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Ohwia caudata extract relieves the IL-17A-induced inflammatory response of synoviocytes through modulation of SOCS3 and JAK2/STAT3 activation

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environmental Toxicology 2023年第8期38卷 1914-1924页

作者： Lu, Cheng-You Kuo, Chia-Hua Kuo, Wei-Wen Hsieh, Dennis Jine-Yuan Wang, Tso-Fu Shih, Cheng-Yen Lin, Pi-Yu Lin, Shinn-Zong Ho, Tsung-Jung Huang, Chih-Yang Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan Department of Sports Sciences University of Taipei Taipei Taiwan Department of Biological Science and Technology China Medical University Taichung Taiwan Ph.D. Program for Biotechnology Industry China Medical University Taichung Taiwan School of Medical Laboratory and Biotechnology Chung Shan Medical University Taichung Taiwan Clinical Laboratory Chung Shan Medical University Hospital Taichung Taiwan Department of Hematology and Oncology Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Department of Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Tzu Chi University Hualien Taiwan Buddhist Tzu Chi Medical Foundation Hualien Taiwan Buddhist Compassion Relief Tzu Chi Foundation Hualien Taiwan Bioinnovation Center Buddhist Tzu Chi Medical Foundation Hualien Taiwan Department of Neurosurgery Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Integration of Chinese Medicine and Modern Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Department of Chinese Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Department of Biological Science and Technology Asia University Taichung Taiwan Center of General Education Buddhist Tzu Chi Medical Foundation Tzu Chi University of Science and Technology Hualien Taiwan

Fibroblast-like synoviocytes accumulation, proliferation and activation, and the subsequent inflammatory mediators production play a key role in the progression of rheumatoid arthritis (RA). It is well established that Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling triggers inflammation, and induces cytokine levels in RA. Ohwia caudata have long been used against many disorders. However, in RA, the effects of O. caudata have not been elucidated. In the current study, synoviocytes were used to evaluate the suppressive effects of O. caudate extract (OCE) on the pro-inflammatory cytokines production. In vitro, the underlying mechanisms by which OCE inhibits inflammatory response through regulation of suppressors of cytokine signaling 3 (SOCS3) and JAK2/STAT3 expression in IL-17A-treated HIG-82 synoviocytes were investigated. The results demonstrated that the proliferation of IL-17A-challenged cells were increased in comparison with non-stimulated control cells. The synoviocyte proliferation was decreased significantly of OCE concentrations in dose dependent manner. The p-JAK2, p-STAT3, interleukin (IL)-1β, and IL-6 were reduced in IL-17A-challenged cells treated with OCE. Furthermore, AZD1480 (a JAK2-specific inhibitor) or WP1066 (a STAT3-specific inhibitor) affected the inflammatory mediators production in IL-17A-challenged synoviocytes, and OCE failed to mitigate the IL-17A-induced inflammatory mediators and SOCS3, acting as a feedback inhibitor of the JAK/STAT3 pathway, in the presence of SOCS3 siRNA, indicating that the beneficial effects of OCE on the regulation of inflammatory response homeostasis were dependent on SOCS3 and the JAK2/STAT3 signaling pathway. Our study also showed that SOCS3 was markedly activated by OCE in RA fibroblast-like synoviocytes, thereby decreasing the JAK/STAT3 pathway, and the IL-1β, and IL-6 activation. Thus, O. caudate should be further investigated as a candidate anti-inflammatory and anti-a

关键词： Chemical activation

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Tailoring structural and magnetic properties of NiCu nanowires by electrodeposition

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Nano-Structures and Nano-Objects 2024年 39卷

作者： Castro-Lopes, S. Oliveira, D.M. Abrão, J.E. Assis, L.K.C.S. Silva, J.F.O. Neves-Araújo, J. Soares, J.M. Rodrigues, A.R. Padrón-Hernández, E. Federal Institute of Education Science and Technology of Pará (IFPA) PA Altamira 68371-441 Brazil Materials Science Post-Graduate Program Center of Exact and Natural Sciences Federal University of Pernambuco PE Recife 50740-540 Brazil Department of Physics Federal University of Pernambuco PE Recife 50740-540 Brazil University of Pernambuco Polytechnic School of Pernambuco (POLI) PE Recife 50720-001 Brazil NANOlab Center of Excellence Department of Physics University of Antwerp Groenenborgerlaan 171 Antwerp B-2020 Belgium Department of Physics State University of Rio Grande do Norte RN Mossoró 59610-190 Brazil

