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4th International Conference on Energy, Environment, Epidemiology and Information System, ICENIS 2019

作者： Purnaweni, Hartuti Kismartini Prabawani, Bulan Roziqin, Ali Public Administration Department Faculty of Social and Political Sciences Universitas Diponegoro Indonesia Program of Environmental Science School of Post Graduate Undip Indonesia Business Administration Department Faculty of Social and Political Sciences Undip Indonesia Government Science Universitas Muhammadiyah Malang Indonesia

Mining is a very crucial activity of human being and is practiced everywhere in the world, including in Bangka Belitung Province which is rich in tin, making tin is the leading commodity in this area. This study aimed at analyzing the Bangka Belitung profile, tin mining activities in this area and its impact on an environmental conditions in Bangka Belitung Islands. The study applied a descriptive-qualitative method, using data from library study and previous researches dealing with the research topic, as well as data from field observation. It concluded that tin mining has been done since the Dutch era in Bangka Belitung, and is more active today. Therefore, it is concluded that massive environmental degradation will occur should the mining practices are not stopped. The study It is recommended that the government has to strengthen its policy in the form of local regulation on the tin mining activities for erecting a better public administration practices. © The Authors, published by EDP sciences, 2019.

关键词： environmental regulations

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Role of plant genetic resources in encountering climate change challenge 10

Role of plant genetic resources in encountering climate chan...

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10th Annual International Conference 2020 on environmental and Life sciences, AIC-ELS 2020

作者： Ichsan, C.N. Darusman Sulaiman, M.I. Andini, R. Doctoral Program in Agricultural Sciences Post Graduate School Universitas Syiah Kuala Jl. Tgk. Chik Pante Kulu No.3 Banda Aceh Indonesia Department of Soil Science Universitas Syiah Kuala Jl. Tgk. Hasan Krueng Kalee No. 3 Banda Aceh Indonesia Department of Agricultural Product Technology Universitas Syiah Kuala Jl. Tgk. Hasan Krueng Kalee No. 3 Banda Aceh Indonesia Department of Forestry Universitas Syiah Kuala Jl. Tgk. Hasan Krueng Kalee No. 3 Banda Aceh Indonesia

The world is encountering a global threat: Climate change. It is estimated that the average air temperature will raise 3.7-7.8 °C by 2100. The possible impacts will vary, however, agriculture will be adversely affected marked with yield loss of staple crops such as rice and maize and altered post-harvest quality of horticulture products. On the other hand, the world Food and Agriculture Organization (UN-FAO) has set a target 'zero hunger' by 2030', despite the five big challenges ahead: I) protracted conflict, ii) growing inequality, iii) rapid urbanization, iv) economic challenges, v) drought and natural disasters. The existing plant genetic resources, particularly the wild, neglected, and underutilized species has a great role and bears big potential to be exploited and targetted to achieve food and nutrition security, esp. in the densely populated regions with malnutrition problem e.g. in Asia and sub-Saharan regions. However, a key to future and sustainable crop production lies in the collection of crop and their wild relatives stored in ex-situ, or in-situ. This paper aims to explain the importance of plant genetic resources as well as the potential of some underutilized crops closely attributed with drought resistence, such as sorghum (Sorghum bicolor L. Moench), amaranth (Amaranthus sp.). These crops bear potential to support national food security program. © Published under licence by IOP Publishing Ltd.

关键词： Crops

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Phage display-derived alpaca nanobodies as potential therapeutics for Naja atra snake envenomation

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Applied and environmental Microbiology 2024年第8期90卷 e0012124页

作者： Wang, Wei-Chu Chang, Jungshan Lee, Chi-Hsin Chiang, Yu-Wei Leu, Sy-Jye Mao, Yan-Chiao Chiang, Jen-Ron Yang, Chun-Kai Wu, Chao-Jung Yang, Yi-Yuan Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei Taiwan International Master/Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei Taiwan International Ph.D. Program for Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei Taiwan School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan Core Laboratory of Antibody Generation and Research Taipei Medical University Taipei Taiwan Department of Medical Research Taipei Veterans General Hospital Taipei Taiwan Department of Biology and Anatomy National Defense Medical Center Taipei Taiwan Foundation for Poison Control Taipei Taiwan Department of Microbiology and Immunology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan School of Medicine National Defense Medical Centre Taipei Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan Division of Clinical Toxicology Department of Emergency Medicine Taichung Veterans General Hospital Taichung Taiwan Bioproduction Plants National Institute of Infectious Diseases and Vaccinology National Health Research Institutes Miaoli Taiwan Interdisciplinary Research on Ecology and Sustainability National Dong Hwa University Hualien Taiwan

