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arXiv 2024年

作者： Akiyama, Kazunori Niinuma, Kotaro Hada, Kazuhiro Doi, Akihiro Hagiwara, Yoshiaki Higuchi, Aya E. Honma, Mareki Kawashima, Tomohisa Kolev, Dimitar Koyama, Shoko Masui, Sho Ohsuga, Ken Sano, Hidetoshi Takami, Hideki Tsunetoe, Yuh Uzawa, Yoshinori Akahori, Takuya Akiyama, Yuto Galison, Peter Hayashi, Takayuki J. Hirota, Tomoya Inoue, Makoto Iwata, Yuhei Johnson, Michael D. Kino, Motoki Kofuji, Yutaro Mizuno, Yosuke Moriyama, Kotaro Nagai, Hiroshi Nakamura, Kenta Notsu, Shota Ono, Fumie Oya, Yoko Oyama, Tomoaki Rana, Hannah Saida, Hiromi Saito, Ryo Saito, Yoshihiko Sasada, Mahito Sawada-Satoh, Satoko Takahashi, Mikiya M. Takamura, Mieko Tong, Edward Tsuji, Hiroyuki Yoshioka, Shogo Watanabe, Yoshimasa Massachusetts Institute of Technology Haystack Observatory WestfordMA01886 United States Mizusawa VLBI Observatory National Astronomical Observatory of Japan Iwate023-0861 Japan Black Hole Initiative Harvard University CambridgeMA02138 United States Graduate School of Sciences and Technology for Innovation Yamaguchi University Yamaguchi753-8512 Japan The Graduate School of Science Nagoya City University Aichi467-0001 Japan Institute of Space and Astronautical Science Japan Aerospace Exploration Agency Kanagawa252-5210 Japan Department of Space and Astronautical Science The Graduate University for Advanced Studies SOKENDAI Kanagawa229-8510 Japan Natural Science Laboratory Toyo University Tokyo112-8606 Japan Division of Science School of Science and Engineering Tokyo Denki University Saitama350-0394 Japan Department of Astronomy Graduate School of Science The University of Tokyo Tokyo113-0033 Japan Institute for Cosmic Ray Research The University of Tokyo Chiba277-8582 Japan Space Communication Systems Laboratory Wireless Networks Research Center National Institute of Information and Communications Technology Tokyo184-8795 Japan Graduate School of Science and Technology Niigata University Niigata950-2181 Japan Advanced Technology Center National Astronomical Observatory of Japan Tokyo181-8588 Japan Center for Computational Sciences University of Tsukuba Ibaraki305-8577 Japan Faculty of Engineering Gifu University Gifu501-1193 Japan Harvard University CambridgeMA02138 United States Azabu Junior and Senior High School Tokyo106-0046 Japan Astronomical Science Program The Graduate University for Advanced Studies SOKENDAI Tokyo181-8588 Japan Institute of Astronomy and Astrophysics Academia Sinica Taipei10617 Taiwan Center for Astrophysics Harvard & Smithsonian CambridgeMA02138 United States Kogakuin University of Technology & Engineering Academic Support Center 2665-1 Nakano Hachioji Tokyo192-0015 Japan Tsung-Dao Lee Institut

The Black Hole Explorer (BHEX) is a next-generation space very long baseline interferometry (VLBI) mission concept that will extend the ground-based millimeter/submillimeter arrays into space. The mission, closely aligned with the science priorities of the Japanese VLBI community, involves an active engagement of this community in the development of the mission, resulting in the formation of the Black Hole Explorer Japan Consortium. Here we present the current Japanese vision for the mission, ranging from scientific objectives to instrumentation. The Consortium anticipates a wide range of scientific investigations, from diverse black hole physics and astrophysics studied through the primary VLBI mode, to the molecular universe explored via a potential single-dish observation mode in the previously unexplored 50-70 GHz band that would make BHEX the highest-sensitivity explorer ever of molecular oxygen. A potential major contribution for the onboard instrument involves supplying essential elements for its high-sensitivity dual-band receiving system, which includes a broadband 300 GHz SIS mixer and a space-certified multi-stage 4.5K cryocooler akin to those used in the Hitomi and XRISM satellites by the Japan Aerospace Exploration Agency. Additionally, the Consortium explores enhancing and supporting BHEX operations through the use of millimeter/submillimeter facilities developed by the National Astronomical Observatory of Japan, coupled with a network of laser communication stations operated by the National Institute of Information and Communication technology. Copyright © 2024, The Authors. All rights reserved.

