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SBMO/IEEE MTT-S International Microwave and Optoelectronics Conference, IMOC 2015

作者： Neto, Alfrêdo Gomes E Silva, Jefferson C. De Carvalho, Joabson Nogueira Cruz, Josiel Do Nascimento Ferreira, Hillner De Paiva Almeida Group of Telecom. and Applied Electromagnetism Federal Inst. of Educ. Science and Technology of Paraíba GTEMA IFPB João PessoaPB Brazil Post-Graduate Program in Electrical Engineering Federal University of Campina Grande Campina Grande Brazil

ISBN: (纸本)9781467394925

In this paper the resonant behavior of frequency selective surfaces, FSS, using matryoshka geometry is analyzed considering polarizations x and y. The basics of the FSS using matryoshka geometry are described for usual and open cases, including an expression to estimate the first resonant frequency. Initially, the FSS with two concentric square rings is considered and its resonant behavior analyzed. Then, the resonant behavior of FSS with two rings matryoshka geometry is examined. The analysis is based on the electric current distribution obtained using the commercial software ANSYS-Designer. With a better understanding of the resonance nature in matryoshka geometry the design parameters can be better adjusted and desired frequency responses properly achieved. © 2015 IEEE.

关键词： Geometry

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Bioaccessibility of phenolic compounds from Brazilian grape juices using a digestion model with intestinal barrier passage

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food Bioscience 2023年第2期52卷 1343-1351页

作者： Maria da Conceicao Prudencio Dutra Ana Beatriz Martins da Silva Ederlan de Souza Ferreira Ana Julia de Brito Araujo Carvalho Marcos dos Santos Lima Aline Camarao Telles Biasoto Graduate Program in Food Science Faculty of PharmacyFederal University of BahiaSalvadorBahiaBrazil Federal Institute of Education Science and Technology of Sertao PernambucanoLiquid Chromatography LaboratoryCampus IndustrialPetrolinaPernambucoBrazil Brazilian Agricultural Research Corporation Embrapa Semi-arid RegionPetrolinaPernambucoBrazil Brazilian Agricultural Research Corporation Embrapa EnvironmentJaguariunaSao PauloBrazil

Grape juices are rich in bioactive compounds;however,for these compounds to exert their functionality,they must be ***,the present study evaluated a simulated digestion process on the main bioactive compounds of monovarietal grape juices of five Brazilian hybrid cultivars(*** x ***).Characterization of the chemical profiles in liquid chromatography(HPLC-DAD-RID),behaviour of phenolics in the stages of digestion and bioaccessibility through the INFOGEST protocol plus intestinal barrier passage were carried *** the 24 polyphenols identified in the grape juice samples,11 were bioaccessible,with emphasis on the class of *** B2(101-426%),(+)-catechin(169-370%)and gallic acid(61-230%)stood out in all juices,showing that these compounds are key to the functionality of these *** were observed to differ between juices,demonstrating that factors such as the cultivar should be explored more extensively in studies on functional *** study also suggests that quality components such as sugars and organic acids influence the bioaccessibility of beverages.

关键词： Grape cultivars Functional beverages Phytochemicals Digestion simulation Bioactivity

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An alleviative effect of Lonicerae japonicae flos water extract against liver fibrogenesis in vitro and in vivo

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Environmental Toxicology 2024年第5期39卷 2881-2892页

作者： Lin, Yi-Ling Wu, Yi-Hsieng Samuel Chao, Ming-Yuan Yang, Deng-Jye Liu, Cheng-Wei Tseng, Jung-Kai Chen, Yi-Chen Department of Animal Science and Technology National Taiwan University Taipei Taiwan Undergraduate and Graduate Programs of Nutrition Science National Taiwan Normal University Taipei Taiwan Institute of Food Safety and Health Risk Assessment National Yang Ming Chiao Tung University Taipei Taiwan Department of Smart and Quality Agriculture MingDao University Changhua Taiwan Department of Optometry Asia University Taichung Taiwan Master Program in Global Agriculture Technology and Genomic Science International College National Taiwan University Taipei Taiwan

Lonicerae japonicae (L. japonicae) flos is a medical and food homology herb. This study investigated the phenolic acid and flavonoid contents in L. japonicae flos water extract solution (LJWES) and the preventive effects of LJWES against liver fibrogenesis via FL83B cells and rats. LJWES contains many polyphenols, such as chlorogenic acid, morin, and epicatechin. LJWES increased cell viability and decreased cytotoxicity in thioacetamide (TAA)-treated FL83B cells (75 mM) (p © 2024 Wiley Periodicals LLC.

