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International Wireless Communications and Mobile Computing Conference, IWCMC

作者： M. C. Dias L. A. Caldeira A. Perkusich Post-graduate Program in Electrical Engineering - PpgEE - COPELE Federal University of Campina Grande - UFCG Campina Grande Brazil Electrical Engineering Coordination Federal Institute of Education Science and Technology of Paraíba - IFPB João Pessoa Brazil

Congestion control algorithms exist for decades to prevent package loss in intense traffic networks. Several solutions developed over the years tried to solve this problem, including the creation of new algorithms. However, hybrid wired and wireless networks, or wired-cum-wireless, common in modern days, bring new challenges to programmers and engineers who try to overcome the numerous new problems that this kind of network presents. This work carries out a performance comparison, in a wired-cum-wireless network, using TCP congestion control algorithms variants: New Reno and CUBIC. The comparison is to determine which of those algorithms performs better in several situations, like multiple disconnections caused by mobility, interference and congested links. The results showed that the CUBIC is a more stable and fair algorithm, but it has a significantly less data flow than New Reno.

关键词： Standards Interference Receivers Mobile handsets Transmitters Wireless communication Algorithm design and analysis

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Recognizing malnutrition in adults with critical illness: Guidance statements from the Global Leadership Initiative on Malnutrition

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Clinical Nutrition 2025年 49卷 202-208页

作者： Fukushima, R. Compher, C.W. Correia, M.I.T.D. Gonzalez, M.C. McKeever, L. Nakamura, K. Lee, Z.Y. Patel, J.J. Singer, P. Stoppe, C. Ayala, J.C. Barazzoni, R. Berger, M.M. Cederholm, T. Chittawatanarat, K. Cotoia, A. Lopez-Delgado, J.C. Earthman, C.P. Elke, G. Hartl, W. Hasan, M.S. Higashibeppu, N. Jensen, G.L. Lambell, K.J. Lew, C.C.H. Mechanick, J.I. Mourtzakis, M. Nogales, G.C.C. Oshima, T. Peterson, S.J. Rice, T.W. Rosenfeld, R. Sheean, P. Silva, F.M. Tah, P.C. Uyar, M. Department of Surgery Teikyo University School of Medicine Department of Health and Dietetics Faculty of Health and Medical Science Teikyo Heisei University Tokyo Japan Biobehavioral Health Sciences Department and Nutrition Programs University of Pennsylvania School of Nursing Philadelphia PA United States Department of Surgery Universidade Federal de Minas Gerais Belo Horizonte Brazil Postgraduate Program in Nutrition and Food Federal University of Pelotas RS Brazil Department of Clinical Nutrition Rush University Medical Center Chicago IL United States Department of Critical Care Medicine Yokohama City University Hospital Kanagawa Japan Department of Anaesthesiology Faculty of Medicine University of Malaya Kuala Lumpur 50603 Malaysia Department of Cardiac Anesthesiology and Intensive Care Medicine Charité Berlin Berlin Germany Division of Pulmonary and Critical Care Medicine Medical College of Wisconsin 9200 West Wisconsin Avenue HUB 8th floor Milwaukee 53225 WI United States Intensive Care Unit Herzlia Medical Center Reichman University Herzlia and Institute for Nutrition Research Intensive Care Department Beilinson Hospital Rabin Medical Center Petah Tikva Israel Department of Anaesthesiology Intensive Care Emergency and Pain Medicine University Hospital Würzburg Würzburg Germany Department of Surgery Clinica del Country of Medicine FUCS Bogotá Colombia Department of Medical Technological and Translational Sciences University of Trieste Ospedale di Cattinara Trieste Italy Faculty of Biology and Medicine Lausanne University Lausanne Switzerland Department of Public Health and Caring Sciences Clinical Nutrition and Metabolism Uppsala University Uppsala and Theme Inflammation & Aging Karolinska University Hospital Stockholm Sweden Division of Trauma and Surgical Critical Care Clinical Surgical Research Center Department of Surgery Faculty of Medicine Chiang Mai University Chiang Mai 50200 Thailand Department of Medical and Surgical Sc

