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SSRN 2023年

作者： Siagian, Viktor Siregar, Hermanto Fariyanti, Anna Nainggolan, Kaman Haloho, Lermansius Hutapea, Ronald Suratman Salim, Zamroni Wamaer, Demas da Silva, Helena Ekaswati, Rini Rusdiana, Supardi Marwati, Tri Toha, Mohammad Sondakh, Joula Marpaung, Imelda Research Center for Macro Economic and Finance Research Organization for Governance Economy and Community Welfare National Research and Innovation Agency Jakarta12710 Indonesia IPB University Faculty of Economics and Management Bogor16680 Indonesia College of Management and Computer Science Nusa Mandiri Jakarta12540 Indonesia Research Center for Cooperative Corporation and People's Economy National Research and Innovation Agency Jakarta12710 Indonesia Universitas Islam Malang Indonesia Research Center for Behavioral and Circular Economics National Research and Innovation Agency Jakarta12710 Indonesia Research Center for Animal Research Organization for Agriculture and Food National Research and Innovation Agency Cibinong-Bogor 16128 Indonesia Research Center for Food and Technology Processing Research Organization for Agriculture and Food National Research and Innovation Agency Serpong15314 Indonesia Ph.D. Study Program Natural Resources and Environmental Management Graduate School of IPB University Campus IPB Baranangsiang Bogor16144 Indonesia National Research and Innovation Agency Indonesia

The area of the rice harvest in Banten Province in 2021 was 319,558 ha with a production of 1,63 million tons of unhusked rice or with a productivity of 5.1 tons/ha (CBS,2022). The objectives of this study were: 1) to optimize the target of rice and corn production in Banten Province, and 2) to optimize the target farmers' income in Banten Province. The study method used was a survey, with purposive sampling at the farmer level. Data were analyzed qualitatively (uses descriptive tabulation) and quantitatively (uses goal programming). The results of this study were:1) The target of rice production in the Banten Province of 2.1 million tons of unhusked rice can be achieved with the optimal area of irrigated paddy of 299,755.7 ha and the optimal area of field/dry land of 87,750.9 ha. The target for maize production of 1.75 million tonnes in Banten Province can be achieved with an optimal planting area of 342.211.7 ha of dry land. 2) The optimal area of food crops to achieve the farmer's income target in Banten Province in 2018 is IDR. 8.79 trillion comes from the planting area of lowland rice covering an area of 391,222.1 ha, the corn planting area of 169,059.9 ha, soybean planting area of 23,074.82 ha and cassava planting area of 2,832.77 ha. © 2023, The Authors. All rights reserved.

关键词： Agriculture

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Influence of Dentin Priming with Tannin-Rich Plant Extracts on the Longevity of Bonded Composite Restorations

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Scientific World Journal 2021年第1期2021卷 1614643页

作者： Polassi, Mackeler Ramos Oliveira, Thales De Sá Carvalho, Ana Calheiros De Medeiros, Lívia Soman De Medeiros Veiga, Thiago André Moura Graeff, Carlos Frederico De Oliveira González, Alejandra Hortencia Miranda Marcucci, Maria Cristina Grecco, Simone Dos Santos Dalpino, Paulo Henrique Perlatti Universidade Anhanguera de São Paulo São Paulo Brazil Department of Chemistry Universidade Federal de São Paulo SP Diadema Brazil São Paulo State University (UNESP) School of Sciences POSMAT - Post-Graduate Program in Materials Science and Technology SP Bauru Brazil Triplet Biotechnology Solutions São Paulo Brazil Science and Technology Institute Universidade Estadual Paulista - UNESP SP São José dos Campos Brazil

