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ASME 2000 International Mechanical engineering Congress and Exposition, IMECE 2000

作者： Gau, Jen-Jr Lan, Esther H. Dunn, Bruce Ho, Chih-Ming Biomedical Engineering Interdepartmental Graduate Degree Program University of California Los Angeles United States Department of Materials Science and Engineering University of California Los Angeles United States Department of Mechanical and Aerospace Engineering University of California Los Angeles United States

ISBN: (纸本)9780791819005

This paper describes the characterization and optimization of a reusable DNA microsensor array for rapid biological agent detection developed in previous publications. (Fig.l) [1-3] This MEMS based DNA sensor utilizes a standard three-electrode electrochemical cell configuration with novel micro fabricated structure design to minimize non-specific binding. The sensor module is easily to be adapted to various protocols and can be used for rapid detection of macromolecules (DNA, RNA) from targets such as uropathogenic Escherichia coli (E. coli) in urine and microorganisms causing otitis media (middle ear infection). Less than 105 E. coli cells can be detected from the urine sample of a patient with urine tract infection. The sensitivity is enhanced by appropriate sensor characterization and surface modification. The total detection time including sample preparation can be reduced to 25 minutes by using a POD conjugated oligonucleotide. Copyright © 2000 by ASME

关键词： DNA

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engineering the environmentally sound warship for the twenty-first century

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NAVAL ENGINEERS JOURNAL 1999年第3期111卷 189-217页

作者： Markle, SP Gill, SE McGraw, PS Udr. Stephen P. Markle USN is a career Engineering Duty officer assigned to Naval Sea Systems Command Arlington Virginia where he is Deputy Directs Environmental Programs Division (SEA 03L1 B). He is responsible fm program management activities associated with all ahat environmental protection equipment design and selection of environmental protection equipment and systems fm future surface ship designs (DD 21 CVN 7Z CW LPD 17) and serves on several teams designed to promote Nay wide awarmss of environmental protection requirements and Nay programs to meet these challenges. He is a 1993 graduate of the Naval Construction and Engineering Program at the Massachusetts Institute of Technology where he received a naval engineers degree and master of science in mechanical engineering. His interest in environmental issues predates his undergraduate studies at Syracuse Universityl State University of New Ymk College of Environmental Science and Fmestry where he received a bachelm of science degree in fmest engineering from the School of Environmental and Resource Engineering. LCdx Markle has qualified as a Surface Warfare Officer and in submarines through the Engineering Duty Dolphin Program he is a member of the Acquisition Professional Community and a graduate of the Defense Systems Management College Advanced Program Managers Course. He is a professional engineer registered in the State of New York and is a member ofthe American Society of Naval Engineers National Society of Professional Engineers American Society for Testing and Materials Society of Naval Architects and Marine Engineers and Society of Automotive Engineers. Peter 5. McGraw is current the Acting Branch Head ofthe Solid Waste Management Branch (Code 634) of the Environmental Quality Dwrtment of the Naval Surfice Warfare Centel: Carderock Division. As such he is responsible for among other things: the Shipboard Advanced Incinerator RDT&E Program the Submarine Plastic Waste RDT&E Program Solid Waste Processing Equipment Design Acquisitio

The past twenty-five years has been marked by the introduction ed marine environmental regulations that have had a profound effect on how ships are designed, built and operated. Ships being designed and built today must accommodate not only current regulations but anticipate those enacted over their thirty to fifty year life cycles. U.S. Chief of Naval Operations, Office of Environmental, Safety and Health (CNO N45) has articulated a vision for the Environmentally Sound Warship of the Twenty-first Century. This vision incorporates the "Sense of Congress" for a naval ship designed to operate in full compliance with environmental regulations worldwide. The task of the Navy engineering team is to translate this vision into reality;a ship capable of prevailing in time of war and able to conduct operations in all areas of the globe, unencumbered by special procedures for environmental compliance. The keys to this warship design are the early integration of environmentally sound principles, materials, and processes into the ship acquisition process;minimization of both hazardous materials and generation of post shipboard consumer waste during operation;adaptation of integrated systems to reduce the volume of wastes and enhance processing efficiency;reduced manpower requirements;and crew indoctrination in environmental protection.

