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Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries (vol 55, pg 89, 2023)

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NATURE GENETICS 2023年第3期55卷 519-520页

作者： Fernandez-Rozadilla, Ceres Timofeeva, Maria Chen, Zhishan Law, Philip Thomas, Minta Schmit, Stephanie Diez-Obrero, Virginia Hsu, Li Fernandez-Tajes, Juan Palles, Claire Sherwood, Kitty Briggs, Sarah Svinti, Victoria Donnelly, Kevin Farrington, Susan Blackmur, James Vaughan-Shaw, Peter Shu, Xiao-ou Long, Jirong Cai, Qiuyin Guo, Xingyi Lu, Yingchang Broderick, Peter Studd, James Huyghe, Jeroen Harrison, Tabitha Conti, David Dampier, Christopher Devall, Mathew Schumacher, Fredrick Melas, Marilena Rennert, Gad Obon-Santacana, Mireia Martin-Sanchez, Vicente Moratalla-Navarro, Ferran Oh, Jae Hwan Kim, Jeongseon Jee, Sun Ha Jung, Keum Ji Kweon, Sun-Seog Shin, Min-Ho Shin, Aesun Ahn, Yoon-Ok Kim, Dong-Hyun Oze, Isao Wen, Wanqing Matsuo, Keitaro Matsuda, Koichi Tanikawa, Chizu Ren, Zefang Gao, Yu-Tang Jia, Wei-Hua Hopper, John Jenkins, Mark Win, Aung Ko Pai, Rish Figueiredo, Jane Haile, Robert Gallinger, Steven Woods, Michael Newcomb, Polly Duggan, David Cheadle, Jeremy Kaplan, Richard Maughan, Timothy Kerr, Rachel Kerr, David Kirac, Iva Bohm, Jan Mecklin, Lukka-Pekka Jousilahti, Pekka Knekt, Paul Aaltonen, Lauri Rissanen, Harri Pukkala, Eero Eriksson, Johan Cajuso, Tatiana Hanninen, Ulrika Kondelin, Johanna Palin, Kimmo Tanskanen, Tomas Renkonen-Sinisalo, Laura Zanke, Brent Mannisto, Satu Albanes, Demetrius Weinstein, Stephanie Ruiz-Narvaez, Edward Palmer, Julie Buchanan, Daniel Platz, Elizabeth Visvanathan, Kala Ulrich, Cornelia Siegel, Erin Brezina, Stefanie Gsur, Andrea Campbell, Peter Chang-Claude, Jenny Hoffmeister, Michael Brenner, Hermann Slattery, Martha Potter, John Tsilidis, Konstantinos Schulze, Matthias Gunter, Marc Murphy, Neil Castells, Antoni Castellvi-Bel, Sergi Moreira, Leticia Arndt, Volker Shcherbina, Anna Stern, Mariana Pardamean, Bens Bishop, Timothy Giles, Graham Southey, Melissa Idos, Gregory McDonnell, Kevin Abu-Ful, Zomoroda Greenson, Joel Shulman, Katerina Lejbkowicz, Flavio Offit, Kenneth Su, Yu-Ru Steinfelder, Robert Keku, Temitope van Guelpen, Bethany Hudson, Thomas Hampel, Heather Pearlman, Edinburgh Cancer Research Centre Institute of Genomics and Cancer University of Edinburgh Edinburgh UK Genomic Medicine Group Instituto de Investigacion Sanitaria de Santiago Santiago de Compostela Spain Colon Cancer Genetics Group Medical Research Council Human Genetics Unit Institute of Genetics and Cancer University of Edinburgh Edinburgh UK Danish Institute for Advanced Study Department of Public Health University of Southern Denmark Odense Denmark Division of Epidemiology Department of Medicine Vanderbilt-Ingram Cancer Center Vanderbilt Epidemiology Center Vanderbilt University Medical Center Nashville TN USA Division of Genetics and Epidemiology Institute of Cancer Research London UK Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle WA USA Genomic Medicine Institute Cleveland Clinic Cleveland OH USA Population and Cancer Prevention Program Case Comprehensive Cancer Center Cleveland OH USA Colorectal Cancer Group ONCOBELL Program Bellvitge Biomedical Research Institute Barcelona Spain Oncology Data Analytics Program Catalan Institute of Oncology Barcelona Spain Consortium for Biomedical Research in Epidemiology and Public Health Madrid Madrid Spain Department of Clinical Sciences Faculty of Medicine University of Barcelona Barcelona Spain Department of Biostatistics School of Public Health University of Washington Seattle WA USA Institute of Cancer and Genomic Sciences College of Medical and Dental Sciences University of Birmingham Birmingham UK Department of Public Health Richard Doll Building University of Oxford Oxford UK Department of Biomedical Informatics Vanderbilt University School of Medicine Nashville TN USA Department of Preventive Medicine USC Norris Comprehensive Cancer Center Keck School of Medicine University of Southern California Los Angeles CA USA Center for Public Health Genomics Department of Public Health Sciences University of Virginia Charlottesville VA USA Department of Populat

Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and east Asian ancestry, identifying 205 independent risk associations, of which 50 were unreported. We performed integrative genomic, transcriptomic and methylomic analyses across large bowel mucosa and other tissues. Transcriptome- and methylome-wide association studies revealed an additional 53 risk associations. We identified 155 high-confidence effector genes functionally linked to CRC risk, many of which had no previously established role in CRC. These have multiple different functions and specifically indicate that variation in normal colorectal homeostasis, proliferation, cell adhesion, migration, immunity and microbial interactions determines CRC risk. Crosstissue analyses indicated that over a third of effector genes most probably act outside the colonic mucosa. Our findings provide insights into colorectal oncogenesis and highlight potential targets across tissues for new CRC treatment and chemoprevention strategies.