Objective. This in vitro study evaluated the influence of bioactive plant extracts as dentin biomodifying agents to improve the longevity of bonded restorations. For that, plant extracts were applied to the dentin surface prior to the adhesive system. Materials and Methods. Bovine incisors were ground flat to obtain 2 mm thick slices in which conical preparations were made (N = 10). Tannin-containing plant extracts were applied to dentin before the application of the restorative system, as follows: control group (untreated, CTL), chlorhexidine 0.12% (CHX), mastruz (Dysphania ambrosioides, MTZ), cat's claw (Uncaria tomentosa, CTC), guarana (Paullinia cupana, GUA), galla chinensis (Rhus chinensis, GCH), and tannic acid (extracted from Acacia decurrens, TNA). The push-out bond strength test was conducted (0.5 mm/min). Dentin biomodification was assessed by the modulus of elasticity and mass change in bovine tooth sections (0.5 × 1.7 × 7.0 mm). The dentin staining after extract treatments of dentin slices was compared. The dentin surface wettability was also evaluated by means of the contact angles of the adhesive system with the dentin surface and compared with the untreated control group. Data were subjected to ANOVA/Tukey's test (α = 0.05). Results. The bond strength of the restoratives to dentin was not significantly improved by the plant extracts, irrespective of the evaluation time (p>0.05). Except for TNA, the elastic modulus of demineralized dentin significantly reduced after treatment with the plant extracts (p<0.05). The dentin staining correlated with the tannin content of the extracts. The contact angle was significantly reduced when treated with CTC, GCH, and TNA. Conclusions. The tannin-containing extracts had a questionable effect on the longevity of bonded restorations. The dentin modulus was negatively affected by the extract treatments. Although some of the extracts changed the contact angle, which seems to improve the adhesive monomer permeation, the

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food coating using vegetable sources: importance and industrial potential, gaps of knowledge, current application, and future trends

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Applied food Research 2022年第1期2卷

作者： Rios, Danielle Alves da Silva Nakamoto, Monica Masako Braga, Anna Rafaela Cavalcante da Silva, Elisabeth Mary Cunha Graduate Program in Food Science and Technology (PPGCTA) Center of Agrarian Sciences Federal University of Ceará (UFC) Campus do Pici - Bloco 710 CEP 60455-900 Fortaleza CE Brazil Department of Biosciences Universidade Federal de São Paulo (UNIFESP) Rua Silva Jardim 136 CEP 11015-020 Santos SP Brazil Department of Chemical Engineering Universidade Federal de São Paulo (UNIFESP) Rua Artur Riedel 275 CEP 09972-270 Diadema SP Brazil

The food packaging market has been seeking to meet consumer health and personal standards. In this sense, plant-based ingredients and food such as vegetable extracts are the future. Among the trends, active packaging stands out since it can extend the shelf-life of packaged food or improve its sensory properties and food safety. In this work, a watchful literature review was conducted to identify studies on food packaging coatings and vegetable extracts coating and their benefits. The innovations and technological advances in the food area have collaborated in several aspects, allowing the improvement of food quality, the protection of bioactive compounds from adverse effects of harsh environment, and the replacement of conventional plastics. The use of vegetable extracts and nanocomposites in edible coatings and films has shown positive results in different types of food and is a promising material for being considered a safe compound and a sustainable alternative. © 2022

关键词： Bioactive compounds Edible coating food packaging Shelf-life

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Frailty in chronic myeloid leukemia: evidence from 2016–2018 Nationwide Inpatient Sample of the US

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BMC Geriatrics 2023年第1期23卷 334-334页

作者： Huan-Tze, Lin Yun-Ru, Liu Kuan-Der, Lee Huey-En, Tzeng Department of Internal Medicine Division of Hematology and Oncology Taipei Medical University Hospital Taipei Taiwan Joint Biobank Office of Human Research Taipei Medical University Taipei Taiwan Department of Medical Research Taichung Veterans General Hospital 1650 Boulevard Sect. 4 Taichung City 40705 Taiwan Department of Medicine Division of Hematology/Medical Oncology Taichung Veterans General Hospital Taichung City Taiwan Ph.D. Program for Cancer Molecular Biology and Drug Discovery and Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan

Background: Frailty is a marker of poor prognosis in older adults with hematologic malignancies and contributes to the severe vulnerability of the aging population to adverse health outcomes. This study aimed to determine the association between frailty and outcomes in hospitalized patients with chronic myeloid leukemia (CML). Methods: The International Classification of Diseases (ICD-10) identified data on hospitalized patients 20 years or older admitted with CML between 2016 and 2018 in the US National Inpatient Sample (NIS) database. The cohort was further divided into groups of patients with or without frailty. Logistic regression analysis was performed to determine associations between study variables and clinical outcomes. A stratified analysis of the association between frailty and in-hospital mortality by age group was also performed. Results: A total of 13,849 hospitalized patients with CML were included, 49.6% of whom had frailty. The mean age of the patients was 65.1 years, and 7,619 (56.2%) of them were male. Frailty was associated with nearly 4 times the risk of in-hospital mortality, 3 times the risk of unfavorable discharge, 3 times the risk of prolonged LOS, and significantly more in total hospital costs. In addition, frailty was associated with a significantly increased risk of in-hospital mortality in all age subgroups (< 40 years, 40–59 years, and > 60 years) compared with no frailty. Conclusions: Frailty strongly predicts poor clinical outcomes in US patients with CML. © 2023, The Author(s).