In this work, we investigated the tailoring of structural and magnetic properties of NiCu nanowires through electrodeposition. Continuous (S1) and composition-modulated (S2) wires were fabricated by electrodeposition using porous alumina membranes as a template. Morphological characterization revealed that the total length of the wires was 8 ± 3 µm in both S1 and S2. For the composition-modulated wires, the length of the segments with the lowest and highest Cu concentrations was 1.2 ± 0.4 µm and 226 ± 65 nm, respectively. Mapping by energy dispersive spectroscopy (EDS) revealed that the concentration of copper and nickel varied along the length of the composition-modulated nanowires, while the continuous nanowires contained a relatively constant concentration of both metals. It is demonstrated that the change in Cu concentration along the wire modifies the lattice parameter, average crystallite size (D) and lattice strain (ε) of Ni. This result is pivotal for understanding the magnetic properties of the wires, as nickel is primarily responsible for the magnetic behavior of the wires. From the ferromagnetic resonance (FMR) results, the linewidth and resonance field values for samples S1 and S2 were determined. It was demonstrated that the greater deformation in the nickel lattice in NiCu nanowires increases the angular dependence of the resonance field. Furthermore, the smaller nickel crystallite size was shown to increase spin dispersion and magnetic damping, leading to complex behavior in FMR responses. Finally, it was demonstrated how Cu can influence the magnetic properties such as coercivity (H_C) and squareness (M_R/M_S) of the wires. Overall, this work contributes to understanding the tailoring of structural and magnetic properties of NiCu nanowires through electrodeposition. © 2024 Elsevier B.V.

关键词： Electrodeposition Magnetic properties Nanowires

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Comparison of the effectiveness electrocoagulation of dye (batik waste water) using iron and zinc as an anodes 3

Comparison of the effectiveness electrocoagulation of dye (b...

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3rd International Conference on Chemical and Material Engineering, ICCME 2018

作者： Suhartana, S. Purwanto, P. Darmawan, Adi Doctoral Program in Environmental Science Diponegoro University Indonesia Post Graduate Diponegoro University Indonesia Inorganic Chemistry Laboratory Chemistry Departement Faculty of Sciences and Mathematics Diponegoro University Indonesia

This study aims to obtain dye (batik waste water) treatment by electrocoagulation with optimal results. The performance of electrocoagulation process was carried out in batch reactor. Four variables were taken which thought to greatly influence the electrocoagulation process, such as: distance between electrodes, voltage, acidity (pH) and electrolysis time. In this process, samples of 20 mL were taken out from the batch at 5, 10, 15, 20, 25, 30, 35, 40, 45 dan 50 minutes of contact time. Results obtained show that the most effective removal efficiency could be achieved at alkaline condition. Research that has been done shows that the percentage of wastewater treatment results is strongly influenced by the four variable changes. The study demonstrated that the lowest degradation efficiency occours at acid pH, while an increase temperature has only a slight effect on the electrocoagulation process. The maximum results from the electrocoagulation processes was obtained, with determine by measurement of chemical oxygen demand (COD). The results showed that, iron is better used as an anode than zinc. The effectiveness electrocoagulation reached optimal at 96.54% (at Fe anode) and 81.65% (at Zn anode), at alkaline condition (pH > 9), electrolysis time of 30 minutes, electrode distance of 1 cm and temperature at 70°C. © 2019 Published under licence by IOP Publishing Ltd.

关键词： Anodes

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The relationship between work period and use of personal protective equipment with respiratory disorder complaints in brick craftsman in Sintuk Toboh Gadang District Padang Pariaman Regency 2017 1

The relationship between work period and use of personal pro...

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1st International Conference on environmental sciences, ICES 2018

作者： Lastri, Pirna Dewata, Indang Sari, Mila Department of Environmental Science Post Graduate Program Universitas Negeri Padang Prof. Dr. Hamka Street West Air Tawar Padang-West Sumatera25131 Indonesia

