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arXiv 2021年

作者： Heller, Matthieu Armstrong, T. Bellato, M. Bergnoli, A. Bernardos, M. Bernasconi, E. Biland, A. Charbon, E. Corti, D. Dalchenko, M. della Volpe, D. Depaoli, D. Di Pierro, F. Emery, G. Gascón, D. Gómez, S. López-Coto, R. Mariotti, M. Miranda, L.D.M. Montaruli, T. Nagai, A. Rando, R. Saito, T. Tajima, H. Zietara, K. Abe, H. Aguasca, A. Agudo, I. Antonelli, L.A. Aramo, C. Armstrong, T. Artero, M. Asano, K. Ashkar, H. Aubert, P. Baktash, A. Bamba, A. Baquero Larriva, A. Baroncelli, L. Barres de Almeida, U. Barrio, J.A. Batkovic, I. Becerra González, J. Bernardos, M.I. Berti, A. Biederbeck, N. Bigongiari, C. Blanch, O. Bonnoli, G. Bordas, P. Bose, D. Bulgarelli, A. Burelli, I. Buscemi, M. Cardillo, M. Caroff, S. Carosi, A. Cassol, F. Cerruti, M. Chai, Y. Cheng, K. Chikawa, M. Chytka, L. Contreras, J.L. Cortina, J. Costantini, H. Dalchenko, M. de Angelis, A. de Bony de Lavergne, M. Deleglise, G. Delgado, C. Delgado Mengual, J. della Volpe, D. Depaoli, D. Di Venere, L. Díaz, C. Dominik, R.M. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Elsässer, D. Emery, G. Escudero, J. Fiasson, A. Foffano, L. Fonseca, M.V. Freixas Coromina, L. Fukami, S. Fukazawa, Y. Garcia, E. Garcia López, R. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Green, D. Grespan, P. Gunji, S. Hackfeld, J. Hadasch, D. Hahn, A. Hassan, T. Hayashi, K. Heckmann, L. Heller, M. Herrera Llorente, J. Hirotani, K. Hoffmann, D. Horns, D. Houles, J. Hrabovsky, M. Hrupec, D. Hui, D. Hütten, M. Inada, T. Inome, Y. Iori, M. Ishio, K. Iwamura, Y. Jacquemont, M. Jimenez Martinez, I. Jouvin, L. Jurysek, J. Kagaya, M. Karas, V. Katagiri, H. Kataoka, J. Kerszberg, D. Kobayashi, Y. Kong, A. Kubo, H. Kushida, J. Lamanna, G. Lamastra, A. Le Flour, T. Longo, F. López-Coto, R. López-Moya, M. López-Oramas, A. Luque-Escamilla, P.L. Majumdar, P. Makariev, M. Mandat, D. Manganaro, M. Mannheim, K. Mariotti, M. Marquez, P. Marsella, G. Martí, J. Martinez, O. Martínez, G. Martínez, M. DPNC - Université de Genève 24 Quai Ernest Ansermet GenèveCH-1211 Switzerland Aix Marseille Univ CNRS/IN2P3 CPPM Marseille France INFN Sezione di Padova Via Marzolo Padova8 - 35131 Italy INFN Sezione di Torino via P. Giuria Torino1 - 10125 Italy Università degli Studi di Torino Dipartimento di Fisica via P. Giuria Torino1 - 10125 Italy Institute for Space–Earth Environmental Research and Kobayashi–Maskawa Institute for the Origin of Particles and the Universe Nagoya University Nagoya464-8601 Japan AQUA EPFL Neuchâtel Switzerland ETH Zurich Institute for Particle Physics Otto-Stern-Weg 5 Zurich8093 Switzerland Institute of Cosmos Sciencies - University of Barcelona Martí i Franquès 1 Barcelona08028 Spain Institute for Cosmic Ray Research The University of Tokyo Japan Astronomical Observatory Jagiellonian University ul. Orla 171 Kraków30-244 Poland Institute for Cosmic Ray Research University of Tokyo Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Instituto de Astrofísica de Andalucía-CSIC INAF - Osservatorio Astronomico di Roma INFN Sezione di Napoli Aix Marseille Univ CNRS/IN2P3 CPPM The Barcelona Institute of Science and Technology IRFU CEA Université Paris-Saclay LAPP Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS-IN2P3 Annecy France Universität Hamburg Institut für Experimentalphysik Graduate School of Science University of Tokyo EMFTEL department IPARCOS Universidad Complutense de Madrid INAF - Osservatorio di Astrofisica e Scienza dello spazio di Bologna Centro Brasileiro de Pesquisas Físicas INFN Sezione di Padova Università degli Studi di Padova Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Max-Planck-Institut für Physik Department of Physics TU Dortmund University Saha Institute of Nuclear Physics INFN Sezione di Trieste Università degli Studi di Udine INFN Sezione di Catania University of Geneva Département de physique nucléair