关键词： Chronic myeloid leukemia (CML) Frailty In-hospital outcome Nationwide Inpatient Sample (NIS)

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MiR34 contributes to spinal muscular atrophy and AAV9-mediated delivery of MiR34a ameliorates the motor deficits in SMA mice

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Molecular therapy. Nucleic acids 2023年 32卷 144-160页

作者： Tai-Heng Chen Shih-Hsin Chang Yu-Fu Wu Ya-Ping Yen Fang-Yu Hsu Yen-Chung Chen Yang Ming Ho-Chiang Hsu Yi-Ching Su Sheng-Tang Wong Jui-Hung Hung Shih-Hwa Chiou Yuh-Jyh Jong Jun-An Chen PhD Program in Translational Medicine Kaohsiung Medical University Kaohsiung 80708 and Academia Sinica Taipei 11529 Taiwan. Institute of Molecular Biology Academia Sinica Taipei 11529 Taiwan. Department of Pediatrics Kaohsiung Medical University Kaohsiung 80708 Taiwan. School of Post-Baccalaureate Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan. Neuroscience Program of Academia Sinica Academia Sinica Taipei 11529 Taiwan. Department of Computer Science National Yang Ming Chiao Tung University Hsinchu 30093 Taiwan. Institute of Pharmacology School of Medicine National Yang Ming Chiao Tung University Taipei 11221 Taiwan. Innovative Cellular Therapy Center Department of Medical Research Taipei Veterans General Hospital Taipei 11217 Taiwan. Department of Laboratory Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan. Translational Research Center of Neuromuscular Diseases Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung 80708 Taiwan. Graduate Institute of Clinical Medicine College of Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan. Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung 80708 Taiwan. Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu 30093 Taiwan.

Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by the selective loss of spinal motor neurons (MNs) and concomitant muscle weakness. Mutation of is known to cause SMA, and restoring SMN protein levels via antisense oligonucleotide treatment is effective for ameliorating symptoms. However, this approach is hindered by exorbitant costs, invasive procedures, and poor treatment responses of some patients. Here, we seek to circumvent these hurdles by identifying reliable biomarkers that could predict treatment efficacy. We uncovered that MiR34 exhibits consistent downregulation during SMA progression in both human and rodent contexts. Importantly, family-knockout mice display axon swelling and reduced neuromuscular junction (NMJ) endplates, recapitulating SMA pathology. Introducing MiR34a via scAAV9 improved the motor ability of SMNΔ7 mice, possibly by restoring NMJ endplate size. Finally, we observed a consistent decreasing trend in MiR34 family expression in the cerebrospinal fluid (CSF) of type I SMA patients during the loading phase of nusinersen treatment. Baseline CSF MiR34 levels before nusinersen injection proved predictive of patient motor skills 1 year later. Thus, we propose that MiR34 may serve as a biomarker of SMA since it is associated with the pathology and can help evaluate the therapeutic effects of nusinersen.

关键词： ASO MT: Non-coding RNAs MiR34 SMA biomarker microRNA nusinersen spinal muscular atrophy

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Organic composts as A vehicle for the entry of microplastics into the environment: A comprehensive review

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The science of the total environment 2023年 892卷 164758页

作者： Van-Re Le Minh-Ky Nguyen Hoang-Lam Nguyen Chitsan Lin Md Refat Jahan Rakib Van-Anh Thai Van-Giang Le Guilherme Malafaia Abubakr M Idris Ho Chi Minh City University of Food Industry (HUFI) 140 Le Trong Tan Street Tan Phu District Ho Chi Minh City 700000 Viet Nam. Faculty of Environment and Natural Resources Nong Lam University of Ho Chi Minh City Hamlet 6 Linh Trung Ward Thu Duc City Ho Chi Minh City 700000 Viet Nam Ph.D. Program in Maritime Science and Technology National Kaohsiung University of Science and Technology Kaohsiung 81157 Taiwan. Electronic address: nmky@hcmuaf.edu.vn. Department of Civil Engineering McGill University Montreal Canada. Ph.D. Program in Maritime Science and Technology National Kaohsiung University of Science and Technology Kaohsiung 81157 Taiwan Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung 81157 Taiwan. Department of Fisheries and Marine Science Faculty of Science Noakhali Science and Technology University Noakhali 3814 Bangladesh. Electronic address: rifatjahanrakib@***. Institute of Aquatic Science and Technology National Kaohsiung University of Science and Technology Kaohsiung City 81157 Taiwan. Central Institute for Natural Resources and Environmental Studies Vietnam National University Hanoi 111000 Viet Nam. Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia Uberlândia MG Brazil Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás Goiânia GO Brazil Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute Urutaí GO Brazil. Electronic address: guilhermeifgoiano@***. Department of Chemistry College of Science King Khalid University 61431 Abha Saudi Arabia Research Center for Advanced Materials Science (RCAMS) King Khalid University Abha 61421 Saudi Arabia.