关键词： Ships Environmental regulations engineering ARTICULATED Navy environmental security

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Contributory presentations/posters

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Journal of Biosciences 1999年第1期24卷 33-198页

作者： N. Manoj V. R. Srinivas A. Surolia M. Vijayan K. Suguna R. Ravishankar R. Schwarzenbacher K. Zeth Diederichs G. M. Kostner A. Gries P. Laggner R. Prassl Madhusudan Pearl Akamine Nguyen-huu Xuong Susan S. Taylor M. Bidva Sagar K. Saikrishnan S. Roy K. Purnapatre P. Handa U. Varshney B. K. Biswal N. Sukumar J. K. Mohana Rao A. Johnson Vasantha Pattabhi S. Sri Krishna Mira Sastri H. S. Savithri M. R. N. Murthy Bindu Pillai Kannan M. V. Hosur Mukesh Kumar Swati Patwardhan K. K. Kannan B. Padmanabhaa S. Sasaki-Sugio M. Nukaga T. Matsuzaki S. Karthikevan S. Sharma A. K. Sharma M. Paramasivam P. Kumar J. A. Khan S. Yadav A. Srinivasan T. P. Singh S. Gourinath Neelima Alam A. Srintvasan Vikas Chandra Punit Kaur Ch. Betzel S. Ghosh A. K. Bera S. Bhattacharya S. Chakraborty A. K. Pal B. P. Mukhopadhyay I. Dey U. Haldar Asok Baneriee Jozef Sevcik Adriana Solovicova K. Sekar M. Sundaralingam N. Genov Dong-cai Liang Tao Jiang Ji-ping Zhang Wen-rui Chang Wolfgang Jahnke Marcel Blommers S. C. Panchal R. V. Hosur Bindu Pillay Puniti Mathur S. Srivatsun Ratan Mani Joshi N. R. Jaganathan V. S. Chauhan H. S. Atreya S. C. Sahu K. V. R. Chary Girjesh Govil Elisabeth Adjadj Éric Quinjou Nadia Izadi-Pruneyre Yves Blouquit Joël Mispelter Bernadette Heyd Guilhem Lerat Philippe Milnard Michel Desmadreil Y. Lin B. D. Nageswara Rao Vidva Raghunathan Mei H. Chau Prashant Pesais Sudha Srivastava Evans Coutinho Anil Saran Leizl F. Sapico Jayson Gesme Herbert Lijima Raymond Paxton Thamarapu Srikrishnan C. R. Grace G. Nagenagowda A. M. Lynn Sudha M. Cowsik Sarata C. Sahu S. Chauhan A. Bhattacharya G. Govil Anil Kumar Maurizio Pellecchia Erik R. P. Zuiderweg Keiichi Kawano Tomoyasu Aizawa Naoki Fujitani Yoichi Hayakawa Atsushi Ohnishi Tadayasu Ohkubo Yasuhiro Kumaki Kunio Hikichi Katsutoshi Nitta V. Rani Parvathy R. M. Kini Takumi Koshiba Yoshihiro Kobashigawa Min Yao Makoto Demura Astushi Nakagawa Isao Tanaka Kunihiro Kuwajima Jens Linge Seán O. Donoghue Michael Nilges G. Chakshusmathi Girish S. Ratnaparkhi P. K. Madhu R. Varadarajan C. Tetreau Molecular Biophysics Unit Indian Institute of Science Bangalore India Austrian Academy of Sciences Institute of Biophysics and X-ray Structure Research Graz Austria Faculty of Biology University of Konstanz Germany Institute of Medical Biochemistry University of Graz Austria Howard Huges Medical Institute Department of Chemistry & Biochemistry University of California La Jolla USA Department of Chemistry & Biochemistry University of California San Diego La Jolla USA Molecular Biophysics Unit India Department of Microbiology &Cell Biology Indian Institute of Science Bangalore India Macromolecular Structure Laboratory NCI - Frederick Cancer Research and Development Center ABL - Basic Research Program Frederick USA Department of Crystallography and Biophysics University of Madras Chennai Biochemistry Department Indian Institute of Science Bangalore India Condensed Matter Physics Division B.A.R.C. Trombay Mumbai Condensed Matter Physics Division Bhabha Atomic Research Centre Trombay Mumbai IMCB The University of Tokyo Tokyo Japan Mitsubishi Chemical Corporation Yokohama Research Center Yokohama Japan Faculty of Pharmaceutical Sciences Chiba University Chiba Japan Department of Biophysics All India Institute of Medical Sciences New Delhi India Department of Biophysics All India Institute of Medical sciences New Delhi India Institüt Physiologische Chemie Hamburg Germany Biophysics Department Bose Institute Calcutta India Slovak Academy of Sciences Institute of Molecular Biology Bratislava Slovakia Indian Institute of Science Bioinformatics Centre Bangalore Departments of Chemistry and Biochemistry Biological Macromolecular Structure Center USA Bulgarian Academy of Sciences Institute of Organic Chemistry Sofia Bulgaria Chinese Academy of Sciences Institute of Biophysics Beijing China Novartis Pharma AG Preclinical Research Basel Switzerland Department of Chemical Sciences Tata Institute of Fundamental Research Mumbai India Solid State Physics Div

