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Preference of Dogs Towards Feeding Toys Made of Natural Rubber, and Their Potential to Improve Canine Behaviour: A Study Based on Owners' Observations

SSRN

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SSRN 2023年

作者： Boonhoh, Worakan Saramolee, Prachid Sriphavatsarakom, Prarom Amaek, Waluka Waran, Natalie Wongtawan, Tuempong Animal Behaviour Research Group Akkhraratchakumari Veterinary College Walailak University Nakhon Si Thammarat80160 Thailand Center of Excellence in Innovation on Essential Oil and Bioactive Compounds Walailak University Nakhon Si Thammarat80160 Thailand One Health Research Center Walailak University Nakhon Si Thammarat80160 Thailand Material Sciences and Engineering Program School of Engineering and Resources Walailak University Nakhon Si Thammarat80161 Thailand Department of Preclinic and Applied Animal Science Faculty of Veterinary Science Mahidol University Nakhon Pathom73170 Thailand College of Graduate Studies Walailak University Nakhon Si Thammarat80160 Thailand Faculty of Education Humanities and Health Science Eastern Institute of Technology Hawke's Bay 4142 New Zealand

Improper feeding methods can be linked to canine behaviour problems, as the conventional bowl-feeding approach fail to mimic natural behaviour and is associated with obesity. Feeding toys can potentially contribute to the enhancement of dog behaviour by mimicking natural hunting behaviour and promoting increased canine activity. Para rubber is a natural rubber with high flexibility and is tolerant of animal teeth, making it safer for animals compared to plastic and silicone. This study had two main objectives: firstly, to examine dogs' preferences for the scent and colour added to a para rubber product;and secondly, to explore the impact of using para rubber feeding toys on dog behaviours. The feeding toys were produced from natural rubber, with added scents and colours incorporated during their production. Subsequently, these toys were distributed to dog owners for evaluation. Owners completed the Thai version of the C-BARQ questionnaire, which evaluate canine behaviour both prior to and following a month of interaction with the toys. The findings indicated that dogs exhibited a preference for yellow toys over blue ones, as well as a preference for vanilla-scented toys compared to those with a beef scent. Following one month of consistent use of the para rubber toy, dogs tended to reduce various undesirable behaviours. Notably, overexcitement behaviour showed a nearly threefold decrease, and this reduction was statistically significant (p = 0.003). These outcomes emphasise the potential of natural rubber feeding toys in mitigating excitation-related behaviours, while also highlighting dogs' preference towards specific colours and scents. Consequently, there is a suggestion that enhancing toys with appealing scents or colours might foster greater interaction between dogs and their toys, potentially leading to a positive influence on their overall behavioural welfare. © 2023, The Authors. All rights reserved.

关键词： Color

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Bioactivity, Efficacy, and Safety of a Wound Healing Ointment With Medicinal Plant Bioactives: In Vitro and In Vivo Preclinical Evaluations

Scientific World Journal

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Scientific World Journal 2025年第1期2025卷 9466270页

作者： Floriano, Juliana Ferreira Rodrigues, Daniel Ohara, Rie Almeida, Nara Lígia Martins Lara, Vanessa Soares Sartorelli, Patricia Graeff, Carlos Frederico de Oliveira Grecco, Simone dos Santos González, Alejandra Hortencia Miranda D’Alpino, Paulo Henrique Perlatti Imperial College London National Heart and Lung Institute imperial.ac.uk GBR London United Kingdom Botucatu Medical School São Paulo State University (UNESP) São Paulo unesp.br BRA Botucatu Brazil Bioengineering and Biomaterials Group School of Pharmaceutical Sciences São Paulo State University (UNESP) unesp.br BRA Araraquara São Paulo Brazil Biotechnology and Innovation in Health Program Universidade Anhanguera de São Paulo (UNIAN) São Paulo BRA Brazil Brazil Department of Health Management Fundação Nacional de Gestão de Saúde São Paulo Brazil Undergraduate Program Medical School Universidade Nove de Julho Bauru São Paulo Brazil Department of Surgery Stomatology Pathology and Radiology Bauru School of Dentistry University of São Paulo (USP) São Paulo usp.br BRA Bauru Brazil Department of Chemistry Institute of Environmental Chemical and Pharmaceutical Sciences Federal University of São Paulo São Paulo unifesp.br BRA Diadema Brazil Department of Physics School of Sciences POSMAT-Post-Graduate Program in Materials Science and Technology São Paulo State University (UNESP) São Paulo Bauru Brazil Department of Research and Development (RD) and Innovation Center Triplet Biotechnology Solutions Inc Bauru São Paulo Brazil Post-Graduate Program in Dentistry Uniderp Anhanguera University Mato Grosso do Sul Campo Grande Brazil Post-Graduate Program in Integrated Dental Sciences University of Cuiabá (UNIC) Mato Grosso do Sul Cuiabá Brazil Department of Physics School of Sciences São Paulo State University (UNESP) São Paulo unesp.br BRA Bauru Brazil