Background: Patients with critical illness may present with disease-related malnutrition upon intensive care unit (ICU) admission. They are at risk of development and progression of malnutrition over the disease trajectory because of inflammation, dysregulated metabolism, and challenges with feeding. Methods: The Global Leadership Initiative on Malnutrition (GLIM) convened a panel of 36 clinical nutrition experts to develop consensus-based guidance statements addressing the diagnosis of malnutrition during critical illness, using a modified Delphi approach with a requirement of ≥75% agreement. Results: 1. To identify pre-existing malnutrition, we suggest evaluation within 48 hours of ICU admission when feasible (100% agreement) or within 4 days (94% agreement). 2. To identify the development and progression of malnutrition, we suggest reevaluation of all patients every 7-10 days (97% agreement). 3. To identify progressive loss of muscle mass, we suggest evaluation of muscle mass as soon as feasible (92% agreement), and again after 7-10 days (89% agreement). 4. To identify the development and progression of malnutrition prior to and after ICU discharge, we suggest reevaluating nutritional status prior to ICU discharge and during clinical visits that follow (100% agreement). Conclusion: Research using consistent etiologic and phenotypic variables offers great potential to assess the efficacy of nutrition interventions for critically ill patients with malnutrition. Assessment of these variables at during and beyond the ICU stay will clarify the trajectory of malnutrition and enable exploration of impactful treatment modalities at each juncture. GLIM offers a diagnostic approach that can be used to identify malnutrition in critically ill patients. © 2025 The Authors

关键词： Global Leadership Initiative on Malnutrition ICU Malnutrition Muscle mass

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Bioactive extracts from annona hypoglauca

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Chemical Engineering Transactions 2018年 64卷 289-294页

作者： dos Santos, Ricardo C. Chagas, Edvan A. de Melo Filho, Antônio A. Takahashi, Jacqueline A. Montero, Ismael F. Chagas, Pollyana C. Ribeiro, Pedro R. E. de Melo, Cristina G. R. National Postdoctoral Program of CAPES associated to POSAGRO/UFRR Campus Cauamé BR 174 s/n Km 12 District Monte Cristo Boa Vista-RRCEP 69310-250 Brazil Embrapa Rodovia 174 Km 8 Industrial District Boa VistaRRCEP 69301970 Brazil Post-Graduate Program in Chemistry Center for Research and Graduate Studies in Science and Technology UFRR Campus Paricarana Boa Vista-RRCEP 69304-000 Brazil Department of Chemistry Institute of Exact Sciences Universidade Federal de Minas Gerais UFMG Av Antonio Carlos no. 6627 Pampulha Belo Horizonte-MGCEP 31270-901 Brazil Post Graduate Program in Biodiversity and Biotechnology Bionorte State Coordination of Roraima UFRR Campus Paricarana Boa Vista-RRCEP 69304-000 Brazil Post Graduate in Agronomy POSAGRO UFRR Campus Paricarana Boa Vista-RRCEP 69304-000 Brazil Post-Graduate in Natural Resources Program Federal University of Roraima Boa Vista-RR Brazil

ISBN: (纸本)9788895608563

The aim was to analyze the bioactive potential of hexane and ethanolic extracts from leaves of Annona hypoglauca, Roraima, Brazil, against fungi (Aspergillus flavus and Fusarium proliferatum) and yeast (Candida albicans) and gram-positive bacteria (Staphylococcus aureus and Streptococcus sanguinis) and gram-negative (Escherichia coli and Salmonella typhimurium), antioxidant, antiacetylcholinesterase and cytotoxic activities against Artemia salina, in addition to verify a phytochemical screening. Antioxidant activity of the leaves ethanolic extract 51% to 50 µg mL-1, 16% at the same concentration for the hexane extract. The antiacetylcholinesterase activity presented high variation of the ethanolic extract and 59.76% in the hexane extract. The cytotoxic activity against A. salina was more efficient for the ethanolic extract of the leaves in 27% to 500 µg mL-1. The bioactivity of fungi and yeasts, the ethanolic extract of the leaves of A. hypoglauca showed no inhibition on the fungi F. proliferatum and A. flavus, but the hexane extract inhibited 40.0% and 59.5% on these fungi, respectively. For the inhibition of C. albicans, the extracts hexane (94.5-96.9%) and ethanolic (89.2-92.6%) of the leaves of A. hypoglauca, at all concentrations. Excellent inhibitions on gram-positive bacteria were given by the hexane extract in 100% to 500 µg mL-1, but low inhibition for the ethanolic extract for S. aureus in 21.6% to 125 µg mL-1 and for S. Sanguinis 35.5% to 500 µg mL-1. Inhibitions on gram-negative bacteria varied from 26.1% to 42.4% in ethanolic extract and 10.7% to 18.6% in hexanic extract for E. coli;as inhibition of S. typhimurium occurred from 9.3% to 61.1% in ethanolic extract and from 9.1% to 41.2% in hexane extract. Regarding phytochemical screening, the class of compounds observed qualitatively suggests the presence of saponins, flavonoids, triterpenoids and tannins. Copyright © 2018, AIDIC Servizi S.r.l.