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Applying fuzzy functions and sequential coordination to optimization of machinery arrangement and pipe routing

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NAVAL ENGINEERS JOURNAL 1998年第6期110卷 43-54页

作者： Wu, BC Young, GS Schmidt, W Choppella, K Dr. Bi-Chu Wu:received a PhD in Mechanical Engineering from the University of Maryland College Park in 1991. She has worked on projects involving naval architecture design optimization solid mechanics and database development. Presently a senwr engineer with Angle Incorporated Dr Wu's research interests are in design optimization and fuzzy logic applications. Dr. Gin-Shu Young: a senior engineer with Angle Incorporated holds a PhD in Mechanical Engineering from the University of Maryland College Park. As a guest researcher with National Institute of Standards and Technologies from 1990 to 1993 he worked on vision-based navigation for autonomous vehicles. His experience also includes applications of optimization fuzzy logic neural network and genetic algorithm methods to engineering system design Mr. William Schmidt:co-founded Angle Incorporated in 1990 and has served as Vice PresidentlChiefScientist during this tame. He holds a B.Sc. in Applied Science from the Naval Acadt?my and an M.Sc. in Physics from the Naval Post Graduate School. He has cner 20 years experience in technical leadership material and personnel management. He has led the application of computer aided design (CAD) and Product Model Information Exchange to the shipbuilding industry. His experience also includes leading the amlication of model based operational analysis to support the Live Fire Test Program for DDG 51 Class Destroyers. Mr. Krishna M. Choppella:is a Sofware Engineer at Eidea Laboratories Incotporated where he works on componentbased distributed enterpvise frameworks. He has been involved in creating data analysis tools for the US Nay by integrating CAD modeis databases and graphical front ends. His work in the Masters degree program in Mechanical Engineering at the University of Texas at Austin was in di0ddase.r spectroscopy of combustion products in porous-matri burners. He received his Bachelors degree in Electrical Engineering in India. He was a Research Associate at the Centre for Laser Technology and Project Engi

Ship design is often multidisciplinary involving several design elements with various types of objectives and constraints (O/C) some easily described as mathematical formulas, others better modeled as descriptive assertions. This paper describes a method based on fuzzy functions and an integrated performance index to model O/C using descriptive assertions to be used with mathematical formulas in optimization. Another issue addressed in this paper concerns the coordination of design elements when sequentially coupled, that is, when one leads the other and the performance of the follower depends greatly on the design of the leader. Based on neuro-fuzzy techniques, the method described here coordinates and optimizes sequentially coupled elements. The two methods are applied to machinery arrangement (MA) and pipe routing (PR). Preliminary models for optimization of MA and PR are described considering convenience, producibility: engine room size, interference and location as factors in the O/C set. Some test results from MA/PR applications are presented and discussed. The methods are generic and can be extended to other elements in ship design. They are mutually independent and may be used separately Two advantages of their use are an improvement in overall performance and a reduction in the need for redesign of elements.