关键词： Colorectal cancer Epigenomics Genome-wide association studies Transcriptomics

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Correction to: Species-level characterization of gut microbiota and their metabolic role in kidney stone formation using full-length 16S rRNA sequencing

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Urolithiasis 2024年第1期52卷 150页

作者： Bashir Hussain Chin-Chia Wu Hsin-Chi Tsai Jung-Sheng Chen Aslia Asif Ming-Chin Cheng Yeong-Chin Jou Bing-Mu Hsu Department of Earth and Environmental Sciences National Chung Cheng University Chiayi County Taiwan. Department of Biomedical Sciences National Chung Cheng University Chiayi County Taiwan. Division of Colorectal Surgery Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi County Taiwan. College of Medicine Tzu Chi University Hualien Taiwan. School of Post-Baccalaureate Chinese Medicine Tzu Chi University Hualien Taiwan. Department of Psychiatry School of Medicine Tzu Chi University Hualien Taiwan. Department of Psychiatry Tzu-Chi General Hospital Hualien Taiwan. Department of Medical Research E-Da Hospital I-Shou University Kaohsiung Taiwan. nicky071214@***. Doctoral Program in Science Technology Environment and Mathematics National Chung Cheng University Chiayi Taiwan. Department of Urology Ditmanson Medical Foundation Chiayi Christian Hospital Chiayi County Taiwan. Department of Urology St. Martin De Porres Hospital Chiayi County Taiwan. Department of Medical Research Dalin Tzu Chi Hospital The Buddhist Tzu Chi Medical Foundation Chiayi County Taiwan.

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Author Correction: RADICL-seq identifies general and cell type-specific principles of genome-wide RNA-chromatin interactions

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Nature communications 2021年第1期12卷 3128页

作者： Alessandro Bonetti Federico Agostini Ana Maria Suzuki Kosuke Hashimoto Giovanni Pascarella Juliette Gimenez Leonie Roos Alex J Nash Marco Ghilotti Christopher J F Cameron Matthew Valentine Yulia A Medvedeva Shuhei Noguchi Eneritz Agirre Kaori Kashi Joachim Luginbühl Riccardo Cazzoli Saumya Agrawal Nicholas M Luscombe Mathieu Blanchette Takeya Kasukawa Michiel de Hoon Erik Arner Boris Lenhard Charles Plessy Gonçalo Castelo-Branco Valerio Orlando Piero Carninci RIKEN Center for Integrative Medical Sciences Yokohama Kanagawa 230-0045 Japan. alessandro.bonetti@riken.jp. Laboratory of Molecular Neurobiology Department Medical Biochemistry and Biophysics Karolinska Institutet Stockholm Sweden. alessandro.bonetti@riken.jp. The Francis Crick Institute 1 Midland Road London NW1 1AT UK. RIKEN Center for Integrative Medical Sciences Yokohama Kanagawa 230-0045 Japan. Department of Medicine (H7) Karolinska Institutet Stockholm 141 86 Sweden. Epigenetics and Genome Reprogramming Laboratory IRCCS Fondazione Santa Lucia Rome Italy. Faculty of Medicine Imperial College London Institute of Clinical Sciences London W12 0NN UK. MRC London Institute of Medical Sciences London W12 0NN UK. School of Computer Science McGill University Montréal QC Canada. Department of Biochemistry and Goodman Cancer Research Centre McGill University Montréal QC Canada. Institute of Bioengineering Research Centre of Biotechnology Russian Academy of Science 117312 Moscow Russia. Department of Computational Biology Vavilov Institute of General Genetics Russian Academy of Science 119991 Moscow Russia. Department of Biological and Medical Physics Moscow Institute of Physics and Technology 141701 Dolgoprudny Moscow Region Russia. Laboratory of Molecular Neurobiology Department Medical Biochemistry and Biophysics Karolinska Institutet Stockholm Sweden. Department of Experimental Oncology IEO European Institute of Oncology IRCCS Milan Italy. UCL Genetics Institute University College London London WC1E 6BT UK. Okinawa Institute of Science and Technology Graduate University 1919-1 Tancha Onna-son Kunigami-gun Okinawa 904-0495 Japan. Sars International Centre for Marine Molecular Biology University of Bergen 5008 Bergen Norway. Epigenetics and Genome Reprogramming Laboratory IRCCS Fondazione Santa Lucia Rome Italy. valerio.orlando@kaust.edu.sa. KAUST Environmental Epigenetics Program King Abdullah University of Science and Technology (KAUS

