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SSRN 2025年

作者： Wang, Tzu-Wei Chen, Hao-Xuan Chen, Shih-Heng Chen, Shih-Hsien Liu, Yu-Chung Wu, Chen-Te Kuan, Chen-Hsiang Huang, Wei-Yuan Department of Materials Science and Engineering National Tsing Hua University Hsinchu Taiwan Department of Plastic and Reconstructive Surgery Chang-Gung Memorial Hospital Chang-Gung University Medical College Taoyuan Taiwan Department of Biomedical Engineering University of Michigan Ann ArborMI United States Department of Medical Imaging and Intervention Chang Gung Memorial Hospital Taoyuan Taiwan Taipei Taiwan Graduate Institute of Clinical Medicine College of Medicine National Taiwan University Taipei Taiwan Research Center for Developmental Biology and Regenerative Medicine National Taiwan University Taipei Taiwan Precision Medicine Program National Tsing Hua University Hsinchu Taiwan Institute of Oral Biology National Yang Ming Chiao Tung University Taiwan Department of Biomedical Engineering Linkou Chang Gung Memorial Hospital Taiwan

Currently used tendon grafts, including autologous and allogeneic options, are hindered by limitations such as availability, donor site morbidity, and the risk of immune rejection. While offering potential alternatives, artificial tendons still have drawbacks, including creep, stress relaxation, fatigue, and poor tissue integration. To overcome these challenges with unmet clinical needs, this study develops a biomimetic tendon graft using interfacial polyelectrolyte complexation spinning techniques combined with customized twisting and weaving reinforcements. Hierarchical tendon biomimicry addresses anatomical and physiological features crucial for tendon repair and regeneration. The dynamic strengthening culture and growth factor incorporation with spatial-controlled delicacy further enhance the integration and functionality of the substitute with tendon-related protein secretion, both of which are valuable characteristics in native tissues. As demonstrated in fatigue tests, the durability and viscoelasticity of the braided scaffolds under loading-unloading cycles highlight their suitability for daily activities. This bottom-up assembly approach replicates the physiological, biological, and mechanical properties of native tendon tissue. For future perspective, this study represents a significant advancement in tendon tissue engineering, offering bioinspired woven biotextiles that hold great promise for tendon replacement. © 2025, The Authors. All rights reserved.

关键词： Tissue regeneration

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Immobilization of poly(hexamethylene biguanide) to cellulose acetate- and cellulose-based nanofiber membranes for antibacterial and cytotoxic studies

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Biochemical engineering Journal 2024年 205卷

作者： Dinh Thi My Huong Chi-Yun Wang Pin-Yi Chen Chien Wei Ooi Xue Er Crystal Thew Bing-Lan Liu Chen-Yaw Chiu Shen-Long Tsai Kuei-Hsiang Chen Yu-Kaung Chang Department Chemical Technology and Environment University of Technology and Education the University of Da Nang Da Nang City Viet Nam Department Chemical Engineering/ Graduate School of Biochemical Engineering Ming Chi University of Technology New Taipei City 243303 Taiwan Department Chemical Engineering National Taiwan University of Science and Technology Taipei City 10607 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Bone and Joint Research Centre Chang Gung Memorial Hospital Taoyuan City 333423 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Chemical Engineering Department School of Engineering Monash University Malaysia Jalan Lagoon Selatan Bandar Sunway Selangor 47500 Malaysia Advanced Engineering Platform School of Engineering Monash University Malaysia Jalan Lagoon Selatan 47500 Bandar Sunway Selangor Malaysia Department of Applied Chemistry Chaoyang University of Technology Taichung 413310 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Zhongli Dist Taoyuan City 320315 Taiwan

To develop the environmental antibacterial membrane, the physical attachments of poly (hexamethylene biguanide) hydrochloride (PHMB) on the cellulose acetate (CA) and regenerated cellulose (RC) electrospun nanofiber membranes were employed. The immobilization of PHMB increased the antibacterial efficacy ( AE , %) of nanofiber membranes from 65.67% to approximately 86.13% for CA-PHMB and from 35.09% to approximately 100% for RC-PHMB. The results of the chemical and physical characteristics indicate that the degree of deacetylation of CA nanofiber, the surface charge of the nanofiber, and the density of PHMB immobilized onto the nanofiber primarily affect the antibacterial efficacy. The use of mathematical models, such as the Temkin equilibrium model for PHMB immobilization and the Monod-type model for the relationship between antibacterial activity and immobilization density of PHMB provides a deeper understanding of the interactions and kinetics involved. The rapid achievement of ∼100% AE after only 10 min of contact with Escherichia coli ( E. coli ) is a notable finding, indicating the quick and efficient antibacterial action of RC-PHMB nanofiber membranes. Furthermore, maintaining approximately 100% AE after 20 days of storage underscores the long-term stability of PHMB immobilized on RC nanofiber membranes. The findings suggest that RC-PHMB holds great promise as an antibacterial material for biomedical applications, food packaging industries, and filtration or treatment of water.

