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Neisseria meningitidis: analysis of pili and LPS in emerging Brazilian strains

Therapeutic Advances in Vaccines and Immunotherapy 2020年第8期8卷 2515135520919195页

作者： Portilho, Amanda Izeli Trzewikoswki de Lima, Gabriela De Gaspari, Elizabeth Departament of Immunology Adolfo Lutz Institute São Paulo Brazil Post-Graduate Program Interunity in Biotechnology Biomedical Sciences Institute São Paulo University São Paulo Brazil Departament of Immunology Adolfo Lutz Institute Dr Arnaldo Avenue 355 11 floor o São Paul 01246-902 SP Brazil

Background: Neisseria meningitidis is the main cause of bacterial meningitis in Brazil, where the main serogroups isolated are B and C;however, the serogroup W has recently emerged. LPS and type IV pili are important virulence factors that increase meningococci pathogenicity. Methods: The characterization of Lipopolysaccharide (LPS) and type IV pili in 19 meningococci strains of serogroup B, 21 of serogroup C, 45 of serogroup W and 28 of serogroup Y, isolated in Brazil between 2011 and 2017, was conducted using the Enzyme-linked Immunosorbent Assay (Dot- ELISA) technique and monoclonal antibodies. Results: We would like to emphasize the importance of characterizing relevant antigens, such as pili and LPS, the use of monoclonal antibodies to support it, and how such studies improve vaccine development and monitoring. Most of the strains studied presented L3,7,9 LPS and type IV pili;both antigens are associated with the capacity to cause invasive disease. Conclusion: Due to the impact of meningococcal disease, it is important to maintain and improve vaccine studies. Epitopes characterization provides data about the virulence of circulating strains. The use of monoclonal antibodies and serological techniques are relevant and support vaccine development. © The Author(s), 2020.

关键词： invasive meningococcal disease LPS Neisseria meningitidis pili serotyping

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