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SSRN 2023年

作者： Similatan, Kaye M. Arcadio, Cris Gel Loui A. Navarro, Carl Kenneth P. Capangpangan, Rey Y. Bacosa, Hernando P. Environmental Science Graduate Program Department of Biological Sciences College of Science and Mathematics Mindanao State University-Iligan Institute of Technology Iligan9200 Philippines Palawan Bataraza5306 Philippines Mindanao State University-Main Campus Lanao del Sur Marawi9700 Philippines REY Laboratories Research Division Mindanao State University at Naawan Misamis Oriental Naawan9200 Philippines Department of Physical Sciences and Mathematics College of Marine and Allied Sciences Mindanao State University at Naawan Naawan9023 Philippines

The Philippines is an archipelago that relies on marine resources. Butuan Bay in the Philippines supports aquaculture, which can contribute to and can be impacted by plastic pollution. However, the microplastics (MP) in milkfish, an important aquaculture species in the area, are yet to be ascertained. This study determined the prevalence of microplastics in the surrounding seawater and in the stomach of adult milkfish from cages in Butuan and Nasipit in Butuan Bay. Water samples in Nasipit and Butuan contain 0.20 items/L and 1.00 items/L, respectively. MPs in milkfish in Butuan (10.27 items/individual) were significantly higher than in Nasipit (5.40 items/individual). A total of 235 MPs in 29 out of 30 fish samples (97%) from the two sites were detected. The dominant MP shape and color were fiber and blue, respectively. The presence of microplastics in the milkfish may indicate a possible risk to the fish species and human health. © 2023, The Authors. All rights reserved.

关键词： Microplastic

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Application of construction and demolition waste (gypsum and mortar) for the removal of metal ions, Pb 2+ , Cu 2+ , and Ni 2+

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Cleaner Chemical Engineering 2025年 11卷

作者： Jefferson Luiz Alves Marinho Francisco Assis Bezerra da Cunha Raimundo Nonato Pereira Teixeira Henrique Douglas Melo Coutinho Jorge Marcell Coelho Menezes Francisco José de Paula Filho Lucia Raquel de Lima Cícera Datiane de Morais Oliveira Tintino Hyan Thompson Oliveira Lopes Paulo Ives Pereira de Alcântara Post-Graduate Program in Biological Chemistry - PPQB at the Regional University of Cariri - URCA Crato Ceará Brazil Science and Technology Center at the Federal University of Cariri - UFCA Juazeiro do Norte Ceará Brazil Pharmacotoxicological Prospection of Bioactive Products Laboratory - UFPE Recife Pernambuco Brazil Analytical and Environmental Chemistry Laboratory - URCA Crato Ceará Brazil

The intensification of human activities, consumption, production, and exploitation of raw materials, coupled with rapid population growth and industrial activity development, has led to significant environmental impacts. As civilization progresses, the level of environmental pollution with toxic metals has also intensified. The ability to quickly detect heavy metal pollution in wastewater and find its source is critical for environmental monitoring and protection. In the search for cheaper and more economical materials to be used as precipitants, civil construction waste has been used for this application. In this context, the present study aimed to evaluate the utilization of construction and demolition waste (gypsum and cementitious mortar) in the retention of Copper, Lead, and Nickel metal ions. The assessment of the removal capacity of these metal ions using gypsum powder and cementitious mortar was conducted through chemical precipitation using batch experiments. The results obtained for Pb 2+ ions showed that increasing the mass of gypsum from 10 to 100 g resulted in precipitation rates ranging from 97.29 to 98.31 %. Gypsum also proved to be a viable alternative for Cu 2+ precipitation with rates of 92.99 to 96.65 %, while the most significant retention rate for Ni 2+ was observed for the mass of 100 g, reaching 94.63 %. In experiments using different types of cementitious mortar (ACI, ACII, ACIII, and common) as precipitants in a solution contaminated with copper at a constant concentration of 600 mg/L, it was found that the precipitation rates were practically the same, with ACIII mortar showing the highest percentage of precipitation. Therefore, the results obtained demonstrated that construction and demolition waste by-products rich in gypsum and cementitious mortar are efficient in removing toxic metals, representing promising alternatives for wastewater decontamination.