关键词： Radio astronomy

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Investigations on Structural, Optical and Dielectric Properties of Titanium Dioxide Via Doping of Nitrogen and Copper Ions

SSRN

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SSRN 2024年

作者： Kaur, Gagandeep Thakur, Shailja Negi, Puneet Konwar, Ruhit Jyoti Kumar, Hemaunt Devi, Nisha Verma, Yogita Sharma, Anchal Sati, Prakash Chandra Dadhich, Himanshu Maru, Apexa Jhala, I.G. Shah, N.A. Solanki, P.S. Department of Physics Akal College of Basic Sciences Eternal University Baru Sahib 173101 India Centre of Excellence in Nanotechnology Faculty of Engineering & Technology Assam Down Town University Guwahati781026 India Department of Applied Science and Humanities Rajkiya Engineering College Bijnor246725 India Materials Science and Sensor Application CSIR-Central Scientific Instruments Organisation Chandigarh160030 India Academy of Scientific and Innovative Research Ghaziabad201002 India Department of Physics Rajiv Gandhi Government Post Graduate College Mandsaur458001 India Department of Physics Faculty of Basic and Applied Sciences Vivekananda Global University Jaipur303012 India Department of Physics Saurashtra University Rajkot360005 India

Pure anatase TiO2 nanoparticles and its mono–doped/co–doped derivatives [i.e. (TiN0.007O1.993), (Ti0.998Cu0.002O2) (Ti0.998Cu0.002N0.007O1.993)] were prepared by sol–gel auto–combustion technique. Further, the effects of copper (Cu) and nitrogen (N) dopants have been investigated on structural, optical and dielectric properties of nanostructured TiO2 using X–ray diffraction (XRD), Raman spectroscopy, UV–visible spectroscopy and dielectric spectroscopy measurement respectively. The Rietveld refinement analysis of XRD data and Raman spectra revealed that all the synthesized samples have pure anatase phase having tetragonal structure with space group of I41/amd. The pure anatase phase of doped samples illustrate the substitution of Cu2+ at Ti4+ sites and N3– at O2– sites in the TiO2 host lattice. The crystallite size of TiO2 and its derivatives has been observed in the range of 11–14 nm. The band gap of TiO2 reduced from 3.20 to 1.90 eV with mono–doping and co–doping of the N and Cu in TiO2 lattice as confirmed by UV–visible spectroscopy. This red–shift might be occur due to the possible formation of N–2p and Cu–3d localized levels during mono–doping, and the creation of isolated intermediate states in the case of co–doping. The dielectric spectroscopy was performed to investigate the electrical properties in details and explained in terms of structural and inherent ionic behaviour of various dopants. The detected band gap energies in N/Cu mono–doped and co–doped samples of anatase TiO2 fall within the visible spectrum, rendering them suitable for harnessing solar energy in photocatalysis and photovoltaic applications. © 2024, The Authors. All rights reserved.

关键词： Titanium dioxide

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Optically Tunable Many-Body Exciton-Phonon Quantum Interference

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Advanced science 2024年第40期11卷 e2404741页

作者： Chang, Si-Jie Huang, Po-Chun Su, Jia-Sian Hsieh, Yu-Wei Quiroz Reyes, Carlos Jose Fan, Ting-Hsuan Sun, Han-Sheng Nguyem, Ai-Phuong Liu, Te-I Cheng, Ho-Wen Lin, Ching-Wei Hayashi, Michitoshi Yong, Chaw-Keong Department of Physics National Taiwan University Taipei10617 Taiwan Institute of Atomic and Molecular Sciences Academia Sinica Taipei106319 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University New Taipei235603 Taiwan Department of Chemistry National Tsing Hua University Hsinchu300044 Taiwan International Graduate Program of Molecular Science and Technology National Taiwan University Taipei106319 Taiwan Center for Condensed Matter Sciences National Taiwan University Taipei10617 Taiwan Center of Atomic Initiative for New Materials National Taiwan University Taipei10617 Taiwan National Center for Theoretical Sciences Taipei10617 Taiwan