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Failure analysis of hanger for superheater tube

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AIP Conference Proceedings 2020年第1期2262卷

作者： Husaini Ardy Deri Andika Bangun Arie Wibowo 1Materials Science and Engineering Research Group Bandung Institute of Technology Bandung 40132 Indonesia 2Graduate Program of Materials Engineering Department Bandung Institute of Technology Bandung 40132 Indonesia

Seven out of 12 pieces of hangers for superheater pipe were failed after one year in service. Failure analysis has been conducted to find out the root cause of failure. Hanger material is ASTM A182 Grade F22 Class 1. Fractography examinations revealed that the fracture mode is due to mechanical fatigue. Tensile test results show a tensile strength of 1015 MPa which is far beyond the minimum standard requirement of 415 MPa. The hardness of the failed hanger is between 270 to 325 HB, and un-failed hanger is around 245 HB, which are higher than the maximum standard requirement of 170 HB. The Charpy impact energy is 3 J, far below the standard requirement of 54 J. The microstructure in the bend area and the straight section contained tempered martensite and ferrite. Further examinations were conducted by heat treatment simulations to explore properties after heat treatment. materials are subjected to full annealing treatment at 900°C, and normalizing at 955°C followed by tempering at 675°C. The average hardness is 154 HB after annealing, and 235 HB after normalizing and tempering. According to heat treatment simulation results, hanger material was supposed to be supplied under annealing condition where the hardness fulfils the standard requirement. Failure of superheater pipe hanger is due to improper heat treatment which promote brittleness and initiate premature crack during start-up. Crack initiation might also occur during post forging quenching. Fatigue crack propagation occur during service by small amplitude vibration.

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Pulmonary Disease Pattern Recognition on X-Ray Radiography Image Using Artificial Neural Network (ANN) Method

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Journal of Physics: Conference Series 2020年第1期1505卷

作者： N Fitriyah L D Kurniawati E Purwanti S D Astuti Department of Physics Faculty of Science and Technology Universitas Airlangga Surabaya Indonesia 60115 Biomedical Engineering Study Program Faculty of Science and Technology Universitas Airlangga Surabaya Indonesia 60115 Department of Biomedical Engineering Post-Graduate Program Faculty of Science and Technology Universitas Airlangga Surabaya Indonesia 60115

This research aims to recognize the pattern of pulmonary disease on x-ray radiography image using artificial neural network (ANN) method. The images, which were used such as images of healthy pulmonary, pulmonary tuberculosis, and pulmonary tumour. Pattern recognition was using an extraction feature of GLCM (Gray Level Co-occurrence Matrix) and back propagation method. Before being identified, the images were processed by median filter and adaptive histogram equalization. The GLCM features that used were homogeneity, energy, contrast, variance and correlation. The parameters were learning rate and hidden layer. Learning rate was 0.3 and hidden layer was 25. Back propagation training showed 100% accuracy, which all of 44 images were used had been successfully identified. From the result, the healthy pulmonary showed 60% accuracy, 83.3% for pulmonary tuberculosis and 100% for pulmonary tumor. Hence, the overall result showed 81.25% accuracy, which 13 of 16 images had been successfully identified. From these result, extraction feature of GLCM using back propagation method was capable to recognize the pattern of pulmonary disease. However, due to narrow range of the feature, this application may not be used optimally for comparing features in every category of images. Therefore, the further research is needed to determine the best features and parameters of training back propagation.

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Detection of gas concentrations based on age on Staphylococcus aureus biofilms with gas array sensors

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AIP Conference Proceedings 2020年第1期2314卷

作者： A. A. S. Pradhana S. D. Astuti M. Khasanah R. K. D. Ardianti 1)Biomedical Engineering Master Program Post Graduate School Universitas Airlangga Surabaya 60115 Indonesia 2)Department of Physics Faculty Science and Technology Universitas Airlangga Surabaya 60115 Indonesia 3)Department of Physics Faculty Science and Technology Universitas Airlangga Surabaya 60115 Indonesia 4)Biomedical Engineering Bachelor Program Post Graduate School Universitas Airlangga Surabaya 60115 Indonesia

