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Common genetic variants associated with risk of Parkinson’s disease in non-European populations:A PROSPERO registered systematic review based on genome-wide association studies

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LabMed Discovery 2024年第2期1卷 17-26页

作者： Júlio César Claudino dos Santos Howard Lopes Ribeiro Junior Jackson Frederico Pires Gabriela Braga Cabrera Mano Fabricyo de Faria Esposito Dias João Vitor Caetano Goes Camilla Teixeira Pinheiro Gusmão André Rodrigues da Cunha Barreto-Vianna Ettore José Filippi Carlo Tayenne Nélly de Lucena Viana Camila de Almeida Lins Jonas Nogueira Ferreira Maciel Gusmão Renata Ferreira de Carvalho Leitão Center for Research and Drug Development(NPDM) Federal University of CearáFortalezaCeará60430-275Brazil Postgraduate Program in Morphofunctional Sciences Federal University of Ceará-UFCFortalezaCeará60430-170Brazil Christus University Center-UNICHRISTUS FortalezaCeará60160-196Brazil Post-Graduate Program in Pathology Federal University of CearáFortalezaCeará60416-030Brazil Post-Graduate Program in Translational Medicine Federal University of CearáFortalezaCeará60430-275Brazil Faculty of Medicine Universidade Nove de JulhoBauruSão Paulo 01504-001Brazil Faculty of Medical Sciences Santa Casa de São PauloSão PauloSão Paulo 01221-020Brazil Departament of Biocience Federal University of ParanaPalotinaParaná85950-000Brazil Music Therapyst of Center Neurosinc São PauloSão Paulo 04127-000Brazil Faculty of Medicine Universidade de FortalezaFortalezaCeará60811-905Brazil Centro Universitario IBMR Rio de JaneiroRio de Janeiro 22631-002Brazil

Parkinson’s disease(PD)is a complex genetic neurodegenerative *** genetic discoveries have increased our understanding of the molecular contributors to Parkinson’s pathophysiology,especially when associated with the advent of genome-wide association studies(GWAS)technologies in the discovery of the risk linked to common germline genetic *** biggest limitation of those studies on genetic susceptibility to PD is the lack of information describing the impact of individuals’ancestry on risk associations,especially in non-European *** genetic data are mainly based on individuals of European origin,particularly those included in the UK biobank *** effects of these ethical discrepancies can directly impact the discovery of risk variants associated with PD susceptibility and clinical management of PD patients in admixture populations,for ***,we performed a PROSPERO-registered systematic review to elucidate the current state of the art about the role of common genetic variants based on GWAS studies in advancing precision medicine for PD susceptibility and pathobiology in multiethnic and non-European ***,we discuss whether there are similarities or discrepancies of these data in relation to genomic data obtained in studies with PD patients of European origin.

关键词： Genome-wide association studies Common variants Risk Parkinson’s disease

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POS1241 RELIABILITY OF HISTOPATHOLOGICAL SALIVARY GLAND BIOPSY ASSESSMENT IN SJÖGREN’S DISEASE

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Annals of the Rheumatic Diseases 2024年 83卷 868-869页

作者： C. Xavier D. Calderaro S. Araújo L.A. Tanure G. Resende D. Wanderley G.A. Ferreira Faculdade de Medicina da Universidade Federal de Minas Gerais Post Graduate Program in Sciences Applied to Adult Health Care Belo Horizonte Brazil Faculdade de Medicina da Universidade Federal de Minas Gerais Department of Locomotor System Belo Horizonte Brazil Hospital das Clínicas da Universidade Federal de Minas Gerais Department of Pathology Belo Horizonte Brazil Hospital das Clínicas da Universidade Federal de Minas Gerais Department of Rheumatology Belo Horizonte Brazil Institute of Nephropathology Brasil Brazil