Naja atra, the Chinese cobra, is a major cause of snake envenomation in Asia, causing hundreds of thousands of clinical incidents annually. The current treatment, horse serum-derived antivenom, has unpredictable side effects and presents manufacturing challenges. This study focused on developing new-generation snake venom antidotes by using microbial phage display technology to derive nanobodies from an alpaca immunized with attenuated N. atra venom. Following confirmation of the immune response in the alpaca, we amplified VHH genes from isolated peripheral blood mononuclear cells and constructed a phage display VHH library of 1.0 × 107 transformants. After four rounds of biopanning, the enriched phages exhibited increased binding activity to N. atra venom. Four nanobody clones with high binding affinities were selected: aNAH1, aNAH6, aNAH7, and aNAH9. Specificity testing against venom from various snake species, including two Southeast Asian cobra species, revealed nanobodies specific to the genus Naja. An in vivo mouse venom neutralization assay demonstrated that all nanobodies prolonged mouse survival and aNAH6 protected 66.6% of the mice from the lethal dosage. These findings highlight the potential of phage display-derived nanobodies as valuable antidotes for N. atra venom, laying the groundwork for future applications in snakebite treatment. Copyright © 2024 American Society for Microbiology. All Rights Reserved.

关键词： Mammals

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Multi Effect of Rain Harvesting in the Floating Village of Malahing on the Coast Bontang Developed by the CSR of PKT

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IOP Conference Series. Earth and environmental science 2020年第1期448卷

作者： Ekowati, S D Hadi, S P Doctoral Program in Environmental Science Post-Graduate Program Diponegoro University Semarang-Indonesia Graduate Program of Environmental Science Diponegoro University Semarang-Indonesia

The residents of the floating village of Malahing, Bontang, East Kalimantan, earn their living as fish catching fishermen and seaweed farming. Residents even experience a clean water crisis, every month they require a budget IDR 300, 000 until IDR 400, 000 to buy clean water at Tanjung Laut by ketinting. The PKT programmed rain harvesting for Malahing residents to supply clean water. The method used was field observations and surveys as well as simple calculations using the program of Office Excel. The PKT carried out gutter procurement for every resident’s house, provided three plastic drums of 200 litres to collect rainwater, provided filters to filter rain water, train the residents to care for and repair the filters. As a result, the residents get clean water to meet their daily basic, grow vegetables for family needs and do greening in their yard and water them. They can also water communal latrines so that defecation is not carried out at sea. Malahing residents can save IDR. 356, 000 until IDR 456.000 per month, help save fossil fuels and reduce carbon dioxide emissions so they become healthier, prosperous and environmentally friendly.

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The role of input imaging combination and ADC threshold on segmentation of acute ischemic stroke lesion using U-Net

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European Radiology 2023年第9期33卷 6157-6167页