Silicon photomultipliers (SiPMs) have become the baseline choice for cameras of the small-sized telescopes (SSTs) of the Cherenkov Telescope Array (CTA). On the other hand, SiPMs are relatively new to the field and covering large surfaces and operating at high data rates still are challenges to outperform photomultipliers (PMTs). The higher sensitivity in the near infra-red and longer signals compared to PMTs result in higher night sky background rate for SiPMs. However, the robustness of the SiPMs represents a unique opportunity to ensure long-term operation with low maintenance and better duty cycle than PMTs. The proposed camera for large size telescopes will feature 0.05◦ pixels, low power and fast front-end electronics and a fully digital readout. In this work, we present the status of dedicated simulations and data analysis for the performance estimation. The design features and the different strategies identified, so far, to tackle the demanding requirements and the improved performance are described. Copyright © 2021, The Authors. All rights reserved.

关键词： Photomultipliers

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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

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Nature 2024年第8003期627卷 347-357页

作者： Ken Suzuki Konstantinos Hatzikotoulas Lorraine Southam Henry J Taylor Xianyong Yin Kim M Lorenz Ravi Mandla Alicia Huerta-Chagoya Giorgio E M Melloni Stavroula Kanoni Nigel W Rayner Ozvan Bocher Ana Luiza Arruda Kyuto Sonehara Shinichi Namba Simon S K Lee Michael H Preuss Lauren E Petty Philip Schroeder Brett Vanderwerff Mart Kals Fiona Bragg Kuang Lin Xiuqing Guo Weihua Zhang Jie Yao Young Jin Kim Mariaelisa Graff Fumihiko Takeuchi Jana Nano Amel Lamri Masahiro Nakatochi Sanghoon Moon Robert A Scott James P Cook Jung-Jin Lee Ian Pan Daniel Taliun Esteban J Parra Jin-Fang Chai Lawrence F Bielak Yasuharu Tabara Yang Hai Gudmar Thorleifsson Niels Grarup Tamar Sofer Matthias Wuttke Chloé Sarnowski Christian Gieger Darryl Nousome Stella Trompet Soo-Heon Kwak Jirong Long Meng Sun Lin Tong Wei-Min Chen Suraj S Nongmaithem Raymond Noordam Victor J Y Lim Claudia H T Tam Yoonjung Yoonie Joo Chien-Hsiun Chen Laura M Raffield Bram Peter Prins Aude Nicolas Lisa R Yanek Guanjie Chen Jennifer A Brody Edmond Kabagambe Ping An Anny H Xiang Hyeok Sun Choi Brian E Cade Jingyi Tan K Alaine Broadaway Alice Williamson Zoha Kamali Jinrui Cui Manonanthini Thangam Linda S Adair Adebowale Adeyemo Carlos A Aguilar-Salinas Tarunveer S Ahluwalia Sonia S Anand Alain Bertoni Jette Bork-Jensen Ivan Brandslund Thomas A Buchanan Charles F Burant Adam S Butterworth Mickaël Canouil Juliana C N Chan Li-Ching Chang Miao-Li Chee Ji Chen Shyh-Huei Chen Yuan-Tsong Chen Zhengming Chen Lee-Ming Chuang Mary Cushman John Danesh Swapan K Das H Janaka de Silva George Dedoussis Latchezar Dimitrov Ayo P Doumatey Shufa Du Qing Duan Kai-Uwe Eckardt Leslie S Emery Daniel S Evans Michele K Evans Krista Fischer James S Floyd Ian Ford Oscar H Franco Timothy M Frayling Barry I Freedman Pauline Genter Hertzel C Gerstein Vilmantas Giedraitis Clicerio González-Villalpando Maria Elena González-Villalpando Penny Gordon-Larsen Myron Gross Lindsay A Guare Sophie Hackinger Liisa Hakaste Sohee Han Andrew T Hattersley Christian Herder Momoko Horikoshi Annie-Green Howard Willa Centre for Genetics and Genomics Versus Arthritis Centre for Musculoskeletal Research Division of Musculoskeletal and Dermatological Sciences University of Manchester Manchester UK. Department of Diabetes and Metabolic Diseases Graduate School of Medicine University of Tokyo Tokyo Japan. Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. konstantinos.hatzikotoulas@helmholtz-munich.de. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. Center for Precision Health Research National Human Genome Research Institute National Institutes of Health Bethesda MD USA. British Heart Foundation Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge Cambridge UK. Heart and Lung Research Institute University of Cambridge Cambridge UK. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Department of Biostatistics and Center for Statistical Genetics University of Michigan Ann Arbor MI USA. Corporal Michael J. Crescenz VA Medical Center Philadelphia PA USA. Department of Systems Pharmacology and Translational Therapeutics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Department of Genetics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Programs in Metabolism and Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA. Diabetes Unit and Center for Genomic Medicine Massachusetts General Hospital Boston MA USA. TIMI Study Group Division of Cardiovascular Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA. William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London L