Plastic pollution is a widespread issue that poses a threat to agroecosystems. Recent data on microplastic (MP) pollution from compost and its application to soil have highlighted the potential impact of micropollutants that may be transferred from compost. Thus, we aim with this review to elucidate the distribution-occurrence, characterization, fate/transport, and potential risk of MPs from organic compost to gain comprehensive knowledge and mitigate the adverse impacts of compost application. The concentration of MPs in compost was up to thousands of items/kg. Among micropollutants, fibers, fragments, and films are the most common, with small MPs having a higher potential to absorb other pollutants and cause harm to organisms. Various synthetic polymers, including polyethylene (PE), polypropylene (PP), polyethylene terephthalate (PET), polystyrene (PS), polyvinyl chloride (PVC), polyester (PES), and acrylic polymers (AP), have been widely used of plastic items. MPs are emerging pollutants that can have diverse effects on soil ecosystems, as they can transfer potential pollutants from MPs to compost and then to the soil. Following the microbial degradation scheme, the transfer chain from plastics to compost to soil can be broken down into main stages, i.e., colonization - (bio)fragmentation - assimilation - and mineralization. Microorganisms and adding biochar play an essential role during composting, which can be an effective solution to enhance MP degradation. Findings have shown that stimulating free radical generation could promote the biodegradation efficacy of MPs and possibly remove their occurrence in compost, thereby reducing their contribution to ecosystem pollution. Furthermore, future recommendations were discussed to reduce ecosystem risks and health challenges.

关键词： Emerging contaminants Free radicals Mineralization Organic waste Plastic pollution Polymers

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Potential of Eggshell Waste Derived Calcium for Sustainable Production of Biogas from Cassava Wastewater

SSRN

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SSRN 2022年

作者： Cruz, Ianny Andrade Andrade, Larissa Renata Santos de Jesus, Anderson Alles de Vasconcelos, Bruna Rego Bharagava, Ram Naresh Bilal, Muhammad Figueiredo, Renan Tavares de Souza, Ranyere Lucena Romanholo Ferreira, Luiz Fernando Graduate Program in Process Engineering Tiradentes University Av. Murilo Dantas 300 Farolândia SE Aracaju49032-490 Brazil Universidade Federal do Maranhão Campus Balsas MA Balsas65800-000 Brazil Biomass Technology Laboratory Department of Chemical Engineering and Biotechnology Engineering Université de Sherbrooke 2500 Boul. de L’Université SherbrookeQCJ1K 2R1 Canada Vidya Vihar Raebareli Road Uttar Pradesh Lucknow226 025 India School of Life Science and Food Engineering Huaiyin Institute of Technology Huaian223003 China Institute of Technology and Research Av. Murilo Dantas 300 Farolândia SE Aracaju49032-490 Brazil

Cassava is a staple crop that plays a significant role in the food security of many countries. However, its processing produces a liquid by-product known as cassava wastewater (CW), which can have adverse environmental consequences if discarded without treatment. Despite its cyanide content, CW has a high organic content and may be profitable when used to produce biogas. In this study, the influence of calcium particles from eggshell residues was investigated on the anaerobic digestion of CW. Moreover, the performance of the bioreactor was remotely monitored. Calcium particles from milled-calcined chicken eggshells were added to the bioreactor, and biogas production was investigated for 21 days. Adding 1 g/L and 3 g/L of calcium particles increased biogas (Bio H 2 + Bio CH 4 ) production by 195% and 338%, respectively. Finally, the requirement for digestate post-treatment before use in agriculture was observed after assessing its phytotoxicity through the germination and root growth of L. sativa seeds. © 2022, The Authors. All rights reserved.