Respiratory disorders are not only caused by high concentration of dust, but also affected by employee's habit and characteristics. Based on the data from Sintuk Health Center, there are 145 cases of ISPA in this region. Over all, the brick craftsman smoke and don't use the personal protective equipment. This study aims to determine the relationship between work periods and use of personal protective equipment with respiratory disorders on brick craftsman in Sintuk Toboh Gadang, Padang Pariaman Regency 2017. The research is descriptive analytic research with cross sectional approach which was conducted on 11-21 August 2017. This study used Cluster Sampling with 73 people of total sampling which then using Accidental Sampling and questionnaire to collect the data. The data analysed by using Chi-Square test. The result shows that among 73 respondents, there were 47 people (64,4%) infected respiratory disorders, 41 (56,2%) of times work, 39 (53,4%) work periods, and 55 people (75,3%) do not use personal protective equipment while working. Statistical test revealed that the variables which have relationship with the habit of respiratory disorders were times work (p=0,003, OR=5,304), work periods (p=0,000, OR=7,857), and use of personal protective equipment variables (p=0,004, OR=5,857). From the research, it was found that times work, work periods, and use of personal protective equipment have a strong impact to respiratory disorders. It is suggested that brick craftsman need to use the personal protective equipment in producing craftsman. Therefore, long work periods do not give impact to the respiratory disorders. © 2019 Published under licence by IOP Publishing Ltd.

关键词： Brick

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AstroPix: A Pixelated HVCMOS Sensor for Space-Based Gamma-Ray Measurement

arXiv

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arXiv 2025年

作者： Steinhebel, Amanda L. Caputo, Regina Violette, Daniel P. Affolder, Anthony Bauman, Autumn Chinatti, Carolyn Deshmukh, Aware Fadayev, Vitaliy Fukazawa, Yasushi Jadhav, Manoj Kierans, Carolyn Kim, Bobae Kim, Jihee Klest, Henry Kroger, Olivia Kumar, Kavic Kushima, Shin Lauenstein, Jean-Marie Leys, Richard Martinez-Mckinney, Forest Metcalfe, Jessica Metzler, Zachary Mitchell, John W. Nakano, Norito Ott, Jennifer Peric, Ivan Perkins, Jeremy S. Rudin, Max R. Shin, Taylor K.W. Sommer, Grant Striebig, Nicolas Suda, Yusuke Tajima, Hiroyasu Valverde, Janeth Zurek, Maria NASA Postdoctoral Program NASA Goddard Space Flight Center MD United States University of California Santa CruzCA United States University of Colorado DenverCO United States NASA Office of STEM Engagement WashingtonDC United States Carleton College Minnesota United States Center for Research and Exploration in Space Science and Technology Maryland United States Physics Program Graduate School of Advanced Science and Engineering Hiroshima University Japan Argonne National Laboratory Illinois United States University of Maryland MD United States Institute for Space-Earth Environmental Research Nagoya University Japan Karlsruher Institut für Technologie Germany Rice University TX United States The George Washington University WashingtonDC United States Kobayashi-Maskawa Institute for the Origin of Particles and the Universe Nagoya University Japan Department of Physics Center for Space Sciences and Technology University of Maryland Baltimore CountyMD United States

A next-generation medium-energy gamma-ray telescope targeting the MeV range would address open questions in astrophysics regarding how extreme conditions accelerate cosmic-ray particles, produce relativistic jet outflows, and more. One concept, AMEGO-X, relies upon the mission-enabling CMOS Monolithic Active Pixel Sensor silicon chip AstroPix. AstroPix is designed for space-based use, featuring low noise, low power consumption, and high scalability. Desired performance of the device include an energy resolution of 5 keV (or 10% FWHM) at 122 keV and a dynamic range per-pixel of 25 − 700 keV, enabled by the addition of a high-voltage bias to each pixel which supports a depletion depth of 500 μm. This work reports on the status of the AstroPix development process with emphasis on the current version under test, version three (v3), and highlights of version two (v2). Version 3 achieves energy resolution of 10.4 ± 3.2% at 59.5 keV and 94 ± 6 μm depletion in a low-resistivity test silicon substrate. © 2025, CC BY.

关键词： Cosmology

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Decreasing level of heavy metals Fe and Mn use the wetland method at coal open mining PT Bukit Asam South Sumatra Province 1

Decreasing level of heavy metals Fe and Mn use the wetland m...

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1st International Conference on environmental sciences, ICES 2018

作者： Prabowo, Heri Amran, Ali Arbain, Ardinis Department of Environmental Science Post Graduate Program Universitas Negeri Padang Prof. Dr. Hamka Street West Air Tawar Padang-West Sumatra25131 Indonesia

PT. Bukit Asam, Tbk is a coal mining company that directly produces waste water. For this reason, it is necessary to treat wastewater to neutralize substances that pollute the wastewater, one of the methods used is constructed wetland. The method used is descriptive quantitative method. Where this study will produce the influence of the constructed wetland method in neutralizing waste water from the coal mining process at PT. Bukit Asam, Tbk. Based on the results of the study it can be seen that the waste treatment caused by the Constructed Wetland coal mining process can increase the Ph value from 3 samples averaging 2.6 mg / l, reducing the Fe metal content from 3 samples averaging 9.98 mg / l, and lowering the metal content of Mn from 3 samples averaging 0.75 mg / l and decreasing the level of Total Suspended Solid from 3 samples averaging 486 mg / l. The constructed wetland method that has been implemented at PT. BA has succeeded in neutralizing Fe and Mn metals and TSS according to the standard quality values that meet the standards set by the government. © 2019 Published under licence by IOP Publishing Ltd.