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Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021

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The Lancet 2023年第10397期402卷 203-234页

作者： Ong, Kanyin Liane Stafford, Lauryn K. McLaughlin, Susan A. Boyko, Edward J. Vollset, Stein Emil Smith, Amanda E. Dalton, Bronte E. Duprey, Joe Cruz, Jessica A. Hagins, Hailey Lindstedt, Paulina A. Aali, Amirali Abate, Yohannes Habtegiorgis Abate, Melsew Dagne Abbasian, Mohammadreza Abbasi-Kangevari, Zeinab Abbasi-Kangevari, Mohsen ElHafeez, Samar Abd Abd-Rabu, Rami Abdulah, Deldar Morad Abdullah, Abu Yousuf Md Abedi, Vida Abidi, Hassan Aboagye, Richard Gyan Abolhassani, Hassan Abu-Gharbieh, Eman Abu-Zaid, Ahmed Adane, Tigist Demssew Adane, Denberu Eshetie Addo, Isaac Yeboah Adegboye, Oyelola A. Adekanmbi, Victor Adepoju, Abiola Victor Adnani, Qorinah Estiningtyas Sakilah Afolabi, Rotimi Felix Agarwal, Gina Aghdam, Zahra Babaei Agudelo-Botero, Marcela Arriagada, Constanza Elizabeth Aguilera Agyemang-Duah, Williams Ahinkorah, Bright Opoku Ahmad, Danish Ahmad, Rizwan Ahmad, Sajjad Ahmad, Aqeel Ahmadi, Ali Ahmadi, Keivan Ahmed, Ali Ahmed, Luai A. Ahmed, Syed Anees Ajami, Marjan Akinyemi, Rufus Olusola Al Hamad, Hanadi Al Hasan, Syed Mahfuz AL-Ahdal, Tareq Mohammed Ali Alalwan, Tariq A. Al-Aly, Ziyad AlBataineh, Mohammad T. Alcalde-Rabanal, Jacqueline Elizabeth Alemi, Sharifullah Ali, Hassam Alinia, Tahereh Aljunid, Syed Mohamed Almustanyir, Sami Al-Raddadi, Rajaa M. Alvis-Guzman, Nelson Amare, Firehiwot Ameyaw, Edward Kwabena Amiri, Sohrab Amusa, Ganiyu Adeniyi Andrei, Catalina Liliana Anjana, Ranjit Mohan Ansar, Adnan Ansari, Golnoosh Ansari-Moghaddam, Alireza Anyasodor, Anayochukwu Edward Arabloo, Jalal Aravkin, Aleksandr Y. Areda, Demelash Arifin, Hidayat Arkew, Mesay Armocida, Benedetta Arnlov, Johan Artamonov, Anton A. Arulappan, Judie Aruleba, Raphael Taiwo Arumugam, Ashokan Aryan, Zahra Asemu, Mulu Tiruneh Asghari-Jafarabadi, Mohammad Askari, Elaheh Asmelash, Daniel Astell-Burt, Thomas Athar, Mohammad Athari, Seyyed Shamsadin Atout, Maha Moh'd Wahbi Avila-Burgos, Leticia Awaisu, Ahmed Azadnajafabad, Sina Darshan, B.B. Babamohamadi, Hassan Badar, Muhammad Badawi, Alaa Badiye, Ashish D. Baghcheghi, Nayereh Baghe Institute for Health Metrics and Evaluation School of Medicine General Medicine Service Department of Veterans Affairs Seattle WA United States Department of Health Metrics Sciences School of Medicine Faculty of Medicine France Department of Clinical Governance and Quality Improvement Aleta Wondo Hospital Aleta Wondo Ethiopia Department of Nursing Woldia University Woldia Ethiopia Department of Nursing Department of Orthopedic Surgery Orthopaedic Surgery Social Determinants of Health Research Center Non-communicable Diseases Research Center Epidemiology Department Evidence-Based Practice Center Community and Maternity Nursing Unit University of Duhok Duhok Iraq School of Planning Faculty of Environment Department of Public Health Sciences Penn State College of Medicine Pennsylvania State University Hershey PA United States Biocomplexity Institute Virginia Tech Blacksburg VA United States College of Medicine Department of Public Health Laboratory Technology Sciences Department Department of Family and Community Health University of Health and Allied Sciences Ho Ghana Research Center for Immunodeficiencies Department of Biosciences and Nutrition Karolinska University Hospital Huddinge Sweden Clinical Sciences Department Department of Surgery Department of Surgery Department of Obstetrics & Gynecology College of Graduate Health Sciences University of Tennessee Memphis TN United States Department of Obstetrics & Gynecology Department of Clinical and Psychosocial Epidemiology Department of Anesthesia and Critical Care Centre for Social Research in Health Quality and Systems Performance Unit Cancer Institute NSW Sydney NSW Australia Department of Public Health and Tropical Medicine HIV and Infectious Diseases Department Jhpiego Abuja Nigeria Adolescent Research and Care Department Adolescent Friendly Research Initiative and Care Ado Ekiti Nigeria Department of Epidemiology Department of Epidemiology and Medical Statistics Department of Family Medicine McMaster University