关键词： Hexane

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Correction to: 4-Chloro-3-nitro-N-butylbenzenesulfonamide acts on KV3.1 channels by an open-channel blocker mechanism

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Amino acids 2018年第1期50卷 199-200页

作者： Carlos Alberto Zanutto Bassetto Junior Wamberto Antonio Varanda Eduardo René Pérez González Fine Organic Chemistry Laboratory Department of Chemistry and Biochemistry Faculty of Science and Technology São Paulo State University (Unesp)-Campus of Presidente Prudente Presidente Prudente SP Brazil. cbjunior@fc.unesp.br. Post-Graduate Program in Science and Material Technology Presidente Prudente SP Brazil. cbjunior@fc.unesp.br. Department of Physiology Ribeirão Preto Medical School University of São Paulo Ribeirão Preto Brazil. Fine Organic Chemistry Laboratory Department of Chemistry and Biochemistry Faculty of Science and Technology São Paulo State University (Unesp)-Campus of Presidente Prudente Presidente Prudente SP Brazil. Post-Graduate Program in Science and Material Technology Presidente Prudente SP Brazil.

Unfortunately, grey trace on Figure 2c was missing in the original publication of the article.

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Demineralized crab and shrimp shell powder: Cost effective medium for bacillus Sp. R2 growth and chitinase production

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Procedia Manufacturing 2018年 22卷 413-419页

作者： Ben Amar Cheba Taha Ibrahim Zaghloul Ahmad Rafik EL-Mahdy Department of Biology College of Science Aljouf University Kingdom of Saudi Arabia (KSA) Department of Biotechnology Faculty of Nature and Life Sciences University of Sciences and Technology of Oran -Mohamed Boudiaf (USTOMB) BP 1505 Al Mnaouar Oran 31000 Algeria Department of Biotechnology Institute of Post Graduate Studies and Research University of Alexandria- Alexandria –Egypt Department of Food Science and Technology-Faculty of Agriculture-University of Alexandria- Alexandria-Egypt

Crustaceous wastes such as shrimp, crab and lobster, are chitinous solid waste of the shellfish processing industry. to select the best substrates for bacterial growth and enzyme activity, different poor and enriched media were investigated, furthermore, the non-dematerialized and dematerialized shells powders of crab, shrimp, prawn and the mixed powders of crab+ shrimp shells and crab+ prawn shells were tested as substrates for and chitinase production by the chitin degrading bacterium Bacillus sp. R2 in a submerged fermentation (SMF) culture. The results revealed that, the tested poor media failed to enhance enzyme production, whereas the tested enriched media promote growth and protein content efficiently, in contrast the demineralized chitinous wastes were generally good carbon and nitrogen sources for growth and chitinase production. The most favorable substrates were demineralized crab + prawn followed by crab + shrimp. The obtained results would certainly encourage the utilization of shellfish processing (Crab and Shrimp Shell) waste for the industrial production of chitinase via submerged fermentation (SMF).

关键词： Bacillus sp. R2 chitinous waste crab shrimp shell chitinase production

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Structure-Guided Discovery of PD-1/PD-L1 Interaction Inhibitors: Peptide Design, Screening, and Optimization via Computation-Aided Phage Display Engineering

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Journal of Chemical Information and Modeling 2024年第5期64卷 1615-1627页

作者： Tseng, Tien-Sheng Lee, Chao-Chang Chen, Po-Juei Lin, Chiu-Yuen Chen, Wang-Chuan Lee, Yu-Ching Lin, Jiun-Han Chen, Kaun-Wen Tsai, Keng-Chang Institute of Molecular Biology National Chung Hsing University Taichung40202 Taiwan National Research Institute of Chinese Medicine Ministry of Health and Welfare Taipei11221 Taiwan The School of Chinese Medicine for Post Baccalaureate I-Shou University Kaohsiung824005 Taiwan Department of Chinese Medicine E-Da Hospital Kaohsiung824005 Taiwan TMU Research Center of Cancer Translational Medicine Taipei Medical University Taipei11031 Taiwan Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei11031 Taiwan Department of Industrial Technology Ministry of Economic Affairs Taipei100210 Taiwan Food Industry Research and Development Institute Hsinchu30062 Taiwan Molecular Science and Digital Innovation Center Genetics Generation Advancement Corporation Taipei11949 Taiwan

