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Biological Evaluation of Sulfonate and Sulfate Analogues of Lithocholic Acid: A Bioisosterism-Guided Approach Towards the Discovery of Potential Sialyltransferase Inhibitors for Antimetastatic Study

SSRN

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SSRN 2023年

作者： Perez, Ser John Lynon P. Chen, Chia-Ling Chang, Tzu-Ting Li, Wen-Shan Institute of Chemistry Academia Sinica Taipei115 Taiwan Department of Applied Chemistry National Yang Ming Chiao Tung University Hsinchu300 Taiwan Sustainable Chemical Science and Technology Taiwan International Graduate Program Academia Sinica Taipei115 Taiwan Biomedical Translation Research Center Academia Sinica Taipei115 Taiwan Department of Medicinal and Applied Chemistry College of Life Science Kaohsiung Medical University Kaohsiung807 Taiwan Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University Taiwan Doctoral Degree Program in Marine Biotechnology National Sun Yat-Sen University Kaohsiung804 Taiwan Department of Chemistry College of Science Tamkang University New Taipei City251 Taiwan

The naturally occurring bile acid lithocholic acid (LCA) has been a crucial core structure for many non-sugar-containing sialyltranferase (ST) inhibitors documented in literature. With the aim of elucidating the impact of the terminal carboxyl acid substituent of LCA on its ST inhibition, in this present study, we report the (bio)isosteric replacement-based design and synthesis of sulfonate and sulfate analogues of LCA. Among these compounds, the sulfate analogue SPP-002 was found to selectively inhibit N-glycan sialylation by at least an order of magnitude, indicating a substantial improvement in both potency and selectivity when compared to the unmodified parent bile acid. Molecular docking analysis supported the stronger binding of the synthetic analogue in the enzyme active site. Treatment with SPP-002 also hampered the migration, adhesion, and invasion of MDA-MB-231 cells in vitro by suppressing the expression of signaling proteins involved in the cancer metastasis-associated FAK/paxillin pathway. In totality, these findings offer not only a novel structural scaffold but also valuable insights for the future development of more potent and selective ST inhibitors with potential therapeutic effects against tumor cancer metastasis. © 2023, The Authors. All rights reserved.

关键词： Sulfur compounds

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Microplastic Ingestion by Adult Milkfish Chanos Chanos (Forsskål, 1775) in Aquaculture System: The Case of Butuan Bay, Philippines

SSRN

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SSRN 2023年

作者： Similatan, Kaye M. Arcadio, Cris Gel Loui A. Navarro, Carl Kenneth P. Capangpangan, Rey Y. Bacosa, Hernando P. Environmental Science Graduate Program Department of Biological Sciences College of Science and Mathematics Mindanao State University-Iligan Institute of Technology Iligan9200 Philippines Palawan Bataraza5306 Philippines Mindanao State University-Main Campus Lanao del Sur Marawi9700 Philippines REY Laboratories Research Division Mindanao State University at Naawan Misamis Oriental Naawan9200 Philippines Department of Physical Sciences and Mathematics College of Marine and Allied Sciences Mindanao State University at Naawan Naawan9023 Philippines

The Philippines is an archipelago that relies on marine resources. Butuan Bay in the Philippines supports aquaculture, which can contribute to and can be impacted by plastic pollution. However, the microplastics (MP) in milkfish, an important aquaculture species in the area, are yet to be ascertained. This study determined the prevalence of microplastics in the surrounding seawater and in the stomach of adult milkfish from cages in Butuan and Nasipit in Butuan Bay. Water samples in Nasipit and Butuan contain 0.20 items/L and 1.00 items/L, respectively. MPs in milkfish in Butuan (10.27 items/individual) were significantly higher than in Nasipit (5.40 items/individual). A total of 235 MPs in 29 out of 30 fish samples (97%) from the two sites were detected. The dominant MP shape and color were fiber and blue, respectively. The presence of microplastics in the milkfish may indicate a possible risk to the fish species and human health. © 2023, The Authors. All rights reserved.