关键词： Rats

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The Effect of AIDA Model to Purchasing Decision: The Case of HappyFresh Instagram Promotion 9

The Effect of AIDA Model to Purchasing Decision: The Case of...

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9th International Conference on Cyber and IT Service Management, CITSM 2021

作者： Pratiwi, Noviana Maman, Ujang Junaidi Danapriatna, Nana Mukri, Rusdiono Hejazziey, Djawahir Universitas Islam Negeri Syarif Hidayatullah Jakarta Agribusiness Undergraduate Program Faculty of Science and Technology Indonesia Universitas Islam '45' Bekasi Agribusiness Undergraduate Program Faculty of Agriculture Bekasi Indonesia Sahid Islamic Entrepreneurial University Madrasah Ibtidaiyyah Teacher Program Faculty of Tarbiyah and Teacher Training Bogor Indonesia Universitas Islam Negeri Syarif Hidayatullah Jakarta Post Graduate Program of Sharia Economic Law Indonesia

ISBN: (纸本)9781665435482

The high use of internet especially social media has made this virtual world as a marketing tool. Therefore, this study aims: to determine the effect of Instagram-social media promotion on purchasing decisions, the level of AIDA (Attention, Interest, Desire and Action) among consumers;its influence on purchasing decisions;and to determine the suitable AIDA model for fresh products. The research population is Instagram followers @HappyFresh_id. The sample is 100 people based on five-percent-error-probability of Slovin formula, and it is derived by a simple random sampling technique. The data collected during March-April 2021, and adopting multiple linear regression analysis, proves AIDA simultaneously influences purchasing decisions with a determination level of 67%. Likewise, the interest, desire, and action have a significant effect on buying decisions. Accordingly, the research presents three variations of AIDA model for effective social media marketing, but it needs further analysis. © 2021 IEEE.

关键词： Social networking (online)

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Chronic obstructive pulmonary disease and heart rate variability: A literature update

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International Archives of Medicine 2014年第1期7卷 1-8页

作者： Roque, Adriano L. Valenti, Vitor E. Massetti, Thais Da Silva, Talita Dias Monteiro, Carlos Bandeira De Mello Oliveira, Fernando R. De Almeida Junior, Álvaro Dantas Lacerda, Sheylla Nadjane Batista Pinasco, Gustavo Carreiro Nascimento, Viviane Gabriela Granja Filho, Luiz Gonzaga De Abreu, Luiz Carlos Garner, David M Ferreira, Celso Post-graduate Program in Cardiology Federal University of São Paulo Paulista School of Medicine 715 Pedro de Toledo St Vila Clementino São Paulo SP 04039-032 Brazil Post-graduate Program in Physical Therapy Faculty of Science and Technology UNESP Presidente Prudente SP Brazil Post-graduate Program in Rehabilitation Sciences Faculty of Medicine University of São Paulo São Paulo SP Brazil Department of Public Health Laboratory Design of Studies and Scientific Writing School of Medicine of ABC Santo-André SP Brazil Department of Environmental Health Harvard School of Public Health Boston MA United States Cardiorespiratory Research Group Department of Biological and Medical Sciences Oxford Brookes University Gipsy Lane Oxford OX3 0BP United Kingdom

Background: The literature indicates that chronic obstructive pulmonary disease (COPD) affects cardiac autonomic control. In this study, we conducted a literature review in order to investigate the heart rate variability (HRV) in COPD subjects. Methods: A search was performed in Medline database, using the link between the keywords: "autonomic nervous system", "cardiovascular system", "COPD" and "heart rate variability". Results: The search resulted in a total of 40 references. Amongst these references, the first exclusion resulted in the barring of 29 titles and abstracts, which were not clearly related to the purpose of review. This resulted in a total of 11 articles that were then read and utilized in the review. The selected studies indicated that there is significant reduction of HRV in patients with COPD, characterized by reduction of indices that assess parasympathetic activity in addition to dealing with the global autonomic modulation. We also established that supervised exercise can reduce these harmful effects in COPD patients. Also, it was reported that the use of non-invasive ventilation in these patients may contribute to the improvement of respiratory symptoms, with no impairing, and may even induce positive responses in cardiac autonomic regulation. Conclusion: The studies indicate a need for further investigations to guide future therapies to improve the treatment of cardiovascular system in the respiratory diseases. © 2014 Roque et al.;licensee BioMed Central Ltd.

