This study explores the use of thermally treated granite slurry waste to mitigate the mineralization of sisal fibers in fiber-cement composites. Granite waste was thermally treated at 600°C and 900°C, and th...
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Liquid waste with a high amount of total suspended solids (TSS) is one of the significant environmental issues from coal mining activities in Kalimantan island under high precipitation in of an extensive zone of cover...
Liquid waste with a high amount of total suspended solids (TSS) is one of the significant environmental issues from coal mining activities in Kalimantan island under high precipitation in of an extensive zone of coverage. The TSS concentration with Nano-sized particle in mine drainage is caused by clay minerals which are dominated by montmorillonite type. Therefore, a vast chemical agent is usually used to treat TSS concentrations of liquid waste less than 300 mg/L based on government regulation. However, in this case, the chemical flocculant triggers the onset of secondary pollutant because of carcinogenic and non-biodegradable conditions. This study aims to observe specific fungi, Marasmius sp, as bio-flocculant for the treatment of mine drainage with extra high TSS. The fungi can produce a biodegradable polymer that precipitate the montmorillonite with two-mode action, namely bio-flocculant polymerization and mycelial trapping. A role model was performed in a laboratory-scale less than 1 L in several graduated/measuring cylinders under 22-30 °C. The results of clarity and flocculation rate tests indicated that the minerals in the mine drainage samples from *** mining excavation area, had been precipitated rapidly. The clarity test by using spectrophotometer indicated that eighty six percent (86%) clarity value averagely in one-hour treatment, while the TSS concentration amount decreased down to 110.1 mg/L from original measured at 11,000 mg/L based on the flocculation rate test.
AIMS:The beneficial effects of exercise on reducing the risk of cardiovascular disease are established. However, the potential interaction between genetic risk for type 2 diabetes and physical activity on cardiovascul...
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AIMS:The beneficial effects of exercise on reducing the risk of cardiovascular disease are established. However, the potential interaction between genetic risk for type 2 diabetes and physical activity on cardiovascular outcomes remains elusive. We aimed to investigate the effect of type 2 diabetes genetic risk-physical activity interaction on cardiovascular outcomes in individuals with diabetes.
METHODS AND RESULTS:Using the UK Biobank cohort, we investigated the effect of type 2 diabetes genetic risk-physical activity interaction on three-point and four-point major adverse cardiovascular events (MACE), in 25 701 diabetic participants. We used a polygenic risk score for type 2 diabetes (PRS_T2D) as a measure of genetic risk for type 2 diabetes. We observed a significant interaction between PRS_T2D and physical activity on cardiovascular outcomes (three-point MACE: P trend for interaction = 0.0081; four-point MACE: P trend for interaction = 0.0037). Among participants whose PRS_T2D was in the first or second quartile, but not in the third or fourth quartile, each 10 metabolic equivalents (METs) hours per week of physical activity decreased the risk of three-point or four-point MACE. Furthermore, restricted cubic spline analysis indicated that intense physical activity (>80 METs hours per week, which was self-reported by 12.7% of participants) increased the risk of cardiovascular outcomes among participants whose PRS_T2D was in the fourth quartile. Sub-group analysis suggested that negative impact of intense physical activity was observed only in non-insulin users.
CONCLUSION:The beneficial effect of physical activity on cardiovascular outcomes disappeared among those with high genetic risk for type 2 diabetes.
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