关键词： Sustainable development

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Physical characteristics of modified cassava flour wastewater at room temperature

Physical characteristics of modified cassava flour wastewate...

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International Conference on food science and technology 2018, ICFST 2018

作者： Yaqin, N. Al-Baarri, A.N. Legowo, A.M. Widayat Budihardjo, M.A. Program of Environmental Science School of Post-Graduate Studies Diponegoro University Semarang Indonesia Food Technology Department Faculty of Animal and Agricultural Sciences Diponegoro University Semarang Indonesia Chemical Engineering Department Faculty of Engineering Diponegoro University Semarang Indonesia Center of Research and Services Diponegoro University Semarang Indonesia Department of Environmental Engineering Faculty of Engineering Diponegoro University Indonesia

Cassava is an agricultural material that is considered as important raw resources in the industrial sector. The benefits are even greater after being modified using lactic acid bacteria. However, the mocaf industry often causes water and air pollution. Environmental problems arise after the fermentation process. Determination problems with lightness, TDS (Total Dissolved Solid), conductivity and pH analysis are required to measure the impact to the environment. This research was used waste water from mocaf during 3 days fermentation. The wastewater had the highest color level (Lightness) on initial day of fermentation at 83.7±3.73 and then decrease along the day of fermentation at the averages of 65.2±2.0. The highest TDS was resulted from the mocaf wastewater at a value of 1218 ± 4.6 ppm which continued to decline until day 4. The conductivity and pH showed a decrease along the day of fermentation. As conclusion, physical characteristic of wastewater from mocaf production could be analyzed specifically and determined through color, TDS, conductivity, and pH. © 2019 Published under licence by IOP Publishing Ltd.

关键词： Fermentation

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Calycosin Enhances Heat Shock Related-Proteins in H9c2 Cells to Modulate Survival and Apoptosis against Heat Shock

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The American journal of Chinese medicine 2024年第4期52卷 1173-1193页

作者： Pei-Fang Lai Ramasamy Mahendran Bruce Chi-Kang Tsai Cheng-You Lu Chia-Hua Kuo Kuan-Ho Lin Shang-Yeh Lu Yu-Ling Wu Yung-Ming Chang Wei-Wen Kuo Chih-Yang Huang Department of Emergency Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien 970 Taiwan. Department of Medicine Tzu Chi University Hualien 970 Taiwan. Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien 970 Taiwan. Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung 402 Taiwan. Laboratory of Exercise Biochemistry University of Taipei Taipei 111 Taiwan. Institute of Sports Sciences University of Taipei Taipei 111 Taiwan. School of Physical Education and Sports Science Soochow University Suzhou 215021 China. Department of Kinesiology and Health College of William and Mary Williamsburg VA 23185 USA. Department of Emergency Medicine China Medical University Hospital Taichung 404 Taiwan. College of Medicine China Medical University Taichung 406 Taiwan. Division of Cardiovascular Medicine Department of Internal Medicine China Medical University Hospital Taichung 404 Taiwan. The School of Chinese Medicine for Post-Baccalaureate I-Shou University 840 Kaohsiung Taiwan. Chinese Medicine Department E-DA Hospital Kaohsiung 824 Taiwan. 1PT Biotechnology Co. Ltd. Taichung 433 Taiwan. Department of Biological Science and Technology College of Life Sciences China Medical University Taichung 406 Taiwan. Ph.D. Program for Biotechnology Industry China Medical University Taichung 406 Taiwan. School of Pharmacy China Medical University Taichung 406 Taiwan. Graduate Institute of Biomedical Sciences China Medical University Taichung 406 Taiwan. Department of Medical Laboratory Science and Biotechnology Asia University Taichung 413 Taiwan. Center of General Education Buddhist Tzu Chi Medical Foundation Tzu Chi University of Science and Technology Hualien 970 Taiwan. Department of Medical Research China Medical University Hospital China Medical University Taichung 404 Taiwan.