关键词： Autonomic nervous system Cardiovascular system COPD Heart rate variability

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Modification of Porang (Amorphophallus oncophyllus) Flour by Acid and Thermal Process using Conventional Heating in Waterbath and Microwave Irradiation

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Advance Journal of food science and technology 2016年第6期12卷 290-301页

作者： Abdul Manab Hari Purnomo Simon Bambang Widjanarko Lilik Eka Radiati Post Graduate Program Faculty of Animal Husbandry Brawijaya University Department of Animal Food Technology Faculty of Animal Husbandry Brawijaya University Department of Agricultural Product Technology Faculty of Agricultural Technology Brawijaya University Malang East Java Indonesia

Modified porang flour by lactic acid and conventional heating using waterbath (PAW) and microwave radiation (PAM) were determined its functional group using FTIR, the chemical structure were studied using H1NMR, molecular weight were measured using HPLC-SEC and its microstructure were studied using SEM, particles size were measured using PSA and rheology characteristics were determined using Rheometer. The results showed that modified porang either PAW and PAM showed changes on functional group peaks compared to one of native porang flour included OH, CH_3, C-C, C = O, C-O-C, mannose and glucose groups. H1NMR spectra of modified porang flour (PAW and PAM) were similar mainly in proton of CH_3 and CH_2, molecular weight were higher at PAW 2.0×10^6 and PAM 3.0×10^6, while particles size of PAW and PAM were smaller. The microstructure of PAW and PAM were porous and spongy indicated that PAW and PAM had higher moisture accessability on the amorph site. Storage modulus (G') dan loss modulus (G＂) PAW and PAM decreasing with the increased temperature. Lower G' compared to G＂ and modulus (G' and G＂) did not showed crossing indicated that PAW and PAM have a stable visco-elasticity. It can be concluded that functional group peaks of modified porang flour (PAW and PAM) changed differently compared to native porang flour, H1-NMR spectra of modified porang flour were similar, with bigger moleculer weight of PAM than PAW, the microstructure were porous and spongy and rheology characteristics indicated that an unchanged visco-elastic system by thermal treatments.

关键词： Lactic acid microwave modified porang porang flour waterbath

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Physical characteristics of modified cassava flour wastewater at room temperature

Physical characteristics of modified cassava flour wastewate...

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International Conference on food science and technology 2018, ICFST 2018

作者： Yaqin, N. Al-Baarri, A.N. Legowo, A.M. Widayat Budihardjo, M.A. Program of Environmental Science School of Post-Graduate Studies Diponegoro University Semarang Indonesia Food Technology Department Faculty of Animal and Agricultural Sciences Diponegoro University Semarang Indonesia Chemical Engineering Department Faculty of Engineering Diponegoro University Semarang Indonesia Center of Research and Services Diponegoro University Semarang Indonesia Department of Environmental Engineering Faculty of Engineering Diponegoro University Indonesia

Cassava is an agricultural material that is considered as important raw resources in the industrial sector. The benefits are even greater after being modified using lactic acid bacteria. However, the mocaf industry often causes water and air pollution. Environmental problems arise after the fermentation process. Determination problems with lightness, TDS (Total Dissolved Solid), conductivity and pH analysis are required to measure the impact to the environment. This research was used waste water from mocaf during 3 days fermentation. The wastewater had the highest color level (Lightness) on initial day of fermentation at 83.7±3.73 and then decrease along the day of fermentation at the averages of 65.2±2.0. The highest TDS was resulted from the mocaf wastewater at a value of 1218 ± 4.6 ppm which continued to decline until day 4. The conductivity and pH showed a decrease along the day of fermentation. As conclusion, physical characteristic of wastewater from mocaf production could be analyzed specifically and determined through color, TDS, conductivity, and pH. © 2019 Published under licence by IOP Publishing Ltd.