This study introduces a novel paradigm for achieving widely tunable many-body Fano quantum interference in low-dimensional semiconducting nanostructures, beyond the conventional requirement of closely matched energy levels between discrete and continuum states observed in atomic Fano systems. Leveraging Floquet engineering, the remarkable tunability of Fano lineshapes is demonstrated, even when the original discrete and continuum states are separated by over 1 eV. Specifically, by controlling the quantum pathways of discrete phonon Raman scattering using femtosecond laser pulses, the Raman intermediate states across the excitonic Floquet band are tuned. This manipulation yields continuous transitions of Fano lineshapes from antiresonance to dispersive and to symmetric Lorentzian profiles, accompanied by significant variations in Fano parameter q and Raman intensity spanning 2 orders of magnitude. A subtle shift in the excitonic Floquet resonance is further shown, achieved by controlling the intensity of the femtosecond laser, which profoundly modifies quantum interference strength from destructive to constructive interference. The study reveals the crucial roles of Floquet engineering in coherent light-matter interactions and opens up new avenues for coherent control of Fano quantum interference over a broad energy spectrum in low-dimensional semiconducting nanostructures. © 2024 The Author(s). Advanced science published by Wiley-VCH GmbH.

关键词： Femtosecond lasers

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Smart photonic wristband for pulse wave monitoring

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Opto-Electronic science 2024年第12期3卷 12-27页

作者： Renfei Kuang Zhuo Wang Lin Ma Heng Wang Qingming Chen Arnaldo Leal Junior Santosh Kumar Xiaoli Li Carlos Marques Rui Min Center for Cognition and Neuroergonomics State Key Laboratory of Cognitive Neuroscience and LearningBeijing Normal UniversityZhuhai 519087China College of Science Shenyang Aerospace UniversityShenyang 110136China School of Microelectronics Science and Technology Guangdong Provincial Key Laboratory of Optoelectronic Information Processing Chips and SystemsSun Yat-Sen UniversityZhuhai 519082China Graduate Program in Electrical Engineering Federal University of Espírito SantoFernando Ferrari AvenueVitoria 29075-910Brazil Department of Electronics and Communication Engineering Koneru Lakshmaiah Education FoundationVaddeswaramAndhra Pradesh 522302India CICECO-Aveiro Institute of Materials Physics DepartmentUniversity of AveiroAveiro 3810-193Portugal

Real-time acquisition of human pulse signals in daily life is clinically important for cardiovascular disease monitoring and ***,we propose a smart photonic wristband for pulse signal monitoring based on speckle pattern analysis with a polymer optical fiber(POF)integrated into a sports *** different speckle pattern processing algorithms and POFs with different core diameters were *** results indicated that the smart photonic wristband had a high signal-to-noise ratio and low latency,with the measurement error controlled at approximately 3.7%.This optimized pulse signal could be used for further medical diagnosis and was capable of objectively monitoring subtle pulse signal changes,such as the pulse waveform at different positions of Cunkou and pulse waveforms before and after *** the assistance of artificial intelligence(AI),functions such as gesture recognition have been realized through the established prediction model by processing pulse signals,in which the recognition accuracy reaches 95%.Our AI-assisted smart photonic wristband has potential applications for clinical treatment of cardiovascular diseases and home monitoring,paving the way for medical Internet of Things-enabled smart systems.

关键词： smart healthcare specklegram pulse monitoring gesture recognition artificial intelligence wearable sensor

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Ferroelectric transistors based on shear-transformation-mediated rhombohedral-stacked molybdenum disulfide

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Nature Electronics 2024年第1期7卷 29-38页