作者： Li, Ya-Hui Lin, Shao-Chieh Chung, Hsiao-Wen Chang, Chia-Ching Peng, Hsu-Hsia Huang, Teng-Yi Shen, Wu-Chung Tsai, Chon-Haw Lo, Yu-Chien Lee, Tung-Yang Juan, Cheng-Hsuan Juan, Cheng-En Chang, Hing-Chiu Liu, Yi-Jui Juan, Chun-Jung Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan Department of Medical Imaging China Medical University Hsinchu Hospital No. 199 Sec. 1 Xinglong Rd. Zhubei City Hsinchu County 302 Hsinchu Taiwan Ph.D. Program in Electrical and Communication Engineering Feng Chia University Taichung Taiwan Department of Electrical Engineering National Taiwan University Taipei Taiwan Department of Management Science National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu Taiwan Department of Electrical Engineering National Taiwan University of Science and Technology Taipei Taiwan Department of Radiology School of Medicine College of Medicine China Medical University Taichung Taiwan Department of Medical Imaging Medical University Hospital Taichung Taiwan Department of Neurology China Medical University Hospital Taichung Taiwan Cheng Ching Hospital Taichung Taiwan Master’s Program of Biomedical Informatics and Biomedical Engineering Feng Chia University Taichung Taiwan Department of Automatic Control Engineering Feng Chia University No. 100 Wenhwa Rd. Seatwen Taichung 40724 Taiwan Department of Biomedical Engineering The Chinese University of Hong Kong ERB1112 11/F William M.W. Mong Engineering Building N.T Shatin Hong Kong Multi-Scale Medical Robotics Center The Chinese University of Hong Kong N.T Shatin Hong Kong Department of Biomedical Engineering National Defense Medical Center Taipei Taiwan Department of Computer Science and Information Engineering National Taiwan University Taipei Taiwan

Background: To evaluate the effect of the weighting of input imaging combo and ADC threshold on the performance of the U-Net and to find an optimized input imaging combo and ADC threshold in segmenting acute ischemic stroke (AIS) lesion. Methods: This study retrospectively enrolled a total of 212 patients having AIS. Four combos, including ADC-ADC-ADC (AAA), DWI-ADC-ADC (DAA), DWI-DWI-ADC (DDA), and DWI-DWI-DWI (DDD), were used as input images, respectively. Three ADC thresholds including 0.6, 0.8 and 1.8 × 10^–3 mm²/s were applied. Dice similarity coefficient (DSC) was used to evaluate the segmentation performance of U-Nets. Nonparametric Kruskal–Wallis test with Tukey–Kramer post-hoc tests were used for comparison. A p <.05 was considered statistically significant. Results: The DSC significantly varied among different combos of images and different ADC thresholds. Hybrid U-Nets outperformed uniform U-Nets at ADC thresholds of 0.6 × 10^–3 mm²/s and 0.8 × 10^–3 mm²/s (p <.001). The U-Net with imaging combo of DDD had segmentation performance similar to hybrid U-Nets at an ADC threshold of 1.8 × 10^–3 mm²/s (p =.062 to 1). The U-Net using the imaging combo of DAA at the ADC threshold of 0.6 × 10^–3 mm²/s achieved the highest DSC in the segmentation of AIS lesion. Conclusions: The segmentation performance of U-Net for AIS varies among the input imaging combos and ADC thresholds. The U-Net is optimized by choosing the imaging combo of DAA at an ADC threshold of 0.6 × 10^–3 mm²/s in segmentating AIS lesion with highest DSC. Key Points: • Segmentation performance of U-Net for AIS differs among input imaging combos. • Segmentation performance of U-Net for AIS differs among ADC thresholds. • U-Net is optimized using DAA with ADC = 0.6 × 10^–3mm²/s. © 2023, The Author(s), under exclusive licence to European Society of Radiology.

关键词： Deep Learning Diffusion Magnetic Resonance Imaging Ischemic Stroke Neural Networks, Computer Retrospective Study

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Studies breeding places of Aedes aegypti and Aedes albopictus in dengue endemic Padang area 1

Studies breeding places of Aedes aegypti and Aedes albopictu...

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1st International Conference on environmental sciences, ICES 2018

作者： Onasis, Aidil Barlian, Eri Razak, Abdul Department of Environmental Science Post Graduate Program Universitas Negeri Padang Prof. Dr. Hamka Street West Air Tawar Padang-West Sumatera25131 Indonesia Padang Health of Polytechnic Environmental Health Departement Siteba Street Padang-West Sumatera25146 Indonesia