关键词： Microplastic

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The capacity of osmotic for the living of aquatic plant at the Area of Tahura KGPAA Mangkunagoro I, the Province of Central Java

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AIP Conference Proceedings 2023年第1期2683卷

作者： Masrochatun Sutrisno Anggoro Ferry Hermawan Master Program of Environmental Science School of Post-Graduate Diponegoro University Semarang - Indonesia Department of Aquatic Resources Faculty of Fisheries and Marine Science Diponegoro University Semarang – Indonesia Department of Civil Engineering Faculty of Engineering Diponegoro University Semarang – Indonesia

The existence of aquatic plants has a significant influence on the biota living at wellspring. The osmotic pressure is significant research to understand the adaptation of the environment changing to organism physiology. This research aims to know the Osmotic Work Rate by comparing osmolarity water value to aquatic plant plasma. The research method is the descriptive analysis of laboratory test results. The water sample was taken from the seven locations of the wellspring. Osmotic work rate is taken from comparing the plasma osmolarity value of the aquatic plant to water Osmolarity. Osmotic work rate zero means osmoregulation patterns isosmotic. The osmotic work rate greater than zero implies osmoregulation patterns hyperosmotic regulatory and osmoregulation patterns hypo-osmotic regulatory if the Osmotic work rate is less than zero. The patterns are used from the seven locations of good springs are the same, osmoregulation patterns of Hyperosmotic regulatory to the environment because the plasma osmolarity of water plants is more significant than water osmolarity.

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Small-scale fisheries (SSF) management and conservation schemes and their application in the Philippines

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marine Policy 2024年 161卷

作者： Barboza, Anna Macusi, Edison D. Borazon, Elaine Q. Santos, Mudjekeewis D. Muallil, Richard N. Nallos, Ivy M. International Master of Science in Marine Biological Resources Program University of Ghent Belgium Faculty of Agriculture and Life Sciences Davao Oriental State University Davao Oriental Mati City Philippines International Graduate Program of Education and Human Development (IGPEHD) College of Social Sciences National Sun Yat-sen University Kaohsiung 804 Taiwan National Fisheries Research and Development Institute (NFRDI) Metro Manila Quezon City 1008 Philippines Mindanao State University (MSU) Tawi-Tawi College of Technology and Oceanography Tawi-Tawi Bongao Philippines

To reach balance and harmony, current demand, growth, and sustainability, there is a need to include economic, social, cultural, and biological principles for a holistic approach in fisheries management. However, despite the combined efforts, severe challenges still threaten the sustainability of small-scale fisheries in the Philippines. This study carried out a systematic review of the literature published from 1998 to 2021 in the Philippines. This timeframe was selected to align with the implementation of the Philippines Fisheries Code of 1998 (Republic Act 8550) and its subsequent amendment as Republic Act 10654 in 2015, which legally recognized sustainable fisheries by local governments from 1998 onwards. The literature search came out with a total of 775 articles from Web of science and 345 from SCOPUS, after duplicates were removed, 207 literature were included in the synthesis. The main issues that came out are on fishing, reef, livelihood, catch and protected areas. In the Philippines, the reliance of fishers on their livelihood remains a limiting factor in the effectiveness of management plans as pressure from the increasing population of highly fishery-dependent coastal communities, food insecurity, and catch demand can render tactics ineffective. The root issues are larger and systemic, but stem from a lack of sustainable financing to support the viability of established fishery management schemes. marine conservation programs require consideration of the economic impacts and creating alternatives to diversify income sources so that other larger drivers of unsustainable fisheries can be addressed. © 2024 Elsevier Ltd

关键词： Ecosystem-based management Fisheries management Philippines PRISMA Small-scale fisheries (SSF)

