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9th International Conference on Cyber and IT Service Management, CITSM 2021

作者： Pratiwi, Noviana Maman, Ujang Junaidi Danapriatna, Nana Mukri, Rusdiono Hejazziey, Djawahir Universitas Islam Negeri Syarif Hidayatullah Jakarta Agribusiness Undergraduate Program Faculty of Science and Technology Indonesia Universitas Islam '45' Bekasi Agribusiness Undergraduate Program Faculty of Agriculture Bekasi Indonesia Sahid Islamic Entrepreneurial University Madrasah Ibtidaiyyah Teacher Program Faculty of Tarbiyah and Teacher Training Bogor Indonesia Universitas Islam Negeri Syarif Hidayatullah Jakarta Post Graduate Program of Sharia Economic Law Indonesia

ISBN: (纸本)9781665435482

The high use of internet especially social media has made this virtual world as a marketing tool. Therefore, this study aims: to determine the effect of Instagram-social media promotion on purchasing decisions, the level of AIDA (Attention, Interest, Desire and Action) among consumers;its influence on purchasing decisions;and to determine the suitable AIDA model for fresh products. The research population is Instagram followers @HappyFresh_id. The sample is 100 people based on five-percent-error-probability of Slovin formula, and it is derived by a simple random sampling technique. The data collected during March-April 2021, and adopting multiple linear regression analysis, proves AIDA simultaneously influences purchasing decisions with a determination level of 67%. Likewise, the interest, desire, and action have a significant effect on buying decisions. Accordingly, the research presents three variations of AIDA model for effective social media marketing, but it needs further analysis. © 2021 IEEE.

关键词： Social networking (online)

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Impact of the physicochemical parameters on the sensory characterization of Brazilian coffee by the CATA method

Food Chemistry Advances

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food Chemistry Advances 2023年 3卷

作者： Neves, Anna Luiza Santana Martinez, Jéssica Rosales Maciel, Maria Inês Sucupira de Melo, Michelle Rayssa Pereira Veríssimo, Caio Monteiro Arruda, Luciana Leite de Andrade Lima Food Science and Technology Pos-Graduate Program Universidade Federal Rural de Pernambuco Dois Irmãos Rua Dom Manuel de Medeiros s/n PE Recife CEP 52171-900 Brazil

This research aims to evaluate the sensory description of arabica and canephora coffee by consumers, identify how and canephora coffee by consumers, and identify how physicochemical variables affect sensory perception. Three Brazilian coffees (two arabica and one canephora) were determined sensorial attributes by the Check-All-That-Apply (CATA) method with 190 consumers in a home test, and physicochemical (pH and caffeine content) and chromatic parameters. The results showed that visual perception, brightness, and orange coloration are the main means used to distinguish arabica coffee from commercial coffee. In addition, the perception of sweeter aromas (toffee, vanilla, and caramel spread), chocolate with greater intensity, and the less intense bitterness taste were important typicality markers to differentiate arabica coffee (cv. Typica). The analysis of the correlations between caffeine and bitterness, sweetness, and acidity demonstrates the consumer's ability to perceive basic tastes in the different coffee samples. The chromatic parameters obtained significant correlations with visual, olfactory, and gustatory attributes. This study indicated the consumer's ability to establish typical traits for Arabica coffee depending on the place of cultivation. In addition, consumers perceive the influence of physicochemical variables on sensory attributes, highlighting the need for quality in an increasingly demanding and globalized market. © 2023

关键词： Caffeine Consumers Home use testing Sensorial describe Typica

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Effects of electron-beam (E-beam) irradiation on the postharvest quality of ‘golden’ papayas

Food Physics

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food Physics 2025年 2卷

作者： Oliveira, Patrícia Souza de Coelho, Caroline Corrêa de Souza Campos, Rodrigo da Silveira Freitas-Silva, Otniel Freire Júnior, Murillo Graduate Program in Food Science and Technology Federal Rural University of Rio de Janeiro UFRRJ BR 465 Km 7 RJ Seropédica 23890-000 Brazil Food and Nutrition Graduate Program Federal University of State of Rio de Janeiro UNIRIO Av. Pasteur 296 Rio de Janeiro 22290-240 Brazil Embrapa Agroindústria de Alimentos Av. das Américas 29501 RJ Rio de Janeiro 23020-470 Brazil