Suspect vector of Dengue Haemorrhagic Fever (DHF) and Chickungunya transmitted by Aedes aegypti and Aedes albopictus in container as potential breeding places. This study used a descriptive design, data collection in Kuranji, Nanggalo and Padang Timur and Lubuk Begalung district for 5 months in Padang with populations in house as many as 400 larvae index for density analysis to interpretation. The results container at risk of becoming breeding places of Aedes aegypti in Padang Timur districts 14.25%, and Aedes albopictus in Kuranji 20.75%. 3 classification area analysis are Aedes aegypti and Aedes albopictus in the container in the form of supervision that more routine in Nanggalo compared Kuranji and Lubuk Begalung well as in Padang Timur as well as control by getting rid of that is rare in Kuranji and Padang Timur while in Nanggalo and Lubuk Begalung category often get rid of the landfill. Updating data analysis results in the form of survey results, mosquito density monitoring strategy regularly and periodically by the community with assistance by health workers as well as the risk of transmission as well as the anticipation of Extraordinary Events and prevention of dengue outbreaks. © 2019 Published under licence by IOP Publishing Ltd.

关键词： Containers

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Mo-Terminated Edges in Mos2 for Site-Specific Hydrolysis and DNA Cleavage

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SSRN 2024年

作者： Wang, Cong Wu, Menghan Li, Muqing Zhao, Yingcan Zhao, Mingchuang Zhang, Yunhao Bai, Yichao Gao, Jianxiang Wang, Xiaoxia Tian, Xilin Zhang, Han Chang, Liang Zou, Xiaolong Liu, Bilu Kang, Feiyu Terrones, Mauricio Lei, Yu Institute of Materials Research Shenzhen Key Laboratory of Advanced Layered Materials for Value-added Applications Guangdong Provincial Key Laboratory of Thermal Management Engineering and Materials Center of Double Helix Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen518055 China Institute of Materials Research Shenzhen Geim Graphene Center Shenzhen Key Laboratory of Advanced Layered Materials for Value-added Applications Tsinghua-Berkeley Shenzhen Institute Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen518055 China Environmental Science Program Department of Life Sciences Beijing Normal University-Hong Kong Baptist University United International College Guangdong 519087 China Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen518055 China Department of Physics Department of Chemistry Department of Materials Sciences Center for 2-Dimensional and Layered Materials The Pennsylvania State University University Park PA16802 United States International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology Ministry of Education Institute of Microscale Optoelectronics Shenzhen University Shenzhen518060 China Key Laboratory of Optoelectronic Devices and Systems China

The hydrolysis of DNA serves as the foundational principle for gene engineering that enable precise gene cleavage at the molecular level. This process typically occurs in biological nucleases, which exhibit nucleobase-selective and catalytic hydrolysis capabilities rarely replicated in abiotic nanomaterials. Here, we demonstrate that molybdenum-terminated (Mo-terminated) edges of molybdenum disulfide (MoS2) possess the unique ability to abstract a proton (H+) from water molecules, thereby facilitating catalytic hydrolysis reactions that cleave the phosphodiester bonds in DNA through the action of hydroxide ions. The enhanced proton absorption at Mo-terminated edges of MoS2 significantly reduces the activation energy required for the DNA hydrolysis reaction. Furthermore, the favorable interaction between the Mo-terminated edges and thymine nucleobases promotes both charge transfer and P-O bond cleavage, enabling targeted DNA hydrolysis at 'TTTTTTT' sequences under dark conditions. This discovery underscores the potential of MoS2 as a stable, efficient nanosystem for precise genetic editing, heralding advanced applications in the field of gene engineering. © 2024, The Authors. All rights reserved.

关键词： DNA sequences

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Teaching the concept of adaptive thermal comfort in building design education

Teaching the concept of adaptive thermal comfort in building...

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16th Conference of the International Society of Indoor Air Quality and Climate: Creative and Smart Solutions for Better Built Environments, Indoor Air 2020

作者： Teli, Despoina Hellwig, Runa T. Schweiker, Marcel Choi, Joon-Ho Lee, M.C. Jeffrey Mora, Rodrigo Rawal, Rajan Wang, Zhaojun Al-Atrash, Farah Department of Architecture and Civil Engineering Chalmers University Sweden Department of Architecture Design and Media Technology Aalborg University Denmark Institute for Occupational Social and Environmental Medicine RWTH Aachen University Aachen Germany Building Science School of Architecture University of Southern California United States Department of Interior Design National Taichung University of Science and Technology Taiwan Building Science Graduate Program British Columbia Institute of Technology Canada Centre for Advanced Research in Building Science and Energy CEPT University India School of Architecture Harbin Institute of Technology China School of Architecture and Built Environment German Jordanian University Jordan