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Mapping of spatial features model in developing marine ecotourism in Waerole and Nusa Telu, Maluku Province, Indonesia

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IOP Conference Series: Earth and Environmental science 2021年第1期777卷

作者： A J Ely A S W Retraubun D Sahetapy R Papilaya Marine Science Doctoral Program of Post Graduate Pattimura University Fisheries and Marine Science Faculty of Pattimura University Ambon Indonesia

In the formulation and designation of the ecotourism area, the use of spatial suitability indexes is usually employed. The social, economic, and cultural parameters have almost been ignored in the analysis. These parameters are essential to be included in the development of marine ecotourism to avoid the loss and the impact of these socio-cultural parameters in the development of marine ecotourism. The objective of this research was to construct a conceptual model and thinking perspective and to identify the connectivity of ecology, socio-economy features spatially in designing marine ecotourism areas. Data were collected through observation, participatory mapping, focus group discussion, and interview. Data obtained were then analyzed descriptively and displayed graphically. The conceptual model constructed shows that the marine ecotourism management plan of Waerole and Nuatelu Cape can be categorized into six spatial marine ecotourism explicitly coastal marine e-tourism, snorkeling e-tourism, diving e-tourism, in-shore angling e-tourism, open sea fishing e-tourism, and habitat rehabilitation. The conceptual model for a sustainable management plan for coastal and marine ecotourism suggested the need for holistic and integrated sustainable management comprise of 27 biophysics and socio-economy feature.

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Genetic mutation patterns among glioblastoma patients in the Taiwanese population – insights from a single institution retrospective study

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Cancer Gene Therapy 2024年第6期31卷 894-903页

作者： Huang, Yu-Fen Chiao, Ming-Tsang Hsiao, Tzu-Hung Zhan, Yong-Xiang Chen, Tse-Yu Lee, Chung-Hsin Liu, Szu-Yuan Liao, Chih-Hsiang Cheng, Wen-Yu Yen, Chun-Ming Lai, Chih-Ming Chen, Jun-Peng Shen, Chiung-Chyi Yang, Meng-Yin Department of Neurosurgery Neurological Institute Taichung Veterans General Hospital Taichung Taiwan Department of Medical Research Taichung Veterans General Hospital Taichung 40705 Taiwan Precision Medicine Center Taichung Veterans General Hospital Taichung 40705 Taiwan Doctoral Program in Translational Medicine National Chung Hsing University Taichung Taiwan Rong Hsing Translational Medicine Research Center National Chung Hsing University Taichung Taiwan Institute of Medicine Chung Shan Medical University Taichung 402 Taiwan Graduate Institute of Life Science Department of Life Science College of Life Science National Chung Hsing University Taichung Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan School of Medicine Taipei Medical University Taipei Taiwan Department of Minimally Invasive Skull Base Neurosurgery Neurological Institute Taichung Veterans General Hospital Taichung Taiwan Department of Physical Therapy Hung Kuang University Taichung Taiwan Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan School of Medicine National Defense Medical Center Taipei Taiwan Department of Critical Care Medicine Taichung Veterans General Hospital Taichung Taiwan Functional Neurosurgery Division Neurological Institute Taichung Veterans General Hospital Taichung Taiwan Institute of Molecular Biology College of Life Science National Chung Hsing University Taichung Taiwan Biostatistics Task Force Taichung Veterans General Hospital Taichung Taiwan Basic Medical Education Center Central Taiwan University of Science and Technology Taichung Taiwan

