Damage is defined as any change to the material, geometry or boundary condition that can modify the structure’s properties or response. In the past, damage identification was performed through periodical inspection, ...
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Due to extraordinary electronic and optoelectronic properties, large-scale single-crystal two-dimensional (2D) semiconducting transition metal dichalcogenide (TMD) monolayers have gained significant interest in the de...
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Contamination of aquatic and terrestrial organisms by Perfluoroalkyl substances (PFAS), emerging contaminants, is widespread, as these compounds are present in water, soil, air, and food, owing to their environmental ...
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We investigate the dynamics of entanglement through negativity and witness operators in a system of four noninteracting qubits driven by a classical phase noisy laser characterized by a classical random external field...
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We investigate the dynamics of entanglement through negativity and witness operators in a system of four noninteracting qubits driven by a classical phase noisy laser characterized by a classical random external field(CREF).The qubits are initially prepared in the GHZ-type and W-type states and interact with the CREF in two different qubit-field configurations,namely,common environment and independent environments in which the cases of equal and different field phase probabilities are *** find that entanglement exhibits different decaying behavior,depending on the input states of the qubits,the qubit-field coupling configuration,and field phase *** the one hand,we demonstrate that the coupling of the qubits in a common environment is an alternative and more efficient strategy to completely shield the system from the detrimental impacts of the decoherence process induced by a CREF,independent of the input state and the field phase probabilities ***,we show that GHZ-type states have strong dynamics under CREF as compared to W-type *** the other hand,we demonstrate that in the model investigated the system robustness’s can be greatly improved by increasing the number of qubits constituting the system.
This paper aims to evaluate the impact of lactose free yogurt version on dynamic sensory perception and consumer acceptability. A total of 46 participants evaluated classical (SNY) and lactose-free (SLF-Y) commercial ...
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The high use of internet especially social media has made this virtual world as a marketing tool. Therefore, this study aims: to determine the effect of Instagram-social media promotion on purchasing decisions, the le...
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Background: Pancreatic ductal adenocarcinoma (PDA) is a pernicious disease characterized by an immunosuppressive milieu that is unresponsive to current immunotherapies. Interleukin-1 receptor antagonist (IL-1Ra) is a ...
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Background: Pancreatic ductal adenocarcinoma (PDA) is a pernicious disease characterized by an immunosuppressive milieu that is unresponsive to current immunotherapies. Interleukin-1 receptor antagonist (IL-1Ra) is a natural anti-inflammatory cytokine;however, its contribution to cancer pathogenesis and immunosuppression remains elusive. In this research, we investigated the role and mechanism of IL-1Ra in malignant progression of PDA. Results: Through analyzing clinical dataset and examining the pathological tumor tissues and serum samples, we have demonstrated that IL-1Ra expression is elevated in human PDA and positively associated with malignant progression of PDA. To study the biological function of IL-1Ra in tumors, we generated a set of mouse pancreatic cancer cell lines with a knockout (KO) of the Il1rn gene, encoding IL-1Ra, and compared the tumor growth rates in immune-competent and immune-deficient mice. We found that the Il1rn KO cells exhibited greater tumor inhibition in immune-competent mice, highlighting the crucial role of a functional immune system in Il1rn KO-mediated anti-tumor response. Consistently, we found an increase in CD8+ T cells and a decrease in CD11b+Ly6G− immunosuppressive mononuclear population in the tumor microenvironment of Il1rn KO-derived tumors. To monitor the inhibitory effects of IL-1Ra on immune cells, we utilized a luciferase-based reporter CD4+ T cell line and splenocytes, which were derived from transgenic mice expressing ovalbumin-specific T cell receptors in CD8+ T cells, and mice immunized with ovalbumin. We showed that IL-1Ra suppressed T cell receptor signaling and inhibited antigen-specific interferon-γ (IFN-γ) secretion and cytolytic activity in splenocytes. Conclusions: Our findings illustrate the immunosuppressive properties of the natural anti-inflammatory cytokine IL-1Ra, and provide a rationale for considering IL-1Ra-targeted therapies in the treatment of
This research aims to recognize the pattern of pulmonary disease on x-ray radiography image using artificial neural network (ANN) method. The images, which were used such as images of healthy pulmonary, pulmonary tube...
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The present article portrayed on the killing kinetic of human pathogenic bacteria using bioinspired mesoporous CuAl2O4 nanocomposites (NCs). The NCs was fabricated using leaf extract of medicinal plant Catharanthus ro...
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The large amounts of by-products generated in the coffee industry are a problem for a sustainable agro-industry. The aim of this work was to investigate the occurrence of phenolic compounds in organic coffee husks and...
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