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Antioxidant system alterations and oxidative stress caused by polyfluoroalkyl substances (PFAS) in exposed biota: a review

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science of the Total Environment 2025年 977卷 179395页

作者： Soares, Lorena Oliveira Souza de Araujo, Gabriel Farias Gomes, Thais Braga Júnior, Sidney Fernandes Sales Cuprys, Agnieszka Katarzyna Soares, Raquel Moraes Saggioro, Enrico Mendes Laboratory of Environmental Health Assessment and Promotion Oswaldo Cruz Institute Oswaldo Cruz Foundation Av. Brasil 4365 RJ Rio de Janeiro21045-900 Brazil Post-Graduate Program in Public Health and Environment Sergio Arouca National School of Public Health Oswaldo Cruz Foundation Av. Leopoldo Bulhões 1480 RJ Rio de Janeiro21041-210 Brazil Faculty of Science and Technology Norwegian University of Life Sciences P.O. Box 5003 Ås1432 Norway Post-Graduate Program in Environmental Technology and Water Resources Department of Civil and Environmental Engineering – FT University of Brasília Darcy Ribeiro Campus Via L3 Norte DF Brasília70910-900 Brazil

Contamination of aquatic and terrestrial organisms by Perfluoroalkyl substances (PFAS), emerging contaminants, is widespread, as these compounds are present in water, soil, air, and food, owing to their environmental persistence. PFAS exposure induces biochemical process alterations associated with the disruption of the antioxidant defense system in several species. This review aims to discuss how PFAS-induced antioxidant system alterations lead to changes in biochemical processes in different organisms exposed to these pollutants. This disruption, then leads to an imbalance in antioxidant defense systems, contributing to the formation of reactive oxidative species (ROS), which, in turn, can be exacerbate oxidative stress, induce cellular damage, enhance lipid peroxidation, destabilize lysosomal membranes, and cause genotoxic effects, ultimately compromising DNA integrity. In acute tests, PFAS have led to mortality, growth inhibition, diminished behavioral and locomotor abilities, and reproductive impairment. PFAS-induced effects differ with varying species or types of substances, and further bioaccumulation through food chains exacerbates environmental contamination, carrying considerable risks. These findings demonstrate the complex and enduring impact of PFAS on environmental health, emphasizing the importance of this review in corroborating studies on sub-lethal toxicity in exposed organisms and how these effects reflect on the environment. © 2025 Elsevier B.V.

关键词： Biotic

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Comparative Analysis of Normal and ASD EEG Data Using Hjorth Parameters

Comparative Analysis of Normal and ASD EEG Data Using Hjorth...

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Human-computer Interaction, Optimization and Robotic Applications (HORA), International Congress on

作者： Muliyadi Muliyadi Melinda Melinda Yuwaldi Away Syahrul Gazali Doctoral Program School of Engineering Post Graduate Program Universitas Syiah Kuala Banda Aceh Indonesia Electrical Engineering Department Politeknik Negeri Lhokseumawe Aceh Indonesia Dept. Electrical Engineering and Computer Engineering Faculty Universitas Syiah Kuala Banda Aceh Indonesia Dept. Neurology Universitas Syiah Kuala Banda Aceh Indonesia Mahar Mardjono National Brain Center Hospital Jakarta Indonesia

ISBN: (数字)9798331510886

ISBN: (纸本)9798331510893

The increasing prevalence of autism spectrum disorder (ASD) in recent decades has underscored the need for more accurate and objective diagnostic methods. Electroencephalography (EEG) holds promise as a tool in ASD neurobiological research due to its ability to capture neural oscillatory activity with high temporal resolution. This study aims to analyze the neurophysiological differences between individuals with ASD and neurotypical populations by examining EEG data using Hjorth parameters. The preprocessing stage involved using a Butterworth filter to enhance EEG signal quality by eliminating noise in the frequency range of 4-40 Hz. The Hjorth parameters, including Activity, Mobility, and Complexity, were used to assess the statistical characteristics of the EEG signals. The analysis was conducted on EEG data collected from 5 typical individuals and 5 ASD ASD subjects. Our findings reveal that the Hjorth Activity parameter is notably lower in the ASD group across all regions, with the most significant differences observed in the left and right frontal areas, where average activity measures 0.236 μV 2 and 0.060 μV 2 in ASD individuals, compared to 0.512 μV 2 and 0.138 μV 2 in the neurotypical group. However, the Hjorth Complexity and Mobility values remained consistent between the two groups, implying that the fundamental structure of the EEG signals is relatively preserved. These findings offer insights into the neurobiological mechanisms of ASD and suggest the potential use of Hjorth parameters in developing more targeted interventions for individuals with ASD.