Background: Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), we produced location-specific, age-specific, and sex-specific estimates of diabetes prevalence and burden from 1990 to 2021, the proportion of type 1 and type 2 diabetes in 2021, the proportion of the type 2 diabetes burden attributable to selected risk factors, and projections of diabetes prevalence through 2050. Methods: Estimates of diabetes prevalence and burden were computed in 204 countries and territories, across 25 age groups, for males and females separately and combined;these estimates comprised lost years of healthy life, measured in disability-adjusted life-years (DALYs;defined as the sum of years of life lost [YLLs] and years lived with disability [YLDs]). We used the Cause of Death Ensemble model (CODEm) approach to estimate deaths due to diabetes, incorporating 25 666 location-years of data from vital registration and verbal autopsy reports in separate total (including both type 1 and type 2 diabetes) and type-specific models. Other forms of diabetes, including gestational and monogenic diabetes, were not explicitly modelled. Total and type 1 diabetes prevalence was estimated by use of a Bayesian meta-regression modelling tool, DisMod-MR 2.1, to analyse 1527 location-years of data from the scientific literature, survey microdata, and insurance claims;type 2 diabetes estimates were computed by subtracting type 1 diabetes from total estimates. Mortality and prevalence estimates, along with standard life expectancy and disability weights, were used to calculate YLLs, YLDs, and DALYs. When appropriate, we extrapolated estimates to a hypothetical population with a standardised age structure to allow comparison in populations with different age structures. We used the comparative r

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Search for Gamma-Ray Spectral Lines from Dark Matter Annihilation up to 100 TeV toward the Galactic Center with MAGIC

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Physical Review Letters 2023年第6期130卷 061002-061002页

作者： H. Abe S. Abe V. A. Acciari T. Aniello S. Ansoldi L. A. Antonelli A. Arbet Engels C. Arcaro M. Artero K. Asano D. Baack A. Babić A. Baquero U. Barres de Almeida J. A. Barrio I. Batković J. Baxter J. Becerra González W. Bednarek E. Bernardini M. Bernardos A. Berti J. Besenrieder W. Bhattacharyya C. Bigongiari A. Biland O. Blanch G. Bonnoli Ž. Bošnjak I. Burelli G. Busetto R. Carosi M. Carretero-Castrillo G. Ceribella Y. Chai A. Chilingarian S. Cikota E. Colombo J. L. Contreras J. Cortina S. Covino G. D’Amico V. D’Elia P. Da Vela F. Dazzi A. De Angelis B. De Lotto A. Del Popolo M. Delfino J. Delgado C. Delgado Mendez D. Depaoli F. Di Pierro L. Di Venere E. Do Souto Espiñeira D. Dominis Prester A. Donini D. Dorner M. Doro D. Elsaesser G. Emery V. Fallah Ramazani L. Fariña A. Fattorini L. Font C. Fruck S. Fukami Y. Fukazawa R. J. García López M. Garczarczyk S. Gasparyan M. Gaug J. G. Giesbrecht Paiva N. Giglietto F. Giordano P. Gliwny N. Godinović J. G. Green D. Green D. Hadasch A. Hahn T. Hassan L. Heckmann J. Herrera D. Hrupec M. Hütten R. Imazawa T. Inada R. Iotov K. Ishio I. Jiménez Martínez J. Jormanainen D. Kerszberg Y. Kobayashi H. Kubo J. Kushida A. Lamastra D. Lelas F. Leone E. Lindfors L. Linhoff S. Lombardi F. Longo R. López-Coto M. López-Moya A. López-Oramas S. Loporchio A. Lorini E. Lyard B. Machado de Oliveira Fraga P. Majumdar M. Makariev G. Maneva N. Mang M. Manganaro S. Mangano K. Mannheim M. Mariotti M. Martínez A. Mas Aguilar D. Mazin S. Menchiari S. Mender S. Mićanović D. Miceli T. Miener J. M. Miranda R. Mirzoyan E. Molina H. A. Mondal A. Moralejo D. Morcuende V. Moreno T. Nakamori C. Nanci L. Nava V. Neustroev M. Nievas Rosillo C. Nigro K. Nilsson K. Nishijima T. Njoh Ekoume K. Noda S. Nozaki Y. Ohtani T. Oka J. Otero-Santos S. Paiano M. Palatiello D. Paneque R. Paoletti J. M. Paredes L. Pavletić M. Persic M. Pihet F. Podobnik P. G. Prada Moroni E. Prandini G. Principe C. Priyadarshi I. Puljak W. Rhode M. Ribó J. Rico C. Righi A. Rugliancich N. Sahakyan T. Saito S. Sakurai K. Satalecka F. G. Sat Japanese MAGIC Group: Institute for Cosmic Ray Research (ICRR) The University of Tokyo Kashiwa 277-8582 Chiba Japan Instituto de Astrofísica de Canarias and Departamento de Astrofísica Universidad de La Laguna E-38200 La Laguna Tenerife Spain National Institute for Astrophysics (INAF) I-00136 Rome Italy Università di Udine and INFN Trieste I-33100 Udine Italy Max-Planck-Institut für Physik D-80805 München Germany Università di Padova and INFN I-35131 Padova Italy Institut de Física d’Altes Energies (IFAE) The Barcelona Institute of Science and Technology (BIST) E-08193 Bellaterra (Barcelona) Spain Technische Universität Dortmund D-44221 Dortmund Germany Croatian MAGIC Group: University of Zagreb Faculty of Electrical Engineering and Computing (FER) 10000 Zagreb Croatia IPARCOS Institute and EMFTEL Department Universidad Complutense de Madrid E-28040 Madrid Spain Centro Brasileiro de Pesquisas Físicas (CBPF) 22290-180 URCA Rio de Janeiro (RJ) Brazil University of Lodz Faculty of Physics and Applied Informatics Department of Astrophysics 90-236 Lodz Poland Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n 18008 Granada Spain Deutsches Elektronen-Synchrotron (DESY) D-15738 Zeuthen Germany ETH Zürich CH-8093 Zürich Switzerland Università di Pisa and INFN Pisa I-56126 Pisa Italy Universitat de Barcelona ICCUB IEEC-UB E-08028 Barcelona Spain Armenian MAGIC Group: A. Alikhanyan National Science Laboratory 0036 Yerevan Armenia Centro de Investigaciones Energéticas Medioambientales y Tecnológicas E-28040 Madrid Spain Department for Physics and Technology University of Bergen Norway INFN MAGIC Group: INFN Sezione di Catania and Dipartimento di Fisica e Astronomia University of Catania I-95123 Catania Italy INFN MAGIC Group: INFN Sezione di Torino and Università degli Studi di Torino I-10125 Torino Italy INFN MAGIC Group: INFN Sezione di Bari and Dipartimento Interateneo di Fisica dell’Università e del Politecnico di Bari I-70125 Bari Italy