作者： Yang, Tilo H. Liang, Bor-Wei Hu, Hsiang-Chi Chen, Fu-Xiang Ho, Sheng-Zhu Chang, Wen-Hao Yang, Liu Lo, Han-Chieh Kuo, Tzu-Hao Chen, Jyun-Hong Lin, Po-Yen Simbulan, Kristan Bryan Luo, Zhao-Feng Chang, Alice Chinghsuan Kuo, Yi-Hao Ku, Yu-Seng Chen, Yi-Cheng Huang, You-Jia Chang, Yu-Chen Chiang, Yu-Fan Lu, Ting-Hua Lee, Min-Hung Li, Kai-Shin Wu, Menghao Chen, Yi-Chun Lin, Chun-Liang Lan, Yann-Wen Department of Physics National Taiwan Normal University Taipei Taiwan Taiwan Semiconductor Research Institute National Applied Research Laboratories Hsinchu Taiwan Department of Electrophysics National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Physics National Cheng Kung University Tainan Taiwan School of Physics Huazhong University of Science and Technology Wuhan China Institute of Cellular and Organismic Biology Academia Sinica Taipei Taiwan Department of Mathematics and Physics University of Santo Tomas Manila Philippines Program for Semiconductor Devices Materials and Hetero-integration Graduate School of Advanced Technology National Taiwan University Taipei Taiwan Hsinchu Taiwan Department of Physics National Taiwan University Taipei Taiwan Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology CambridgeMA United States

To develop low-power, non-volatile computing-in-memory device using ferroelectric transistor technologies, ferroelectric channel materials with scaled thicknesses are required. Two-dimensional semiconductors, such as molybdenum disulfide (MoS2), equipped with sliding ferroelectricity could provide an answer. However, achieving switchable electric polarization in epitaxial MoS2 remains challenging due to the absence of mobile domain boundaries. Here we show that polarity-switchable epitaxial rhombohedral-stacked (3R) MoS2 can be used as a ferroelectric channel in ferroelectric memory transistors. We show that a shear transformation can spontaneously occur in 3R MoS2 epilayers, producing heterostructures with stable ferroelectric domains embedded in a highly dislocated and unstable non-ferroelectric matrix. This diffusionless phase transformation process produces mobile screw dislocations that enable collective polarity control of 3R MoS2 via an electric field. Polarization–electric-field measurements reveal a switching field of 0.036 V nm−1 for shear-transformed 3R MoS2. Our sliding ferroelectric transistors are non-volatile memory units with thicknesses of only two atomic layers and exhibit an average memory window of 7 V with an applied voltage of 10 V, retention times greater than 104 seconds and endurance greater than 104 cycles. © 2023, The Author(s), under exclusive licence to Springer Nature Limited.

关键词： Molybdenum disulfide

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Sustainability assessment of groundwater in south-eastern parts of the western region of Ghana for water supply

Cleaner Water

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Cleaner Water 2024年 1卷

作者： Ernest Biney Bernard Akwasi Mintah Ernest Ankomah Albert Elikplim Agbenorhevi Daniel Buston Yankey Ernestina Annan Department of Geomatic Engineering Kwame Nkrumah University of Science and Technology University Post Office Box PMB Kumasi Ghana WASCAL Graduate Research Programme on Climate Change and Land Use Department of Civil Engineering Kwame Nkrumah University of Science and Technology Kumasi Ghana Department of Geological Engineering University of Mines and Technology Tarkwa Ghana Graduate Research Program on Climate Change and Water Resources West African Science Service Center on Climate Change and Adapted Land Use (WASCAL) University of Abomey-Calavi Benin

The study assessed the physicochemical and biological properties of selected groundwater sources in the Southeastern part of the Western Region, to assess the impact on water quality and health risk. The Piper Trilinear plot was used to categorize the water samples into water types based on the dominant anion and cation concentrations. Statistical analysis (One way ANOVA and two sample t-test) was used to determine the sources of variation in the data at 95% confidence interval. The Water Quality Index (WQI) and Hazard Quotient (HQ) were used to estimate the water quality and health risk respectively. TDS and turbidity were above the acceptable WHO guidelines in 16.7% of the samples with a mildly acidic pH in 83.3% of the water samples. Also, 91.7% of the water samples were contaminated with total coliform (TC) and 25% with e-coli. Generally, the groundwater samples were dominated by Ca 2+ and HCO 3- ion water types. The variations between parameters were found not significant for all the parameters (p>0.05). Water samples in the North are of good quality with a mean WQI of 96, but of poor quality in the South with a mean WQI of 144.6. HQ values for all the samples were less than 0.1, suggesting less harmful impacts of the heavy metal concentrations on human health. Overall, the results showed the presence of heavy metals in the groundwater sources sampled, however in quantities with low health risks either through oral or dermal channels. Groundwater within the communities is good for domestic purposes but needs treatment for drinking. To improve upon the study, it is recommended that further studies consider a higher number of samples and include other accessible groundwater stations where possible.