Brazilian papaya production and exports have increased in recent years, and as a phytosanitary requirement, emerging technologies have been introduced into the agricultural chain. Electron beam (E-beam) irradiation has phytosanitary potential for the treatment of fruits, as it is safe and effective in controlling agricultural pests, extending the shelf life of the fruits, and preserving their quality. E-beam irradiation doses of 1, 3, and 5 kGy were applied on 'Golden' papaya fruit, with non-irradiated fruits (0 kGy) used as a control were applied on 'Golden' papaya fruit inoculated with fungi Colletotrichum gloeosporioides and Phoma caricae-papayae to verify if this technology could reduce postharvest diseases from the papaya rot complex. Also, this study evaluated the effects of the same E-beam doses on the postharvest quality of papayas, by analyzing physicochemical characteristics such as titratable acidity (TA), total soluble solids (TSS), Total Phenolic Content (TPC), firmness, and weight loss, as well as enzymatic activity of pectin methylesterase (PME) and polygalacturonase (PG) in the fruit. E-beam irradiation did not affect these variables. A difference was observed among the tested doses on the TA, TSS, TPC, and weight loss with the temperature increase during storage. In the other analysis, PME and PG activity and firmness were not influenced by the irradiation doses. Fruit at the 1 kGy, in general, had similar results as the control ones, this dose also was effective in reducing the growth of C. gloeosporioides and P. caricae-papayae and maintaining the quality of fruit since the doses of 3 and 5 kGy caused injuries to them. © 2025 The Authors

关键词： Enzymes Fruit physiology Fungi postharvest pathology Radiation

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Rosa multiflora fructus and its active compound ellagic acid improve depressive-like behaviors in mice via monoamine oxidase inhibition

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Biomedicine and Pharmacotherapy 2025年 188卷 118169-118169页

作者： Kim, Minji Lim, Dong Wook Kim, Min-Sun Nam, Heejin Shin, Sooim Lee, Changho Um, Min Young Food Functionality Research Division Korea Food Research Institute Wanju 55365 South Korea Department of Food Biotechnology University of Science & Technology Daejeon 34113 South Korea Interdisciplinary Program of Bioenergy and Biomaterials Graduate School College of Engineering Chonnam National University Gwangju 61186 South Korea Department of Biotechnology & Bioengineering College of Engineering Chonnam National University Gwangju 61186 South Korea

Depression is a significant global health challenge, imposing severe social and economic burdens. Rosa multiflora fructus possesses a range of biological properties;however, its role in reducing stress hormone-induced depression remains unclear. This study examined the antidepressant effects of Rosa multiflora fructus extract (RMFE) on corticosterone (CORT)-induced depressive-like behaviors in mice and explored the underlying molecular mechanisms. ICR mice were administered CORT (40 mg/kg/day, i.p.) for 8 weeks to induce depressive-like behaviors. They were then treated with RMFE (100 or 300 mg/kg/day, p.o.) or selegiline (10 mg/kg/day, p.o.) as a positive control. RMFE treatment significantly alleviated depressive-like behaviors, as evaluated by the tail suspension and forced swimming tests. Furthermore, RMFE reduced hippocampal astrocyte hypertrophy and lowered the protein and mRNA expression of monoamine oxidase A and B (MAOA and MAOB). Phytochemical analysis using UPLC-MS/MS identified five flavonoids in RMFE, including ellagic acid (EA), hyperoside, isoquercetin, quercetin, and quercetin-3-glucuronide. In silico molecular docking revealed that these phenolic compounds interact with MAOA and MAOB, with EA exhibiting the strongest binding affinity. Consistently, EA administration effectively alleviated depressive-like behaviors and increased monoamine neurotransmitter levels in CORT-treated mice. These results suggest that RMFE exerts antidepressant effects by inhibiting MAO, restoring monoamine levels, and modulating hippocampal astrocytic hypertrophy, with EA identified as the primary bioactive compound driving its efficacy. © 2025

关键词： Corticosterone Depression Ellagic acid Monoamine oxidase Rosa multiflora fructus

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The effect of pre-treatment on chemical characteristics of pumpkin seeds (Cucurbita moschata Durch)

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AIP Conference Proceedings 2023年第1期2596卷