Heat shock proteins (HSPs), which function as chaperones, are activated in response to various environmental stressors. In addition to their role in diverse aspects of protein production, HSPs protect against harmful protein-related stressors. Calycosin exhibits numerous beneficial properties. This study aims to explore the protective effects of calycosin in the heart under heat shock and determine its underlying mechanism. H9c2 cells, western blot, TUNEL staining, flow cytometry, and immunofluorescence staining were used. The time-dependent effects of heat shock analyzed using western blot revealed increased HSP expression for up to 2[Formula: see text]h, followed by protein degradation after 4[Formula: see text]h. Hence, a heat shock damage duration of 4[Formula: see text]h was chosen for subsequent investigations. Calycosin administered post-heat shock demonstrated dose-dependent recovery of cell viability. Under heat shock conditions, calycosin prevented the apoptosis of H9c2 cells by upregulating HSPs, suppressing p-JNK, enhancing Bcl-2 activation, and inhibiting cleaved caspase 3. Calycosin also inhibited Fas/FasL expression and activated cell survival markers (p-PI3K, p-ERK, p-Akt), indicating their cytoprotective properties through PI3K/Akt activation and JNK inhibition. TUNEL staining and flow cytometry confirmed that calycosin reduced apoptosis. Moreover, calycosin reversed the inhibitory effects of quercetin on HSF1 and Hsp70 expression, illustrating its role in enhancing Hsp70 expression through HSF1 activation during heat shock. Immunofluorescence staining demonstrated HSF1 translocation to the nucleus following calycosin treatment, emphasizing its cytoprotective effects. In conclusion, calycosin exhibits pronounced protective effects against heat shock-induced damages by modulating HSP expression and regulating key signaling pathways to promote cell survival in H9c2 cells.

关键词： Astragalus Membranaceus Calycosin Cardiomyocyte Heart Protection Heat Shock Heat Shock-Related Protein

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Combined effects of a high-fat diet and polyethylene microplastic exposure induce impaired lipid metabolism and locomotor behavior in larvae and adult zebrafish

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The science of the total environment 2023年 902卷 165988页

作者： Seenivasan Boopathi B Haridevamuthu Edrea Mendonca Akash Gandhi P Snega Priya Saad Alkahtani Norah S Al-Johani Selvaraj Arokiyaraj Ajay Guru Jesu Arockiaraj Guilherme Malafaia Toxicology and Pharmacology Laboratory Department of Biotechnology Faculty of Science and Humanities SRM Institute of Science and Technology Kattankulathur 603203 Chengalpattu District Tamil Nadu India. Department of Zoology College of Science King Saud University P. O. Box 2455 Riyadh 11451 Saudi Arabia. Department of Food Science & Biotechnology Sejong University Seoul 05006 Republic of Korea. Department of Cariology Saveetha Dental College and Hospitals SIMATS Chennai 600 077 Tamil Nadu India. Electronic address: ajayguru.sdc@***. Toxicology and Pharmacology Laboratory Department of Biotechnology Faculty of Science and Humanities SRM Institute of Science and Technology Kattankulathur 603203 Chengalpattu District Tamil Nadu India. Electronic address: jesuaroa@srmist.edu.in. Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute Urutaí GO Brazil Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia Uberlândia MG Brazil Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás Goiânia GO Brazil. Electronic address: guilhermeifgoiano@***.

Microplastics (MP), tiny plastic particles, can be ingested by fish through their habitat or contaminated food sources. When combined with a high-fat diet (HFD), MP exposure may lead to increased MP accumulation in fish and negative impacts on their health. However, the underlying mechanisms of how MP and HFD interact to promote fat accumulation in fish remain poorly understood. In this study, we aimed to evaluate the combined effect of HFD and polyethylene MP (PE-MP) in the zebrafish model (Danio rerio) and decipher its molecular mechanisms. Adult zebrafish exposed to the combined HFD and PE-MP showed elevated lipid accumulation, total cholesterol, triglycerides, and abnormal swimming behavior compared to HFD-fed fish. Histological and gene expression analysis revealed severe hepatic inflammation and injury, resembling nonalcoholic fatty liver disease (NAFLD) in the HFD + PE-MP exposed zebrafish. Moreover, HFD and PE-MP exposure upregulated genes related to lipogenesis (SREBP1, FAS, and C/EBPα) and inflammation (tnfα, il1β, and il-6) in the liver. These findings underscore the interactive effect of environmental pollutants and fish diet, emphasizing the importance of improving fish culture practices to safeguard fish health and human consumers from microplastic contamination through the food chain. This research sheds light on the complex interactions between microplastics and diet, providing valuable insights into the potential risks of microplastic pollution in aquatic ecosystems and the implications for human health. Understanding the underlying molecular mechanisms will contribute to international research efforts to mitigate the adverse effects of microplastics on both environmental and public health.

关键词： High-fat diet Lipid accumulation Microplastic Non-alcoholic fatty liver disease Polyethylene

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