Chronic wounds have a significant impact on patients’ quality of life, necessitating the management of pain, infection, bleeding, and emotional challenges. Debridement, which involves the removal of nonviable tissue, is crucial for promoting wound healing. In addition to surgical methods, cost-effective alternatives such as local solutions and ointments with biological properties have been explored. The use of natural compounds with anti-inflammatory, antibacterial, and collagen-synthesizing abilities holds promise for wound healing. This in vitro and in vivo preclinical study aimed to assess the safety and effectiveness of a wound healing ointment containing bioactive ingredients derived from medicinal plants (extracts, essential oils, and vegetable oils). The chemical composition of the ointment was characterized using Fourier transform infrared (FTIR) spectroscopy to gain insights into its synergistic action. Preclinical tests were conducted following standardized protocols. FTIR analysis revealed similarities between the product’s spectrum and that of bioactive compounds. The in vitro tests demonstrated that all formulations of the ointment induced no cell death, DNA damage, or acute toxicity in cell cultures (p < 0.05). No lethal dose was observed, indicating the safety of the ointment at all concentrations. The ointment also stimulated a notably more organized, significantly higher collagen production compared to control groups (p < 0.05). In vivo preclinical analyses also demonstrated no adverse responses being effective in the healing process compared to the control group (silver sulfadiazine) in terms of wound contraction and ulcer re-epithelization (p < 0.05). Significantly higher means of wound contraction were observed in the groups treated with the bioactive-containing ointment when compared to both the positive control group (sulfadiazine) and the control untreated groups (p < 0.05). The regenerative ointment exhibited excellent biocompatibility and bi

关键词： biocompatibility chronic wounds natural compounds preclinical tests wound care

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Harnessing enhanced stability and high-rate capability in lithium-ion batteries using synergistic SnS 2 /MoS 2 2D nanostructures with optimized conversion/alloying reactions

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Journal of Alloys and Compounds 2024年 984卷

作者： Boya Venugopal Ravi Mudike Ranjith Ravi Prasanta Kumar Sahoo Abhishek Tripathi Indrajit Shown Institute of Atomic and Molecular Sciences Academia Sinica Taipei 10617 Taiwan Nanoscience and Technology Program Taiwan International Graduate Program Academia Sinica Taipei 11529 Taiwan Department of Engineering and System Science National Tsing Hua University Hsinchu 30013 Taiwan School of Science Minzu University of China Beijing 100081 China Department of Chemistry Hindustan Institute of Technology and Science Chennai 603103 India National Institute of Hydrology Jalvigyan Bhawan Roorkee 247667 India Department of Metallurgical and Material Engineering Malaviya National Institute of Technology Jaipur 302017 India

Recently, there has been a significant interest in the application of SnS 2 /MoS 2 2D nanostructure composites in lithium-ion batteries (LIBs) due to their advantageous conversion, intercalation, and alloying reactions, leading to high capacity during charge and discharge cycles. In this study, we successfully synthesized SnS 2 /MoS 2 composites with a 2D-nanoplate morphology using a single-step hydrothermal method. Specifically, the optimized SnS 2 /MoS 2 -3:1 composite was tested as anodes in coin cell LIBs, demonstrating an impressive capacity of 710 mAh/g at a current density of 500 mA/g, along with outstanding stability (800 cycles) and remarkable rate capability compared to other composites. The excellent electrochemical performance of the SnS 2 /MoS 2 -3:1 composite can be attributed to the moderately coupled SnS 2 and MoS 2 2D-nanosheets, which provide short lithium-ion transportation lengths, low charge transfer resistance, and dominant capacitive behavior.

