liao, Chih-Hsiang Cheng, Wen-Yu Yen, Chun-Ming Lai, Chih-Ming Chen, Jun-Peng Shen, Chiung-Chyi Yang, Meng-Yin Department of Neurosurgery Neurological Institute Taichung Veterans General Hospital Taichung Taiwan Department of Medical Research Taichung Veterans General Hospital Taichung 40705 Taiwan Precision Medicine Center Taichung Veterans General Hospital Taichung 40705 Taiwan Doctoral Program in Translational Medicine National Chung Hsing University Taichung Taiwan Rong Hsing Translational Medicine Research Center National Chung Hsing University Taichung Taiwan Institute of Medicine Chung Shan Medical University Taichung 402 Taiwan Graduate Institute of Life Science Department of Life Science College of Life Science National Chung Hsing University Taichung Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan School of Medicine Taipei Medical University Taipei Taiwan Department of Minimally Invasive Skull Base Neurosurgery Neurological Institute Taichung Veterans General Hospital Taichung Taiwan Department of Physical Therapy Hung Kuang University Taichung Taiwan Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan School of Medicine National Defense Medical Center Taipei Taiwan Department of Critical Care Medicine Taichung Veterans General Hospital Taichung Taiwan Functional Neurosurgery Division Neurological Institute Taichung Veterans General Hospital Taichung Taiwan Institute of Molecular Biology College of Life Science National Chung Hsing University Taichung Taiwan Biostatistics Task Force Taichung Veterans General Hospital Taichung Taiwan Basic Medical Education Center Central Taiwan University of Science and Technology Taichung Taiwan

This study utilized Next-Generation Sequencing (NGS) to explore genetic determinants of survival duration in Glioblastoma Multiforme (GBM) patients. We categorized 30 primary GBM patients into two groups based on their survival periods: extended survival (over two years, N = 17) and abbreviated survival (under two years, N = 13). For identifying pathogenic or likely pathogenic variants, we leveraged the ClinVar database. The cohort, aged 23 to 66 (median: 53), included 17 patients in Group A (survival >2 years, 10 males, 7 females), and 13 patients in Group B (survival <2 years, 8 males, 5 females), with a 60% to 40% male-to-female ratio. Identified mutations included CHEK2 (c.1477 G > A, p.E493K), IDH1 (c.395 G > A, p.R132H), and TP53 mutations. Non-coding regions exhibited variants in the TERT promoter (c.-146C > T, c.-124C > T) and TP53 RNA splicing site (c.376-2 A > C, c.376-2 A > G). While Group A had more mutations, statistical significance wasn’t reached, likely due to sample size. Notably, TP53, and ATR displayed a trend toward significance. Surprisingly, TP53 mutations were more prevalent in Group A, contradicting Western findings on poorer GBM prognosis. In Taiwanese GBM patients, bevacizumab usage is linked to improved survival rates, affirming its safety and effectiveness. EGFR mutations are infrequent, suggesting potential distinctions in carcinogenic pathways. Further research on EGFR mutations and amplifications is essential for refining therapeutic approaches. TP53 mutations are associated with enhanced survival, but their functional implications necessitate detailed exploration. This study pioneers genetic analysis in Taiwanese GBM patients using NGS, advancing our understanding of their genetic landscape. © The Author(s) 2024.

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Theoretical insights into the chemical bonding, electronic structure, and spectroscopic properties of the lanarkite Pb2SO5 structure

arXiv

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arXiv 2023年

作者： Fabris, Guilherme S.L. Ferrer, Mateus M. Sambrano, Julio R. Almeida, Cláudio R.R. Paskocimas, Carlos A. La Porta, Felipe A. Graduate Program in Materials Science and Engineering Technological Development Center Universidade Federal de Pelotas RS Pelotas96010-610 Brazil Modeling and Molecular Simulation Group São Paulo State University Bauru São Paulo17033-360 Brazil Department of Materials Engineering Federal University of Rio Grande do Norte RN Natal59078-970 Brazil Postgraduate Program in Science and Engineering of Materials Federal University of Rio Grande do Norte RN Natal59078-970 Brazil Federal University of Technology - Paraná Nanotechnology and Computational Chemistry Laboratory Avenida dos Pioneiros 3131 CEP PR Londrina86036-370 Brazil State University of Londrina Post-Graduation Program in Chemistry Rodovia Celso Garcia Cid 445 km 380 CEP PR Londrina86057-970 Brazil