Linelike features in TeV γ rays constitute a “smoking gun” for TeV-scale particle dark matter and new physics. Probing the Galactic Center region with ground-based Cherenkov telescopes enables the search for TeV spectral features in immediate association with a dense dark matter reservoir at a sensitivity out of reach for satellite γ-ray detectors, and direct detection and collider experiments. We report on 223 hours of observations of the Galactic Center region with the MAGIC stereoscopic telescope system reaching γ-ray energies up to 100 TeV. We improved the sensitivity to spectral lines at high energies using large-zenith-angle observations and a novel background modeling method within a maximum-likelihood analysis in the energy domain. No linelike spectral feature is found in our analysis. Therefore, we constrain the cross section for dark matter annihilation into two photons to ⟨σv⟩≲5×10−28 cm3 s−1 at 1 TeV and ⟨σv⟩≲1×10−25 cm3 s−1 at 100 TeV, achieving the best limits to date for a dark matter mass above 20 TeV and a cuspy dark matter profile at the Galactic Center. Finally, we use the derived limits for both cuspy and cored dark matter profiles to constrain supersymmetric wino models.

关键词： Dark matter Gamma ray astronomy Particle dark matter Milky Way Cosmic ray & astroparticle detectors Cosmic rays & astroparticles Electromagnetic radiation astronomy Telescopes

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The eleven-item Alcohol, Smoking and Substance Involvement Screening Test (ASSIST-11): Cross-cultural psychometric evaluation across 42 countries

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Journal of Psychiatric Research 2023年第1期165卷 16-27页