Cancer immunotherapy harnesses the immune system to combat tumors and has emerged as a major cancer treatment modality. The PD-1/PD-L1 immune checkpoint modulates interactions between tumor cells and T cells and has been extensively targeted in cancer immunotherapy. However, the monoclonal antibodies known to target this immune checkpoint have considerable side effects, and novel PD-1/PD-L1 inhibitors are therefore required. Herein, a peptide inhibitor to disrupt PD-1/PD-L1 interactions was designed through structure-driven phage display engineering coupled to computational modification and optimization. BetaPb, a novel peptide library constructed by using the known structure of PD-1/PD-L, was used to develop inhibitors against the immune checkpoint, and specific peptides with high affinity toward PD-1 were screened through enzyme-linked immunosorbent assays, homogeneous time-resolved fluorescence, and biolayer interferometry. A potential inhibitor, B8, was preliminarily screened through biopanning. The binding affinity of B8 toward PD-1 was confirmed through computation-aided optimization. Assessment of B8 variants (B8.1, B8.2, B8.3, B8.4, and B8.5) demonstrated their attenuation of PD-1/PD-L1 interactions. B8.4 exhibited the strongest attenuation efficiency at a half-maximal effective concentration of 0.1 μM and the strongest binding affinity to PD-1 (equilibrium dissociation constant = 0.1 μM). B8.4 outperformed the known PD-1/PD-L1 interaction inhibitor PL120131 in disrupting PD-1/PD-L1 interactions, revealing that B8.4 has remarkable potential for modification to yield an antitumor agent. This study provides valuable information for the future development of peptide-based drugs, therapeutics, and immunotherapies for cancer. © 2024 American Chemical Society.

关键词： Peptides

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Multipurpose Silicon-Based Toothpastes: Decision Making for a Better Oral Health

European Dental Research and Biomaterials Journal

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European Dental Research and Biomaterials Journal 2023年第1/02期03卷 001-002页

作者： Fabiano Vieira Vilhena Paulo Henrique Perlatti D'Alpino Trials Research and Development Inc. São Paulo SP Brazil Triplet Biotechnology Solutions São Paulo SP Brazil São Paulo State University (UNESP) School of Sciences POSMAT – Post-Graduate Program in Materials Science and Technology Bauru SP Brazil

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Study of Machine Learning Techniques for Damage Identification in a Beam 10th

Study of Machine Learning Techniques for Damage Identifica...

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10th International Conference on Wave Mechanics and Vibrations, WMVC 2022

作者： da Silva Coelho, Jefferson de Sousa, Amanda Aryda Silva Rodrigues Machado, Marcela Rodrigues Dutkiewicz, Maciej Department of Mechanical Engineering University of Brasília Campus Universitário Darcy Ribeiro Faculdade de Tecnologia - Asa Norte DF Brasília Brazil Post-Graduate Program - Integrity of Engineering Materials University of Brasília Campus Universitário Darcy Ribeiro Faculdade de Tecnologia - Asa Norte DF Brasília70910-900 Brazil Faculty of Civil Environmental Engineering and Architecture University of Science and Technology Bydgoszcz85-796 Poland

ISBN: (纸本)9783031157578

Damage is defined as any change to the material, geometry or boundary condition that can modify the structure’s properties or response. In the past, damage identification was performed through periodical inspection, non-destructive testing/non-destructive evaluation, or visual observation. Structural health monitoring (SHM) has emerged to transition from offline damage identification to near real-time and online damage assessment. Hence, SHM is a damage detection strategy to monitor a structure for a period using a series of continuous measurement devices, which then collect the system’s characteristics and subsequently perform statistical analysis to assess the current circumstances and health of the structure. One of the first steps for the study of SHM is damage detection followed by monitoring. Machine Learning (ML) techniques can be used to develop viable algorithms to make potential predictions. ML algorithms are therefore providing the tools needed to enhance the capabilities of SHM systems and provide intelligent solutions to past challenges. Preliminary studies have reviewed that the extension of ML into SHM has dramatically increased the system’s capabilities, providing innovative solutions to different research challenges. This work conducts a study of the use of ML to identify damage in a beam and discuss the challenge of usage, performance and implementation of each technique. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Decision trees

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Chemical composition, antioxidant and biological activity of leaves passiflora foetida

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Chemical Engineering Transactions 2018年 64卷 241-246页