Lanarkite is a mineral formed by a combination of lead, sulphur, and oxygen atoms arranged in the general chemical formula Pb2SO5 (PSO) that crystallises with monoclinic symmetry (belonging to the C2/m space group, No. 12). This mineral was first discovered in Lanarkshire, Scotland and was named after its location. PSO has a unique structure comprising alternating penta-coordinated lead [PbO5] and tetra-coordinated sulphur [SO4] clusters. This lanarkite-type structure has recently attracted significant scientific interest and has been the focus of the superconducting material research community. However, its chemistry needs to be explored further. This article presents a comprehensive investigation on the chemical bonding, electronic structure, and spectroscopic properties of the lanarkite-type PSO structure from a computational perspective. Thus, different functionals in the DFT (e.g., PBE, PBE0, PBESOL, PBESOL0, BLYP, WC1LYP37, and B3LYP) were assessed to accurately predict their fundamental properties. All the DFT calculations were performed using a triple-zeta valence plus polarisation basis set. Among all the DFT functionals tested in this study, PBE showed the best agreement with the experimental data available in the literature. Our results also reveal that the [PbO5] clusters are formed with three Pb–O bond lengths, with values of about 2.32, 2.59, and 2.84 Å, respectively, while the [SO4] clusters have the same S–O bond length of 1.57 Å. We performed a complete topological analysis of this system to comprehend these structural differences. Additionally, the PSO structure has an indirect band gap energy of 2.9 eV and an effective mass ratio (mℎ∗ /me∗) of about 0.415 (using PBE calculations) which may, in principle, indicate a low recombination of electron-hole pairs in the lanarkite structure. Therefore, we believe that a detailed understanding of their electronic structures, spectroscopic properties as well as their chemical bonding is critically important

关键词： Lead compounds

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Digitizing Farmers' Land Data Collection Systems in Indonesia with the Use of Tani Millenial Apps

Digitizing Farmers' Land Data Collection Systems in Indonesi...

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International Conference on Cybernetics and Intelligent System (ICORIS)

作者： Mohammad Prasanto Bimantio Dian Pratama Putra Teddy Suparyanto Amallia Ferhat Nanda Satya Nugraha Alam Ahmad Hidayat Bens Pardamean Department of Food and Agricultural Technology Institute of Agriculture STIPER Yogyakarta Indonesia Department of Agrotechnology Institute of Agriculture STIPER Yogyakarta Indonesia Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta Indonesia Department of Agricultural Socio-Economics Institute of Agriculture STIPER Yogyakarta Indonesia Department of Forestry Institute of Agriculture STIPER Yogyakarta Indonesia Computer Science Department BINUS Graduate Program - Master of Computer Science Bina Nusantara University Jakarta Indonesia

ISBN: (纸本)9781665453967

In this era of digital world information, farmers face challenges about information management of huge data and the complexity of processes in precision farming. The data collection carried out so far can cause several difficulties, especially if the data is needed by the government or academics to support decision-making. Agricultural data collection applications only cover 12% of the market share of Android-based agriculture-based applications. In this study, Tani Milenial application is present as an alternative to support agricultural data collection activities in Indonesia. This application encourages farmers to be active and contribute independently to their role as subjects of agricultural development and is accustomed to digitally recording their agricultural activities. In this developed application system, the community, especially farmers and farmer groups, will find it easier to get information about agricultural potential data around where they carry out agricultural activities and can access this information online. Tani Milenial works as a guide to help farmers and transform agriculture but still have some gaps which should be checked and removed. The data collected can be used by various parties for research and decision-making. The app can be further improved to develop new features related to education, market information, and goods.

关键词： Decision making Education Government Transforms Data collection Agriculture Recording

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Sustainability assessment of groundwater in south-eastern parts of the western region of Ghana for water supply

Cleaner Water

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Cleaner Water 2024年 1卷

作者： Ernest Biney Bernard Akwasi Mintah Ernest Ankomah Albert Elikplim Agbenorhevi Daniel Buston Yankey Ernestina Annan Department of Geomatic Engineering Kwame Nkrumah University of Science and Technology University Post Office Box PMB Kumasi Ghana WASCAL Graduate Research Programme on Climate Change and Land Use Department of Civil Engineering Kwame Nkrumah University of Science and Technology Kumasi Ghana Department of Geological Engineering University of Mines and Technology Tarkwa Ghana Graduate Research Program on Climate Change and Water Resources West African Science Service Center on Climate Change and Adapted Land Use (WASCAL) University of Abomey-Calavi Benin