作者： Lee, Chih-Ting Lin, Chung-Ying Koós, Mónika Nagy, Léna Kraus, Shane W. Demetrovics, Zsolt Potenza, Marc N. Ballester-Arnal, Rafael Batthyány, Dominik Bergeron, Sophie Billieux, Joël Burkauskas, Julius Cárdenas-López, Georgina Carvalho, Joana Castro-Calvo, Jesús Chen, Lijun Ciocca, Giacomo Corazza, Ornella Csako, Rita I. Fernandez, David P. Fernandez, Elaine F. Fujiwara, Hironobu Fuss, Johannes Gabrhelík, Roman Gewirtz-Meydan, Ateret Gjoneska, Biljana Gola, Mateusz Grubbs, Joshua B. Hashim, Hashim T. Islam, Md. Saiful Ismail, Mustafa Jiménez-Martínez, Martha Jurin, Tanja Kalina, Ondrej Klein, Verena Költő, András Lee, Sang-Kyu Lewczuk, Karol Lochner, Christine López-Alvarado, Silvia Lukavská, Kateřina Mayta-Tristán, Percy Milea, Ionut Miller, Dan J. Orosová, Oľga Orosz, Gábor Ponce, Fernando P. Quintana, Gonzalo R. Garzola, Gabriel C.Quintero Ramos-Diaz, Jano Rigaud, Kévin Rousseau, Ann Scanavino, Marco De Tubino Schulmeyer, Marion K. Sharan, Pratap Shibata, Mami Shoib, Sheikh Sigre-Leirós, Vera Sniewski, Luke Spasovski, Ognen Steibliene, Vesta Stein, Dan J. Strizek, Julian Ünsal, Berk C. Vaillancourt-Morel, Marie-Pier Van Hout, Marie Claire Bőthe, Beáta Department of Family Medicine National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan Institute of Allied Health Sciences College of Medicine National Cheng Kung University Tainan Taiwan Biostatistics Consulting Center National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan Doctoral School of Psychology ELTE Eötvös Loránd University Budapest Hungary Institute of Psychology ELTE Eötvös Loránd University Budapest Hungary Department of Psychology University of Nevada Las Vegas Las Vegas NV United States Centre of Excellence in Responsible Gaming University of Gibraltar Gibraltar Gibraltar Yale University School of Medicine New Haven CT United States Connecticut Council on Problem Gambling Wethersfield CT United States Departmento de Psicología Básica Clínica y Psicobiología University Jaume I of Castellón Spain Institute for Behavioural Addictions Sigmund Freud University Vienna Austria Département de Psychologie Université de Montréal Montréal Canada Institute of Psychology University of Lausanne Lausanne Switzerland Center for Excessive Gambling Addiction Medicine Lausanne University Hospitals (CHUV) Lausanne Switzerland Laboratory of Behavioral Medicine Neuroscience Institute Lithuanian University of Health Sciences Lithuania Virtual Teaching and Cyberpsychology Laboratory School of Psychology National Autonomous University of Mexico Mexico William James Center for Research Departamento de Educação e Psicologia Universidade de Aveiro CPUP: Center for Psychology at Porto University Aveiro Portugal Department of Personality Assessment and Psychological Treatments University of Valencia Spain Department of Psychology College of Humanity and Social Science Fuzhou University China Section of Sexual Psychopathology Department of Dynamic and Clinical Psychology and Health Studies Sapienza University of Rome Rome Italy Department of Clinical Pharmaceuti

The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) is an instrument to screen substance-use-related health risks. However, little is known whether the ASSIST could be further shortened while remaining psychometrically sound across different countries, languages, gender identities, and sexual-orientation-based groups. The study aimed to validate a shortened 11-item ASSIST (ASSIST-11). Using the International Sex Survey data, 82,243 participants (M _age = 32.39 years) across 42 countries and 26 languages completed questions from the ASSIST-11 regarding gender identity, sexual orientation, and other information. Confirmatory factor analysis (CFA) and multigroup CFA (MGCFA) evaluated the ASSIST-11's structure and tested measurement invariance across groups. Cronbach's α and McDonald's ω were used to examine the internal consistency. Cohen's d and independent t-tests were used to examine known-group validity. The ASSIST-11 was unidimensional across countries, languages, age groups, gender identities (i.e., men, women, and gender-diverse individuals), and sexual orientations (i.e., heterosexual and sexual minority individuals). Cronbach's α was 0.63 and McDonald's ω was 0.68 for the ASSIST-11. Known-group validity was supported by Cohen's d (range between 0.23 and 0.40) with significant differences (p-values<0.001). The ASSIST-11 is a modified instrument with a unidimensional factor structure across different languages, age groups, countries, gender identities, and sexual orientations. The low internal consistency of the ASSIST-11 might be acceptable as it assesses a broad concept (i.e., use of several different substances). Healthcare providers and researchers may use the ASSIST-11 to quickly assess substance-use information from general populations and evaluate the need to follow up with more detailed questions about substance use. © 2023 Elsevier Ltd

关键词： Addictive behaviors Cross-cultural study Factor structure Measurement invariance Psychometrics

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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

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Nature 2024年第8003期627卷 347-357页