关键词： Fermentation

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The Potential of Spirulina and Its Bioactive Metabolites as Ingested Agents for Skin Care

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Industrial Biotechnology 2017年第5期13卷 244-252页

作者： Costa, Jorge Alberto Vieira Moro, Gisele Medianeira Barbieri De Moraes Vaz Batista Filgueira, Daza Corsini, Emanuela Bertolin, Telma Elita Laboratory of Biochemical Engineering College of Chemistry and Food Engineering Federal University of Rio Grande P.O. Box 474 Rio Grande RS96203-900 Brazil Cell Culture Laboratory Institute of Biological Sciences Federal University of Rio Grande Rio Grande RS Brazil Laboratory of Toxicology Department of Pharmacological Sciences and Biomolecular Università degli Studi di Milano Milan Italy Fermentation Laboratory Post-Graduate in Food Science and Technology University of Passo Fundo Passo Fundo RS Brazil

Nutrition is one of the most important parameters involved in modulating skin health and condition. In this regard, the demand for natural compounds capable of promoting skin health and beauty has been attracting the attention of researchers and companies around the world. An interesting option to meet this demand is the use of Spirulina microalga, which has biotechnological potential, including several functional and nutritional applications. Although this microalga has been used in human nutrition since ancient times, it now has new applications and is being studied as a promising ingredient for nutricosmetics. The present review article summarizes Spirulina's most relevant activities, mainly its biologically active metabolites, which are interesting ingredients for nutricosmetic formulations and an important advance for skin care. Copyright © 2017, Mary Ann Liebert, Inc. 2017.

关键词： Microalgae

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In vitro simulated gastrointestinal digestion and bioaccessibility of phenolic compounds and antioxidants of soursop (Annona muricata L.) peel and pulp

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LWT 2024年 208卷

作者： Domingues, Yasmin Ourives Lemes, Geriel Araújo de Oliveira, Fellipe Lopes de Souza, Thamara Rosa Silva, Bibiana Bento, Juliana Aparecida Correia Caldeira Morzelle, Maressa Department of Food and Nutrition Federal University of Mato Grosso MT Cuiabá Brazil Federal University of Mato Grosso Graduate Program in Tropical Agriculture Faculty of Agronomy and Animal Science MT Cuiabá Brazil Graduate Program in Food Nutrition and Food Engineering SP Araraquara Brazil Department of Food Science and Technology Federal University of Santa Catarina SC Florianopolis Brazil

We evaluated the nutritional composition and quantified the bioactive compounds present in the soursop pulp and peel and investigated the impact of in vitro simulated gastrointestinal digestion on antioxidants and phenolic compounds of soursop. Soursop peel had a significant amount of fiber (17.6 g.100 g−1 w.b.), particularly insoluble fiber (16.8 g.100 g−1 w.b.), and higher levels of total phenolic compounds and antioxidant activity than pulp. The pulp has 30% higher levels of ascorbic acid than the peel (40.2 mg ascorbic acid 100 g−1). Gallic acid, benzoic acid, coumaric acid, ferulic acid, and hesperidin were detected in the peel and pulp of soursop. After in vitro simulated gastrointestinal digestion, results show that total phenolic compounds of the peel exhibited stability throughout the gastric and intestinal stages. In the pulp, simulated digestion showed an increase in total phenolic compounds on enteric II stage. About antioxidant compounds, peel showed stability in DPPH assay and higher accessibility in the enteric II stages (40% and 29%) on ABTS and FRAP assays. Soursop pulp increased accessibility in the gastric stage on DPPH and FRAP assay. In the ABTS assay, soursop pulp showed the highest values in enteric phase II. The in vitro accessibility of these compounds offers insights into their potential utilization by the organism. This knowledge holds significant implications for nutrition experts, as it can advise the development of healthier dietary habits. © 2024

关键词： Ascorbic acid

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Computer-aided drug discovery of a dual-target inhibitor for ovarian cancer: therapeutic intervention targeting CDK1/TTK signaling pathway and structural insights in the NCI-60

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Computers in Biology and Medicine 2025年 193卷 110445页