关键词： Toxic metals Chemical precipitation Construction and demolition waste Metal removal Geomaterials

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The capacity of osmotic for the living of aquatic plant at the Area of Tahura KGPAA Mangkunagoro I, the Province of Central Java

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AIP Conference Proceedings 2023年第1期2683卷

作者： Masrochatun Sutrisno Anggoro Ferry Hermawan Master Program of Environmental Science School of Post-Graduate Diponegoro University Semarang - Indonesia Department of Aquatic Resources Faculty of Fisheries and Marine Science Diponegoro University Semarang – Indonesia Department of Civil Engineering Faculty of Engineering Diponegoro University Semarang – Indonesia

The existence of aquatic plants has a significant influence on the biota living at wellspring. The osmotic pressure is significant research to understand the adaptation of the environment changing to organism physiology. This research aims to know the Osmotic Work Rate by comparing osmolarity water value to aquatic plant plasma. The research method is the descriptive analysis of laboratory test results. The water sample was taken from the seven locations of the wellspring. Osmotic work rate is taken from comparing the plasma osmolarity value of the aquatic plant to water Osmolarity. Osmotic work rate zero means osmoregulation patterns isosmotic. The osmotic work rate greater than zero implies osmoregulation patterns hyperosmotic regulatory and osmoregulation patterns hypo-osmotic regulatory if the Osmotic work rate is less than zero. The patterns are used from the seven locations of good springs are the same, osmoregulation patterns of Hyperosmotic regulatory to the environment because the plasma osmolarity of water plants is more significant than water osmolarity.

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Implications of technological improvement and circular agriculture on environmental sustainability of sugarcane production

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Cleaner environmental Systems 2025年 18卷

作者： Aakriti Deuja Min Hein Khant Thapat Silalertruksa Shabbir H. Gheewala Trakarn Prapaspongsa Graduate Program in Environmental and Water Resources Engineering Department of Civil and Environmental Engineering Faculty of Engineering Mahidol University Nakhon Pathom Thailand Department of Environmental Engineering Faculty of Engineering King Mongkut's University of Technology Thonburi Bangkok Thailand The Joint Graduate School of Energy and Environment King Mongkut's University of Technology Thonburi Bangkok Thailand Centre of Excellence on Energy Technology and Environment Ministry of Higher Education Science Research and Innovation Bangkok Thailand

The spatially differentiated environmental impacts and associated costs of technological improvement and circular agricultural practices in sugarcane production were assessed. Analysis of the cause-effect relationship between the key processes and substances each helped develop alternative scenarios for impact reduction. PM 2.5 emissions contributed to 92 % of the total human health impacts from open burning of field residues. Freshwater ecotoxicity, mainly due to ametryn emissions from pesticide application, contributed to 47 % of the total damage to the ecosystem. The environmental costs were 116 % higher than the value of sugarcane production, signifying the critical importance of adopting alternative pathways that provide economic benefits from environmental cost reduction compared to the production value. Scenarios considering green cane harvesting and waste management approaches demonstrated high potential for total impact reduction of 99 % and 97 %, respectively, and economic gains of 202 and 225 billion THB, respectively (5.76 and 6.42 billion USD, respectively). The economic benefits of waste utilization were 137 % higher than the value of sugarcane production, demonstrating the potential benefits of product substitution to help mitigate impacts. The core findings highlight the significance of the PM 2.5 impact-related external costs and underscore the benefits of adopting green cane harvesting in conjunction with on-field waste utilization to mitigate the impact of open burning and produce value-added products. Technological improvement and circular agricultural practices coupled with valuation of spatially differentiated impacts can provide useful and more accurate information to policymakers, to prioritize the implementation of mitigation strategies for enhancing the environmental sustainability of sugarcane production.

