Single walled carbon nanotubes (SWNT) have shown tremendous promise as agents for diagnostic and therapeutic intervention in vivo. We demonstrate how Dextran sulfate (DS) can render SWNT transparent to macrophages, a ...
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The aspartic protease cathepsin E has been shown to induce apoptosis in cancer cells under physiological conditions. Therefore, cathepsin E-activity-enhancing peptides functioning in the physiological pH range are val...
Photonic crystal cavities with tunable surface area via multiple-hole defects were investigated for increased resonance wavelength shifts upon exposure to variable-index analytes. Sensitivity was improved by 10% compa...
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Photonic crystal cavities with tunable surface area via multiple-hole defects were investigated for increased resonance wavelength shins upon exposure to variable-index analytes. Sensitivity was improved by 10% compar...
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The reconstruction and evaporation at graphene nanoribbon (GNR) edges are investigated by tight-binding molecular-dynamics simulations and ab initio calculations. It is observed that reconstruction through the formati...
The reconstruction and evaporation at graphene nanoribbon (GNR) edges are investigated by tight-binding molecular-dynamics simulations and ab initio calculations. It is observed that reconstruction through the formation of pentagon-heptagon pairs can take place quickly along the zigzag edge and it is energetically favorable. At very high temperatures, the armchair edge is found to change into a zigzag edge structure, which further accelerates the evaporation of carbon atoms and leads to the formation of carbon linear chains. The evaporation of carbon atoms from both the zigzag and armchair edges is preceded by the formation of heptagon rings, which serve as a gateway for carbon atoms to escape. In the simulation for a GNR armchair-zigzag-armchair junction, carbon atoms are evaporated row by row from the outermost row of the zigzag edge while the armchair edge remains nearly intact. These results can be applied to nanoelectronic devices fabrication through the temperature-controlled edge structure of GNR.
In Brazil, 70 % of the ceramic tile output is at present produced by the dry route. Increasing global environmental concerns and the recognition of the central role played by water have pointed towards encouraging dry...
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In Brazil, 70 % of the ceramic tile output is at present produced by the dry route. Increasing global environmental concerns and the recognition of the central role played by water have pointed towards encouraging dry processes. In this context, the objective of the present work was to study the feasibility of producing high quality porcelain tiles by the dry route. A brief comparison of the dry and wet routes for producing traditional ceramic tiles shows that there are two major differences: the particle sizes obtained by the wet route are usually considerably finer and the different minerals usually mix better with the wet route. The present work studied the relative importance of these differences and looked for raw materials and operational conditions that would result in better performance and glazed porcelain tiles of good quality.
This paper presents a mechanical cell lysis microfluidic chip with an ultra-sharp nano-blade array fabricated by simple and cost effective crystalline wet etching of (110) silicon. The ultra-sharp nano-blade array is ...
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ISBN:
(纸本)9781424457618;9781424457649
This paper presents a mechanical cell lysis microfluidic chip with an ultra-sharp nano-blade array fabricated by simple and cost effective crystalline wet etching of (110) silicon. The ultra-sharp nano-blade array is simply formed by the undercutting during the crystalline wet etching process. The sharpness of the silicon nano-blade is less than 10 nm after the undercutting. EL4 mouse T-lymphoma cells are used for the demonstration of the mechanical lysis chip, and the cells are easily disrupted by the silicon nano-blade array without helping of additional reagents or electrical sources. The time-resolved observation of the mechanical cell lysis shows that the developed silicon nano-blade array is enough to easily disrupt the cell membrane even at very low flow rate of 0.7 ¿¿/hr.
In this paper, a novel microelectrical impedance spectroscopy (μEIS) with three-dimensional interdigitated electrodes (3D-IDE) is developed to differentiate normal and cancerous cells. The device utilizes a microflui...
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In this paper, a novel microelectrical impedance spectroscopy (μEIS) with three-dimensional interdigitated electrodes (3D-IDE) is developed to differentiate normal and cancerous cells. The device utilizes a microfluidic tunnel structure, which forces cells to be squeezed. Thus, the enlarged contact area between cells and electrodes allows the device to measure the intrinsic electrical signal of the cells with a higher sensitivity than a noncontact case. The cell squeezing is realized by fabricating smaller microfluidic channel than cell size. The electrical impedances are measured through 3D-IDE. The device well distinguishes normal human breast cell (MCF-10A) and early-stage human breast cancer cell (MCF-7) with a phase difference of 1.42° at 500 kHz. The proposed device also features a high repeatability because the phase change is as small as 0.27° (which is sufficiently smaller than the phase difference between normal and cancer cell) before and after the each cell assay.
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