关键词： Health Risk Assessment Groundwater GIS Trace elements Water Quality Index

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Effect of pyrolysis temperature on characteristics of tunable magnetic biochar synthesized from watermelon rind and its tetracycline adsorption performance

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Journal of the Taiwan Institute of Chemical Engineers 2024年 160卷

作者： Thairattananon, Phisit Le, Giang T.T. Matsumura, Yukihiko Wu, Kevin C.W. Charinpanitkul, Tawatchai Department of Chemical Engineering Faculty of Engineering Center of Excellence in Particle and Material Processing Technology Chulalongkorn University Bangkok10330 Thailand Institute of Fundamental and Applied Sciences Duy Tan University Ho Chi Minh700000 Viet Nam Faculty of Environmental and Chemical Engineering Duy Tan University Da Nang550000 Viet Nam Mechanical Engineering Program Graduate School of Advanced Science and Engineering Kagamiyama Hiroshima Higashi-Hiroshima739-8527 Japan Department of Chemical Engineering National Taiwan University Taipei10617 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Chung-Li Taoyuan Taiwan Research Network of NANOTEC-KU on Nanocatalyst and Nanomaterials for Sustainable Energy and Environment Bangkok10900 Thailand

Background: Tetracycline is an emerging contaminant in water reservoirs, causing undesirable influences on human society. The promising usage of magnetic biochar (MBC) derived from watermelon rind has been explored in the adsorption of various contaminants owing to its high specific surface area and separability;however, the temperature-dependent changes of MBC and its sorption ability toward antibiotics have not been widely examined. Method: Tunable MBCs could be synthesized via simple pyrolysis of watermelon rind impregnated with FeCl3 at different temperatures (700–900 °C). The as-synthesized MBCs were characterized using scanning electron microscopy (SEM), an elemental analyzer, N2 adsorption/desorption, Fourier-transform infrared spectroscopy (FTIR), Raman spectroscopy, X-ray diffractometry (XRD), and vibrating sample magnetometry (VSM). Then Tetracycline, an emerging contaminant in water reservoirs, was employed as the target contaminant, while adsorption kinetics, isotherm, the effect of pH, and reusability were investigated. Significant findings: The tunability of as-synthesized MBCs could be observed by their distinct changes in structural characteristics when varying pyrolysis temperature. MBC synthesized at 900 °C (MBC900) possessed a high-specific surface area (401 m2.g−1) and saturation magnetization (55.29 emu.g−1), resulting in a greater amount of sorption sites. Tetracycline adsorption by MBCs followed a pseudo-second-order kinetic model and fitted well with the Freundlich model. MBC900 is an excellent adsorbent with a maximum adsorption capacity of 77.6 mg.g−1 and could be used for at least five cycles with an insignificant decrease in the adsorption capacity. © 2024 Taiwan Institute of Chemical Engineers

关键词： Adsorption

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Enhancement of Self-Trapped Exciton and Near-Infrared Emission in Bi3+/Er3+ Co-Doped Cs2Ag0.4Na0.6InCl6 Double Perovskite for Optical Telecommunications

SSRN

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SSRN 2022年

作者： Dave, Kashyap Huang, Wen-Tse Leśniewski, Tadeusz Lazarowska, Agata Grzegorczyk, Maciej Mahlik, Sebastian Leniec, Grzegorz Kaczmarek, Slawomir M. Liu, Ru-Shi Department of Chemistry National Taiwan University Taipei106 Taiwan Nanoscience and Technology Program Taiwan International Graduate Program Academia Sinica National Taiwan University Taipei115 Taiwan Institute of Experimental Physics Faculty of Mathematics Physics and Informatics University of Gdańsk Gdańsk80-308 Poland Department of Technical Physics Faculty of Mechanical Engineering and Mechatronics West Pomeranian University of Technology in Szczecin Piastow 48 Szczecin70-311 Poland Advanced Research Center of Green Materials Science and Technology National Taiwan University Taipei106 Taiwan