The study assessed the physicochemical and biological properties of selected groundwater sources in the Southeastern part of the Western Region, to assess the impact on water quality and health risk. The Piper Trilinear plot was used to categorize the water samples into water types based on the dominant anion and cation concentrations. Statistical analysis (One way ANOVA and two sample t-test) was used to determine the sources of variation in the data at 95% confidence interval. The Water Quality Index (WQI) and Hazard Quotient (HQ) were used to estimate the water quality and health risk respectively. TDS and turbidity were above the acceptable WHO guidelines in 16.7% of the samples with a mildly acidic pH in 83.3% of the water samples. Also, 91.7% of the water samples were contaminated with total coliform (TC) and 25% with e-coli. Generally, the groundwater samples were dominated by Ca 2+ and HCO 3- ion water types. The variations between parameters were found not significant for all the parameters (p>0.05). Water samples in the North are of good quality with a mean WQI of 96, but of poor quality in the South with a mean WQI of 144.6. HQ values for all the samples were less than 0.1, suggesting less harmful impacts of the heavy metal concentrations on human health. Overall, the results showed the presence of heavy metals in the groundwater sources sampled, however in quantities with low health risks either through oral or dermal channels. Groundwater within the communities is good for domestic purposes but needs treatment for drinking. To improve upon the study, it is recommended that further studies consider a higher number of samples and include other accessible groundwater stations where possible.

关键词： Health Risk Assessment Groundwater GIS Trace elements Water Quality Index

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Exploring Morchella esculenta polysaccharide extracts: In vitro digestion, fermentation characteristics, and prebiotic potential for modulating gut microbiota and function

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International Journal of Biological Macromolecules 2025年 318卷

作者： Bingshu Liu Putsawee Tomtong Suvimol Charoensiddhi Wanwipa Vongsangnak Interdisciplinary Graduate Program in Bioscience Faculty of Science Kasetsart University Bangkok 10900 Thailand Department of Food Science and Technology Faculty of Agro-Industry Kasetsart University Bangkok 10900 Thailand Department of Zoology Faculty of Sciences Kasetsart University Bangkok 10900 Thailand Omics Center for Agriculture Bioresources Food and Health Kasetsart University (OmiKU) Bangkok 10900 Thailand

Morchella esculenta , a nutritious and medicinal edible mushroom, has gained an increasing attention due to the bioactive properties of its polysaccharides. This study employed in vitro simulated human digestion and fecal fermentation models to evaluate the effects of M. esculenta polysaccharide on gut microbiota composition and short-chain fatty acids (SCFAs) production. Additionally, a relationship between M. esculenta polysaccharide composition, gut microbiota, and functional role was constructed to elucidate their interactions. The results revealed that 44.87 % of M. esculenta polysaccharide was digested, leading to a reduction in molecular weight and alterations in monosaccharide composition, including decreased glucose and increased galactose and mannose. Fermentation of M. esculenta polysaccharide significantly enhanced SCFAs production and promoted the growth of beneficial gut bacteria, such as Bacteroides, Collinsella, and Bifidobacterium , while notably reducing Ruminococcus torques . Carbohydrate metabolism was enriched in Collinsella and Bifidobacterium which positively correlated with SCFAs biosynthesis e.g., propanoate and butanoate biosynthesis. These findings provide valuable insights into M. esculenta polysaccharide as prebiotic potential, highlighting its functional role in modulating gut microbiota and promoting gut health.

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Ohwia caudata extract relieves the IL-17A-induced inflammatory response of synoviocytes through modulation of SOCS3 and JAK2/STAT3 activation

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Environmental Toxicology 2023年第8期38卷 1914-1924页

作者： Lu, Cheng-You Kuo, Chia-Hua Kuo, Wei-Wen Hsieh, Dennis Jine-Yuan Wang, Tso-Fu Shih, Cheng-Yen Lin, Pi-Yu Lin, Shinn-Zong Ho, Tsung-Jung Huang, Chih-Yang Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan Department of Sports Sciences University of Taipei Taipei Taiwan Department of Biological Science and Technology China Medical University Taichung Taiwan Ph.D. Program for Biotechnology Industry China Medical University Taichung Taiwan School of Medical Laboratory and Biotechnology Chung Shan Medical University Taichung Taiwan Clinical Laboratory Chung Shan Medical University Hospital Taichung Taiwan Department of Hematology and Oncology Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Department of Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Tzu Chi University Hualien Taiwan Buddhist Tzu Chi Medical Foundation Hualien Taiwan Buddhist Compassion Relief Tzu Chi Foundation Hualien Taiwan Bioinnovation Center Buddhist Tzu Chi Medical Foundation Hualien Taiwan Department of Neurosurgery Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Integration of Chinese Medicine and Modern Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Department of Chinese Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Department of Biological Science and Technology Asia University Taichung Taiwan Center of General Education Buddhist Tzu Chi Medical Foundation Tzu Chi University of Science and Technology Hualien Taiwan