Background: Diagnosis of Sjogren’s disease relies on a combination of clinical and laboratory findings. Minor Salivary Gland biopsy (MSGB) abnormalities hold significant relevance within the diagnostic framework. However, previous research has noted limited concordance with MSGB assessments, attributed to variations in histological criteria and underestimation of characteristics such as focus score (FS) and germinal centers. Objectives: This study aimed to assess the interobserver and intraobserver reliability of MSGB analysis, using the recommendations published by the EULAR group in 2017. Methods: The intra and interobserver reproducibility of MSGB of 196 adult patients, aged ≥18, with suspicion of Sjogren’s disease was analyzed by two pathologists. Examiner A (ExA) reviewed the slides twice, with a two-month gap, using a standardized blind procedure. Examiner B (ExB) assessed 115 slides randomly. ExA’s first-round assessments were compared with the routine examiners (ExR) and ExB (interobserver analysis), and with the second-round assessments (intraobserver analysis). All pathologists, including ExR, underwent prior training for MSGB analysis following the EULAR 2017 recommendations. Agreement of the pathologists on qualitative variables was analyzed using the Kappa coefficient. For quantitative FS agreement, the Intraclass Correlation Coefficient (ICC) was calculated. Results: Overall, interobserver and intraobserver analyses showed good agreement (k ≥ 0.6) for area, dichotomized FS (presence or absence of FS ≥ 1), and histological diagnosis of focal lymphocytic sialadenitis. Conversely, assessment of structural damage indicated only modest to fair agreement (k ≤ 0.4) for interobserver reliability. A comparable pattern, although with higher values, was seen in the intraobserver analysis. Table 1 depicts the results for each parameter. The ICC for FS was 0.71 (95% CI 0.63-0.77) when comparing the ExR and ExA evaluations, 0.86 (95% CI 0.77-0.91) when comparing the

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Tumor-derived interleukin-1 receptor antagonist exhibits immunosuppressive functions and promotes pancreatic cancer

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Cell and Bioscience 2023年第1期13卷 1页

作者： Fan, Yu-Ching Fong, Yu-Cin Kuo, Chun-Tse Li, Chia-Wei Chen, Wei-Yu Lin, Jian-Da Bürtin, Florian Linnebacher, Michael Bui, Quoc Thang Lee, Kuan-Der Tsai, Yuan-Chin Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University and Academia Sinica Taipei Taiwan Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan Institute of Biomedical Sciences Academia Sinica Taipei Taiwan Department of Pathology Wan Fang Hospital Taipei Medical University Taipei Taiwan Department of Pathology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Biochemical Science and Technology College of Life Science National Taiwan University Taipei City 10617 Taiwan Center for Computational and Systems Biology National Taiwan University Taipei City 10617 Taiwan Clinic of General Surgery University Medical Center Rostock Schillingallee 35 Rostock 18057 Germany Clinic of General Surgery Molecular Oncology and Immunotherapy University Medical Center Rostock Schillingallee 69 Rostock 18057 Germany International Ph.D. Program for Cell Therapy and Regeneration Medicine (IPCTRM) School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Post-Baccalaureate Medicine College of Medicine Natioanl Chung Hsing University Taichung Taiwan Cell Therapy and Regenerative Medicine Center and Comprehensive Cancer Center Taichung Veterans General Hospital Taichung Taiwan Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan

Background: Pancreatic ductal adenocarcinoma (PDA) is a pernicious disease characterized by an immunosuppressive milieu that is unresponsive to current immunotherapies. Interleukin-1 receptor antagonist (IL-1Ra) is a natural anti-inflammatory cytokine;however, its contribution to cancer pathogenesis and immunosuppression remains elusive. In this research, we investigated the role and mechanism of IL-1Ra in malignant progression of PDA. Results: Through analyzing clinical dataset and examining the pathological tumor tissues and serum samples, we have demonstrated that IL-1Ra expression is elevated in human PDA and positively associated with malignant progression of PDA. To study the biological function of IL-1Ra in tumors, we generated a set of mouse pancreatic cancer cell lines with a knockout (KO) of the Il1rn gene, encoding IL-1Ra, and compared the tumor growth rates in immune-competent and immune-deficient mice. We found that the Il1rn KO cells exhibited greater tumor inhibition in immune-competent mice, highlighting the crucial role of a functional immune system in Il1rn KO-mediated anti-tumor response. Consistently, we found an increase in CD8⁺ T cells and a decrease in CD11b⁺Ly6G⁻ immunosuppressive mononuclear population in the tumor microenvironment of Il1rn KO-derived tumors. To monitor the inhibitory effects of IL-1Ra on immune cells, we utilized a luciferase-based reporter CD4⁺ T cell line and splenocytes, which were derived from transgenic mice expressing ovalbumin-specific T cell receptors in CD8⁺ T cells, and mice immunized with ovalbumin. We showed that IL-1Ra suppressed T cell receptor signaling and inhibited antigen-specific interferon-γ (IFN-γ) secretion and cytolytic activity in splenocytes. Conclusions: Our findings illustrate the immunosuppressive properties of the natural anti-inflammatory cytokine IL-1Ra, and provide a rationale for considering IL-1Ra-targeted therapies in the treatment of