Bacteria that have developed in the biofilm phase will be more resistant to antibiotics and emit gases that have certain characteristics. One dose of culture from Trypticase Soy Broth (TSB) (Merck, Germany) was inoculated into 10 mL of Trypticase Soy Broth (TSB) (Merck, Germany) and homogenized for a concentration of 0.5 McFarland (10-13 CFU / mL). The suspension was detected by ELISA reader (λ 595nm)Based on the results that have been obtained, the sensor on the gas array instrument can detect both a variety of distinctive gas patterns in S. Variations in shelf life and variations in the types of samples provided can be tracked both by the entire sensor. This is indicated by the emergence of a unique and different sensor voltage output pattern in each variation. The processing of sensor output using the PCA (Principal Component Analysis) method can accommodate 86.45% of the data variation, including the first component and the second component respectively 70.4% and 18.1%. Through the PCA method, each variation of bacterial treatment can be classified properly, so it can be used to clearly distinguish the age of bacteria and biofilm age. When loading the PCA plot, the MQ2 sensor shows the most responsive results to gas changes. Meanwhile, the MQ136 sensor ranks second as the most responsive sensor to measure the life span of bacteria and biofilms.

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Managing the invisible threat of microplastics in marine ecosystems: Lessons from coast of the Bay of Bengal

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The science of the total environment 2023年 889卷 164224页

作者： Al-Nure Mubin Shahoriar Arefin Md Sonir Mia Abu Reza Md Towfiqul Islam A B M Mainul Bari Md Saiful Islam Mir Mohammad Ali Md Abu Bakar Siddique M Safiur Rahman Venkatramanan Senapathi Abubakr M Idris Guilherme Malafaia Department of Disaster Management Begum Rokeya University Rangpur 5400 Bangladesh. Department of Disaster Management Begum Rokeya University Rangpur 5400 Bangladesh Department of Development Studies Daffodil International University Dhaka 1216 Bangladesh. Electronic address: towfiq_dm@brur.ac.bd. Department of Industrial and Production Engineering Bangladesh University of Engineering and Technology Dhaka 1000 Bangladesh. Department of Soil Science Patuakhali Science and Technology University Dumki Patuakhali 8602 Bangladesh. Department of Aquaculture Sher - e - Bangla Agricultural University Dhaka 1207 Bangladesh. Institute of National Analytical Research and Service (INARS) Bangladesh Council of Scientific and Industrial Research (BCSIR) Dhanmondi Dhaka 1205 Bangladesh. Analytical Chemistry Laboratory Chemistry Division Atomic Energy Centre Dhaka (AECD) Bangladesh Atomic Energy Commission Dhaka 1000 Bangladesh. Department of Disaster Management Alagappa University Karaikudi Tamilnadu India. Department of Chemistry College of Science King Khalid University Abha 62529 Saudi Arabia Research Center for Advanced Materials Science (RCAMS) King Khalid University Abha Saudi Arabia. Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute Urutaí GO Brazil Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia Uberlândia MG Brazil Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás Goiânia GO Brazil. Electronic address: guilhermeifgoiano@***.

Invisible microplastics (MP) have become a significant problem worldwide in recent years. Although many studies have highlighted the sources, effects, and fate of MPs pollution on various ecosystems in developed countries, there is limited information on MPs in the marine ecosystem along the northeastern coast of the Bay of Bengal (BoB). Coastal ecosystems along the BoB coasts are critical to a biodiverse ecology that supports human survival and resource extraction. However, the multi-environmental hotspots, ecotoxicity effects, transport mechanisms, fates, and intervention measures to control MP pollution initiatives along the BoB coasts have received little attention. Therefore, this review aims to highlight the multi-environmental hotspots, ecotoxicity effects, sources, fates, and intervention measures of MP in the northeastern BoB to understand how MP spreads in the nearshore marine ecosystem. This study critically evaluates the hotspots and ecotoxic effects of pollution from MP on the coastal multi-environment, e.g., soil, sediment, salt, water, and fish, as well as current intervention measures and additional mitigation recommendations. This study identified the northeastern part of the BoB as a hotspot for MP. In addition, the transport mechanisms and fate of MP in different environmental compartments are highlighted, as are research gaps and potential future research areas. Research on the ecotoxic effects of MP on BoB marine ecosystems must be a top priority, given the increasing use of plastics and the presence of significant marine products worldwide. The knowledge gained from this study would inform decision-makers and stakeholders in a way that could reduce the impact of the legacy of micro- and nanoplastics in the area. This study also proposes structural and non-structural measures to mitigate the effects of MPs and promote sustainable management.