作者： Ken Suzuki Konstantinos Hatzikotoulas Lorraine Southam Henry J Taylor Xianyong Yin Kim M Lorenz Ravi Mandla Alicia Huerta-Chagoya Giorgio E M Melloni Stavroula Kanoni Nigel W Rayner Ozvan Bocher Ana Luiza Arruda Kyuto Sonehara Shinichi Namba Simon S K Lee Michael H Preuss Lauren E Petty Philip Schroeder Brett Vanderwerff Mart Kals Fiona Bragg Kuang Lin Xiuqing Guo Weihua Zhang Jie Yao Young Jin Kim Mariaelisa Graff Fumihiko Takeuchi Jana Nano Amel Lamri Masahiro Nakatochi Sanghoon Moon Robert A Scott James P Cook Jung-Jin Lee Ian Pan Daniel Taliun Esteban J Parra Jin-Fang Chai Lawrence F Bielak Yasuharu Tabara Yang Hai Gudmar Thorleifsson Niels Grarup Tamar Sofer Matthias Wuttke Chloé Sarnowski Christian Gieger Darryl Nousome Stella Trompet Soo-Heon Kwak Jirong Long Meng Sun Lin Tong Wei-Min Chen Suraj S Nongmaithem Raymond Noordam Victor J Y Lim Claudia H T Tam Yoonjung Yoonie Joo Chien-Hsiun Chen Laura M Raffield Bram Peter Prins Aude Nicolas Lisa R Yanek Guanjie Chen Jennifer A Brody Edmond Kabagambe Ping An Anny H Xiang Hyeok Sun Choi Brian E Cade Jingyi Tan K Alaine Broadaway Alice Williamson Zoha Kamali Jinrui Cui Manonanthini Thangam Linda S Adair Adebowale Adeyemo Carlos A Aguilar-Salinas Tarunveer S Ahluwalia Sonia S Anand Alain Bertoni Jette Bork-Jensen Ivan Brandslund Thomas A Buchanan Charles F Burant Adam S Butterworth Mickaël Canouil Juliana C N Chan Li-Ching Chang Miao-Li Chee Ji Chen Shyh-Huei Chen Yuan-Tsong Chen Zhengming Chen Lee-Ming Chuang Mary Cushman John Danesh Swapan K Das H Janaka de Silva George Dedoussis Latchezar Dimitrov Ayo P Doumatey Shufa Du Qing Duan Kai-Uwe Eckardt Leslie S Emery Daniel S Evans Michele K Evans Krista Fischer James S Floyd Ian Ford Oscar H Franco Timothy M Frayling Barry I Freedman Pauline Genter Hertzel C Gerstein Vilmantas Giedraitis Clicerio González-Villalpando Maria Elena González-Villalpando Penny Gordon-Larsen Myron Gross Lindsay A Guare Sophie Hackinger Liisa Hakaste Sohee Han Andrew T Hattersley Christian Herder Momoko Horikoshi Annie-Green Howard Willa Centre for Genetics and Genomics Versus Arthritis Centre for Musculoskeletal Research Division of Musculoskeletal and Dermatological Sciences University of Manchester Manchester UK. Department of Diabetes and Metabolic Diseases Graduate School of Medicine University of Tokyo Tokyo Japan. Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. konstantinos.hatzikotoulas@helmholtz-munich.de. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. Center for Precision Health Research National Human Genome Research Institute National Institutes of Health Bethesda MD USA. British Heart Foundation Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge Cambridge UK. Heart and Lung Research Institute University of Cambridge Cambridge UK. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Department of Biostatistics and Center for Statistical Genetics University of Michigan Ann Arbor MI USA. Corporal Michael J. Crescenz VA Medical Center Philadelphia PA USA. Department of Systems Pharmacology and Translational Therapeutics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Department of Genetics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Programs in Metabolism and Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA. Diabetes Unit and Center for Genomic Medicine Massachusetts General Hospital Boston MA USA. TIMI Study Group Division of Cardiovascular Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA. William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London L

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms that are often specific to cell type. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P < 5 × 10) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.

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Gamma-ray Spectral Line emission search from Dark Matter Annihilation up to 100 TeV towards the Galactic Centre with MAGIC 38

Gamma-ray Spectral Line emission search from Dark Matter Ann...

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38th International Cosmic Ray Conference, ICRC 2023