ISBN: (纸本)9781713823605

Traditional building design education in the disciplines of building services, civil engineering, mechanical engineering, etc. focusses on quantifiable factors, i.e. factors which can be subject of calculation, simulation and dimensioning. Since non-quantifiable factors are not part of calculation or simulation models, there is a tendency that they are not adequately considered in education and, as a result, in building planning and operation. In the case of human thermal comfort, building professionals are required to understand the mechanisms and impact of non-quantifiable factors related to human thermal comfort and health, most of which are part of the adaptive thermal comfort concept. This paper identifies the challenges in teaching the concept of adaptive thermal comfort through a collection of lived experiences of the authors. The paper then proposes appropriate intended learning outcomes and teaching methods to equip students with the background knowledge, understanding and skills required to consider human adaptation in their designs. © 2020 16th Conference of the International Society of Indoor Air Quality and Climate: Creative and Smart Solutions for Better Built Environments, Indoor Air 2020. All rights reserved.

关键词： Students

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Gold Nanoparticle Decorated Bismuth Vanadate Casting on Screen-Printed Electrode for Chlortetracycline Detection in Tap Water

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SSRN 2024年

作者： Ngo, Duy Ba Gopi, Praveen Kumar Rajkumar, Muniyandi Chen, Shen-Ming Rijiravannich, Patsamon Khownarumit, Porntip Somasundrum, Mithran Surareungchai, Werasak Bangkhuntien-chaitalay Rd. Bangkok10150 Thailand Analytical Sciences and National Doping Test Institute Mahidol University Rama VI Rd. Bangkok10400 Thailand Electroanalysis and Bioelectrochemistry Lab Department of Chemical Engineering and Biotechnology National Taipei University of Technology No.1 Section 3 Chung-Hsiao East Rd. Taipei106 Taiwan Bioscience and System Biology Research Team National Center for Genetic Engineering and Biotechnology National Sciences and Technology Development Agency at KMUTT Bangkhuntien-chaitalay Rd. Bangkok10150 Thailand Pilot Plant Development and Training Institute KMUTT Bangkhuntien-chaitalay Rd. Bangkok10150 Thailand Nanoscience and nanotechnology graduate program Faculty of Science KMUTT Pracha Uthit Rd. Bangkok10140 Thailand PSG College of Arts and Science Civil Aerodrome Post Tamil Nadu Coimbatore641014 India Quarter 6 Linh Trung Ward Thu Duc City Ho Chi Minh City720400 Viet Nam

Background Chlortetracycline (CTC) belongs to the class of tetracycline’s compounds, which is known for its antibacterial activity. CTC was largely consumed by farm animals than humans, which leads to the growth antibiotic – resistant bacteria and environmental contamination. So far no one reported the electrochemical detection and determination of CTC by using AuNPs@BiVO4 composite. Some reports have been reported using conventional chromatography which is most expensive, time-consuming and highly equipped method. Results Here, we report a simple method for preparing gold nanoparticle decorated bismuth vanadate (AuNPs@BiVO4), which was dropped cast on a screen-printed carbon electrode (SPCE). The AuNPs@BiVO4 and AuNPs@BiVO4/SPCE materials were characterized using TEM, SEM-EDX, XPS, DLS, ELS, EIS, and CV. The as-prepared AuNPs@BiVO4/SPCE was used to detect and determine chlortetracycline (CTC) by different pulse potentials in phosphate buffer pH 7.0. The electrode possessed a wide linear range of 0.99 – 19.06 µM, with obtained LOD = 0.15 µM, LOQ = 0.49 µM, and sensitivity = 0.059 μA μM-1 cm-2. It also exhibited good selectivity, stability, and repeatability, recovering 87.14% - 100% for detecting CTC in Mili Q and tap water. Significance Facile and rapid synthesis of AuNPs@BiVO4 nanocomposite film modified electrode at physiological pH conditions has been prepared and A highly electrochemical detection and determination of CTC using AuNPs@BiVO4 nanocomposite film has been developed for the first time. Thus, the proposed electrode could be applied for the detection and determination of CTC in water sources and has the potential to be used for real sample analysis. © 2024, The Authors. All rights reserved.