关键词： IFN-γ Immunosuppression interleukin-1 receptor antagonist Pancreatic adenocarcinoma Patient-derived xenograft Tumor microenvironment

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Influence of Teachers' Vocal Quality on Students' Learning and/or Cognition: A Scoping Review

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Journal of Voice 2023年

作者： da Silva, Kelly Ribeiro, Vanessa Veis Santos, Allicia Diely Nunes Almeida, Sabryna Beatriz Santos Cruz, Pablo Jordão Alcântara Behlau, Mara Speech-Language Pathology Course Campus Lagarto Universidade Federal de Sergipe – UFS SE Lagarto Brazil Post-graduate program in Human Communication Disorders Universidade Federal de São Paulo SP São Paulo Brazil Faculdade de Ceilândia Speech-Language Pathology Course Universidade de Brasília – UnB DF Brasília Brazil Voice Specialization Course Centro de Estudos da Voz SP São Paulo Brazil

Objective: To verify if the teacher's vocal quality can influence the student's cognition. Methods: The present study is a scoping review performed to answer the research question: Can the teacher's vocal quality influence the student's learning and cognition?. To verify if the teacher's vocal quality can influence the student's cognition. The electronic search was performed in PubMed, Lilacs, SciELO, Scopus, Web of Science, Embase, and databases, in addition to a manual search in citation and gray literature. Two independent authors performed selection and extraction. Data were extracted about the study design: the sample, the cognitive tests used, the assessed cognitive skills, the type of altered voice (real or simulated), the assessment of the vocal quality, alone or associated with environmental noise, and the main outcomes evaluated. Results: The initial research identified 476 articles, and 13 were selected for analysis. Seven (54%) studies evaluated the impact of altered voices in an isolated way on cognitive abilities. From these, they verified that the altered voices could negatively influence children's cognitive performance. Other 6 studies (46%) associated altered voices with competitive noise in their analysis, and 4 concluded that competitive noise rather than altered voices influenced students' cognitive performance. Conclusion: The altered voice seems to affect the cognitive tasks involved in the learning process. The competitive noise associated with the presentation of deviant voices had a stronger influence on cognitive performance than altered voice alone, demonstrating that cognitive performance is sensitive to the stages of information acquisition (input of acoustic signals). © 2023 The Voice Foundation

关键词： Voice disorders—Occupational diseases—Teacher—Voice professionals—Voice

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Bruxism in Childhood: A Scoping Review

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Journal of the California Dental Association 2024年第1期52卷

作者： Cristine da Silva Furtado Amaral Jennifer Guedes Sobral Flávia Cariús Tesch Ferreira Alves Claudia Maria Pereira Flávio Rodrigues Ferreira Alves a Post Graduate Program in Dentistry (PPGO) Grande Rio University (UNIGRANRIO) Universidade Veiga de Almeida Rio de Janeiro Brazil b Post Graduate Program in Dentistry (PPGO) Grande Rio University (UNIGRANRIO) Rio de Janeiro Brazil c Faculty of Dentistry Grande Rio University (UNIGRANRIO) Rio de Janeiro Brazil d Department of Pathology and Oral Diagnosis Faculty of Dentistry Federal University of Rio de Janeiro Rio de Janeiro Brazil