关键词： Life cycle assessment On-site and supply chain emissions Human health Ecosystem environmental cost environmental sustainability

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The unseen invaders: Tracking phylogeographic dynamics and genetic diversity of cryptic Pomacea canaliculata and P. maculata (Golden apple snails) across Taiwan

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Ecology and Evolution 2024年第4期14卷 e11268页

作者： Banerjee, Pritam Dey, Gobinda Maity, Jyoti Prakash Stewart, Kathryn A. Sharma, Raju Kumar Chan, Michael W. Y. Lee, Kuanhsuen Chen, Chien-Yen Department of Environmental Science Policy and Management University of California Berkeley CA United States Department of Biomedical Sciences Graduate Institute of Molecular Biology National Chung Cheng University Chiayi County Min-Hsiung Taiwan Department of Agricultural Chemistry National Taiwan University Taipei Taiwan Environmental Science Laboratory Department of Chemistry Biological Laboratory School of Applied Sciences KIIT Deemed to be University Odisha Bhubaneswar India Institute of Environmental Sciences Leiden University Leiden Netherlands Doctoral Program in Science Technology Environment and Mathematics Department of Earth and Environmental Sciences National Chung Cheng University Chiayi County Min-Hsiung Taiwan Department of Earth and Environmental Sciences National Chung Cheng University Chiayi County Min-Hsiung Taiwan Department of Emergency Medicine Ditmanson Medical Foundation Chia-Yi Christian Hospital Chiayi Taiwan Center for Nano Bio-Detection Center for Innovative Research on Aging Society AIM-HI National Chung Cheng University Chiayi Taiwan

The cryptic invasion of golden apple snails (Pomacea canaliculata and P. maculata) in Taiwan has caused significant ecological and economical damage over the last few decades, however, their management remains difficult due to inadequate taxonomic identification, complex phylogeny, and limited population genetic information. We aim to understand the current distribution, putative population of origin, genetic diversity, and potential path of cryptic invasion of Pomacea canaliculata and P. maculata across Taiwan to aid in improved mitigation approaches. The present investigation conducted a nationwide survey with 254 samples collected from 41 locations in 14 counties or cities across Taiwan. We identified P. canaliculata and P. maculata based on mitochondrial COI and compared their genetic diversity across Taiwan, as well as other introduced and native countries (based on publicly available COI data) to understand the possible paths of invasion to Taiwan. Based on mitochondrial COI barcoding, sympatric and heterogeneous distributions of invasive P. canaliculata and P. maculata were noted. Our haplotype analysis and mismatch distribution results suggested multiple introductions of P. canaliculata in Taiwan was likely originated directly from Argentina, whereas P. maculata was probably introduced from a single, or a few, introduction event(s) from Argentina and Brazil. Our population genetic data further demonstrated a higher haplotype and genetic diversity for P. canaliculata and P. maculata in Taiwan compared to other introduced regions. Based on our current understanding, the establishment of P. canaliculata and P. maculata is alarming and widespread beyond geopolitical borders, requiring a concerted and expedited national and international invasive species mitigation program. © 2024 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd.

关键词： agricultural pest biological invasion DNA barcoding golden apple snails mitochondrial COI Pomacea population genetics

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Genetic mutation patterns among glioblastoma patients in the Taiwanese population – insights from a single institution retrospective study

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Cancer Gene Therapy 2024年第6期31卷 894-903页

作者： Huang, Yu-Fen Chiao, Ming-Tsang Hsiao, Tzu-Hung Zhan, Yong-Xiang Chen, Tse-Yu Lee, Chung-Hsin Liu, Szu-Yuan Liao, Chih-Hsiang Cheng, Wen-Yu Yen, Chun-Ming Lai, Chih-Ming Chen, Jun-Peng Shen, Chiung-Chyi Yang, Meng-Yin Department of Neurosurgery Neurological Institute Taichung Veterans General Hospital Taichung Taiwan Department of Medical Research Taichung Veterans General Hospital Taichung 40705 Taiwan Precision Medicine Center Taichung Veterans General Hospital Taichung 40705 Taiwan Doctoral Program in Translational Medicine National Chung Hsing University Taichung Taiwan Rong Hsing Translational Medicine Research Center National Chung Hsing University Taichung Taiwan Institute of Medicine Chung Shan Medical University Taichung 402 Taiwan Graduate Institute of Life Science Department of Life Science College of Life Science National Chung Hsing University Taichung Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan School of Medicine Taipei Medical University Taipei Taiwan Department of Minimally Invasive Skull Base Neurosurgery Neurological Institute Taichung Veterans General Hospital Taichung Taiwan Department of Physical Therapy Hung Kuang University Taichung Taiwan Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan School of Medicine National Defense Medical Center Taipei Taiwan Department of Critical Care Medicine Taichung Veterans General Hospital Taichung Taiwan Functional Neurosurgery Division Neurological Institute Taichung Veterans General Hospital Taichung Taiwan Institute of Molecular Biology College of Life Science National Chung Hsing University Taichung Taiwan Biostatistics Task Force Taichung Veterans General Hospital Taichung Taiwan Basic Medical Education Center Central Taiwan University of Science and Technology Taichung Taiwan