作者： de Melo Filho, Antonio A. Kamezaki, Ângela Kinuko Ribeiro, Pedro R. E. de Melo, Ana Cristina G. R. Fernández, Ismael M. Santos, Ricardo C. Chagas, Edvan A. Chagas, Pollyana C. Post-Graduate Program in Chemistry PPGQ Center for Research and Graduate Studies in Science and Technology NPPGCT UFRR Paricarana Campus Boa Vista-RRCEP 69304-000 Brazil Departament of Chemistry UFRR Paricarana Campus Boa Vista-RRCEP 69304-000 Brazil Post-Graduate in Natural Resources Program Federal University of Roraima UFRR Paricarana Campus Boa Vista-RRCEP 69304-000 Brazil Post Graduate Program in Biodiversity and Biotechnology Bionorte State Coordination of Roraima UFRR Paricarana Campus Boa Vista-RRCEP 69304-000 Brazil National Postdoctoral Program of CAPES PNPD/CAPES associated to the Postgraduate Program in Agronomy POSAGRO/UFRR and Embrapa Boa Vista-RR Brazil Embrapa CNPq Research Produtivity Scholarship Rodovia 174 Km 8 Industrial District Boa VistaRRCEP 69301970 Brazil POSAGRO/UFRR Cauame Campus Boa Vista-RR Brazil

ISBN: (纸本)9788895608563

The aim of this study was to determine the chemical composition (IR), characterize minerals (ICP-OES), antioxidant activity, total phenols, inhibition of acetylcholinesterase (AChE) and antimicrobial activity of leaf extract of wild passion fruit (Passiflora foetida L.). The results obtained by Infrared of the hexane extract indicate the presence of aliphatic compounds such as fatty acids and esters, long chain alcohols and steroids. The major minerals were: phosphorus (1093.00 mg L-1), magnesium (418.77 mg L-1), sulfur (282.56 mg L-1) and potassium (157.46 mg L-1). The total phenolic content was 16.78 mg of gallic acid equivalent 100 g-1 extract. The hexane extract showed inhibition of 17.97% for antioxidant activity. The activity on AChE was 96.46% inhibition. As for microorganisms, the extract showed inhibition on Gram-positive bacteria Bacillus cereus (77.93%), Staphylococcus aureus (88.25%), Gram-negative Citrobacter freundii (82.74%), Salmonella typhimurium (83.21%) and yeast C. albicans (53.29%). Copyright © 2018, AIDIC Servizi S.r.l.

关键词： Hexane

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Direct Identification of Intact Proteins Using a Low-Resolution Mass Spectrometer with CIDn/ETnoD

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Journal of the American Society for Mass Spectrometry 2024年第7期35卷 1507-1515页

作者： Kuo, Cheng-Yu Zheng, Yi-Feng Wang, Wei-Chen Toh, Jie-Teng Hsu, Yu-Ming Chien, Han-Ju Chang, Chih-Jui Lai, Chien-Chen Institute of Molecular Biology National Chung Hsing University Taichung402 Taiwan Department of Biochemical Science and Technology National Chiayi University Chiayi600 Taiwan Department of Molecular Biology and Human Genetics Tzu Chi University Hualien City970 Taiwan Advanced Plant and Food Crop Biotechnology Center National Chung Hsing University Taichung402 Taiwan Graduate Institute of Chinese Medical Science China Medical University Taichung406 Taiwan Doctoral Program in Translational Medicine National Chung Hsing University Taichung402 Taiwan Rong Hsing Translational Medicine Research Center National Chung Hsing University Taichung402 Taiwan

Over the past decades, proteomics has become increasingly important and a heavily discussed topic. The identification of intact proteins remains a major focus in this field. While most intact proteins are analyzed using high-resolution mass spectrometry, identifying them through low-resolution mass spectrometry continues to pose challenges. In our study, we investigated the capability of identifying various intact proteins using collision-induced dissociation (CID) and electron transfer without dissociation (ETnoD). Using myoglobin as our test protein, stable product ions were generated with CID, and the identities of the product ions were identified with ETnoD. ETnoD uses a short activation time (AcT, 5 ms) to create sequential charge-reduced precursor ion (CRI). The charges of the fragments and their sequences were determined with corresponding CRI. The product ions can be selected for subsequent CID (termed CIDn) combined with ETnoD for further sequence identification and validation. We refer to this method as CIDn/ETnoD. The use of a multistage CID activation (CIDn) and ETnoD protocol has been applied to several intact proteins to obtain multiple sequence identifications. © 2024 The Authors. Published by American Chemical Society.

关键词： Dissociation

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