High-throughput data such as microarrays make it possible to investigate the molecular-level mechanism of cancer more efficiently. Computational methods boost the microarray analysis by managing large and complex data...
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High-throughput microarrays inform us on different outlooks of the molecular mechanisms underlying the function of cells and organisms. While computational analysis for the microarrays show good performance, it is sti...
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Chemical reaction networks by which individual cells gather and process information about their chemical environments have been dubbed "signal transduction" networks. Despite this suggestive terminology, the...
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ISBN:
(纸本)9780262195683
Chemical reaction networks by which individual cells gather and process information about their chemical environments have been dubbed "signal transduction" networks. Despite this suggestive terminology, there have been few attempts to analyze chemical signaling systems with the quantitative tools of information theory. Gradient sensing in the social amoeba Dictyostelium discoideum is a well characterized signal transduction system in which a cell estimates the direction of a source of diffusing chemoattractant molecules based on the spatiotemporal sequence of ligand-receptor binding events at the cell membrane. Using Monte Carlo techniques (MCell) we construct a simulation in which a collection of individual ligand particles undergoing Brownian diffusion in a three-dimensional volume interact with receptors on the surface of a static amoeboid cell. Adapting a method for estimation of spike train entropies described by Victor (originally due to Kozachenko and Leonenko), we estimate lower bounds on the mutual information between the transmitted signal (direction of ligand source) and the received signal (spatiotemporal pattern of receptor binding/unbinding events). Hence we provide a quantitative framework for addressing the question: how much could the cell know, and when could it know it? We show that the time course of the mutual information between the cell's surface receptors and the (unknown) gradient direction is consistent with experimentally measured cellular response times. We find that the acquisition of directional information depends strongly on the time constant at which the intracellular response is filtered.
This paper presents a decentralized infrastructure, called Web2Peer, which makes Web pages available on Internet through P2P networks. Different from the conventional Web, the proposed approach does not need, for inst...
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This paper presents a decentralized infrastructure, called Web2Peer, which makes Web pages available on Internet through P2P networks. Different from the conventional Web, the proposed approach does not need, for instance, a HTTP address or a central Web Server. Web2Peer provides a set of functions for publishing, locating, and replicating Web pages on Internet ensuring high availability and fault tolerance. Our infrastructure allows anyone who has a computer connected to the Internet, even through a domestic ADSL connection, to publish Web pages through their own machines without any additional cost
In order to assist driver's vision, a real-time recognition system for traffic signs is proposed. After detecting sign candidates, biologically inspired opponent-color filters are used to extract symbol parts of s...
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ISBN:
(纸本)9781617387777
In order to assist driver's vision, a real-time recognition system for traffic signs is proposed. After detecting sign candidates, biologically inspired opponent-color filters are used to extract symbol parts of signs. After normalizing the size of symbol, structural features are calculated to identify the sign. 5572 segmented images are used to design the algorithm. In a real-time system, the same sign in a sequence of frames is tracked, and a majority vote is used to integrate the recognition results. For test data, 93.8% recall rate and 99.3% precision rate could be attained. In-vehicle experiment also showed high recall and precision rates.
This paper evaluates how well a significant number of broadcasting protocols for MANETs behave when under a realistic scenario of momentary failures and topology changes, which is represented by an omission fault mode...
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This paper evaluates how well a significant number of broadcasting protocols for MANETs behave when under a realistic scenario of momentary failures and topology changes, which is represented by an omission fault model. Reliable protocols which use additional mechanisms to ensure higher delivery rates beyond best- effort guarantees - have been proposed, but they exhibit unacceptably high end-to-end delays. As a result of the study conducted, a new mechanism that helps to enhance the reliability of deterministic broadcasting protocols is proposed. The mechanism allows for scalability, and is capable of ensuring good delivery rates (in spite of failures) while maintaining lower end-to-end delays. Simulation results demonstrate the efficacy of the mechanism.
Intrusion detection systems (IDSs) have been substantially improved in recent past. However, network attacks have become more sophisticated and increasingly complex: many of current attacks are coordinated and origina...
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Intrusion detection systems (IDSs) have been substantially improved in recent past. However, network attacks have become more sophisticated and increasingly complex: many of current attacks are coordinated and originated in multiple networks. To detect these attacks, IDSs need to obtain information on network events from multiple networks or administrative domains. This work demonstrates that a Distributed IDS (DIDS) can be composed of existing IDSs, improving the detection of misuses in a multiple network environment. We use a grid middleware for creating a service-based intrusion detection grid. We demonstrate through experimental results that the proposed DIDS allows the integration of heterogeneous existing IDSs and improves the detection of attacks by exploring the synergy between existing IDSs.
We have proposed and studied another modification of the Szasz Operator that arises from a statistical perspective of the problem. The study is supported and illustrated by an empirical simulation study aimed at illus...
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With support from HBCU-UP (Historically Black College and University Undergraduateprogram) at National science Foundation (NSF), the ACTION (Advanced Curriculum and Technology-Based Instructional Opportunities Networ...
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