This study utilized Next-Generation Sequencing (NGS) to explore genetic determinants of survival duration in Glioblastoma Multiforme (GBM) patients. We categorized 30 primary GBM patients into two groups based on their survival periods: extended survival (over two years, N = 17) and abbreviated survival (under two years, N = 13). For identifying pathogenic or likely pathogenic variants, we leveraged the ClinVar database. The cohort, aged 23 to 66 (median: 53), included 17 patients in Group A (survival >2 years, 10 males, 7 females), and 13 patients in Group B (survival <2 years, 8 males, 5 females), with a 60% to 40% male-to-female ratio. Identified mutations included CHEK2 (c.1477 G > A, p.E493K), IDH1 (c.395 G > A, p.R132H), and TP53 mutations. Non-coding regions exhibited variants in the TERT promoter (c.-146C > T, c.-124C > T) and TP53 RNA splicing site (c.376-2 A > C, c.376-2 A > G). While Group A had more mutations, statistical significance wasn’t reached, likely due to sample size. Notably, TP53, and ATR displayed a trend toward significance. Surprisingly, TP53 mutations were more prevalent in Group A, contradicting Western findings on poorer GBM prognosis. In Taiwanese GBM patients, bevacizumab usage is linked to improved survival rates, affirming its safety and effectiveness. EGFR mutations are infrequent, suggesting potential distinctions in carcinogenic pathways. Further research on EGFR mutations and amplifications is essential for refining therapeutic approaches. TP53 mutations are associated with enhanced survival, but their functional implications necessitate detailed exploration. This study pioneers genetic analysis in Taiwanese GBM patients using NGS, advancing our understanding of their genetic landscape. © The Author(s) 2024.

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Mapping of rain water harvesting potential at Keduang Sub-watershed, Central Java, Indonesia

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IOP Conference Series: Earth and environmental science 2021年第1期824卷

作者： H R Dwiatmojo Komariah A H Ramelan E Priyanto Master Program of Environmental Science Post Graduate School Sebelas Maret University Soil Science Dept. Faculty of Agriculture Sebelas Maret University Environmental Science Post Graduate School Sebelas Maret University Watershed Management Technology Centre Ministry of Environmental and Forestry

One of the main issues in agriculture in this climate change era is the water crisis. It caused a drought that affected the delay of rice cultivation. A study found that Wonogiri Regency has very critical with a value of 163.1%. Hence, it is necessary to have an alternative solution to overcome it. In this case, utilizing rain by harvesting rainwater (RWH) can be used as an alternative to meet water needs during the dry season and for various other uses. One of the RWH applications is a small-farm reservoir (SFR). To identify the potential locations for RWH is using location suitability modelling based on GIS. The determination of the location depends on biophysical criteria such as rainfall, slope, soil texture, stream order, and land use. The socio-economic attributes consist of the distance to the river, road, settlement, and agriculture. To obtain the suitability location, after all of the maps are generated, next is reclassify the value to 0 and 1. In the end, the maps calculate with a raster calculator to define the suitability location that has value 1. Location and dimension details can find out. This study aims to determine the potential of RWH for agriculture (in specific, SFR) at Keduang Sub-watershed as a consideration for stakeholders' decision. The results showed 226 areas are potential for SFR implementation and will make it easier for stakeholders to decide by comparing the suitability location map and the long-term strategic map.