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms that are often specific to cell type. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P < 5 × 10) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.

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Gamma-ray Spectral Line emission search from Dark Matter Annihilation up to 100 TeV towards the Galactic Centre with MAGIC 38

Gamma-ray Spectral Line emission search from Dark Matter Ann...

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38th International Cosmic Ray Conference, ICRC 2023

作者： Inada, Tomohiro Kerszberg, Daniel Hütten, Moritz Rico, Javier Teshima, Masahiro Kohri, Kazunori Hiroshima, Nagisa Abe, H. Abe, S. Abhir, J. Acciari, V.A. Agudo, I. Aniello, T. Ansoldi, S. Antonelli, L.A. Arbet Engels, A. Arcaro, C. Artero, M. Asano, K. Baack, D. Babić, A. Baquero, A. Barres de Almeida, U. Barrio, J.A. Batković, I. Baxter, J. Becerra González, J. Bednarek, W. Bernardini, E. Bernardos, M. Bernete, J. Berti, A. Besenrieder, J. Bigongiari, C. Biland, A. Blanch, O. Bonnoli, G. Bošnjak, Ž. Burelli, I. Busetto, G. Campoy-Ordaz, A. Carosi, A. Carosi, R. Carretero-Castrillo, M. Castro-Tirado, A.J. Ceribella, G. Chai, Y. Chilingarian, A. Cifuentes, A. Cikota, S. Colombo, E. Contreras, J.L. Cortina, J. Covino, S. D’Amico, G. D’Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. De Lotto, B. Del Popolo, A. Delfino, M. Delgado, J. Delgado Mendez, C. Depaoli, D. Di Pierro, F. Di Venere, L. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Elsaesser, D. Emery, G. Escudero, J. Fariña, L. Fattorini, A. Foffano, L. Font, L. Fröse, S. Fukami, S. Fukazawa, Y. García López, R.J. Garczarczyk, M. Gasparyan, S. Gaug, M. Giesbrecht Paiva, J.G. Giglietto, N. Giordano, F. Gliwny, P. Godinović, N. Grau, R. Green, D. Green, J.G. Hadasch, D. Hahn, A. Hassan, T. Heckmann, L. Herrera, J. Hrupec, D. Hütten, M. Imazawa, R. Inada, T. Iotov, R. Ishio, K. Jiménez Martínez, I. Jormanainen, J. Kerszberg, D. Kluge, G.W. Kobayashi, Y. Kouch, P.M. Kubo, H. Kushida, J. Láinez Lezáun, M. Lamastra, A. Lelas, D. Leone, F. Lindfors, E. Linhoff, L. Lombardi, S. Longo, F. López-Coto, R. López-Moya, M. López-Oramas, A. Loporchio, S. Lorini, A. Lyard, E. Machado de Oliveira Fraga, B. Majumdar, P. Makariev, M. Maneva, G. Mang, N. Manganaro, M. Mangano, S. Mannheim, K. Mariotti, M. Martínez, M. Martínez-Chicharro, M. Mas-Aguilar, A. Mazin, D. Menchiari, S. Mender, S. Mićanović, S. Miceli, D. Miener, T. Miranda, J.M. Mirzoyan, R. Molero González, M. Molina, E. Mondal, H.A. Institute for Cosmic Ray Research Kashiwa-no-ha 5-1-5 Kashiwa-shi Chiba Japan The Barcelona Institute of Science and Technology CampusUAB Bellaterra Barcelona08193 Spain Max-Planck-Institut für Physik Föhringer Ring 6 München80805 Germany Theory Center IPNS KEK