作者： Akbar Suhaji Meta Mahendradatta Zainal Graduate School of Food Science and Technology Master Program Hasanuddin University Makassar Indonesia Food Science and Technology Study Program Hasanuddin University Makassar Indonesia

Pumpkin seeds (Cucurbita moschata Durch) are high in nutrients and health-promoting components. Pumpkin seeds also have anti-nutritional compounds that can reduce the availability of minerals and proteins. Since an antinutrient, phytic acid has negative qualities, as it may bind to several vital minerals, rendering them inaccessible. This study aims to determine the effect of pre-treatment on phytic acid and the proximate composition of pumpkin seeds. Pre-treatments of pumpkin seeds (Cucurbita moschata Durch) were done by soaking at 45 ℃, fermentation with LAB (L. Plantarum), and germination. Proximate analysis and phytic acid content analysis were performed and obtained the best treatment for each nutrient content. The highest carbohydrate content (13.88%) was obtained from the soaking pre-treatment at 45 ℃. The highest fat (34.72%) and ash ((3.11%) content were obtained from fermentation pre-treatment. The highest protein content (39.85%) and the highest water content (3.71%) were obtained from the germination pre-treatment. The highest fiber content (8.04%) was obtained from untreated pumpkin seeds. The lowest phytic acid (0.062%) was obtained from germination pre-treatment, while phytic acid content obtained from fermentation and soaking pre-treatments was 0.072% and 0.065%, respectively. In conclusion, pre-treatments on pumpkin seeds in this study have decreased phytic acid content and changed their proximate composition.

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Tumor-derived interleukin-1 receptor antagonist exhibits immunosuppressive functions and promotes pancreatic cancer

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Cell and Bioscience 2023年第1期13卷 1页

作者： Fan, Yu-Ching Fong, Yu-Cin Kuo, Chun-Tse Li, Chia-Wei Chen, Wei-Yu Lin, Jian-Da Bürtin, Florian Linnebacher, Michael Bui, Quoc Thang Lee, Kuan-Der Tsai, Yuan-Chin Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University and Academia Sinica Taipei Taiwan Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan Institute of Biomedical Sciences Academia Sinica Taipei Taiwan Department of Pathology Wan Fang Hospital Taipei Medical University Taipei Taiwan Department of Pathology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Biochemical Science and Technology College of Life Science National Taiwan University Taipei City 10617 Taiwan Center for Computational and Systems Biology National Taiwan University Taipei City 10617 Taiwan Clinic of General Surgery University Medical Center Rostock Schillingallee 35 Rostock 18057 Germany Clinic of General Surgery Molecular Oncology and Immunotherapy University Medical Center Rostock Schillingallee 69 Rostock 18057 Germany International Ph.D. Program for Cell Therapy and Regeneration Medicine (IPCTRM) School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Post-Baccalaureate Medicine College of Medicine Natioanl Chung Hsing University Taichung Taiwan Cell Therapy and Regenerative Medicine Center and Comprehensive Cancer Center Taichung Veterans General Hospital Taichung Taiwan Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan

Background: Pancreatic ductal adenocarcinoma (PDA) is a pernicious disease characterized by an immunosuppressive milieu that is unresponsive to current immunotherapies. Interleukin-1 receptor antagonist (IL-1Ra) is a natural anti-inflammatory cytokine;however, its contribution to cancer pathogenesis and immunosuppression remains elusive. In this research, we investigated the role and mechanism of IL-1Ra in malignant progression of PDA. Results: Through analyzing clinical dataset and examining the pathological tumor tissues and serum samples, we have demonstrated that IL-1Ra expression is elevated in human PDA and positively associated with malignant progression of PDA. To study the biological function of IL-1Ra in tumors, we generated a set of mouse pancreatic cancer cell lines with a knockout (KO) of the Il1rn gene, encoding IL-1Ra, and compared the tumor growth rates in immune-competent and immune-deficient mice. We found that the Il1rn KO cells exhibited greater tumor inhibition in immune-competent mice, highlighting the crucial role of a functional immune system in Il1rn KO-mediated anti-tumor response. Consistently, we found an increase in CD8⁺ T cells and a decrease in CD11b⁺Ly6G⁻ immunosuppressive mononuclear population in the tumor microenvironment of Il1rn KO-derived tumors. To monitor the inhibitory effects of IL-1Ra on immune cells, we utilized a luciferase-based reporter CD4⁺ T cell line and splenocytes, which were derived from transgenic mice expressing ovalbumin-specific T cell receptors in CD8⁺ T cells, and mice immunized with ovalbumin. We showed that IL-1Ra suppressed T cell receptor signaling and inhibited antigen-specific interferon-γ (IFN-γ) secretion and cytolytic activity in splenocytes. Conclusions: Our findings illustrate the immunosuppressive properties of the natural anti-inflammatory cytokine IL-1Ra, and provide a rationale for considering IL-1Ra-targeted therapies in the treatment of