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Preparation of cellulose adsorbent based on banana peel waste (Musa paradisiaca): Green activation and adsorption of Rhodamine B from the aquatic environment

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Nano-Structures and Nano-Objects 2024年 38卷

作者： Neolaka, Yantus A.B. Baunsele, Since Dortia Nitbani, Febri Odel de Rozari, Philiphi Widyaningrum, Bernadeta Ayu Lawa, Yosep Amenaghawon, Andrew Nosakhare Darmokoesoemo, Handoko Kusuma, Heri Septya Department of Chemical Education Faculty of Education and Teachers Training University of Nusa Cendana Nusa Tenggara Timur Kupang Indonesia Department of Environmental Science Post Graduate Study University of Nusa Cendana Nusa Tenggara Timur Kupang Indonesia Department of Chemistry Faculty of Science and Engineering University of Nusa Cendana Nusa Tenggara Timur Kupang Indonesia Research Center for Biomass and Bioproducts National Research and Innovation Agency (BRIN) Jalan Raya Bogor Km.46 Cibinong Bogor Indonesia Bioresources Valorization Laboratory Department of Chemical Engineering University of Benin Edo State Benin City Nigeria Department of Chemistry Faculty of Science and Technology Airlangga University Mulyorejo Surabaya Indonesia Department of Chemical Engineering Faculty of Industrial Technology Universitas Pembangunan Nasional “Veteran” Yogyakarta Indonesia

In this study, the successful development of an adsorbent based on banana peel (Musa paradisiaca) activated using lime juice (Citrus aurantifolia) has been reported. The physicochemical parameters of the adsorbent were investigated using an XRD instrument, which showed that the crystal structure of the banana peel (BP) and green activated banana peel (ABP) had a 2θ peak between 18 and 25°, which is the typical peak of cellulose 1. The FTIR spectra showed that green activation of BP specifically changes BP's structure. A bonded O–H group is seen at a wavelength of 3300 cm⁻¹, a peak at 2921 cm⁻¹ is assigned to C-H stretching, the peak at 1615 cm⁻¹ is typical for C[dbnd]O stretching, the peak at 1598 cm⁻¹ is the characteristic peak of C-C aromatic skeletal vibration and the peak at 1034 cm⁻¹ is from the C-O-C and C-C stretch. The FESEM image showed that the morphology of ABP looks rougher and more porous than the morphology of BP. BET-BJH data showed the weak interactions during adsorption can lead to a higher adsorption capacity because these interactions are reversible. The adsorption of RhB with a maximum initial concentration was 70 mg L⁻¹ on 0.2 g of ABP at pH 6, in 10 min at 323 K. The adsorption mechanism followed a pseudo-second-order kinetic model, while the isotherm adsorption followed the Freundlich model. Thermodynamic analysis revealed that the adsorption process is exothermic and spontaneous, as indicated by the enthalpy value of −25.342 kJ mol⁻¹ and entropy of 0.572 kJ mol⁻¹. In summary, this adsorbent can effectively eliminate coloured pollutants from wastewater. © 2024 Elsevier B.V.

关键词： Banana peel Green activation Musa paradisiaca Rhodamine B Wastewater

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Carbon Nanofibers in Predicted environmentally Relevant Concentrations Intensify Monocystis Sp. Infection and Affect the Lumbricus Terrestris Earthworms' Health