Ibaraki Tsukuba305-0801 Japan 1-1 Oho Ibaraki Tsukuba305-0801 Japan UTIAS The University of Tokyo Chiba Kashiwa277-8583 Japan Department of Physics University of Toyama 3190 Gofuku Toyama930-8555 Japan RIKEN iTHEMS Saitama Wako351-0198 Japan The University of Tokyo Chiba Kashiwa277-8582 Japan ETH Zürich ZürichCH-8093 Switzerland Instituto de Astrofísica de Canarias Dpto. de Astrofísica Universidad de La Laguna Tenerife La LagunaE-38200 Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain RomeI-00136 Italy Università di Udine INFN Trieste UdineI-33100 Italy Università di Padova INFN PadovaI-35131 Italy Technische Universität Dortmund DortmundD-44221 Germany Zagreb10000 Croatia IPARCOS Institute EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain URCA RJ Rio de Janeiro22290-180 Brazil University of Lodz Faculty of Physics and Applied Informatics Department of Astrophysics Lodz90-236 Poland Centro de Investigaciones Energéticas Medioambientales y Tecnológicas MadridE-28040 Spain Departament de Física CERES-IEEC Universitat Autònoma de Barcelona BellaterraE-08193 Spain Università di Pisa INFN Pisa PisaI-56126 Italy Universitat de Barcelona ICCUB IEEC-UB BarcelonaE-08028 Spain Armenian MAGIC Group A. Alikhanyan National Science Laboratory Yerevan0036 Armenia Department for Physics and Technology University of Bergen Norway INFN MAGIC Group INFN Sezione di Catania Dipartimento di Fisica e Astronomia University of Catania CataniaI-95123 Italy INFN MAGIC Group INFN Sezione di Torino Università degli Studi di Torino TorinoI-10125 Italy INFN MAGIC Group INFN Sezione di Bar

The detection of line-like TeV gamma-ray features configures as a smoking gun for the discovery of TeV-scale particle dark matter. We report the first search for dark matter spectral lines in the Galactic Centre region up to gamma-ray energies of 100 TeV with the MAGIC telescopes (La Palma, Canary Islands). The Galactic Centre region is expected to host the closest dark matter halo of considerable size and is therefore well suited for this kind of searches. Observations at large zenith angles improve sensitivity for gamma rays in the TeV regime due to the increased telescope collection area. We present the results obtained with more than 200 hours of large-zenith angle observations of the Galactic Centre region, which allow us to obtain competitive limits to the dark matter annihilation cross-section at high particle masses (−28 cm3 s−1 at 1 TeV and −25 cm3 s−1 at 100 TeV), improving the best current constraints above 20 TeV. In addition, we also study the impact of an inner cored dark matter halo on probing the annihilation cross-section. Finally, we use the derived limits to constrain super-symmetric wino models. © Copyright owned by the author(s) under the terms of the Creative Commons.