This study utilized Next-Generation Sequencing (NGS) to explore genetic determinants of survival duration in Glioblastoma Multiforme (GBM) patients. We categorized 30 primary GBM patients into two groups based on their survival periods: extended survival (over two years, N = 17) and abbreviated survival (under two years, N = 13). For identifying pathogenic or likely pathogenic variants, we leveraged the ClinVar database. The cohort, aged 23 to 66 (median: 53), included 17 patients in Group A (survival >2 years, 10 males, 7 females), and 13 patients in Group B (survival <2 years, 8 males, 5 females), with a 60% to 40% male-to-female ratio. Identified mutations included CHEK2 (c.1477 G > A, p.E493K), IDH1 (c.395 G > A, p.R132H), and TP53 mutations. Non-coding regions exhibited variants in the TERT promoter (c.-146C > T, c.-124C > T) and TP53 RNA splicing site (c.376-2 A > C, c.376-2 A > G). While Group A had more mutations, statistical significance wasn’t reached, likely due to sample size. Notably, TP53, and ATR displayed a trend toward significance. Surprisingly, TP53 mutations were more prevalent in Group A, contradicting Western findings on poorer GBM prognosis. In Taiwanese GBM patients, bevacizumab usage is linked to improved survival rates, affirming its safety and effectiveness. EGFR mutations are infrequent, suggesting potential distinctions in carcinogenic pathways. Further research on EGFR mutations and amplifications is essential for refining therapeutic approaches. TP53 mutations are associated with enhanced survival, but their functional implications necessitate detailed exploration. This study pioneers genetic analysis in Taiwanese GBM patients using NGS, advancing our understanding of their genetic landscape. © The Author(s) 2024.

关键词： Cancer genetics CNS cancer

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Ocean current signals propagation along the Outer Banda Arcs 3

Ocean current signals propagation along the Outer Banda Arcs

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3rd EMBRIO International Workshop on marine Biodiversity: Understanding, Utilization, Conservation, EIW 2018

作者： Masoleh, V.C. Atmadipoera, A.S. Purba, M. Graduate Program in Marine Sciences Bogor Agricultural University Bogor Indonesia Physical Oceanography Laboratory Dept. of Marine Science and Technology-IPB Bogor Indonesia

Equatorial Pacific Rossby waves may enter into the interior of the Indonesian Throughflow (ITF)'s eastern pathway, such as along the Outer Banda Arcs (OBA). This study aimed to investigate the dynamics of the ITF along the OBA channel from Ceram Sea to Aru Basin to Western Timor Passage. This is necessary because it can provide information about the physical oceanographic conditions, especially the dynamics of the current in the study area. Based on the Hovmoller diagram, a propagation of the signal from kinetic energy was found along the OBA which its phase speed theoretically appears to be trapped in Rossby waves, because of the similarity of the speed phase. The normal mode analysis shows that the oscillation in Ceram Sea, Aru Basin, and Timor Passage has the same pattern based on the potential density and Brunt-Vaisala frequency profiles. The transport's coherence between Indo-Pacific meridional winds and transport volume in Aru Basin shows a strong coherence value (0.94) which is dominated by an annual variability with a period of 341 days. The results suggest that zonal winds along the equator Pacific Ocean act as a remotely forced Rossby waves that propagate westward, entering the interior of Indonesian Seas. © Published under licence by IOP Publishing Ltd.

关键词： Kinetic energy

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Theoretical insights into the chemical bonding, electronic structure, and spectroscopic properties of the lanarkite Pb2SO5 structure

arXiv

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arXiv 2023年

作者： Fabris, Guilherme S.L. Ferrer, Mateus M. Sambrano, Julio R. Almeida, Cláudio R.R. Paskocimas, Carlos A. La Porta, Felipe A. Graduate Program in Materials Science and Engineering Technological Development Center Universidade Federal de Pelotas RS Pelotas96010-610 Brazil Modeling and Molecular Simulation Group São Paulo State University Bauru São Paulo17033-360 Brazil Department of Materials Engineering Federal University of Rio Grande do Norte RN Natal59078-970 Brazil Postgraduate Program in Science and Engineering of Materials Federal University of Rio Grande do Norte RN Natal59078-970 Brazil Federal University of Technology - Paraná Nanotechnology and Computational Chemistry Laboratory Avenida dos Pioneiros 3131 CEP PR Londrina86036-370 Brazil State University of Londrina Post-Graduation Program in Chemistry Rodovia Celso Garcia Cid 445 km 380 CEP PR Londrina86057-970 Brazil