关键词： Human computer interaction Autism Frontal lobe Noise Neural activity Electroencephalography Complexity theory Signal resolution Robots Optimization

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Local and global sensitivity analyses on the overflow probability of Abadia de Goiás radioactive near surface repository

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Nuclear Engineering and Design 2025年 439卷

作者： Teixeira, D.G. Frutuoso e Melo, P.F. Alvim, L.G.M. Alvim, A.C.M. Alves, A.S.M. Graduate Program of Nuclear Engineering COPPE Federal University of Rio de Janeiro RJ Rio de Janeiro Brazil Department of Computer Science Multidisciplinary Institute Federal Rural University of Rio de Janeiro UFRRJ RJ Nova Iguaçu Brazil Eletronuclear S. A. RJ Rio de Janeiro Brazil

This work presents a sensitivity analysis of the overflow probability of the near- surface radioactive repository built after the Abadia de Goiás accident, where radioactive 137Cs was released. The purpose of the analysis is to help the repository owner and the regulatory body make decisions on design parameters that affect the overflow probability. The following parameters have been considered: degradation function of the repository ceiling, internal porosity of the repository, internal area of the repository base, repository base and wall thicknesses, repository height, height of the liquid column inside the repository, average rainfall rate, evapotranspiration rate, surface runoff and hydraulic conductivity of the repository concrete. The choice for the range of each parameter is discussed. An investigation of the role of the mentioned parameters is detailed based on results obtained in a previous paper, and the dependencies among the rate parameters on the average rainfall rate is emphasized and modeled. To give a deeper perspective, local and global sensitivity analyses have been performed. In the case of global analysis, two approaches have been followed: in the first, the concept of Normalized Mutual Information and the other one leverages Shapley values derived from Light Gradient Boosting Machine and Shapley values have been used for investigating non-linearities. For some parameters the lowest values are to be considered, e.g., the repository base thickness and the average rainfall rate, while for others the highest value is desirable, like the evapotranspiration rate and the surface runoff in order to obtain lower overflow probabilities. These results should be looked with care because nonlinearities have been identified by the Shapley value analysis. Overall, the degradation function and the evapotranspiration rate emerge as the most influential parameters. The legacy of this work lies in the robust methodological framework it provides, paving the way fo

关键词： Nuclear reactor accidents

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Contract-Inspired Contest Theory for Controllable Image Generation in Mobile Edge Metaverse

arXiv

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arXiv 2025年

作者： Liu, Guangyuan Du, Hongyang Wang, Jiacheng Niyato, Dusit Kim, Dong In College of Computing and Data Science The Energy Research Institute @ NTU Interdisciplinary Graduate Program Nanyang Technological University Singapore Department of Electrical and Electronic Engineering University of Hong Kong Hong Kong College of Computing and Data Science Nanyang Technological University Singapore Department of Electrical and Computer Engineering Sungkyunkwan University Korea Republic of

The rapid advancement of immersive technologies has propelled the development of the Metaverse, where the convergence of virtual and physical realities necessitates the generation of high-quality, photorealistic images to enhance user experience. However, generating these images, especially through Generative Diffusion Models (GDMs), in mobile edge computing environments presents significant challenges due to the limited computing resources of edge devices and the dynamic nature of wireless networks. This paper proposes a novel framework that integrates contract-inspired contest theory, Deep Reinforcement Learning (DRL), and GDMs to optimize image generation in these resource-constrained environments. The framework addresses the critical challenges of resource allocation and semantic data transmission quality by incentivizing edge devices to efficiently transmit high-quality semantic data, which is essential for creating realistic and immersive images. The use of contest and contract theory ensures that edge devices are motivated to allocate resources effectively, while DRL dynamically adjusts to network conditions, optimizing the overall image generation process. Experimental results demonstrate that the proposed approach not only improves the quality of generated images but also achieves superior convergence speed and stability compared to traditional methods. This makes the framework particularly effective for optimizing complex resource allocation tasks in mobile edge Metaverse applications, offering enhanced performance and efficiency in creating immersive virtual environments. © 2025, CC BY.