关键词： Optimization

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Numerical analysis of compressible fluids and elastic structures interactions

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Applied Mechanics Reviews 1995年第11/2期48卷 S195页

作者： Vaz, dos Santos, M.A. Awruch, A.M. Department of Materials Science and Building Fundac¸a˜o Universidade do Rio Grande Rua Eng Alfredo Huch 475 96201-900 Rio Grande RS Brazil Graduate Program in Civil and Mechanical Engineering Universidade Federal do Rio Grande do Sul Av Osvaldo Aranha 99 3° Andar 90035-190 Porto Alegre RS Brazil

A finite element algorithm to simulate two dimensional flows of viscous and inviscid compressible fluids for a wide range of Mach numbers is presented in this work. This model is coupled to immersed deformable structures through equilibrium and compatibility conditions in order to analyze its dynamic behavior. For the fluid, time integration is performed by a two-step Taylor-Galerkin explicit scheme and Newmark’s method is used to obtain the dynamic response of the structure. An arbitrary mixed Euler-Lagrange description is used to re-define a new finite element mesh in the presence of the immersed structure displacements. Finally, several examples are included showing the model behavior and possibilities for future expansions.

关键词： Dynamic response Mach number Fluids Flow (Dynamics) Equilibrium (Physics) Numerical analysis Algorithms Finite element analysis

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Evaluation of the Recreio Flowsheet — COPELMI

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Fuel 1993年第5期72卷 722-722页

作者： C.H. Sampaio L.A.C. Klujszo G.F. Cavalcante Post-Graduate Program on Metallurgical and Materials Engineering (PPGEMM) Federal University of Rio Grande do Sul (UFRGS) Porto Alegre Brazil

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EPAS APPROACH TO VADOSE ZONE MONITORING AT RCRA FACILITIES

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GROUND WATER MONITORING AND REMEDIATION 1993年第1期13卷 151-158页

作者： DURANT, ND MYERS, VB ECCLES, LA Washington D.C. 20460) has worked as an environmental scientist in the RCRA corrective action program at EPA since 1989. After graduating from Colgate University in 1987 Durant worked for GeoTrans Inc. conducting hydrogeologic investigations at numerous waste disposal sites throughout the northeastern United States. At present Durant is pursuing an M.S. degree in environmental science from The Johns Hopkins University. His research is focused on enhancing in situ biodegradation of aromatic organic compounds in the subsurface. Washington D. C. 20460) graduated from The Johns Hopkins University in 1972 with a B.A. degree in natural sciences. Myers received a Ph.D. in oceanography from Florida State University in 1977. During 1978 he held a post doctoral fellowship at University of Florida in the Department of Environmental Engineering and Science. From 1979 to 1983 Myers was employed by the Florida Department of Environmental Regulation where he worked on environmental restoration projects. Since 1984 Myers has worked at EPA managing RCRA ground water monitoring and corrective action programs. Lawrence A. Eccles (U.S. Environmental Protection Agency Environmental Monitoring Systems Laboratory P.O. Box 93478 Las Vegas NV 89193–3478) is a hydrologist with the EPA Environmental Monitoring Systems Research Laboratory in Las Vegas Nevada. Eccles is responsible for the development of vadose zone and in situ monitoring techniques and guidelines. After graduating from Monmouth College with a B.S. degree in chemistry Eccles performed graduate work in chemical engineering at New Mexico State University. He received formal training in hydrology in 1969 from the U.S. Geological Survey in Denver and worked with that agency before joining EPA at Las Vegas in 1984. One of his co-authored articles was chosen for the Best Paper Award by the journal Ground Water in 1975 and another was the subject of a cover story for Water Well Journal in 1977.

The U.S. Environmental Protection Agency (EPA) recently proposed to amend federal regulations to require vadose zone monitoring at certain hazardous waste facilities. To support this proposal, EPA evaluated previous policy on vadose zone monitoring and examined advances in vadose zone monitoring technology. Changes in EPA vadose zone monitoring policy were driven by demonstrated advances in the available monitoring technology and improvements in understanding of vadose zone processes. When used under the appropriate conditions, currently available direct and indirect monitoring methods can effectively detect contamination that may leak from hazardous waste facilities into the vadose zone. Direct techniques examined include soil-core monitoring and soil-pore liquid monitoring. Indirect techniques examined include soil-gas monitoring, neutron moderation, complex resistivity, ground-penetrating radar, and electrical resistivity. Properly designed vadose zone monitoring networks can act as a complement to saturated zone monitoring networks at numerous hazardous waste facilities. At certain facilities, particularly those in arid climates where the saturated zone is relatively deep, effective vadose zone monitoring may allow a reduction in the scope of saturated zone monitoring programs.