SSRN

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SSRN 2023年

作者： Montalvão, Mateus Flores Gomes, Alex Rodrigues Guimarães, Abraão Tiago Batista Rodrigues, Aline Sueli de Lima de Matos, Letícia Paiva Mendonça, Juliana dos Santos da Luz, Thiarlen Marinho da Silva Matos, Stênio Gonçalves Rahman, M. Safiur Ragavendran, Chinnasamy Senthil-Nathan, Sengottayan Guru, Ajay Rakib, Md. Refat Jahan Mubarak, Nabisab Mujawar Rahman, Md. Mostafizur Rocha, Thiago Lopes Islam, Abu Reza Md. Towfiqul Malafaia, Guilherme Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia MG Uberlândia Brazil Laboratory of Toxicology Applied to the Environment Goiano Federal Institute Urutaí Campus. Rodovia Geraldo Silva Nascimento 25 km Zona Rural GO Urutaí Brazil Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute GO Urutaí Brazil Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás GO Goiânia Brazil Bangladesh Atomic Energy CommissionBangladesh Bangladesh Periyar University India Division of Biopesticides and Environmental Toxicology Sri Paramakalyani Centre for Excellence in Environmental Sciences Manonmaniam Sundaranar University Tirunelveli Tamil Nadu Alwarkurichi627 412 India Department of Cariology Saveetha Dental College and Hospitals SIMATS Tamil Nadu Chennai600 077 India Noakhali Science and Technology University Noakhali Bangladesh Petroleum and Chemical Engineering Faculty of Engineering Universiti Teknologi Brunei Bandar Seri BegawanBE1410 Brunei Jahangirnagar University Dhaka1342 Bangladesh Laboratory of Environmental Biotechnology and Ecotoxicology Institute of Tropical Pathology and Public Health Federal University of Goiás Goiás Goiania Brazil Department of Disaster Management Begum Rokeya University Rangpur5400 Bangladesh

We aimed at the ecotoxicity of CNFs (at 10 and 100 mg/kg) in Lumbricus terrestris earthworms naturally infected with Monocystis sp. After 28-d of exposure, treatments did not affect the survival rate. However, we observed a significant loss of body biomass, and Monocystis sp. infection in seminal vesicles was potentiated by exposure to CNFs. Earthworms exposed to CNFs showed a redox imbalance in the seminal vesicle, muscle, and intestine and an alteration in nitric oxide production in these organs. In muscles, we also noticed a significant reduction in AChE activity in earthworms exposed to CNFs. The histopathological analyses revealed the treatments' significant effect on the structures of the different evaluated tissues. When taken together and after applying IBRv2 and PCA, we noticed that the response of earthworms to CNFs at 100 mg/kg showed a more significant deviation from the unexposed group. Thus, we demonstrate that CNFs increase the parasite load of Monocystis sp. of adult L. terrestris earthworms and induce biochemical changes and histopathological changes, especially at 100 mg/kg. Our results point to the additional impact these nanomaterials can have on the health of earthworms, signaling the need for greater attention to their disposal and ecotoxicological effects on soil organisms. © 2023, The Authors. All rights reserved.

关键词： Muscle

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technology Roadmap for Flexible Sensors

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ACS NANO 2023年第6期17卷 5211-5295页