关键词： Mobile edge computing

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Joint Source Decomposition of Concurrent EEG-FMRI Data in Epilepsy and Control Groups

Joint Source Decomposition of Concurrent EEG-FMRI Data in Ep...

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IEEE International Symposium on Biomedical Imaging

作者： J. Mason Harding Haatef Pourmotabbed Yamin Li Kimberly Rogge-Obando Kate Wang Sarah E. Goodale Shiyu Wang Camden Bibro Bergen Allee Caroline Martin Victoria L. Morgan Dario J. Englot Catie Chang Department of Electrical and Computer Engineering Vanderbilt University Department of Biomedical Engineering Vanderbilt University Department of Computer Science Vanderbilt University Neuroscience Graduate Program Vanderbilt University Vanderbilt Memory and Alzheimer's Center Vanderbilt University Medical Center Department of Neurological Surgery Vanderbilt University Medical Center Department of Radiology Vanderbilt University Medical Center

ISBN: (数字)9798331520526

ISBN: (纸本)9798331520533

EEG and fMRI are complementary, noninvasive technologies for investigating human brain function. These modalities have been used to uncover large-scale functional networks and their disruptions in clinical populations. Given the high temporal resolution of EEG and high spatial resolution of fMRI, integrating these modalities can provide a more holistic understanding of brain activity. This work explores a multimodal source decomposition technique for extracting shared modes of temporal variation between fMRI BOLD signals and EEG spectral power fluctuations in the resting state. The resulting components are then compared between patients with focal epilepsy and controls, revealing multimodal network differences between groups.

关键词： Neuroimaging Brain Fluctuations Epilepsy Functional magnetic resonance imaging Electroencephalography Pattern recognition Hemodynamics Spatial resolution Signal resolution

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Observation of Photonic Chiral Flatbands

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Physical Review Letters 2025年第10期134卷 103801-103801页

作者： Minho Choi Andrea Alù Arka Majumdar Department of Electrical and Computer Engineering University of Washington Seattle Washington 98195 USA Photonics Initiative Advanced Science Research Center City University of New York New York New York 10031 USA and Physics Program Graduate Center City University of New York New York New York 10031 USA Department of Electrical and Computer Engineering University of Washington Seattle Washington 98195 USA and Department of Physics University of Washington Seattle Washington 98195 USA

Distinct selectivity to the spin angular momenta of photons has garnered significant attention in recent years, for its relevance in basic science and for imaging and sensing applications. While nonlocal metasurfaces with strong chiral responses to the incident light have been reported, these responses are typically limited to a narrow range of incident angles. In this study, we demonstrate a nonlocal metasurface that showcases strong chirality, characterized by circular dichroism (∼0.6), over a wide range of incident angles ±5°. Its quality factor, circular dichroism and resonant frequency can be optimized by design. These findings pave the way to further advance the development of valley-selective optical cavities and augmented reality applications.

关键词： Natural frequencies

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ALPINE: An Interpretable Approach for Decoding Phenotypes from Multi-condition Sequencing Data 29th

ALPINE: An Interpretable Approach for Decoding Phenotypes ...

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29th International Conference on Research in Computational Molecular Biology, RECOMB 2025

作者： Lee, Wei-Hao Li, Lechuan Dannenfelser, Ruth Yao, Vicky Systems Synthetic and Physical Biology Graduate Program Rice University Houston United States Department of Computer Science Rice University Houston United States Ken Kennedy Institute Rice University Houston United States Rice Synthetic Biology Institute Rice University Houston United States

ISBN: (纸本)9783031902512

Advancements in sequencing technology have expanded data availability, capturing diverse phenotypic traits and biological perturbations. However, increased resolution also raises complexity, as studies now examine multiple dimensions, including donor phenotypes, anatomical regions, cell types, and time points. Integrating datasets across studies promises insights into health and disease beyond the scope of individual experiments, but this requires methods that can separate technical artifacts from meaningful biological signals while providing interpretable insights into condition-related genetic factors. Existing approaches tend to focus on either integration or interpretability, rarely addressing both simultaneously. To overcome these challenges, we introduce ALPINE, a joint supervised-unsupervised non-negative matrix factorization framework that disentangles technical and biological variation while directly identifying condition-associated genes. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.