关键词： IFN-γ Immunosuppression interleukin-1 receptor antagonist Pancreatic adenocarcinoma Patient-derived xenograft Tumor microenvironment

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Extraction of Cocoa Butter (Theobroma Cacao) Using Supercritical Carbon Dioxide as Solvente: Thermodynamic Modeling and Kinetic Parameters

SSRN

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SSRN 2023年

作者： de Aguiar, Ivonete Quaresma da Silva Santos, Patrícia Oliveira Lima, Giulia Victória Silva Menezes, Eduardo Gama Ortiz Carvalho Júnior, Raul Nunes de Department of Food Technology Center for Natural Sciences and Technology University of the State of Pará Travessa Enéas Pinheiro 2626 Belém66.095-100 Brazil Extraction Laboratory Graduate Program in Food Science and Technology Federal University of Pará Belém66075-110 Brazil Center for the Valorization of Bioactive Compounds in the Amazon Guamá Science and Technology Park Avenida Perimetral da Ciência km 01 Belém66.095-780 Brazil Federal Institute of Education Science and Technology of Rondônia IFRO Rondônia Porto Velho Brazil

Extraction with supercritical carbon dioxide is highly efficient to solubilize and obtain non-polar extracts with high added value and, therefore, has been widely used to extract vegetable oils and fats of interest to the food industry. However, despite its proven efficiency, studies on the application and mathematical modeling of supercritical fluid technology to obtain cocoa butter are still scarce. This present work aimed to extract cocoa butter from cocoa shells using supercritical carbon dioxide through experimental tests in the isotherms of 40 and 80°C combined with the pressures of 200, 300, and 400 bar, and mathematical modeling made to estimate the characteristic times, thermodynamic solubility and extraction rates. The best extraction yield (14.64±0.70% on a dry basis) was obtained at 80°C, and 300 bar, with the highest extraction rate in the first minutes of extraction © 2023, The Authors. All rights reserved.

关键词： Supercritical fluids

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Pulmonary Disease Pattern Recognition on X-Ray Radiography Image Using Artificial Neural Network (ANN) Method 3

Pulmonary Disease Pattern Recognition on X-Ray Radiography I...

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3rd Annual Scientific Meeting on Medical Physics and Biophysics, PIT-FMB in conjunction with the 17th South-East Asia Congress of Medical Physics, SEACOMP 2019

作者： Fitriyah, N. Kurniawati, L.D. Purwanti, E. Astuti, S.D. Department of Physics Faculty of Science and Technology Universitas Airlangga Surabaya60115 Indonesia Biomedical Engineering Study Program Faculty of Science and Technology Universitas Airlangga Surabaya60115 Indonesia Department of Biomedical Engineering Post-Graduate Program Faculty of Science and Technology Universitas Airlangga Surabaya60115 Indonesia

This research aims to recognize the pattern of pulmonary disease on x-ray radiography image using artificial neural network (ANN) method. The images, which were used such as images of healthy pulmonary, pulmonary tuberculosis, and pulmonary tumour. Pattern recognition was using an extraction feature of GLCM (Gray Level Co-occurrence Matrix) and back propagation method. Before being identified, the images were processed by median filter and adaptive histogram equalization. The GLCM features that used were homogeneity, energy, contrast, variance and correlation. The parameters were learning rate and hidden layer. Learning rate was 0.3 and hidden layer was 25. Back propagation training showed 100% accuracy, which all of 44 images were used had been successfully identified. From the result, the healthy pulmonary showed 60% accuracy, 83.3% for pulmonary tuberculosis and 100% for pulmonary tumor. Hence, the overall result showed 81.25% accuracy, which 13 of 16 images had been successfully identified. From these result, extraction feature of GLCM using back propagation method was capable to recognize the pattern of pulmonary disease. However, due to narrow range of the feature, this application may not be used optimally for comparing features in every category of images. Therefore, the further research is needed to determine the best features and parameters of training back propagation. © Published under licence by IOP Publishing Ltd.