关键词： Bay of Bengal coast Marine ecosystem Marine pollution Microplastic Sustainable management

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The ALCHEMI atlas: principal component analysis reveals starburst evolution in NGC 253

arXiv

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arXiv 2024年

作者： Harada, Nanase Meier, David S. Martín, Sergio Muller, Sebastien Sakamoto, Kazushi Saito, Toshiki Gorski, Mark D. Henkel, Christian Tanaka, Kunihiko Mangum, Jeffrey G. Aalto, Susanne Aladro, Rebeca Bouvier, Mathilde Colzi, Laura Emig, Kimberly L. Herrero-Illana, Rubén Huang, Ko-Yun Kohno, Kotaro König, Sabine Nakanishi, Kouichiro Nishimura, Yuri Takano, Shuro Rivilla, Víctor M. Viti, Serena Watanabe, Yoshimasa van der Werf, Paul P. Yoshimura, Yuki National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Institute of Astronomy and Astrophysics Academia Sinica 11F of AS/NTU Astronomy-Mathematics Building No.1 Sec. 4 Roosevelt Rd Taipei10617 Taiwan Astronomical Science Program Graduate Institute for Advanced Studies SOKENDAI 2-21-1 Osawa Mitaka Tokyo181-1855 Japan New Mexico Institute of Mining and Technology 801 Leroy Place SocorroNM87801 United States National Radio Astronomy Observatory PO Box O 1003 Lopezville Road SocorroNM87801 United States European Southern Observatory Alonso de Córdova 3107 Vitacura Santiago763-0355 Chile Joint ALMA Observatory Alonso de Córdova 3107 Vitacura Santiago763-0355 Chile Department of Space Earth and Environment Chalmers University of Technology Onsala Space Observatory OnsalaSE-439 92 Sweden Department of Physics and Astronomy Northwestern University EvanstonIL60208 United States Max-Planck-Institut für Radioastronomie Auf dem Hügel 69 Bonn53121 Germany Astronomy Department Faculty of Science King Abdulaziz University P. O. Box 80203 Jeddah21589 Saudi Arabia Department of Physics Faculty of Science and Technology Keio University 3-14-1 Hiyoshi Kanagawa Yokohama223-8522 Japan National Radio Astronomy Observatory 520 Edgemont Road CharlottesvilleVA22903-2475 United States Department of Space Earth and Environment Chalmers University of Technology GöteborgSE-412 96 Sweden Leiden Observatory Leiden University P.O. Box 9513 Leiden2300 RA Netherlands CSIC-INTA Ctra. de Ajalvir Km. 4 Torrejón de Ardoz Madrid28850 Spain Campus UAB Carrer de Magrans BarcelonaE-08193 Spain Institute of Astronomy Graduate School of Science The University of Tokyo 2-21-1 Osawa Mitaka Tokyo181-0015 Japan Department of Astronomy The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-0033 Japan ALMA Project National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Department of Physic

Molecular lines are powerful diagnostics of the physical and chemical properties of the interstellar medium (ISM). These ISM properties, which affect future star formation, are expected to differ in starburst galaxies from those of more quiescent galaxies. We investigate the ISM properties in the central molecular zone of the nearby starburst galaxy NGC 253 using the ultra-wide millimeter spectral scan survey from the ALMA Large program ALCHEMI. We present an atlas of velocity-integrated images at a 1′′. 6 resolution of 148 unblended transitions from 44 species, including the first extragalactic detection of HCNH+ and the first interferometric images of C3H+, NO, HCS+. We conduct a principal component analysis (PCA) on these images to extract correlated chemical species and to identify key groups of diagnostic transitions. To the best of our knowledge, our dataset is currently the largest astronomical set of molecular lines to which PCA has been applied. The PCA can categorize transitions coming from different physical components in NGC 253 such as i) young starburst tracers characterized by high-excitation transitions of HC3N and complex organic molecules (COMs) versus tracers of on-going star formation (radio recombination lines) and high-excitation transitions of CCH and CN tracing PDRs, ii) tracers of cloud-collision-induced shocks (low-excitation transitions of CH3OH, HNCO, HOCO+, and OCS) versus shocks from star-formation-induced outflows (high-excitation transitions of SiO), as well as iii) outflows showing emission from HOC+, CCH, H3O+, CO isotopologues, HCN, HCO+, CS, and CN. Our findings show these intensities vary with galactic dynamics, star formation activities, and stellar feedback. © 2024, CC BY.