Lanarkite is a mineral formed by a combination of lead, sulphur, and oxygen atoms arranged in the general chemical formula Pb2SO5 (PSO) that crystallises with monoclinic symmetry (belonging to the C2/m space group, No. 12). This mineral was first discovered in Lanarkshire, Scotland and was named after its location. PSO has a unique structure comprising alternating penta-coordinated lead [PbO5] and tetra-coordinated sulphur [SO4] clusters. This lanarkite-type structure has recently attracted significant scientific interest and has been the focus of the superconducting material research community. However, its chemistry needs to be explored further. This article presents a comprehensive investigation on the chemical bonding, electronic structure, and spectroscopic properties of the lanarkite-type PSO structure from a computational perspective. Thus, different functionals in the DFT (e.g., PBE, PBE0, PBESOL, PBESOL0, BLYP, WC1LYP37, and B3LYP) were assessed to accurately predict their fundamental properties. All the DFT calculations were performed using a triple-zeta valence plus polarisation basis set. Among all the DFT functionals tested in this study, PBE showed the best agreement with the experimental data available in the literature. Our results also reveal that the [PbO5] clusters are formed with three Pb–O bond lengths, with values of about 2.32, 2.59, and 2.84 Å, respectively, while the [SO4] clusters have the same S–O bond length of 1.57 Å. We performed a complete topological analysis of this system to comprehend these structural differences. Additionally, the PSO structure has an indirect band gap energy of 2.9 eV and an effective mass ratio (mℎ∗ /me∗) of about 0.415 (using PBE calculations) which may, in principle, indicate a low recombination of electron-hole pairs in the lanarkite structure. Therefore, we believe that a detailed understanding of their electronic structures, spectroscopic properties as well as their chemical bonding is critically important

关键词： Lead compounds

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Sustainability assessment of groundwater in south-eastern parts of the western region of Ghana for water supply

Cleaner Water

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Cleaner Water 2024年 1卷

作者： Ernest Biney Bernard Akwasi Mintah Ernest Ankomah Albert Elikplim Agbenorhevi Daniel Buston Yankey Ernestina Annan Department of Geomatic Engineering Kwame Nkrumah University of Science and Technology University Post Office Box PMB Kumasi Ghana WASCAL Graduate Research Programme on Climate Change and Land Use Department of Civil Engineering Kwame Nkrumah University of Science and Technology Kumasi Ghana Department of Geological Engineering University of Mines and Technology Tarkwa Ghana Graduate Research Program on Climate Change and Water Resources West African Science Service Center on Climate Change and Adapted Land Use (WASCAL) University of Abomey-Calavi Benin

The study assessed the physicochemical and biological properties of selected groundwater sources in the Southeastern part of the Western Region, to assess the impact on water quality and health risk. The Piper Trilinear plot was used to categorize the water samples into water types based on the dominant anion and cation concentrations. Statistical analysis (One way ANOVA and two sample t-test) was used to determine the sources of variation in the data at 95% confidence interval. The Water Quality Index (WQI) and Hazard Quotient (HQ) were used to estimate the water quality and health risk respectively. TDS and turbidity were above the acceptable WHO guidelines in 16.7% of the samples with a mildly acidic pH in 83.3% of the water samples. Also, 91.7% of the water samples were contaminated with total coliform (TC) and 25% with e-coli. Generally, the groundwater samples were dominated by Ca 2+ and HCO 3- ion water types. The variations between parameters were found not significant for all the parameters (p>0.05). Water samples in the North are of good quality with a mean WQI of 96, but of poor quality in the South with a mean WQI of 144.6. HQ values for all the samples were less than 0.1, suggesting less harmful impacts of the heavy metal concentrations on human health. Overall, the results showed the presence of heavy metals in the groundwater sources sampled, however in quantities with low health risks either through oral or dermal channels. Groundwater within the communities is good for domestic purposes but needs treatment for drinking. To improve upon the study, it is recommended that further studies consider a higher number of samples and include other accessible groundwater stations where possible.