Fibroblast-like synoviocytes accumulation, proliferation and activation, and the subsequent inflammatory mediators production play a key role in the progression of rheumatoid arthritis (RA). It is well established that Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling triggers inflammation, and induces cytokine levels in RA. Ohwia caudata have long been used against many disorders. However, in RA, the effects of O. caudata have not been elucidated. In the current study, synoviocytes were used to evaluate the suppressive effects of O. caudate extract (OCE) on the pro-inflammatory cytokines production. In vitro, the underlying mechanisms by which OCE inhibits inflammatory response through regulation of suppressors of cytokine signaling 3 (SOCS3) and JAK2/STAT3 expression in IL-17A-treated HIG-82 synoviocytes were investigated. The results demonstrated that the proliferation of IL-17A-challenged cells were increased in comparison with non-stimulated control cells. The synoviocyte proliferation was decreased significantly of OCE concentrations in dose dependent manner. The p-JAK2, p-STAT3, interleukin (IL)-1β, and IL-6 were reduced in IL-17A-challenged cells treated with OCE. Furthermore, AZD1480 (a JAK2-specific inhibitor) or WP1066 (a STAT3-specific inhibitor) affected the inflammatory mediators production in IL-17A-challenged synoviocytes, and OCE failed to mitigate the IL-17A-induced inflammatory mediators and SOCS3, acting as a feedback inhibitor of the JAK/STAT3 pathway, in the presence of SOCS3 siRNA, indicating that the beneficial effects of OCE on the regulation of inflammatory response homeostasis were dependent on SOCS3 and the JAK2/STAT3 signaling pathway. Our study also showed that SOCS3 was markedly activated by OCE in RA fibroblast-like synoviocytes, thereby decreasing the JAK/STAT3 pathway, and the IL-1β, and IL-6 activation. Thus, O. caudate should be further investigated as a candidate anti-inflammatory and anti-a

关键词： Chemical activation

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A first-principles study on the quantum tunneling of methylhydroxycarbene isomerization in various solvents 4

A first-principles study on the quantum tunneling of methylh...

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4th Padjadjaran International Physics Symposium 2019, PIPS 2019

作者： Susanti, E.D. Rusydi, F. Puspitasari, I. Fadilla, R.N. Aisyah, N.D. Ahmad, A. Research Center for Quantum Engineering Design Faculty of Science and Technology Universitas Airlangga Jl. Mulyorejo Surabaya60115 Indonesia Department of Physics Faculty of Science and Technology Universitas Airlangga Jl. Mulyorejo Surabaya60115 Indonesia Precision Sciences and Technology and Applied Physics Graduate School of Engineering Osaka University Suita565-0871 Japan Information System Study Program Faculty of Science and Technology Universitas Airlangga Jl. Mulyorejo Surabaya60115 Indonesia School of Chemical Science and Food Technology Faculty of Science and Technology Universiti Kebangsaan Malaysia Bangi Selangor43600 Malaysia

Quantum tunneling phenomenon allows a high-barrier reaction to occur even though thermal energy is not sufficient to surmount the barrier. The phenomenon has been suggested to exist in the isomerization of methylhydroxycarbene which occured at 11 K. Here we study the quantum tunneling that occured in the isomerization of methylhydroxycarbene to acetaldehyde and to vinyl alcohol based on density functional calculations. The isomerization pathways are determined under the effect of various solvents which are modeled by polarizable continuum model (PCM). We use Wentzel-Kramers-Brillouin (WKB) approximation to calculate the tunneling probability (T) and extend the usefulness of T into isomerization rate. The results show that the solvents give a significant effect on the isomerization rate of methylhydroxycarbene to acetaldehyde but an insignificant one on the isomerization rate to vinyl alcohol. © 2020 IOP Publishing Ltd. All rights reserved.