Erbium (Er) complexes are used as optical gain material for signal generation in the telecom C-band at 1540 nm, but they need a sensitizer to enhance absorption. Na+ substitution at Ag+ and Bi3+ doping at the In3+ site are possible strategies to enhance broadband emission in Cs2AgInCl6, which could be used as sensitizers to energy transfer into rare-earth elements. Herein, self-trapped exciton (STE) energy transfer to Er3+ at 1540 nm for low loss optical telecommunication applications is reported. An acid precipitation method is used to synthesize Cs2AgInCl6 and its derivative with Er3+, Bi3+, and Na+. Bare Cs2AgInCl6:Er emission signals are found to be weak at 1540 nm, but Bi3+ doping increased by 12 times, and Bi3+ and Na+ doping increased by up to 25 times signal intensity. Electron paramagnetic resonance spectroscopy characterized a decrease in axial symmetry over the Er3+ ion after substitutions of Na+ and Bi3+ in Cs2AgInCl6 at low temperature ( © 2022, The Authors. All rights reserved.

关键词： Bismuth compounds

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Bioactivity, Efficacy, and Safety of a Wound Healing Ointment With Medicinal Plant Bioactives: In Vitro and In Vivo Preclinical Evaluations

Scientific World Journal

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Scientific World Journal 2025年第1期2025卷 9466270页

作者： Floriano, Juliana Ferreira Rodrigues, Daniel Ohara, Rie Almeida, Nara Lígia Martins Lara, Vanessa Soares Sartorelli, Patricia Graeff, Carlos Frederico de Oliveira Grecco, Simone dos Santos González, Alejandra Hortencia Miranda D’Alpino, Paulo Henrique Perlatti Imperial College London National Heart and Lung Institute imperial.ac.uk GBR London United Kingdom Botucatu Medical School São Paulo State University (UNESP) São Paulo unesp.br BRA Botucatu Brazil Bioengineering and Biomaterials Group School of Pharmaceutical Sciences São Paulo State University (UNESP) unesp.br BRA Araraquara São Paulo Brazil Biotechnology and Innovation in Health Program Universidade Anhanguera de São Paulo (UNIAN) São Paulo BRA Brazil Brazil Department of Health Management Fundação Nacional de Gestão de Saúde São Paulo Brazil Undergraduate Program Medical School Universidade Nove de Julho Bauru São Paulo Brazil Department of Surgery Stomatology Pathology and Radiology Bauru School of Dentistry University of São Paulo (USP) São Paulo usp.br BRA Bauru Brazil Department of Chemistry Institute of Environmental Chemical and Pharmaceutical Sciences Federal University of São Paulo São Paulo unifesp.br BRA Diadema Brazil Department of Physics School of Sciences POSMAT-Post-Graduate Program in Materials Science and Technology São Paulo State University (UNESP) São Paulo Bauru Brazil Department of Research and Development (RD) and Innovation Center Triplet Biotechnology Solutions Inc Bauru São Paulo Brazil Post-Graduate Program in Dentistry Uniderp Anhanguera University Mato Grosso do Sul Campo Grande Brazil Post-Graduate Program in Integrated Dental Sciences University of Cuiabá (UNIC) Mato Grosso do Sul Cuiabá Brazil Department of Physics School of Sciences São Paulo State University (UNESP) São Paulo unesp.br BRA Bauru Brazil

Chronic wounds have a significant impact on patients’ quality of life, necessitating the management of pain, infection, bleeding, and emotional challenges. Debridement, which involves the removal of nonviable tissue, is crucial for promoting wound healing. In addition to surgical methods, cost-effective alternatives such as local solutions and ointments with biological properties have been explored. The use of natural compounds with anti-inflammatory, antibacterial, and collagen-synthesizing abilities holds promise for wound healing. This in vitro and in vivo preclinical study aimed to assess the safety and effectiveness of a wound healing ointment containing bioactive ingredients derived from medicinal plants (extracts, essential oils, and vegetable oils). The chemical composition of the ointment was characterized using Fourier transform infrared (FTIR) spectroscopy to gain insights into its synergistic action. Preclinical tests were conducted following standardized protocols. FTIR analysis revealed similarities between the product’s spectrum and that of bioactive compounds. The in vitro tests demonstrated that all formulations of the ointment induced no cell death, DNA damage, or acute toxicity in cell cultures (p < 0.05). No lethal dose was observed, indicating the safety of the ointment at all concentrations. The ointment also stimulated a notably more organized, significantly higher collagen production compared to control groups (p < 0.05). In vivo preclinical analyses also demonstrated no adverse responses being effective in the healing process compared to the control group (silver sulfadiazine) in terms of wound contraction and ulcer re-epithelization (p < 0.05). Significantly higher means of wound contraction were observed in the groups treated with the bioactive-containing ointment when compared to both the positive control group (sulfadiazine) and the control untreated groups (p < 0.05). The regenerative ointment exhibited excellent biocompatibility and bi