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Application of construction and demolition waste (gypsum and mortar) for the removal of metal ions, Pb 2+ , Cu 2+ , and Ni 2+

Cleaner Chemical Engineering

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Cleaner Chemical Engineering 2025年 11卷

作者： Jefferson Luiz Alves Marinho Francisco Assis Bezerra da Cunha Raimundo Nonato Pereira Teixeira Henrique Douglas Melo Coutinho Jorge Marcell Coelho Menezes Francisco José de Paula Filho Lucia Raquel de Lima Cícera Datiane de Morais Oliveira Tintino Hyan Thompson Oliveira Lopes Paulo Ives Pereira de Alcântara Post-Graduate Program in Biological Chemistry - PPQB at the Regional University of Cariri - URCA Crato Ceará Brazil Science and Technology Center at the Federal University of Cariri - UFCA Juazeiro do Norte Ceará Brazil Pharmacotoxicological Prospection of Bioactive Products Laboratory - UFPE Recife Pernambuco Brazil Analytical and Environmental Chemistry Laboratory - URCA Crato Ceará Brazil

The intensification of human activities, consumption, production, and exploitation of raw materials, coupled with rapid population growth and industrial activity development, has led to significant environmental impacts. As civilization progresses, the level of environmental pollution with toxic metals has also intensified. The ability to quickly detect heavy metal pollution in wastewater and find its source is critical for environmental monitoring and protection. In the search for cheaper and more economical materials to be used as precipitants, civil construction waste has been used for this application. In this context, the present study aimed to evaluate the utilization of construction and demolition waste (gypsum and cementitious mortar) in the retention of Copper, Lead, and Nickel metal ions. The assessment of the removal capacity of these metal ions using gypsum powder and cementitious mortar was conducted through chemical precipitation using batch experiments. The results obtained for Pb 2+ ions showed that increasing the mass of gypsum from 10 to 100 g resulted in precipitation rates ranging from 97.29 to 98.31 %. Gypsum also proved to be a viable alternative for Cu 2+ precipitation with rates of 92.99 to 96.65 %, while the most significant retention rate for Ni 2+ was observed for the mass of 100 g, reaching 94.63 %. In experiments using different types of cementitious mortar (ACI, ACII, ACIII, and common) as precipitants in a solution contaminated with copper at a constant concentration of 600 mg/L, it was found that the precipitation rates were practically the same, with ACIII mortar showing the highest percentage of precipitation. Therefore, the results obtained demonstrated that construction and demolition waste by-products rich in gypsum and cementitious mortar are efficient in removing toxic metals, representing promising alternatives for wastewater decontamination.

关键词： Toxic metals Chemical precipitation Construction and demolition waste Metal removal Geomaterials

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Hatching performances of native chicken supplemented L-arginine in ration and in Ovo injection

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AIP Conference Proceedings 2023年第1期2628卷

作者： I. Muing W. Pakiding S. Purwanti Student of Animal Husbandry Science and Technology Study Program Post Graduate School Hasanuddin University Makassar Indonesia Department of Animal Production Faculty of Animal Husbandry Hasanuddin University Makassar Indonesia Department of Animal Nutrition Faculty of Animal Husbandry Hasanuddin University Makassar Indonesia