关键词： Gamma rays

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Publisher Correction: Firn on ice sheets

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Nature Reviews Earth & Environment 2024年 330页

作者： Charles Amory Christo Buizert Sammie Buzzard Elizabeth Case Nicole Clerx Riley Culberg Rajashree Tri Datta Devon Dunmire Jan T. M. Lenaerts Megan Thompson-Munson Nander Wever Rahul Dey Reinhard Drews Falk M. Oraschewski Clare Eayrs Nicolaj Hansen Sebastian B. Simonsen Angelika Humbert Athul Kaitheri Kaitlin Keegan Ian McDowell Peter Kuipers Munneke Stef Lhermitte Sophie de Roda Husman Bert Wouters Doug Mair Jessica Mejia Colin R. Meyer Elizabeth Morris Dorothea Moser Elizabeth R. Thomas Emma Pearce Nicole-Jeanne Schlegel Timm Schultz C. Max Stevens Institut des Géosciences de l’Environnement University Grenoble Alpes CNRS Grenoble France College of Earth Ocean and Atmospheric Sciences Oregon State University Corvallis OR USA School of Earth and Environmental Sciences Cardiff University Cardiff UK Department of Geography and Environmental Sciences Northumbria University Newcastle upon Tyne UK Department of Earth and Environmental Sciences Columbia University NY USA Department of Geosciences Université de Fribourg Fribourg Switzerland Department of Earth and Atmospheric Sciences Cornell University Ithaca NY USA Department of Atmospheric and Oceanic Sciences University of Colorado Boulder Boulder CO USA Cooperative Institute for Research in Environmental Sciences (CIRES) University of Colorado Boulder Boulder CO USA WSL Institute for Snow and Avalanche Research SLF Davos Switzerland National Centre for Polar and Ocean Research (NCPOR) Ministry of Earth Sciences Vasco da Gama Goa India Department of Geosciences University of Tübingen Tübingen Germany Center for Global Sea Level Change New York University Abu Dhabi Abu Dhabi UAE Department of Glacial Environment Research Korea Polar Research Institute Incheon Republic of Korea Geodesy and Earth Observation DTU Space Technical University of Denmark Kongens Lyngby Denmark Danish Meteorological Institute Copenhagen Denmark Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research Bremerhaven Germany Faculty of Geosciences University of Bremen Bremen Germany Observatoire de la Côte d’Azur Université Côte d’Azur CNRS Valbonne France Department of Geological Sciences and Engineering University of Nevada Reno USA Graduate Program of Hydrologic Sciences University of Nevada Reno NV USA Institute for Marine and Atmospheric Research (IMAU) Utrecht University Utrecht The Netherlands Department of Earth and Environmental Sciences KU Leuven Leuven Belgium Department of Geoscience and Remote Sensing Delft University of Technology (TUDel

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Bioactive extracts from swartzia latifolia

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Chemical Engineering Transactions 2018年 64卷 211-216页

作者： da Costa, Gilzonia Veloso da Costa, Habdel N. R. dos Santos, Ricardo C. de Melo Filho, Antônio A. Chagas, Edvan A. Montero, Ismael F. Chagas, Pollyana C. de Melo, Ana Cristina G. R. Campus Paricarana Boa Vista-RRCEP 69304-000 Brazil Post-Graduate Program in Chemistry PPGQ Center for Research and Graduate Studies in Science and Technology NPPGCT UFRR and Chemistry Department UFRR Campus Paricarana Boa Vista-RRCEP 69304-000 Brazil National Postdoctoral Program of CAPE associated to POSAGRO/UFRR Campus Cauamé BR 174 s/n Km 12 District Monte Cristo Boa Vista-RRCEP 69310-250 Brazil Embrapa Rodovia 174 Km 8 Industrial District Boa Vista-RRCEP 69301970 Brazil Post Graduate Program in Biodiversity and Biotechnology Bionorte State Coordination of Roraima UFRR Campus Paricarana Boa Vista-RRCEP 69304-000 Brazil Post Graduate in Agronomy POSAGRO UFRR Campus Paricarana Boa Vista-RRCEP 69304-000 Brazil

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Physical Characteristics of Modified Cassava Flour Wastewater at Room Temperature

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IOP Conference Series: Earth and environmental science 2019年第1期292卷

作者： N Yaqin A N Al-Baarri A M Legowo Widayat M A Budihardjo Program of Environmental Science School of Post Graduate Studies Diponegoro University Semarang Indonesia Center of Research and Services-Diponegoro University Semarang Indonesia Food Technology Department Faculty of Animal and Agricultural Sciences Diponegoro University Semarang Indonesia Chemical Engineering Department Faculty of Engineering Diponegoro University Semarang Indonesia Department of Environmental Engineering Faculty of Engineering Diponegoro University Indonesia