ABSTRACTBruxism is characterized by repetitive clenching or grinding of teeth and jaw muscle activity. It is a complex condition with various factors contributing to its development and can exert abnormal loads on the stomatognathic *** scoping review aimed to explore various aspects of bruxism in children, including its causes, prevalence, diagnosis, and multidisciplinary *** comprehensive search was conducted in the PUBMED-MEDLINE database focused on studies published from 2018 to *** criteria encompassedCross-sectional, longitudinal, comparative studies, and randomized and non-randomized clinical trials published in English. Retained full texts were assessed and excluded if inclusion criteria were not met. Methodological quality was assessed using the Joanna Briggs Institute critical appraisal tools for the different types of *** 498 initial studies, 26 were selected for full reading and 19 met the inclusion criteria. Most studies were cross-sectional (14 studies) and showed a wide prevalence of sleep *** scoping review highlights that bruxism is an important issue in children that should be observed by parents/guardians and evaluated by health professionals. Due to its multifactorial nature, a collaborative approach involving a diverse team of professionals is essential for the effective prevention and treatment of bruxism in pediatric patients.

关键词： Bruxism child diagnosis prevalence treatment

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80P Trop-2 expression and its role as a prognostic factor in patients with luminal early breast cancer

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ESMO Open 2023年第1期8卷 101303-101303页

作者： R. Correa Coelho R.D. Graudenz M.S. Graudenz Medical Sciences Post Graduate Program UFRGS-Universidade Federal do Rio Grande do Sul Porto Alegre Brazil Pathology UFRGS-Universidade Federal do Rio Grande do Sul Porto Alegre Brazil

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Bioactivity, Efficacy, and Safety of a Wound Healing Ointment With Medicinal Plant Bioactives: In Vitro and In Vivo Preclinical Evaluations

Scientific World Journal

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Scientific World Journal 2025年第1期2025卷 9466270页

作者： Floriano, Juliana Ferreira Rodrigues, Daniel Ohara, Rie Almeida, Nara Lígia Martins Lara, Vanessa Soares Sartorelli, Patricia Graeff, Carlos Frederico de Oliveira Grecco, Simone dos Santos González, Alejandra Hortencia Miranda D’Alpino, Paulo Henrique Perlatti Imperial College London National Heart and Lung Institute imperial.ac.uk GBR London United Kingdom Botucatu Medical School São Paulo State University (UNESP) São Paulo unesp.br BRA Botucatu Brazil Bioengineering and Biomaterials Group School of Pharmaceutical Sciences São Paulo State University (UNESP) unesp.br BRA Araraquara São Paulo Brazil Biotechnology and Innovation in Health Program Universidade Anhanguera de São Paulo (UNIAN) São Paulo BRA Brazil Brazil Department of Health Management Fundação Nacional de Gestão de Saúde São Paulo Brazil Undergraduate Program Medical School Universidade Nove de Julho Bauru São Paulo Brazil Department of Surgery Stomatology Pathology and Radiology Bauru School of Dentistry University of São Paulo (USP) São Paulo usp.br BRA Bauru Brazil Department of Chemistry Institute of Environmental Chemical and Pharmaceutical Sciences Federal University of São Paulo São Paulo unifesp.br BRA Diadema Brazil Department of Physics School of Sciences POSMAT-Post-Graduate Program in Materials Science and Technology São Paulo State University (UNESP) São Paulo Bauru Brazil Department of Research and Development (RD) and Innovation Center Triplet Biotechnology Solutions Inc Bauru São Paulo Brazil Post-Graduate Program in Dentistry Uniderp Anhanguera University Mato Grosso do Sul Campo Grande Brazil Post-Graduate Program in Integrated Dental Sciences University of Cuiabá (UNIC) Mato Grosso do Sul Cuiabá Brazil Department of Physics School of Sciences São Paulo State University (UNESP) São Paulo unesp.br BRA Bauru Brazil