关键词： Matrix factorization

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Simulated prosthetic vision identifies checkerboard as an effective raster pattern for retinal implants

arXiv

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arXiv 2025年

作者： Kasowski, Justin M. Beyeler, Michael Interdepartmental Graduate Program in Dynamical Neuroscience University of California Santa BarbaraCA93106 United States Department of Computer Science University of California Santa BarbaraCA93106 United States Department of Psychological & Brain Sciences University of California Santa BarbaraCA93106 United States

Objective: This study systematically evaluates the impact of raster patterns-specific spatial arrangements of sequential electrode activation-on performance and perceived difficulty in simulated prosthetic vision (SPV). By addressing a critical gap in the literature, we aimed to identify patterns that optimize functional vision in retinal implants. Approach: Sighted participants completed letter recognition and motion discrimination tasks under four raster patterns (horizontal, vertical, checkerboard, and random) using an immersive SPV system. The simulations employed psychophysically validated models of electrode activation, phosphene appearance, and temporal dynamics, ensuring realistic representation of prosthetic vision. Performance accuracy and self-reported difficulty were analyzed to assess the effects of raster patterning. Main Results: The checkerboard pattern consistently outperformed other raster patterns, yielding significantly higher accuracy and lower difficulty ratings across both tasks. The horizontal and vertical patterns introduced biases aligned with apparent motion artifacts, while the checkerboard minimized such effects. Random patterns resulted in the lowest performance, underscoring the importance of structured activation. Significance: These findings provide the first systematic evaluation of raster patterns, suggesting that the checkerboard configuration may enhance usability and perceptual clarity in retinal implants. While based on simulated environments, this study establishes a foundation for optimizing spatial and temporal electrode activation strategies in next-generation devices. © 2025, CC BY.

关键词： Prosthetics

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Baseflow CO₂ fluxes in small tropical rivers driven by hydrological dynamics

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science of the Total Environment 2025年 970卷 179015页

作者： Machado, Daniela Vasconcelos Marques, Eduardo Duarte Carvalho, Andréa da Consolação de Oliveira Viglio, Eduardo Paim dos Santos, Everton Assunção Martins Marins, Rozane Valente da Silva Júnior, Gerson Cardoso Silva-Filho, Emmanoel Vieira Chemistry Institute RJ Brazil Post-Graduate Program in Geology Geosciences Institute RJ Rio de Janeiro Brazil Belo Horizonte Regional Office MG Belo Horizonte Brazil Federal University of Ceará Marine Science Institute/LABOMAR Av. da Abolição 3207 60 CE Fortaleza165-081 Brazil Rio de Janeiro Office Rio de Janeiro Brazil

Dry season CO2 fluxes were estimated for 1418 small rivers and streams in the Upper São Francisco Basin (USFB), Brazil. This first basin-scale estimate revealed a substantial contribution of 1.52 Pg C yr−1 (95 % confidence interval: 1.40 to 1.64 Pg C yr−1). pCO2 values, calculated from pH and total alkalinity (TA) and subsequently corrected, ranged from 66 to 20,200 μatm (2191 ± 1791 μatm;coefficient of variation of 82 %). Approximately 95 % of rivers exhibited evasive fluxes with bed friction dissipation as the dominant control on turbulence in over 85 %. Analysis of gas transfer velocity (k600) parameterizations revealed significant inter-equation differences, high spatial variability, and strong slope influence. These findings highlight the potentially role of small tropical rivers and streams in global carbon cycling and provide the first CO2 emission estimate for the USFB. © 2025 Elsevier B.V.

关键词： Tropical cyclone

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A GRAPH MODEL FOR SOFTWARE EVOLUTION

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IEEE TRANSACTIONS ON SOFTWARE ENGINEERING 1990年第8期16卷 917-927页

作者： LUQI Department of Computer Science. Naval Post-graduate School. Monterey. CA 93943

This paper presents a graph model of software evolution. We seek to formalize the objects and activities involved in software evolution in sufficient detail to enable automatic assistance for maintaining the consistency and integrity of an evolving software system. This includes automated support for propagating the consequences of a change to a software system. [ABSTRACT FROM AUTHOR]

关键词： consistency Index Terms: Configuration control maintenance management software evolution

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