Cassava is an agricultural material that is considered as important raw resources in the industrial sector. The benefits are even greater after being modified using lactic acid bacteria. However, the mocaf industry often causes water and air pollution. environmental problems arise after the fermentation process. Determination problems with lightness, TDS (Total Dissolved Solid), conductivity and pH analysis are required to measure the impact to the environment. This research was used waste water from mocaf during 3 days fermentation. The wastewater had the highest color level (Lightness) on initial day of fermentation at 83.7±3.73 and then decrease along the day of fermentation at the averages of 65.2±2.0. The highest TDS was resulted from the mocaf wastewater at a value of 1218 ± 4.6 ppm which continued to decline until day 4. The conductivity and pH showed a decrease along the day of fermentation. As conclusion, physical characteristic of wastewater from mocaf production could be analyzed specifically and determined through color, TDS, conductivity, and pH.

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Development of a Measurement Software for the Characterization of WORM Devices for Novel Memory Storage Applications

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Journal of Computer and Communications 2018年第9期6卷 1-13页

作者： Mirko Congiu Miguel H. Boratto Paride Pica Carlos F. O. Graeff POSMAT—Post-Graduate Program in Materials Science and Technology School of Sciences UNESP—S&#227 o Paulo State University Bauru SP Brazil Department of Chemistry-Piazzale Aldo Moro University of Rome “La Sapienza” Rome RM Italy Department of Physics School of Sciences UNESP—S&#227 o Paulo State University Bauru SP Brazil

We hereby propose a software solution to perform high quality electrical measurements for the characterization of WORM (write-once read many), a new generation memory device which is being intensively studied for non-volatile data storage. The as-proposed software is completely based on .NET framework and sample C# code. The paper performed a relevant measurement based on this software. Working WORM devices, based on a polymeric matrix embedded with gold and copper sulfide nanoparticles, have been used for test measurements. The aim of this paper is to show the main steps to develop a fully working measurement software without using any expensive dedicated software.

关键词： WORM Memristor Electrical Measurements Memory Devices

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Biological activity of hexane extracts of the northern amazon species capsicum spp.

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Chemical Engineering Transactions 2018年 64卷 277-282页

作者： Morais, Karla S. de Melo Filho, Antonio A. Vilarinho, Lucianne B. O. Morais, Bruna S. Chagas, Pollyana C. dos Santos, Ricardo C. Reis Melo, Ana C. G. Takahashi, Jacqueline A. Department of Health Federal Institute of Roraima IFRR Boa Vista Campus CEP 69.303-340 Boa Vista-RR Brazil Post-Graduate in Biotechnology and Biodiversity Program Departament of Chemistry and Post-Graduate Program in Chemistry PPGQ Center for Research and Graduate Studies in Science and Technology NPPGCT Federal University of Roraima UFRR Paricarana Campus Boa Vista-RRCEP 69304-000 Brazil Post Graduate in Agronomy POSAGRO UFRR Campus Paricarana Boa Vista-RRCEP 69304-000 Brazil Cauamé Campus BR 174 s/n Km 12 District Monte Cristo Boa Vista-RRCEP 69.301-970 Brazil Department of Chemistry Institute of Exact Sciences Federal University of Minas Gerais UFMG CEP 31270-901 Belo HorizonteMinas Gerais Brazil

ISBN: (纸本)9788895608563

The objective of this study was to evaluate the presence of inhibitory substances from the fruits of Capsicum spp. var. Canaimé against micro-organisms indicators. Mature fruits (1.0 kg) were purchased at an agricultural fair, dried in an oven, and then was continuously extracted on a Soxhlet apparatus for 6 h, using 500 mL of hexane. Gram-positive Staphylococcus aureus (ATCC 25923), Listeria monocytogenes (ATCC 15313) and Bacillus cereus (ATCC 49456) were used to perform the antibacterial activity, as well as three Gram-negative strains: Salmonella typhimurium (ATCC 14028), Citrobacter freundi (ATCC 8090) and Pseudomonas aeruginosa (ATCC 25922). The antibacterial activity of hexane extract of Capsicum spp. fruits in some concentrations, was quite high when compared with the antibiotic. The level of inhibition was better towards Gram (-) bacteria compared to Gram (+) bacteria. The excellent bioactivity of the extract against S. typhimurium may be related to its selectivity. The present study demonstrated the efficacy of Capsicum spp. extract against pathogens that affect the health of human beings and presence of chemical assets that aid in the prevention of diseases. However, more in-depth studies are still needed to consolidate its use and application in pharmaceutical area. Copyright © 2018, AIDIC Servizi S.r.l.