This study aims to determine the effect of supplemented by L-Arginine in ration and Treated by L-Arginine in-ovo injection on the hatching performance of native chickens. This study used 60 fertile eggs obtained from hens supplemented by 0% L-Arginine in ration and 60 fertile eggs obtained from hens supplemented by 0.25% L-Arginine in ration. Eggs are arranged by Randomized Block Design with 4 treatments and 3 groups. The treatment consists of P0 (Control=Ration+0% L-Arginine and no L-Arginine injection), P1 (Ration+0% L-Arginine and 2% L-Arginine injection), P2 (Ration+0.25% and without L-Arginine injection), and P3 (Ration+0.25% and injection 2% L-Arginine). The results showed that supplemented by L-Arginine in ration and Treated by L-Arginine in-ovo injection no significant (P>0.05) on the hatching performance of native chickens. We conclude that supplemented by L-Arginine in ration and Treated by L-Arginine in-ovo injection no significant on hatching performance of native chickens although there is a tendency that supplemented of the L-Arginine in ration and Treated by L-Arginine in-ovo injection shows a better trend.

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Preliminary study: Production and quality of signal grass (Brachiaria decumbens) on the post mining land

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AIP Conference Proceedings 2023年第1期2628卷

作者： N. A. A. Toputri R. A. Habibi E. Harri Sema R. F. Utamy S. Hasan Animal Husbandry and Technology Post-Graduate Program Hasanuddin University Makassar Indonesia Nursery PT. Vale Sorowako East Luwu South Sulawesi Indonesia Animal Nutrition and Feed Technology Faculty of Agriculture Puangrimaggalatung University Sengkang Indonesia Faculty of Animal Science Universitas Hasanuddin Makassar South Sulawesi Indonesia

The post-mining land decrease soil fertility. Soil fertility is required for plant growth. One way to minimize this soil fertility is by planting grass and legume in a mixed-cropping system. This preliminary study was aimed to evaluate the production and quality of signal grass and legume on the post-mining land of PT Vale Indonesia, Tbk. This study used a descriptive/survey method such as direct measurements and observations in the field. The results showed the average production of fresh weight (7.5 tons/Ha), dry matter (1.5 tons/Ha), chlorophyll (30 mg/g leaves), and leaf area (22.5 cm) of signal grass without legumes. Meanwhile, the average production of fresh weight (15.80 tons/Ha), dry matter (3.16 tons/Ha), chlorophyll (38 mg/g leaves), and leaf area (35.6 cm) of signal grass with legumes.

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Terahertz Landau Polaritons in Nano-slots: Ultrastrong Coupling under Extreme Spatial Confinement

Terahertz Landau Polaritons in Nano-slots: Ultrastrong Coupl...

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International Conference on Infrared and Millimeter Waves

作者： Dasom Kim Sunghwan Kim Dukhyung Lee Shuang Liang Fuyang Tay Michael J. Manfra Dai-Sik Kim Junichiro Kono Department of Electrical and Computer Engineering Rice University Houston TX USA Applied Physics Graduate Program Smalley-Curl Institute Rice University Houston TX USA Department of Physics Long-wavelength Nanotechnology Laboratory and Quantum Photonics Institute Ulsan National Institute of Science and Technology (UNIST) Ulsan South Korea Department of Physics and Astronomy Purdue University West Lafayette IN USA Birck Nanotechnology Center Purdue University West Lafayette IN USA Elmore Family School of Electrical and Computer Engineering Purdue University West Lafayette IN USA School of Materials Engineering Purdue University West Lafayette IN USA Department of Physics and Astronomy Rice University Houston TX USA Department of Material Science and NanoEngineering Rice University Houston TX USA

We report ultrastrong coupling of the cyclotron resonance of a two-dimensional electron gas in a GaAs quantum well to terahertz cavity photons under extreme confinement to the nanometer scale. This was realized by an array of nano-slots fabricated close to the quantum well layer on the GaAs substrate. Our terahertz magnetospectroscopic measurements revealed two polariton branches as a function of applied magnetic field. While the photon-like part of the two polariton branches was clearly observed, the matter-like part was generally elusive. Our electromagnetic simulations quantitatively reproduce our observation for the upper-polariton branch. However, for the lower-polariton branch, our simulations predict a pronounced resonance, which was absent in experimental spectra. This discrepancy may be a consequence of the breakdown of the dipole approximation in this extreme confinement situation.