关键词： Wetlands

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Ibuprophen Removal from Synthetic Effluents Using Electrocoagulation-Peroxidation (ECP)

Research Square

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Research Square 2021年

作者： Behling, Laura da Luz, Vilson Conrado Pasquali, Gean Delise Leal Bazoti, Suzana Fátima Rosa, Clarissa Dalla Pereira, Paulo Post-Graduation Program in Science and Environmental Technology Federal University of Fronteira Sul ERS 135 -Km 72 No 200 PO Box 764 Erechim – RS 99700-970 Brazil Environmental and Sanitary Engineering Department Federal University of Fronteira Sul ERS 135 -Km 72 No 200 PO Box 764 Erechim – RS 99700-970 Brazil

Concerning water resources, several ordinances and legislation determine standards and conditions for the discharge of effluents into water bodies. However, several contaminants are not covered by these guidelines because they are found in low concentrations and due to little knowledge of their long-term effects. These contaminants are called emergents, and this category includes drugs, such as anti-inflammatory drugs. The electrocoagulation process associated with advanced oxidation comes up as an alternative to conventional effluent treatment processes, and the objective of this work was to evaluate this process using scrap iron as sacrificial electrodes in the treatment of synthetic effluents containing Ibuprofen. High performance liquid chromatography (HPLC) was used to quantify the drug in synthetic effluents. The CCRD 24 was used in an experimental design, having as independent variables evaluated the concentration of contaminants, applied current, the concentration of the primary oxidizing agent H2O2 and the reaction time. The optimized conditions determined by statistical analysis were drug concentration of 5 mg.L-1, H2O2 concentration of 200 mg.L-1, current of 5 A and 150 min. The removals obtained under these conditions were higher than 92% in the aqueous phase, showing that ECP technique has the potential to treat contaminants such as drugs present in effluents and waters. © 2021, CC BY.

关键词： High performance liquid chromatography

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Ginkgo biloba extract (GbE) restores gut microbiota dysbiosis in a rat model of lard-rich diet-induced obesity

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Phytomedicine Plus 2023年第3期3卷 100467-100467页

作者： Hirata, Bruna K.S. Aono, Alexandre H. Machado, Meira M.F. Joyce, Ellen C. Bueno, Allain A. Kuroshu, Reginaldo M. Oyama, Lila M. Ribeiro, Eliane B. Niero, Cristina V. Telles, Monica M. Graduate Program in Chemical Biology Universidade Federal de São Paulo SP Diadema Brazil Department of Science and Technology Universidade Federal de São Paulo SP São José dos Campos Brazil College of Health Life and Environmental Sciences University of Worcester Worcester United Kingdom Discipline of Nutrition Physiology Departament of Physiology Universidade Federal de São Paulo SP São Paulo Brazil

Background: Gut microbiota (GM) modulation has been considered a nutritional approach to manage obesity. Reduced Firmicutes/Bacteroidetes ratio (F/B) is associated with reduced energy harvesting capacity from the diet, ameliorates endotoxemia and inflammation, and restores gut hormone signaling related to hypothalamic control of energy homeostasis. As anti-obesogenic and anti-inflammatory properties have been attributed to Ginkgo biloba extract (GbE), the present study investigated whether GbE supplementation for two weeks modulates the GM composition of obese rats. Method: Fifty-six 2-month-old male Wistar rats were submitted to a lard-rich diet-induced obesity protocol for 60 days (high-fat diet, HFD). Following the obesity-inducing period, rats were gavaged daily with GbE at 500 mg/kg (HFD+G group), or saline (HFD group), for 14 days. A 3rd group (pair-fed group, PF) was performed by mimicking the HFD group (saline administration) but with its food intake matched to the HFD+G group. Rats were euthanized on the 14th supplementation day. Stool DNA was extracted and amplified with V3–V4 region primers of the 16S rRNA gene. Results: In comparison to both HFD and PF groups, GbE supplementation increased the number of Bacteroidetes colon community and concomitantly reduced the abundance of Firmicutes, reducing the F/B ratio. Hierarchical clustering showed that communities of the HFD+G group were less likely related to HFD and PF groups. Conclusion: As GbE modulated the GM structure and diversity in GbE-supplemented obese rats, our results show that GbE possesses phytotherapeutic potential to modulate obesity by improving GM and lessening the consequences of obesity-related GM dysbiosis. © 2023