关键词： Fruits

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Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries (vol 55, pg 89, 2023)

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NATURE GENETICS 2023年第3期55卷 519-520页

作者： Fernandez-Rozadilla, Ceres Timofeeva, Maria Chen, Zhishan Law, Philip Thomas, Minta Schmit, Stephanie Diez-Obrero, Virginia Hsu, Li Fernandez-Tajes, Juan Palles, Claire Sherwood, Kitty Briggs, Sarah Svinti, Victoria Donnelly, Kevin Farrington, Susan Blackmur, James Vaughan-Shaw, Peter Shu, Xiao-ou Long, Jirong Cai, Qiuyin Guo, Xingyi Lu, Yingchang Broderick, Peter Studd, James Huyghe, Jeroen Harrison, Tabitha Conti, David Dampier, Christopher Devall, Mathew Schumacher, Fredrick Melas, Marilena Rennert, Gad Obon-Santacana, Mireia Martin-Sanchez, Vicente Moratalla-Navarro, Ferran Oh, Jae Hwan Kim, Jeongseon Jee, Sun Ha Jung, Keum Ji Kweon, Sun-Seog Shin, Min-Ho Shin, Aesun Ahn, Yoon-Ok Kim, Dong-Hyun Oze, Isao Wen, Wanqing Matsuo, Keitaro Matsuda, Koichi Tanikawa, Chizu Ren, Zefang Gao, Yu-Tang Jia, Wei-Hua Hopper, John Jenkins, Mark Win, Aung Ko Pai, Rish Figueiredo, Jane Haile, Robert Gallinger, Steven Woods, Michael Newcomb, Polly Duggan, David Cheadle, Jeremy Kaplan, Richard Maughan, Timothy Kerr, Rachel Kerr, David Kirac, Iva Bohm, Jan Mecklin, Lukka-Pekka Jousilahti, Pekka Knekt, Paul Aaltonen, Lauri Rissanen, Harri Pukkala, Eero Eriksson, Johan Cajuso, Tatiana Hanninen, Ulrika Kondelin, Johanna Palin, Kimmo Tanskanen, Tomas Renkonen-Sinisalo, Laura Zanke, Brent Mannisto, Satu Albanes, Demetrius Weinstein, Stephanie Ruiz-Narvaez, Edward Palmer, Julie Buchanan, Daniel Platz, Elizabeth Visvanathan, Kala Ulrich, Cornelia Siegel, Erin Brezina, Stefanie Gsur, Andrea Campbell, Peter Chang-Claude, Jenny Hoffmeister, Michael Brenner, Hermann Slattery, Martha Potter, John Tsilidis, Konstantinos Schulze, Matthias Gunter, Marc Murphy, Neil Castells, Antoni Castellvi-Bel, Sergi Moreira, Leticia Arndt, Volker Shcherbina, Anna Stern, Mariana Pardamean, Bens Bishop, Timothy Giles, Graham Southey, Melissa Idos, Gregory McDonnell, Kevin Abu-Ful, Zomoroda Greenson, Joel Shulman, Katerina Lejbkowicz, Flavio Offit, Kenneth Su, Yu-Ru Steinfelder, Robert Keku, Temitope van Guelpen, Bethany Hudson, Thomas Hampel, Heather Pearlman, Edinburgh Cancer Research Centre Institute of Genomics and Cancer University of Edinburgh Edinburgh UK Genomic Medicine Group Instituto de Investigacion Sanitaria de Santiago Santiago de Compostela Spain Colon Cancer Genetics Group Medical Research Council Human Genetics Unit Institute of Genetics and Cancer University of Edinburgh Edinburgh UK Danish Institute for Advanced Study Department of Public Health University of Southern Denmark Odense Denmark Division of Epidemiology Department of Medicine Vanderbilt-Ingram Cancer Center Vanderbilt Epidemiology Center Vanderbilt University Medical Center Nashville TN USA Division of Genetics and Epidemiology Institute of Cancer Research London UK Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle WA USA Genomic Medicine Institute Cleveland Clinic Cleveland OH USA Population and Cancer Prevention Program Case Comprehensive Cancer Center Cleveland OH USA Colorectal Cancer Group ONCOBELL Program Bellvitge Biomedical Research Institute Barcelona Spain Oncology Data Analytics Program Catalan Institute of Oncology Barcelona Spain Consortium for Biomedical Research in Epidemiology and Public Health Madrid Madrid Spain Department of Clinical Sciences Faculty of Medicine University of Barcelona Barcelona Spain Department of Biostatistics School of Public Health University of Washington Seattle WA USA Institute of Cancer and Genomic Sciences College of Medical and Dental Sciences University of Birmingham Birmingham UK Department of Public Health Richard Doll Building University of Oxford Oxford UK Department of Biomedical Informatics Vanderbilt University School of Medicine Nashville TN USA Department of Preventive Medicine USC Norris Comprehensive Cancer Center Keck School of Medicine University of Southern California Los Angeles CA USA Center for Public Health Genomics Department of Public Health Sciences University of Virginia Charlottesville VA USA Department of Populat

Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and east Asian ancestry, identifying 205 independent risk associations, of which 50 were unreported. We performed integrative genomic, transcriptomic and methylomic analyses across large bowel mucosa and other tissues. Transcriptome- and methylome-wide association studies revealed an additional 53 risk associations. We identified 155 high-confidence effector genes functionally linked to CRC risk, many of which had no previously established role in CRC. These have multiple different functions and specifically indicate that variation in normal colorectal homeostasis, proliferation, cell adhesion, migration, immunity and microbial interactions determines CRC risk. Crosstissue analyses indicated that over a third of effector genes most probably act outside the colonic mucosa. Our findings provide insights into colorectal oncogenesis and highlight potential targets across tissues for new CRC treatment and chemoprevention strategies.

关键词： Colorectal cancer Epigenomics Genome-wide association studies Transcriptomics

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Ultrasound-assisted synthesis of adsorbents from groundwater treatment residuals for hexavalent chromium removal from aqueous solutions

引用

Groundwater for Sustainable Development 2017年 5卷 253-260页

作者： Kan, Chi-Chuan Sumalinog, Mario Jose R. Rivera, Kim Katrina P. Arazo, Renato O. de Luna, Mark Daniel G. Institute of Hot Spring Industry Chia-Nan University of Pharmacy and Science Tainan71710 Taiwan Environmental Engineering Program National Graduate School of Engineering University of the Philippines Diliman Quezon City1101 Philippines Department of Chemical Engineering University of the Philippines Diliman Quezon City1101 Philippines College of Engineering and Technology University of Science and Technology of Southern Philippines Claveria9004 Philippines

Groundwater treatment residuals are rich in nano-sized metal oxides which have the potential to remove various water contaminants. In this study, hexavalent chromium adsorbents were synthesized from the residuals of a 30,000 m3 d-1 groundwater treatment plant in Taiwan. The effects of acid type and ratio, acid concentration, ultrasonication time, and heating duration on adsorption capacity were examined. Adsorbents synthesized using dual-acid solutions yielded lower adsorption capacities compared to those which used pure acid solutions. Adsorption capacity decreased with higher ultrasonication time and heating duration. Chromium removal was improved with higher ionic strength and lower pH of the solution. Results showed high correlation between experimental data and the Freundlich isotherm (R2 = 0.9607) and the pseudo-second order kinetic model (R2 = 0.9740) suggesting that the dominant mechanism in the adsorption process is chemisorption. The involvement of Fe and Mn species during chromium adsorption was confirmed by the results of energy dispersive X-ray spectroscopy and Fourier transform infrared (FTIR) spectroscopy analyses. © 2017

关键词： Adsorption

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