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Role of plant genetic resources in encountering climate change challenge 10

Role of plant genetic resources in encountering climate chan...

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10th Annual International Conference 2020 on Environmental and Life sciences, AIC-ELS 2020

作者： Ichsan, C.N. Darusman Sulaiman, M.I. Andini, R. Doctoral Program in Agricultural Sciences Post Graduate School Universitas Syiah Kuala Jl. Tgk. Chik Pante Kulu No.3 Banda Aceh Indonesia Department of Soil Science Universitas Syiah Kuala Jl. Tgk. Hasan Krueng Kalee No. 3 Banda Aceh Indonesia Department of Agricultural Product Technology Universitas Syiah Kuala Jl. Tgk. Hasan Krueng Kalee No. 3 Banda Aceh Indonesia Department of Forestry Universitas Syiah Kuala Jl. Tgk. Hasan Krueng Kalee No. 3 Banda Aceh Indonesia

The world is encountering a global threat: Climate change. It is estimated that the average air temperature will raise 3.7-7.8 °C by 2100. The possible impacts will vary, however, agriculture will be adversely affected marked with yield loss of staple crops such as rice and maize and altered post-harvest quality of horticulture products. On the other hand, the world Food and Agriculture Organization (UN-FAO) has set a target 'zero hunger' by 2030', despite the five big challenges ahead: I) protracted conflict, ii) growing inequality, iii) rapid urbanization, iv) economic challenges, v) drought and natural disasters. The existing plant genetic resources, particularly the wild, neglected, and underutilized species has a great role and bears big potential to be exploited and targetted to achieve food and nutrition security, esp. in the densely populated regions with malnutrition problem e.g. in Asia and sub-Saharan regions. However, a key to future and sustainable crop production lies in the collection of crop and their wild relatives stored in ex-situ, or in-situ. This paper aims to explain the importance of plant genetic resources as well as the potential of some underutilized crops closely attributed with drought resistence, such as sorghum (Sorghum bicolor L. Moench), amaranth (Amaranthus sp.). These crops bear potential to support national food security program. © Published under licence by IOP Publishing Ltd.

关键词： Crops

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Phage display-derived alpaca nanobodies as potential therapeutics for Naja atra snake envenomation

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Applied and Environmental Microbiology 2024年第8期90卷 1页

作者： Wang, Wei-Chu Chang, Jungshan Lee, Chi-Hsin Chiang, Yu-Wei Leu, Sy-Jye Mao, Yan-Chiao Chiang, Jen-Ron Yang, Chun-Kai Wu, Chao-Jung Yang, Yi-Yuan Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei Taiwan International Master/Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei Taiwan International Ph.D. Program for Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei Taiwan School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan Core Laboratory of Antibody Generation and Research Taipei Medical University Taipei Taiwan Department of Medical Research Taipei Veterans General Hospital Taipei Taiwan Department of Biology and Anatomy National Defense Medical Center Taipei Taiwan Foundation for Poison Control Taipei Taiwan Department of Microbiology and Immunology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan School of Medicine National Defense Medical Centre Taipei Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan Division of Clinical Toxicology Department of Emergency Medicine Taichung Veterans General Hospital Taichung Taiwan Bioproduction Plants National Institute of Infectious Diseases and Vaccinology National Health Research Institutes Miaoli Taiwan Interdisciplinary Research on Ecology and Sustainability National Dong Hwa University Hualien Taiwan