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UNDERWATER INSPECTION FOR WELDING AND OVERHAUL

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NAVAL ENGINEERS JOURNAL 1993年第5期105卷 37-42页

作者： MITTLEMAN, J SWAN, L John Mittleman:is a mechanical engineer at the Naval Surface Warfare Center Dahlgren Division Coastal Systems Station in Panama City Florida. His Primary Responsibilities are in the development of underwater nondestructive testing equipment for use by fleet divers and inspectors. He also performs research in the characterization of metal microstructure through ultrasonic scattering measurements. Mr. Mittleman received his BS from Cornell University in 1969 and science master's in ocean engineering from the Massachusetts Institute of Technology in 1970. His research currently supports doctoral studies with Iowa State University. Mr. Mittleman received the American Society of Naval Engineer's Solberg Award in 1981 for his contributions to underwater ship hull inspection. Mr. Mittleman is a member of ASNE ASNT ASTM IoD Sigma Xi Tau Beta Pi and Phi Kappa Phi. Lisa Swan:is a mechanical engineer at the Naval Surface Warfare Center in Panama City Florida. She is involved in nondestructive testing engineering primarily in the underwater arena. Ms. Swan holds a bachelor of science in materials engineering from North Carolina State University. She is a graduate of the Federal Women's Executive Leadership Program. Ms. Swan is a member of ASNT.

Significant progress has been made in making underwater ultrasonic thickness gauging and magnetic particle inspections available to the fleet. Under sponsorship from the Naval Sea Systems Command, Director of Ocean engineering, Underwater Ship Husbandry Division (NavSea 00C5), the Coastal Systems Station has developed complete hardware packages supporting these two nondestructive test methods, and has introduced them to military inspectors at a shore intermediate maintenance activity, a destroyer tender, and a naval shipyard. Performance trials conducted prior to taking the systems to the field have been accepted by NavSea, Ships' Concepts Group, materials Subgroup, Metals Division (NavSea 5142) as evidence that these inspections can reliably be performed underwater. Avenues for certifying specially trained divers and inspectors are being developed;for the first time the Navy will have all of the elements in place for underwater inspections satisfying the requirements of Mil-Std-271 (Requirements for Nondestructive Testing Methods) and the Naval Ships' Technical Manual Chapter 074. Underwater ultrasonic thickness gauging has also been slated for use in the fleet, as data from laboratory and field trials have consistently shown that reliable results can be obtained by a team comprising a certified topside inspector and a diver. In tests performed at the Ship Repair Facility (SRF), Yokosuka, underwater readings were compared to those taken in dry dock by SRF inspectors, and independently by contract inspectors. On the basis of approximately 800 locations, differences between the data sets were found to be randomly distributed, with a standard deviation on the order of 0.02''. This level of accuracy is largely sufficient to distinguish plate which will need replacement during overhaul, or plate which is thick enough to weld on.

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FIELD SAMPLING OF RESIDUAL AVIATION GASOLINE IN SANDY SOIL

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GROUND WATER MONITORING AND REMEDIATION 1991年第2期11卷 107-120页