关键词： Nanocomposites

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INTRODUCTION

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Bulletin of the American Meteorological Society 2024年第8期105卷 S1-S11页

作者： Boyer, T. Blunden, J. Dunn, R.J.H. NOAA/NESDIS National Centers for Environmental Information Silver Spring Maryland NOAA/NESDIS National Centers for Environmental Information Asheville North Carolina Met Office Hadley Centre Exeter United Kingdom European Centre for Medium-Range Weather Forecasts Reading United Kingdom University of Maryland College Park Maryland Scripps Institution of Oceanography University of California San Diego La Jolla California NOAA/NWS National Centers for Environmental Prediction Climate Prediction Center College Park Maryland Brandenburg University of Technology (BTU) Cottbus-Senftenberg Germany Servicio Meteorológico Nacional Buenos Aires Argentina NOAA/OAR Physical Sciences Laboratory Boulder Colorado European Centre for Medium-Range Weather Forecasts Bonn Germany Center for Geophysical Research and School of Physics University of Costa Rica San José Costa Rica Department of Meteorology and National Centre for Earth Observation University of Reading Reading United Kingdom Centro Nacional de Monitoramento e Alertas de Desastres Naturais CEMADEN São Paulo Brazil Université Grenoble Alpes Institut des Géosciences de l’Environnement IRD CNRS Grenoble INP Grenoble France Hampton University Hampton Virginia Seychelles Meteorological Authority Mahe Seychelles Section for Glaciers Ice and Snow Norwegian Water Resources and Energy Directorate Oslo Norway National Research Institute for Agriculture Food and Environment (INRAE) CARRTEL Université Savoie Mont Blanc Thonon les Bains France Graduate School of Agriculture Osaka Metropolitan University Sakai Japan Science Faculty Universidad Nacional de Colombia Bogotá Colombia University of Bremen Bremen Germany NOAA Global Monitoring Laboratory Boulder Colorado Servicio Nacional de Meteorología e Hidrología del Perú Lima Perú Centro de Investigaciones sobre Desertificación – Spanish National Research Council (CSIC-UV-GVA) Valencia Spain Hydro-Climate Extremes Lab (H-CEL) Ghent University Ghent Belgium Department o

In 2023, La Niña conditions that generally prevailed in the eastern Pacific Ocean from mid-2020 into early 2023 gave way to a strong El Niño by October. Atmospheric concentrations of Earth’s major greenhouse gases—carbon dioxide, methane, and nitrous oxide—all increased to record-high levels. The annual global average carbon dioxide concentration in the atmosphere rose to 419.3±0.1 ppm, which is 50% greater than the pre-industrial level. The growth from 2022 to 2023 was 2.8 ppm, the fourth highest in the record since the 1960s. The combined short-term effects of El Niño and the long-term effects of increasing levels of heat-trapping gases in the atmosphere contributed to new records for many essential climate variables reported here. The annual global temperature across land and oceans was the highest in records dating as far back as 1850, with the last seven months (June–December) having each been record warm. Over land, the globally averaged temperature was also record high. Dozens of countries reported record or near-record warmth for the year, including China and continental Europe as a whole (warmest on record), India and Russia (second warmest), and Canada (third warmest). Intense and widespread heatwaves were reported around the world. In Vietnam, an all-time national maximum temperature record of 44.2°C was observed at Tuong Duong on 7 May, surpassing the previous record of 43.4°C at Huong Khe on 20 April 2019. In Brazil, the air temperature reached 44.8°C in Araçuaí in Minas Gerais on 20 November, potentially a new national record and 12.8°C above normal. The effect of rising temperatures was apparent in the cryosphere, where snow cover extent by June 2023 was the smallest in the 56-year record for North America and seventh smallest for the Northern Hemisphere overall. Heatwaves contributed to the greatest average mass balance loss for Alpine glaciers around the world since the start of the record in 1970. Due to rapid volume loss beginning in 2021, St. A

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