关键词： Isomerization

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Lotus seed skin proanthocyanidin extract exhibits potent antioxidant property via activation of the Nrf2-ARE pathway

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生物化学与生物物理学报（英文版） 2019年第1期51卷 31-40页

作者： Tao Li Qili Li Weiguo Wu Yong Li De-xing Hou Hua Xu Baodong Zheng Shaoxiao Zeng Yang Shan Xiangyang Lu Fangming Deng Si Qin Core Research Program 1515 Key Laboratory for Food Science and Biotechnology of Hunan Province College of Food Science and Technology Hunan Agricultural University Changsha 410128 China Hunan Agricultural Product Processing Institute Hunan Academy of Agricultural Sciences Changsha 410125 China Core Research Program 1515 Key Laboratory for Food Science and Biotechnology of Hunan Province College of Food Science and Technology Hunan Agricultural University Changsha 410128 China The United Graduate School of Agricultural Sciences Faculty of Agriculture Kagoshima University Kagoshima 890-0065Japan Department of Pediatrics Steele Children's Research Center University of Arizona Tucson 85724 USA Department of Food Safety College of Food Science Fujian Agriculture and Forestry University Fuzhou 350002 China Core Research Program 1515 Key Laboratory for Food Science and Biotechnology of Hunan Province College of Food Science and Technology Hunan Agricultural University Changsha 410128 China The United Graduate School of Agricultural Sciences Faculty of Agriculture Kagoshima University Kagoshima 890-0065Japan Department of Pediatrics Steele Children's Research Center University of Arizona Tucson 85724 USA

Lotus seed is well known as traditional food and medicine,but its skin is usually *** studies have shown that lotus seed skin contains a high concentration of proanthocyanidins that have multi-functions,such as antioxidation,anti-inflammation,and anti-cancer *** the present study,we aimed to isolate and purify the proanthocyanidins from lotus seed skin by acetone extraction and rotary evaporation,identify their chemical structures by HPLC-MS-MS and NMR,and further investigate the antioxidant properties of the extract purified by macroporous resin (PMR) from lotus seed skin both in vitro and in *** results showed that PMR mainly contained oligomeric proanthocyanidins,especially dimeric procyanidin B1 (PB1),procyanidin B2 and procyanidin *** it had limited ability to directly scavenge radicals in vitro,PMR could significantly enhance the expressions of antioxidant proteins via activation of nuclear factor-E2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway in HepG2 *** data revealed that PB1,a major component in PMR,stabilized Nrf2 by inhibiting the ubiquitination of Nrf2,which led to subsequent activation of the Nrf2-ARE pathway,including the enhancements of Nrf2 nuclear translocation,Nrf2-ARE binding and ARE transcriptional ***,the in vivo results in high fat diet-induced mice further verified the powerful antioxidant property of *** results revealed that lotus seed skin is a promising resource for functional food development.

关键词： lotus seed skin extract proanthocyanidin Nrf2-ARE pathway antioxidant activity

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Integrating Chinese Herbal Medicine into Conventional Care Was Related to Lower Risk of Sarcopenia Among Rheumatid Arthritis Patients: A Retrospective, Population-Based Study

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Journal of Multidisciplinary Healthcare 2023年 16卷 3117-3127页

作者： Li, Hsin-Hua Livneh, Hanoch Huang, Hua-Lung Wang, Yu-Han Lu, Ming-Chi Chen, Wei-Jen Tsai, Tzung-Yi Department of Chinese Medicine Dalin Tzu Chi Hospital The Buddhist Tzu Chi Medical Foundation Chiayi 62247 Taiwan Rehabilitation Counseling Program Portland State University Portland 97207-0751 OR United States Department of Rehabilitation Dalin Tzu Chi Hospital The Buddhist Tzu Chi Medical Foundation Chiayi Taiwan Center of Sports Medicine Dalin Tzu Chi Hospital The Buddhist Tzu Chi Medical Foundation Chiayi 62247 Taiwan Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital The Buddhist Tzu Chi Medical Foundation Chiayi 62247 Taiwan School of Medicine Tzu Chi University Hualien 97004 Taiwan School of Post-Baccalaureate Chinese Medicine Tzu Chi University Hualien 97004 Taiwan Graduate Institute of Sports Science National Taiwan Sport University Taoyuan 33301 Taiwan Department of Medical Research Dalin Tzu Chi Hospital The Buddhist Tzu Chi Medical Foundation Chiayi 62247 Taiwan Department of Nursing Tzu Chi University of Science and Technology Hualien 97004 Taiwan Department of Environmental and Occupational Health College of Medicine National Cheng Kung University Tainan 70428 Taiwan