作者： Sung-Ling Tang Maryam Rachmawati Sumitra Yu-Cheng Kuo Han-Lin Hsu Muhamad Ansar Sheng-Liang Huang Shih-Yu Lee Hong-Jaan Wang Bashir Lawal Alexander T.H. Wu Lung-Ching Chen Hsu-Shan Huang School of Pharmacy National Defense Medical Center Taipei 11490 Taiwan PhD Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei 11031 Taiwan Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei 11031 Taiwan Department of Pharmacology School of Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan School of Post-Baccalaureate Chinese Medicine College of Chinese Medicine China Medical University Taichung 40604 Taiwan Graduate Institute of Clinical Medicine Taipei Medical University Taipei 11031 Taiwan Division of Pulmonary Medicine Department of Internal Medicine Wanfang Hospital Taipei Medical University Taipei 11031 Taiwan Ph.D. Program in the Clinical Drug Development of Herbal Medicine Taipei Medical University Taipei 110301 Taiwan Graduate Institute of Aerospace and Undersea Medicine National Defense Medical Center Taipei 11490 Taiwan UPMC Hillman Cancer Center University of Pittsburgh Pittsburgh PA USA Ph.D. Program of Translational Medicine College of Science and Technology Taipei Medical University Taipei 11031 Taiwan Division of Cardiology Department of Internal Medicine Shin Kong Wu Ho-Su Memorial Hospital Taipei 11101 Taiwan Ph.D. Program in Biotechnology Research and Development College of Pharmacy Taipei Medical University Taipei 11031 Taiwan

Ovarian cancer remains the third most prevalent and deadliest gynecologic malignancy worldwide, with most patients eventually developing resistance to platinum-based chemotherapy. This highlights a critical unmet need for innovative multitargeted therapies to address current treatment challenges. In this study, we identified 35 differentially expressed genes (DEGs) through integrated analysis of four GEO ovarian cancer datasets, with validation using TCGA data. Gene Ontology (GO) and KEGG enrichment analyses highlighted key tumor-associated pathways, and protein–protein interaction (PPI) network modeling prioritized CDK1 and TTK as high-value therapeutic targets. We evaluated the association between molecular genomic features and drug responses across the NCI-60 ovarian cancer cell line panel (IGROV1, OVCAR-3, OVCAR-4, OVCAR-5, OVCAR-8, NCI/ADR-RES, and SK-OV-3), using a series of salicylanilide-derived compounds and four FDA-approved drugs (cabozantinib, paclitaxel, rapamycin, and niclosamide) from the NCI Developmental Therapeutics program (DTP). Among these, NSC765690 (MCC22) emerged as the most promising candidate. It demonstrated potent antiproliferative activity, high target selectivity, and strong binding affinity to both CDK1 and TTK. Multi-omics integration, combined with AI-driven network modeling, further elucidated NSC765690's mechanism of action and its relevance to ovarian cancer pathogenesis. Additionally, ADMET and pharmacokinetic profiling confirmed its favorable drug-like properties and low predicted toxicity. Collectively, these findings establish NSC765690 as a potent dual-target inhibitor and exemplify a rational, data-driven drug discovery pipeline for overcoming chemotherapy resistance in ovarian cancer.

关键词： Ovarian cancer Dual-target small molecule inhibitor Molecular docking NCI-60 panel Machine learning Molecular dynamics simulations OC ovarian cancer ML machine learning NLP natural language processing DEGs Differentially Expressed Genes PPI Protein-Protein Interaction GEO Gene Expression Omnibus GO Gene Ontology IPA Ingenuity Pathway Analysis TCGA The Cancer Genome Atlas KEGG Kyoto Encyclopedia of Genes and Genomes GO-BP Gene Ontology-Biological Process DTP Developmental Therapeutics program NCI National Cancer Institute CC Cellular Component MF Molecular Functions IHC immunohistochemical FDR false discovery rate BBB Blood brain barrier 3D three-dimensional MDS molecular dynamics simulation analysis RMSF analysis Root Mean Square Fluctuation analysis CDKs cyclin-dependent kinases TTK threonine and tyrosine kinase CNS central nervous system OS overall survival CSC cancer stem cells AI artificial intelligence SRB sulforhodamine B assay ADMET absorption, distribution, metabolism, excretion, and toxicity HPA human protein atlas WES whole exome sequencing MDR multidrug resistance HGSOC high-grade serous ovarian cancer TKI tyrosine kinase inhibitor SAC spindle assembly checkpoint HRR homologous recombination repair HRD homologous recombination deficiency

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