关键词： biocompatibility chronic wounds natural compounds preclinical tests wound care

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Ohwia caudata extract relieves the IL-17A-induced inflammatory response of synoviocytes through modulation of SOCS3 and JAK2/STAT3 activation

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Environmental Toxicology 2023年第8期38卷 1914-1924页

作者： Lu, Cheng-You Kuo, Chia-Hua Kuo, Wei-Wen Hsieh, Dennis Jine-Yuan Wang, Tso-Fu Shih, Cheng-Yen Lin, Pi-Yu Lin, Shinn-Zong Ho, Tsung-Jung Huang, Chih-Yang Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan Department of Sports Sciences University of Taipei Taipei Taiwan Department of Biological Science and Technology China Medical University Taichung Taiwan Ph.D. Program for Biotechnology Industry China Medical University Taichung Taiwan School of Medical Laboratory and Biotechnology Chung Shan Medical University Taichung Taiwan Clinical Laboratory Chung Shan Medical University Hospital Taichung Taiwan Department of Hematology and Oncology Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Department of Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Tzu Chi University Hualien Taiwan Buddhist Tzu Chi Medical Foundation Hualien Taiwan Buddhist Compassion Relief Tzu Chi Foundation Hualien Taiwan Bioinnovation Center Buddhist Tzu Chi Medical Foundation Hualien Taiwan Department of Neurosurgery Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Integration of Chinese Medicine and Modern Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Department of Chinese Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Department of Biological Science and Technology Asia University Taichung Taiwan Center of General Education Buddhist Tzu Chi Medical Foundation Tzu Chi University of Science and Technology Hualien Taiwan

Fibroblast-like synoviocytes accumulation, proliferation and activation, and the subsequent inflammatory mediators production play a key role in the progression of rheumatoid arthritis (RA). It is well established that Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling triggers inflammation, and induces cytokine levels in RA. Ohwia caudata have long been used against many disorders. However, in RA, the effects of O. caudata have not been elucidated. In the current study, synoviocytes were used to evaluate the suppressive effects of O. caudate extract (OCE) on the pro-inflammatory cytokines production. In vitro, the underlying mechanisms by which OCE inhibits inflammatory response through regulation of suppressors of cytokine signaling 3 (SOCS3) and JAK2/STAT3 expression in IL-17A-treated HIG-82 synoviocytes were investigated. The results demonstrated that the proliferation of IL-17A-challenged cells were increased in comparison with non-stimulated control cells. The synoviocyte proliferation was decreased significantly of OCE concentrations in dose dependent manner. The p-JAK2, p-STAT3, interleukin (IL)-1β, and IL-6 were reduced in IL-17A-challenged cells treated with OCE. Furthermore, AZD1480 (a JAK2-specific inhibitor) or WP1066 (a STAT3-specific inhibitor) affected the inflammatory mediators production in IL-17A-challenged synoviocytes, and OCE failed to mitigate the IL-17A-induced inflammatory mediators and SOCS3, acting as a feedback inhibitor of the JAK/STAT3 pathway, in the presence of SOCS3 siRNA, indicating that the beneficial effects of OCE on the regulation of inflammatory response homeostasis were dependent on SOCS3 and the JAK2/STAT3 signaling pathway. Our study also showed that SOCS3 was markedly activated by OCE in RA fibroblast-like synoviocytes, thereby decreasing the JAK/STAT3 pathway, and the IL-1β, and IL-6 activation. Thus, O. caudate should be further investigated as a candidate anti-inflammatory and anti-a

关键词： Chemical activation

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