作者： Luo, Yifei Abidian, Mohammad Reza Ahn, Jong-Hyun Akinwande, Deji Andrews, Anne M. Antonietti, Markus Bao, Zhenan Berggren, Magnus Berkey, Christopher A. Bettinger, Christopher John Chen, Jun Chen, Peng Cheng, Wenlong Cheng, Xu Choi, Seon-Jin Chortos, Alex Dagdeviren, Canan Dauskardt, Reinhold H. Di, Chong-an Dickey, Michael D. Duan, Xiangfeng Facchetti, Antonio Fan, Zhiyong Fang, Yin Feng, Jianyou Feng, Xue Gao, Huajian Gao, Wei Gong, Xiwen Guo, Chuan Fei Guo, Xiaojun Hartel, Martin C. He, Zihan Ho, John S. Hu, Youfan Huang, Qiyao Huang, Yu Huo, Fengwei Hussain, Muhammad M. Javey, Ali Jeong, Unyong Jiang, Chen Jiang, Xingyu Kang, Jiheong Karnaushenko, Daniil Khademhosseini, Ali Kim, Dae-Hyeong Kim, Il-Doo Kireev, Dmitry Kong, Lingxuan Lee, Chengkuo Lee, Nae-Eung Lee, Pooi See Lee, Tae-Woo Li, Fengyu Li, Jinxing Liang, Cuiyuan Lim, Chwee Teck Lin, Yuanjing Lipomi, Darren J. Liu, Jia Liu, Kai Liu, Nan Liu, Ren Liu, Yuxin Liu, Yuxuan Liu, Zhiyuan Liu, Zhuangjian Loh, Xian Jun Lu, Nanshu Lv, Zhisheng Magdassi, Shlomo Malliaras, George G. Matsuhisa, Naoji Nathan, Arokia Niu, Simiao Pan, Jieming Pang, Changhyun Pei, Qibing Peng, Huisheng Qi, Dianpeng Ren, Huaying Rogers, John A. Rowe, Aaron Schmidt, Oliver G. Sekitani, Tsuyoshi Seo, Dae-Gyo Shen, Guozhen Sheng, Xing Shi, Qiongfeng Someya, Takao Song, Yanlin Stavrinidou, Eleni Su, Meng Sun, Xuemei Takei, Kuniharu Tao, Xiao-Ming Tee, Benjamin C. K. Thean, Aaron Voon-Yew Trung, Tran Quang Wan, Changjin Wang, Huiliang Wang, Joseph Wang, Ming Wang, Sihong Wang, Ting Wang, Zhong Lin Weiss, Paul S. Wen, Hanqi Xu, Sheng Xu, Tailin Yan, Hongping Yan, Xuzhou Yang, Hui Yang, Le Yang, Shuaijian Yin, Lan Yu, Cunjiang Yu, Guihua Yu, Jing Yu, Shu-Hong Yu, Xinge Zamburg, Evgeny Zhang, Haixia Zhang, Xiangyu Zhang, Xiaosheng Zhang, Xueji Zhang, Yihui Zhang, Yu Zhao, Siyuan Zhao, Xuanhe Zheng, Yuanjin Zheng, Yu-Qing Zheng, Zijian Zhou, Tao Zhu, Bowen Zhu, Ming Zhu, Rong Zhu, Yangzhi Zhu, Yong Zou, Guijin Chen, Xiaodong 08-03 Innovis Singapore 138634 Republic of Singapore Innovative Centre for Flexible Devices (iFLEX) School of Materials Science and Engineering Nanyang Technological University Singapore 639798 Singapore Department of Biomedical Engineering University of Houston Houston Texas 77024 United States School of Electrical and Electronic Engineering Yonsei University Seoul 03722 Republic of Korea Department of Electrical and Computer Engineering The University of Texas at Austin Austin Texas 78712 United States Microelectronics Research Center The University of Texas at Austin Austin Texas 78758 United States Department of Chemistry and Biochemistry California NanoSystems Institute and Department of Psychiatry and Biobehavioral Sciences Semel Institute for Neuroscience and Human Behavior and Hatos Center for Neuropharmacology University of California Los Angeles Los Angeles California 90095 United States Colloid Chemistry Department Max Planck Institute of Colloids and Interfaces 14476 Potsdam Germany Department of Chemical Engineering Stanford University Stanford California 94305 United States Laboratory of Organic Electronics Department of Science and Technology Campus Norrköping Linköping University 83 Linköping Sweden Wallenberg Initiative Materials Science for Sustainability (WISE) and Wallenberg Wood Science Center (WWSC) SE-100 44 Stockholm Sweden Department of Materials Science and Engineering Stanford University Stanford California 94301 United States Department of Biomedical Engineering and Department of Materials Science and Engineering Carnegie Mellon University Pittsburgh Pennsylvania 15213 United States Department of Bioengineering University of California Los Angeles Los Angeles California 90095 United States School of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University Singapore 637457 Singapore Nanobionics Group Department of Chemical and Biological Engineering Monash University Clayton Australia 3800 Monash

Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional rigid counterparts. Despite rapid advancement in bench-side research over the last decade, the market adoption of flexible sensors remains limited. To ease and to expedite their deployment, here, we identify bottlenecks hindering the maturation of flexible sensors and propose promising solutions. We first analyze continued...challenges in achieving satisfactory sensing performance for real-world applications and then summarize issues in compatible sensor-biology interfaces, followed by brief discussions on powering and connecting sensor networks. Issues en route to commercialization and for sustainable growth of the sector are also analyzed, highlighting environmental concerns and emphasizing nontechnical issues such as business, regulatory, and ethical considerations. Additionally, we look at future intelligent flexible sensors. In proposing a comprehensive roadmap, we hope to steer research efforts towards common goals and to guide coordinated development strategies from disparate communities. Through such collaborative

关键词： soft materials mechanics engineering flexible electronics conformable sensors bioelectronics human-machine interfaces body area sensor networks technology translation sustainable electronics

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