Chronic wounds have a significant impact on patients’ quality of life, necessitating the management of pain, infection, bleeding, and emotional challenges. Debridement, which involves the removal of nonviable tissue, is crucial for promoting wound healing. In addition to surgical methods, cost-effective alternatives such as local solutions and ointments with biological properties have been explored. The use of natural compounds with anti-inflammatory, antibacterial, and collagen-synthesizing abilities holds promise for wound healing. This in vitro and in vivo preclinical study aimed to assess the safety and effectiveness of a wound healing ointment containing bioactive ingredients derived from medicinal plants (extracts, essential oils, and vegetable oils). The chemical composition of the ointment was characterized using Fourier transform infrared (FTIR) spectroscopy to gain insights into its synergistic action. Preclinical tests were conducted following standardized protocols. FTIR analysis revealed similarities between the product’s spectrum and that of bioactive compounds. The in vitro tests demonstrated that all formulations of the ointment induced no cell death, DNA damage, or acute toxicity in cell cultures (p < 0.05). No lethal dose was observed, indicating the safety of the ointment at all concentrations. The ointment also stimulated a notably more organized, significantly higher collagen production compared to control groups (p < 0.05). In vivo preclinical analyses also demonstrated no adverse responses being effective in the healing process compared to the control group (silver sulfadiazine) in terms of wound contraction and ulcer re-epithelization (p < 0.05). Significantly higher means of wound contraction were observed in the groups treated with the bioactive-containing ointment when compared to both the positive control group (sulfadiazine) and the control untreated groups (p < 0.05). The regenerative ointment exhibited excellent biocompatibility and bi

关键词： biocompatibility chronic wounds natural compounds preclinical tests wound care

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Acai (Euterpe oleracea Mart) Consumption and Prevention of Chronic Diseases: Is There an Association? A Preliminary Study

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Scientific World Journal 2020年第1期2020卷 5782485页

作者： Silva, Dulcelena Ferreira Custodio Neto Da Silva, Marcos Antonio Rodrigues, Gabrielle Meirelles Vidal, Flavia Castello Branco Barbosa, Maria Do Carmo Lacerda Oliveira Brito, Luciane Maria Bezerra, Geusa Felipa De Barros Muniz Filho, Walbert Edson Borges, Katia Regina Assuncao Rosa, Ivone Garros De Carvalho, Joao Ernesto Soares Brandao Nascimento, Maria Do Desterro Morphology Department Federal University of Maranhao Sao Luis Maranhao Brazil Post-Graduate Program in Internal Medicine Medical Science School State University of Campinas Campinas Sao Paulo Brazil Federal University of Maranhao Sao Luis Maranhao Brazil Morphology Department Post-Graduate Program in Adult Health Federal University of Maranhao Sao Luis Maranhao Brazil Medicine i Department Federal University of Maranhao Sao Luis Maranhao Brazil Medicine III Department Post-Graduate Program in Adult Health Federal University of Maranhao Sao Luis Maranhao Brazil Pathology Department Post-Graduate Program in Adult Health Federal University of Maranhao Sao Luis Maranhao Brazil Pathology Department Federal University of Maranhao Sao Luis Maranhao Brazil Pathology Department Health and Environment Post-Graduate Program Federal University of Maranhao Sao Luis Maranhao Brazil Pharmaceutic Science School Post-Graduate Program in Internal Medicine State University of Campinas Campinas Sao Paulo Brazil

Background. Flavonoids from a variety of fruits, including açaí, have beneficial antioxidant activity in several diseases, including cancer. Breast cancer is the second most prevalent cancer among Brazilian women. Studies have shown the action of flavonoids on neoplastic cells, as well as on diabetes and neurodegenerative and cardiovascular diseases. Objective. To analyze the relationship between the consumption of açaí and the presence of chronic diseases in women residing in the rural area of São Luís, Maranhão. Methods. A convenience sample of 150 women residing in the Maracanã neighborhood in São Luís, Maranhão, was used;the collected data included sociodemographic characteristics, habits, sexual and reproductive history, consumption of açaí, and history of cancer and other chronic diseases. The sample was divided into women who consumed açaí at least once a week (cases) and women who did not consume açaí (controls). Statistical analysis was performed to assess the relationships between those variables and the consumption of açaí. Results. A total of 141 women (94%) consumed açaí. Among these, 79.3% were aged between 20 and 50 years, 78.67% were farmers or housewives, 64.67% were Pardo (mixed race), 76.67% were nonsmokers, 70% were not receiving hormonal therapy, 40.67% had already undergone mammography, 28% had already undergone breast ultrasound, and 27.33% had a family history of cancer, with breast cancer being the second most prevalent cancer. There was a higher prevalence of hypertension among women who did not consume açaí than that among those who did;however, previous cancer, family history of cancer, heart disease, and diabetes were more prevalent among the consumers of açaí. There were no statistically significant relationships. Conclusion. Flavonoids are known to have a beneficial effect on some types of neoplastic cells and other diseases;therefore, larger studies are necessary to better evaluate the beneficial effects of consuming foods containing