关键词： Health Risk Assessment Groundwater GIS Trace elements Water Quality Index

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Ohwia caudata extract relieves the IL-17A-induced inflammatory response of synoviocytes through modulation of SOCS3 and JAK2/STAT3 activation

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Environmental Toxicology 2023年第8期38卷 1914-1924页

作者： Lu, Cheng-You Kuo, Chia-Hua Kuo, Wei-Wen Hsieh, Dennis Jine-Yuan Wang, Tso-Fu Shih, Cheng-Yen Lin, Pi-Yu Lin, Shinn-Zong Ho, Tsung-Jung Huang, Chih-Yang Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan Department of Sports Sciences University of Taipei Taipei Taiwan Department of Biological Science and Technology China Medical University Taichung Taiwan Ph.D. Program for Biotechnology Industry China Medical University Taichung Taiwan School of Medical Laboratory and Biotechnology Chung Shan Medical University Taichung Taiwan Clinical Laboratory Chung Shan Medical University Hospital Taichung Taiwan Department of Hematology and Oncology Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Department of Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Tzu Chi University Hualien Taiwan Buddhist Tzu Chi Medical Foundation Hualien Taiwan Buddhist Compassion Relief Tzu Chi Foundation Hualien Taiwan Bioinnovation Center Buddhist Tzu Chi Medical Foundation Hualien Taiwan Department of Neurosurgery Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Integration of Chinese Medicine and Modern Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Department of Chinese Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Department of Biological Science and Technology Asia University Taichung Taiwan Center of General Education Buddhist Tzu Chi Medical Foundation Tzu Chi University of Science and Technology Hualien Taiwan

Fibroblast-like synoviocytes accumulation, proliferation and activation, and the subsequent inflammatory mediators production play a key role in the progression of rheumatoid arthritis (RA). It is well established that Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling triggers inflammation, and induces cytokine levels in RA. Ohwia caudata have long been used against many disorders. However, in RA, the effects of O. caudata have not been elucidated. In the current study, synoviocytes were used to evaluate the suppressive effects of O. caudate extract (OCE) on the pro-inflammatory cytokines production. In vitro, the underlying mechanisms by which OCE inhibits inflammatory response through regulation of suppressors of cytokine signaling 3 (SOCS3) and JAK2/STAT3 expression in IL-17A-treated HIG-82 synoviocytes were investigated. The results demonstrated that the proliferation of IL-17A-challenged cells were increased in comparison with non-stimulated control cells. The synoviocyte proliferation was decreased significantly of OCE concentrations in dose dependent manner. The p-JAK2, p-STAT3, interleukin (IL)-1β, and IL-6 were reduced in IL-17A-challenged cells treated with OCE. Furthermore, AZD1480 (a JAK2-specific inhibitor) or WP1066 (a STAT3-specific inhibitor) affected the inflammatory mediators production in IL-17A-challenged synoviocytes, and OCE failed to mitigate the IL-17A-induced inflammatory mediators and SOCS3, acting as a feedback inhibitor of the JAK/STAT3 pathway, in the presence of SOCS3 siRNA, indicating that the beneficial effects of OCE on the regulation of inflammatory response homeostasis were dependent on SOCS3 and the JAK2/STAT3 signaling pathway. Our study also showed that SOCS3 was markedly activated by OCE in RA fibroblast-like synoviocytes, thereby decreasing the JAK/STAT3 pathway, and the IL-1β, and IL-6 activation. Thus, O. caudate should be further investigated as a candidate anti-inflammatory and anti-a

关键词： Chemical activation

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