作者： OSTENDORF, DW LEACH, LE HINLEIN, ES XIE, YF 1 David W. Ostendorf is an associate professor in the Environmental Engineering Program of the Civil Engineering Department at the University of Massachusetts (Civil Engineering Department University of Massachusetts Amherst MA 01003). His research interests include unconfined aquifer contamination hazardous waste site remediation and analytical modeling of problems in environmental fluid mechanics. Dr. Ostendorf is a registered professional engineer in Massachusetts and a member of the American Geophysical Union American Society of Civil Engineers Soil Science Society of America Water Pollution Control Federation and Association of Environmental Engineering Professors as well as the National Water Well Association.2 Lowell E. Leach is an environmental engineer with the Robert S. Kerr Environmental Research Laboratory of the U.S. Environmental Protection Agency (RS Kerr Environmental Research Laboratory U.S. EPA P.O. Box 1198 Ada OK74820). Leach received his B.S. ingeological engineering at the University of Oklahoma in 1959 and has been a registered professional engineer in Oklahoma since 1966. With 29 years of experience in field applications of geological engineering he is responsible for developing methodology for sampling ground water and subsurface materials for the Robert S. Kerr Environmental Research Laboratory.3 Erich S. Hinlein is a research assistant in the Environmental Engineering Program of the Civil Engineering Department at the University of Massachusetts (Civil Engineering Department University of Massachusetts Amherst MA 01003). His research interests include ground water pollution hazardous waste site investigation and transport processes in unconfined aquifers. Hinlein graduated with a B.S. in electrical and computer engineering from the University of Massachusetts at Amherst in May 1985 and entered the Environmental Engineering Master's Degree Program in January 1989.4 Yuefeng Xie is a postdoctoral research associate in the Environmental Engineering Program of the Civil E

Two complementary field sampling methods for the determination of residual aviation gasoline content in the contaminated capillary fringe of a fine, uniform, sandy soil were investigated. The first method featured field extrusion of core barrels into pint-size Mason jars, while the second consisted of laboratory partitioning of intact stainless steel core sleeves. The barrel extrusion procedure involved jar headspace sampling in a nitrogen-filled glove box, which delineated the 0.7m thick residually contaminated interval for subsequent core sleeve withdrawal from adjacent boreholes. Soil samples removed from the Mason jars (in the field) and sleeve segments (in the laboratory) were subjected to methylene chloride extraction and gas chromatographic analysis to compare their aviation gasoline content. The barrel extrusion sampling method yielded a vertical profile with 0.10m resolution over an essentially continuous 5.0m interval from the ground surface to the water table. The sleeve segment alternative yielded a more resolved 0.03m vertical profile over a shorter 0.8m interval through the capillary fringe. The two methods delivered precise estimates of the vertically integrated mass of aviation gasoline at a given horizontal location, and a consistent view of the vertical profile as well. In the latter regard, a 0.2m thick lens of maximum contamination was found in the center of the capillary fringe, where moisture filled all voids smaller than the mean pore size. The maximum peak was resolved by the core sleeve data, but was partially obscured by the barrel extrusion observations, so that replicate barrels or a half-pint Mason jar size should be considered for data supporting vertical transport analyses in the absence of sleeve partitions.

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Detailed assessment of partial thermodynamic quantities of tin in molten Bi-Sn alloys from electromotive force measurements

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Metallurgical Transactions B 1990年第1期21卷 87-96页

作者： Cho, Seung-Am Camisotti, Roberto Vélez, Mariano H. Graduate Program of Metallurgy and Materials Science Venezuelan Institute of Scientific Research (IVIC) Caracas 1020A Apartado 21827 Venezuela School of Metallurgical Engineering and Materials Science Central University of Venezuela Caracas 1050A Apartado 50361 Venezuela Conduven Company Caracas Venezuela Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge 02139 MA United States

All the partial thermodynamic quantities, including the activity and activity coefficient of tin, a Sn and γSn, in the liquid Bi-Sn alloys between 300 °C and 500 °C are assessed in detail from electromotive...

All the partial thermodynamic quantities, including the activity and activity coefficient of tin, a_Sn and γ_Sn, in the liquid Bi-Sn alloys between 300 °C and 500 °C are assessed in detail from electromotive force (emf) data. The emf values were obtained from a modified molten salt electrolyte concentration cell that had extraordinary stability within +0.005 mV. The composition dependence of γ_Sn did not follow Darken's quadratic formalism, nor did the alloy behave as a regular solution. The excess partial quantities, Δ-H_Sn, Δ-S_Sn^xs, and Δ-G_Sn^xs, are oscillating across the composition, and the activity curve exhibits double, positive and negative, deviations from Raoult's law. The a_Sn, γ_Sn, and Δ-G_Sn^xs change from positive to negative departure from ideality in the tin-rich region beyond about x_Sn = 0.82. All those partial quantities and γ_Sn^o, including the β° (the α function of tin) at infinite dilution, are determined accurately by means of Chiotti's method. © 1990 The Minerals, Metals & Material Society.

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