Objective: Sarcopenia is a frequently observed comorbidity of rheumatoid arthritis (RA) due to the chronic activation of the innate immune system. Accumulating evidence has indicated that Chinese herbal medicine (CHM) safely suppresses proinflammatory pathways and controls inflammation-associated disease, but its effect in reducing the risk of developing sarcopenia among RA subjects has not been established. We conducted a population-level cohort study to compare the sarcopenia risk in patients with RA who use or do not use CHM. Methods: Using claims from a nationwide insurance database, we recruited patients with newly diagnosed RA and without sarcopenia between 2002 and 2010. Propensity score matching was applied to randomly select sets of CHM users and non-CHM users to compare the sarcopenia risk until the end of 2013. The risk of new-onset sarcopenia was assessed using the Cox proportional hazards model. Results: As compared to non-CHM users, those receiving CHM treatment had a lower incidence of sarcopenia (7.69 vs 9.83 per 1000 person-years). CHM was correlated with a decreased chance of sarcopenia after controlling for potential covariates. Notably, use of CHM for more than two years may diminish the risk of getting sarcopenia by about 47% when taken as prescribed. Prescriptions of several herbal formulae may benefit the reduction of sarcopenia risk, such as Yan-Hu-Suo, Bei-Mu, Da-Huang, Huang Qin, Ping-Wei-San (PWS), Shu-Jing-Huo-Xue-Tang (SJHXT) and Chuan-Xiong-Cha-Tiao-San (CXCTS). Conclusion: This study produced new evidence as it is the first to show that the longer duration of CHM use was correlated to reduced risk of sarcopenia in a dose-dependent manner, implying that CHM treatment could be embraced as a routine care strategy for preventing sarcopenia. © 2023 Li et al.

关键词： Chinese herbal medicine cohort study rheumatoid arthritis sarcopenia

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Tailoring structural and magnetic properties of NiCu nanowires by electrodeposition

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Nano-Structures and Nano-Objects 2024年 39卷

作者： Castro-Lopes, S. Oliveira, D.M. Abrão, J.E. Assis, L.K.C.S. Silva, J.F.O. Neves-Araújo, J. Soares, J.M. Rodrigues, A.R. Padrón-Hernández, E. Federal Institute of Education Science and Technology of Pará (IFPA) PA Altamira 68371-441 Brazil Materials Science Post-Graduate Program Center of Exact and Natural Sciences Federal University of Pernambuco PE Recife 50740-540 Brazil Department of Physics Federal University of Pernambuco PE Recife 50740-540 Brazil University of Pernambuco Polytechnic School of Pernambuco (POLI) PE Recife 50720-001 Brazil NANOlab Center of Excellence Department of Physics University of Antwerp Groenenborgerlaan 171 Antwerp B-2020 Belgium Department of Physics State University of Rio Grande do Norte RN Mossoró 59610-190 Brazil

In this work, we investigated the tailoring of structural and magnetic properties of NiCu nanowires through electrodeposition. Continuous (S1) and composition-modulated (S2) wires were fabricated by electrodeposition using porous alumina membranes as a template. Morphological characterization revealed that the total length of the wires was 8 ± 3 µm in both S1 and S2. For the composition-modulated wires, the length of the segments with the lowest and highest Cu concentrations was 1.2 ± 0.4 µm and 226 ± 65 nm, respectively. Mapping by energy dispersive spectroscopy (EDS) revealed that the concentration of copper and nickel varied along the length of the composition-modulated nanowires, while the continuous nanowires contained a relatively constant concentration of both metals. It is demonstrated that the change in Cu concentration along the wire modifies the lattice parameter, average crystallite size (D) and lattice strain (ε) of Ni. This result is pivotal for understanding the magnetic properties of the wires, as nickel is primarily responsible for the magnetic behavior of the wires. From the ferromagnetic resonance (FMR) results, the linewidth and resonance field values for samples S1 and S2 were determined. It was demonstrated that the greater deformation in the nickel lattice in NiCu nanowires increases the angular dependence of the resonance field. Furthermore, the smaller nickel crystallite size was shown to increase spin dispersion and magnetic damping, leading to complex behavior in FMR responses. Finally, it was demonstrated how Cu can influence the magnetic properties such as coercivity (H_C) and squareness (M_R/M_S) of the wires. Overall, this work contributes to understanding the tailoring of structural and magnetic properties of NiCu nanowires through electrodeposition. © 2024 Elsevier B.V.

关键词： Electrodeposition Magnetic properties Nanowires

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