Naja atra, the Chinese cobra, is a major cause of snake envenomation in Asia, causing hundreds of thousands of clinical incidents annually. The current treatment, horse serum-derived antivenom, has unpredictable side effects and presents manufacturing challenges. This study focused on developing new-generation snake venom antidotes by using microbial phage display technology to derive nanobodies from an alpaca immunized with attenuated N. atra venom. Following confirmation of the immune response in the alpaca, we amplified VHH genes from isolated peripheral blood mononuclear cells and constructed a phage display VHH library of 1.0 × 107 transformants. After four rounds of biopanning, the enriched phages exhibited increased binding activity to N. atra venom. Four nanobody clones with high binding affinities were selected: aNAH1, aNAH6, aNAH7, and aNAH9. Specificity testing against venom from various snake species, including two Southeast Asian cobra species, revealed nanobodies specific to the genus Naja. An in vivo mouse venom neutralization assay demonstrated that all nanobodies prolonged mouse survival and aNAH6 protected 66.6% of the mice from the lethal dosage. These findings highlight the potential of phage display-derived nanobodies as valuable antidotes for N. atra venom, laying the groundwork for future applications in snakebite treatment. Copyright © 2024 American Society for Microbiology. All Rights Reserved.

关键词： Mammals

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Gold Nanoparticle Decorated Bismuth Vanadate Casting on Screen-Printed Electrode for Chlortetracycline Detection in Tap Water

SSRN

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SSRN 2024年

作者： Ngo, Duy Ba Gopi, Praveen Kumar Rajkumar, Muniyandi Chen, Shen-Ming Rijiravannich, Patsamon Khownarumit, Porntip Somasundrum, Mithran Surareungchai, Werasak Bangkhuntien-chaitalay Rd. Bangkok10150 Thailand Analytical Sciences and National Doping Test Institute Mahidol University Rama VI Rd. Bangkok10400 Thailand Electroanalysis and Bioelectrochemistry Lab Department of Chemical Engineering and Biotechnology National Taipei University of Technology No.1 Section 3 Chung-Hsiao East Rd. Taipei106 Taiwan Bioscience and System Biology Research Team National Center for Genetic Engineering and Biotechnology National Sciences and Technology Development Agency at KMUTT Bangkhuntien-chaitalay Rd. Bangkok10150 Thailand Pilot Plant Development and Training Institute KMUTT Bangkhuntien-chaitalay Rd. Bangkok10150 Thailand Nanoscience and nanotechnology graduate program Faculty of Science KMUTT Pracha Uthit Rd. Bangkok10140 Thailand PSG College of Arts and Science Civil Aerodrome Post Tamil Nadu Coimbatore641014 India Quarter 6 Linh Trung Ward Thu Duc City Ho Chi Minh City720400 Viet Nam

Background Chlortetracycline (CTC) belongs to the class of tetracycline’s compounds, which is known for its antibacterial activity. CTC was largely consumed by farm animals than humans, which leads to the growth antibiotic – resistant bacteria and environmental contamination. So far no one reported the electrochemical detection and determination of CTC by using AuNPs@BiVO4 composite. Some reports have been reported using conventional chromatography which is most expensive, time-consuming and highly equipped method. Results Here, we report a simple method for preparing gold nanoparticle decorated bismuth vanadate (AuNPs@BiVO4), which was dropped cast on a screen-printed carbon electrode (SPCE). The AuNPs@BiVO4 and AuNPs@BiVO4/SPCE materials were characterized using TEM, SEM-EDX, XPS, DLS, ELS, EIS, and CV. The as-prepared AuNPs@BiVO4/SPCE was used to detect and determine chlortetracycline (CTC) by different pulse potentials in phosphate buffer pH 7.0. The electrode possessed a wide linear range of 0.99 – 19.06 µM, with obtained LOD = 0.15 µM, LOQ = 0.49 µM, and sensitivity = 0.059 μA μM-1 cm-2. It also exhibited good selectivity, stability, and repeatability, recovering 87.14% - 100% for detecting CTC in Mili Q and tap water. Significance Facile and rapid synthesis of AuNPs@BiVO4 nanocomposite film modified electrode at physiological pH conditions has been prepared and A highly electrochemical detection and determination of CTC using AuNPs@BiVO4 nanocomposite film has been developed for the first time. Thus, the proposed electrode could be applied for the detection and determination of CTC in water sources and has the potential to be used for real sample analysis. © 2024, The Authors. All rights reserved.

关键词： Nanocomposites

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