关键词： Principal component analysis

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Corrigendum to "Development and functional evaluation of a hyaluronic acid coated nano-formulation with kaempferol as a novel intra-articular agent for knee osteoarthritis treatment"[ Biomed. Pharmacother. 175(2024) 116717]

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024年 177卷 116944页

作者： Ching-Yu Lee Yu-Chu Chang Kai-Chiang Yang Yung-Fang Lin Alexander T H Wu Ching-Li Tseng International Ph.D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei 110301 Taiwan Department of Orthopedics Taipei Medical University Hospital Taipei 110301 Taiwan Department of Orthopaedics School of Medicine College of Medicine Taipei Medical University Taipei 110301 Taiwan Orthopedic Research Center Taipei Medical University Hospital Taipei 110301 Taiwan. Department of Biochemistry and Molecular Cell Biology School of Medicine College of Medicine Taipei Medical University Taipei 110301 Taiwan. School of Dental Technology College of Oral Medicine Taipei Medical University Taipei 110301 Taiwan. Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei 110301 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei 110301 Taiwan. The Ph.D. Program for Translational Medicine College of Medical Science and Technology Taipei Medical University Taipei 110301 Taiwan Clinical Research Center Taipei Medical University Hospital Taipei Medical University Taipei 110301 Taiwan. Electronic address: chaw1211@tmu.edu.tw. International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei 110301 Taiwan. Electronic address: chingli@tmu.edu.tw.

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Electronic nose in differentiating and ascertaining clinical status among patients with pulmonary nontuberculous mycobacteria: A prospective multicenter study

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The Journal of infection 2023年第3期87卷 255-258页

作者： Meng-Rui Lee Hung-Ling Huang Wei-Chang Huang Shang-Yu Wu Pang-Chun Liu Jui-Ching Wu Meng-Hsuan Cheng Chau-Chyun Sheu Kea-Tiong Tang Jann-Yuan Wang Chao-Chi Ho Jin-Yuan Shih Inn-Wen Chong Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan. Department of Internal Medicine Kaohsiung Municipal Ta-Tung Hospital Kaohsiung Taiwan Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan. Division of Chest Medicine Department of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan Mycobacteria Center of Excellence Department of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan School of Medicine Chung Shan Medical University Taichung 402 Taiwan Ph.D. Program in Translational Medicine National Chung Hsing University Taichung 402 Taiwan Department of Medical Technology Jen-Teh Junior College of Medicine Nursing and Management Miaoli Taiwan. Department. of Electrical Engineering National Tsing Hua University Hsinchu Taiwan. Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan. Department. of Electrical Engineering National Tsing Hua University Hsinchu Taiwan. Electronic address: kttang@ee.nthu.edu.tw. Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan. Electronic address: jywang@ntu.edu.tw. Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Respiratory Therapy Kaohsiung Medical University Hospital Kaohsiung Taiwan Department of Biological Science & Technology National Chiao Tung University Hsin-Chu Taiwan.

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Effect of Processing Conditions on the Mechanical and Morphological Properties of Elastomeric Poly (Methyl Methacrylate)/Polycarbonate Blends

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Macromolecular Symposia 2019年第1期383卷

作者： de Macedo, Thatiana Cristina Pereira da Silva Reinaldo, Juciklécia Pereira, Laurenice Martins do Rêgo, José Kaio Max Alves Ueki, Marcelo Massayoshi Damasceno, Igor Zumba Ito, Edson Noriyuki Graduate Program in Materials Science and Engineering Federal University of Rio Grande do Norte Avenida Senador Salgado Filho 3000 NatalRN59078-970 Brazil Department of Materials Science and Engineering Federal University of Sergipe Avenida Marechal Rondon São CristóvãoSEs/n 49100-000 Brazil Department of Materials Engineering Federal University of Rio Grande do Norte Avenida Senador Salgado Filho 3000 NatalRN59078-970 Brazil

The aim of this study was to investigate the influence of the processing conditions in single and co-rotational twin screw extruders on the mechanical and morphological properties of elastomeric poly (methyl methacrylate)/polycarbonate (PMMAe/PC) blends until the phase inversion. The characterizations were performed by measuring the melt flow index, capillary rheometry, thermogravimetric analysis, tensile tests, Izod impact, and atomic force microscopy (AFM). The thermal and rheological properties showed that PC had a higher sensitivity to processing conditions than PMMAe. The increase in PC concentration altered the mechanical properties of the PMMAe/PC blends with variations according to processing conditions. The morphology of PMMAe/PC blends up to phase inversion was visualized by AFM, and the results showed that the material processed with a single screw extruder obtained similar morphologies to that material processed in twin screw extruder. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

关键词： Atomic force microscopy

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