关键词： Dysbiosis High-fat diet Metagenomics Obesity Phytotherapy

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Decision Support Systems Selection of Soang Superior Brood Using Weighted Product (WP) and Simple Additive Weighting (SAW) Method 4

Decision Support Systems Selection of Soang Superior Brood U...

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4th International Conference on Energy, Environment, Epidemiology and Information System, ICENIS 2019

作者： Ramadiani Kurniawan, Reynaldi Kridalaksana, Awang Harsa Jundillah, Muhammad Labib Faculty of Computer Science and Information Technology Mulawarman University Samarinda Indonesia Magister Program of Information System School of Post Graduate Studies Diponegoro University Semarang Indonesia

Gurame Soang Latin name Osphronomus Labirynthici gouramy including fish, that as the fish have gills and breathing apparatus in the form of additional gills (Labyrinth). One important factor in fish farming Soang Gurame is holding elections. Superior brood has characteristics identical, to distinguish it needs to experience since it is quite difficult. Some of the assessment factors in selecting a superior brood that could be considered in the cultivation of the fish farmers Gurame Soang as ideal weight, physical disability, movement of fish, the shape of the head, and the body color. All of these factors combined to get an assessment that could help the decision making process fish Gurame Soang superior sires. This study used two methods that have selected the calculation accuracy of the decision-making process. The method used is the Weighted Product and Simple Additive weighting. The results of the research that has been done, it can be concluded the total number of alternative Gurame Soang superior sires data as many as 10 fish, and obtained the results of testing the level of accuracy by using the results of data from a breeder Gurame Soang superior sires, Method of Weighted Product got an accuracy of 80% and methods Simple Additive weighting got an accuracy of 60%. © The Authors, published by EDP sciences, 2019.

关键词： Fish

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A-STEP: The AstroPix Sounding Rocket technology Demonstration Payload

arXiv

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arXiv 2024年

作者： Violette, Daniel P. Steinhebel, Amanda Roy, Abhradeep Boggs, Ryan Caputo, Regina Durachka, David Fukazawa, Yasushi Hashizume, Masaki Hesh, Scott Jadhav, Manoj Kierans, Carolyn Kumar, Kavic Kushima, Shin Leys, Richard Metcalfe, Jessica Metzler, Zachary Nakano, Norito Peric, Ivan Perkins, Jeremy Seo, Lindsey Taylor Shin, K.-W. Striebig, Nicolas Suda, Yusuke Tajima, Hiroyasu NASA Goddard Space Flight Center GreenbeltMD United States United States Physics Program Graduate School of Advanced Science and Engineering Hiroshima University Hiroshima Japan NASA Wallops Flight Facility Wallops IslandVA United States Argonne National Laboratory LemontIL United States Department of Physics University of Maryland College ParkMD United States Institute for Space–Earth Environmental Research Nagoya University Aichi Japan ASIC and Detector Laboratory Karlsruhe Institute of Technology Karlsruhe Germany Institute for Particle Physics University of California Santa CruzCA United States

A next-generation medium-energy (100 keV to 100 MeV) gamma-ray observatory will greatly enhance the identification and characterization of multimessenger sources in the coming decade. Coupling gamma-ray spectroscopy, imaging, and polarization to neutrino and gravitational wave detections will develop our understanding of various astrophysical phenomena including compact object mergers, supernovae remnants, active galactic nuclei and gamma-ray bursts. An observatory operating in the MeV energy regime requires technologies that are capable of measuring Compton scattered photons and photons interacting via pair production. AstroPix is a monolithic high voltage CMOS active pixel sensor which enables future gamma-ray telescopes in this energy range. AstroPix’s design is iterating towards low-power (∼1.5 mW/cm2), high spatial (500 µm pixel pitch) and spectral (2 building block of future large area AstroPix instruments, such as ComPair-2 and AMEGO-X. This payload will be the first demonstration of AstroPix detectors operated in a space environment and will demonstrate the technology’s readiness for future astrophysical and nuclear physics applications. In this work, we overview the design and state of development of the A-STEP payload. Copyright © 2024, The Authors. All rights reserved.

关键词： Photons

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