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Correction to: Effect of photobiomodulation on the behaviour of mesenchymal stem cells in three‑dimensional cultures

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Lasers in medical science 2023年第1期38卷 269页

作者： Ana Laura Martins de Andrade Lucília Pereira da Silva Nivaldo Antonio Parizotto Patrícia Brassolatti Richard Eloin Liebano Alexandra Pinto Marques Physiotherapeutic Resources Laboratory Post‑Graduate Program in Physiotherapy Department of Physiotherapy Federal of University Sao Carlos Sao Carlos Sao Paulo Brazil. Post‑Graduate Program in Biomedical Engineering Department of Biomedical Engineering University Brazil Campus Itaquera Rua Carolina Fonseca 584 Vila Santana Sao Paulo SP 08230030 Brazil. 3B's Research Group Biomaterials Biodegradable and Biomimetics Avepark Parque de Ciencia E Tecnologia Zona Industrial da Gandra 4805‑017 Barco Guimaraes Portugal. ICVS/3B's - PT Government Associate Laboratory 4805‑017 Braga Guimaraes Portugal. Physiotherapeutic Resources Laboratory Post‑Graduate Program in Physiotherapy Department of Physiotherapy Federal of University Sao Carlos Sao Carlos Sao Paulo Brazil. nivaldoaparizotto@***. Post‑Graduate Program in Biomedical Engineering Department of Biomedical Engineering University Brazil Campus Itaquera Rua Carolina Fonseca 584 Vila Santana Sao Paulo SP 08230030 Brazil. nivaldoaparizotto@***. Department of Morphology and Pathology Post‑Graduate Program in Evolutionary Genetics and Molecular Biology Federal University of Sao Carlos (UFSCar) Sao Carlos Sao Paulo Brazil.

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Corrected integrated density: a novel method for liver elastic fibers quantification in chronic hepatitis C

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Surgical and Experimental pathology 2020年第1期3卷 1-7页

作者： Carine Leite Manoel Roberto Maciel Trindade Mário Reis Álvares-da-Silva Carlos Thadeu Schmidt Cerski Rodrigo Tzovenos Starosta Eduardo Neubarth Trindade Post-Graduate Program on Gastroenterology and Hepatology Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre RS Brazil Department of Surgery Hospital de Clínicas de Porto Alegre (HCPA) UFRGS Porto Alegre RS Brazil Department of Gastroenterology HCPA UFRGS Porto Alegre RS Brazil Department of Surgical Pathology HCPA UFRGS Porto Alegre RS Brazil Post-Graduate Program on Genetics and Molecular Biology UFRGS Porto Alegre RS Brazil

BackgroundElastic fibers deposition is triggered during liver fibrosis and is related to worse clinical prognosis in chronic hepatitis C patients. This study aimed to verify if a new method for elastic fiber quantific... 详细信息

Background

Elastic fibers deposition is triggered during liver fibrosis and is related to worse clinical prognosis in chronic hepatitis C patients. This study aimed to verify if a new method for elastic fiber quantification can be used to discriminate between different degrees of fibrosis in liver biopsies of patients with hepatitis C.

Methods

Individuals presenting with different degrees of fibrosis in liver biopsy were included. Slides of liver samples were stained with orcein with and without prior oxidation. Morphometric analysis was proceeded, and quantification accomplished by corrected integrated density.

Results

Twenty-seven patients, mean age 52 years-old, 59% women, were included. Elastic fibers density was higher in advanced fibrosis patients and there was a positive correlation with Metavir score (Spearman r = 0.609, p < 0.001), as well as with the noninvasive scores Fib-4 (Pearson r = 0.46, p = 0.029) and APRI (r = 0.52, p = 0.01).

Conclusion

Morphometric analysis by corrected integrated density demonstrates that elastic fibers abundance is higher in advanced stage of fibrosis in patients with hepatitis C.

关键词： Liver fibrosis Chronic hepatitis C Elastic fibers

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