关键词： Pattern recognition

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Correction to: Holothuria triterpene glycosides: a comprehensive guide for their structure elucidation and critical appraisal of reported compounds

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Phytochemistry Reviews 2022年第4期21卷 1359-1378页

作者： Puspitasari, Yunita Eka De Bruyne, Tess Foubert, Kenn Aulanni’am, Aulanni’am Pieters, Luc Hermans, Nina Tuenter, Emmy Natural Products and Food Research and Analysis (NatuRA) Department of Pharmaceutical Sciences University of Antwerp Antwerp Belgium Doctoral Program of Environmental Studies Post Graduate University of Brawijaya Malang Indonesia Faculty of Fisheries and Marine Sciences University of Brawijaya Malang Indonesia Faculty of Mathematics and Natural Science Department of Chemistry University of Brawijaya Malang Indonesia

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Neutrophil-targeted combinatorial nanosystems for suppressing bacteremia-associated hyperinflammation and MRSA infection to improve survival rates

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Acta Biomaterialia 2024年 174卷 331-344页

作者： Chang, Yen-Tzu Lin, Cheng-Yu Chen, Chih-Jung Hwang, Erica Alshetaili, Abdullah Yu, Huang-Ping Fang, Jia-You Pharmaceutics Laboratory Graduate Institute of Natural Products Chang Gung University Taoyuan Kweishan Taiwan Department of Pathology and Laboratory Medicine Taichung Veterans General Hospital Taichung Taiwan School of Medicine Chung Shan Medical University Taichung Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan Department of Dermatology Yale School of Medicine Yale University New HavenCT United States Department of Pharmaceutics College of Pharmacy Prince Sattam Bin Abdulaziz University Al Kharj Saudi Arabia Department of Anesthesiology Chang Gung Memorial Hospital Taoyuan Kweishan Taiwan School of Medicine College of Medicine Chang Gung University Taoyuan Kweishan Taiwan Research Center for Food and Cosmetic Safety and Research Center for Chinese Herbal Medicine Chang Gung University of Science and Technology Taoyuan Kweishan Taiwan

There is currently no specific and effective treatment for bacteremia-mediated sepsis. Hence, this study engineered a combinatorial nanosystem containing neutrophil-targeted roflumilast-loaded nanocarriers and non-targeted fusidic acid-loaded nanoparticles to enable the dual mitigation of bacteremia-associated inflammation and methicillin-resistant Staphylococcus aureus (MRSA) infection. The targeted nanoparticles were developed by conjugating anti-lymphocyte antigen 6 complex locus G6D (Ly6G) antibody fragment on the nanoparticulate surface. The particle size and zeta potential of the as-prepared nanosystem were about 200 nm and −25 mV, respectively. The antibody-conjugated nanoparticles showed a three-fold increase in neutrophil internalization compared to the unfunctionalized nanoparticles. As a selective phosphodiesterase (PDE) 4 inhibitor, the roflumilast in the nanocarriers largely inhibited cytokine/chemokine release from the activated neutrophils. The fusidic acid-loaded nanocarriers were vital to eliminate biofilm MRSA colony by 3 log units. The nanoparticles drastically decreased the intracellular bacterial count compared to the free antibiotic. The in vivo mouse bioimaging demonstrated prolonged retention of the nanosystem in the circulation with limited organ distribution and liver metabolism. In the mouse bacteremia model, the multifunctional nanosystem produced a 1‒2 log reduction of MRSA burden in peripheral organs and blood. The functionalized nanosystem arrested the cytokine/chemokine overexpression greater than the unfunctionalized nanocarriers and free drugs. The combinatory nanosystem also extended the median survival time from 50 to 103 h. No toxicity from the nanoformulation was found based on histology and serum biochemistry. Furthermore, our data proved that the active neutrophil targeting by the versatile nanosystem efficiently alleviated MRSA infection and organ dysfunction caused by bacteremia. Statement of significance: Bacteremia-mediate

关键词： Nanoparticles

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