作者： Inada, Tomohiro Kerszberg, Daniel Hütten, Moritz Rico, Javier Teshima, Masahiro Kohri, Kazunori Hiroshima, Nagisa Abe, H. Abe, S. Abhir, J. Acciari, V.A. Agudo, I. Aniello, T. Ansoldi, S. Antonelli, L.A. Arbet Engels, A. Arcaro, C. Artero, M. Asano, K. Baack, D. Babić, A. Baquero, A. Barres de Almeida, U. Barrio, J.A. Batković, I. Baxter, J. Becerra González, J. Bednarek, W. Bernardini, E. Bernardos, M. Bernete, J. Berti, A. Besenrieder, J. Bigongiari, C. Biland, A. Blanch, O. Bonnoli, G. Bošnjak, Ž. Burelli, I. Busetto, G. Campoy-Ordaz, A. Carosi, A. Carosi, R. Carretero-Castrillo, M. Castro-Tirado, A.J. Ceribella, G. Chai, Y. Chilingarian, A. Cifuentes, A. Cikota, S. Colombo, E. Contreras, J.L. Cortina, J. Covino, S. D’Amico, G. D’Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. De Lotto, B. Del Popolo, A. Delfino, M. Delgado, J. Delgado Mendez, C. Depaoli, D. Di Pierro, F. Di Venere, L. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Elsaesser, D. Emery, G. Escudero, J. Fariña, L. Fattorini, A. Foffano, L. Font, L. Fröse, S. Fukami, S. Fukazawa, Y. García López, R.J. Garczarczyk, M. Gasparyan, S. Gaug, M. Giesbrecht Paiva, J.G. Giglietto, N. Giordano, F. Gliwny, P. Godinović, N. Grau, R. Green, D. Green, J.G. Hadasch, D. Hahn, A. Hassan, T. Heckmann, L. Herrera, J. Hrupec, D. Hütten, M. Imazawa, R. Inada, T. Iotov, R. Ishio, K. Jiménez Martínez, I. Jormanainen, J. Kerszberg, D. Kluge, G.W. Kobayashi, Y. Kouch, P.M. Kubo, H. Kushida, J. Láinez Lezáun, M. Lamastra, A. Lelas, D. Leone, F. Lindfors, E. Linhoff, L. Lombardi, S. Longo, F. López-Coto, R. López-Moya, M. López-Oramas, A. Loporchio, S. Lorini, A. Lyard, E. Machado de Oliveira Fraga, B. Majumdar, P. Makariev, M. Maneva, G. Mang, N. Manganaro, M. Mangano, S. Mannheim, K. Mariotti, M. Martínez, M. Martínez-Chicharro, M. Mas-Aguilar, A. Mazin, D. Menchiari, S. Mender, S. Mićanović, S. Miceli, D. Miener, T. Miranda, J.M. Mirzoyan, R. Molero González, M. Molina, E. Mondal, H.A. Institute for Cosmic Ray Research Kashiwa-no-ha 5-1-5 Kashiwa-shi Chiba Japan The Barcelona Institute of Science and Technology CampusUAB Bellaterra Barcelona08193 Spain Max-Planck-Institut für Physik Föhringer Ring 6 München80805 Germany Theory Center IPNS KEK Ibaraki Tsukuba305-0801 Japan 1-1 Oho Ibaraki Tsukuba305-0801 Japan UTIAS The University of Tokyo Chiba Kashiwa277-8583 Japan Department of Physics University of Toyama 3190 Gofuku Toyama930-8555 Japan RIKEN iTHEMS Saitama Wako351-0198 Japan The University of Tokyo Chiba Kashiwa277-8582 Japan ETH Zürich ZürichCH-8093 Switzerland Instituto de Astrofísica de Canarias Dpto. de Astrofísica Universidad de La Laguna Tenerife La LagunaE-38200 Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain RomeI-00136 Italy Università di Udine INFN Trieste UdineI-33100 Italy Università di Padova INFN PadovaI-35131 Italy Technische Universität Dortmund DortmundD-44221 Germany Zagreb10000 Croatia IPARCOS Institute EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain URCA RJ Rio de Janeiro22290-180 Brazil University of Lodz Faculty of Physics and Applied Informatics Department of Astrophysics Lodz90-236 Poland Centro de Investigaciones Energéticas Medioambientales y Tecnológicas MadridE-28040 Spain Departament de Física CERES-IEEC Universitat Autònoma de Barcelona BellaterraE-08193 Spain Università di Pisa INFN Pisa PisaI-56126 Italy Universitat de Barcelona ICCUB IEEC-UB BarcelonaE-08028 Spain Armenian MAGIC Group A. Alikhanyan National Science Laboratory Yerevan0036 Armenia Department for Physics and Technology University of Bergen Norway INFN MAGIC Group INFN Sezione di Catania Dipartimento di Fisica e Astronomia University of Catania CataniaI-95123 Italy INFN MAGIC Group INFN Sezione di Torino Università degli Studi di Torino TorinoI-10125 Italy INFN MAGIC Group INFN Sezione di Bar

The detection of line-like TeV gamma-ray features configures as a smoking gun for the discovery of TeV-scale particle dark matter. We report the first search for dark matter spectral lines in the Galactic Centre region up to gamma-ray energies of 100 TeV with the MAGIC telescopes (La Palma, Canary Islands). The Galactic Centre region is expected to host the closest dark matter halo of considerable size and is therefore well suited for this kind of searches. Observations at large zenith angles improve sensitivity for gamma rays in the TeV regime due to the increased telescope collection area. We present the results obtained with more than 200 hours of large-zenith angle observations of the Galactic Centre region, which allow us to obtain competitive limits to the dark matter annihilation cross-section at high particle masses (−28 cm3 s−1 at 1 TeV and −25 cm3 s−1 at 100 TeV), improving the best current constraints above 20 TeV. In addition, we also study the impact of an inner cored dark matter halo on probing the annihilation cross-section. Finally, we use the derived limits to constrain super-symmetric wino models. © Copyright owned by the author(s) under the terms of the Creative Commons.

关键词： Gamma rays

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Publisher Correction: Firn on ice sheets

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Nature Reviews Earth & Environment 2024年 330页

作者： Charles Amory Christo Buizert Sammie Buzzard Elizabeth Case Nicole Clerx Riley Culberg Rajashree Tri Datta Devon Dunmire Jan T. M. Lenaerts Megan Thompson-Munson Nander Wever Rahul Dey Reinhard Drews Falk M. Oraschewski Clare Eayrs Nicolaj Hansen Sebastian B. Simonsen Angelika Humbert Athul Kaitheri Kaitlin Keegan Ian McDowell Peter Kuipers Munneke Stef Lhermitte Sophie de Roda Husman Bert Wouters Doug Mair Jessica Mejia Colin R. Meyer Elizabeth Morris Dorothea Moser Elizabeth R. Thomas Emma Pearce Nicole-Jeanne Schlegel Timm Schultz C. Max Stevens Institut des Géosciences de l’Environnement University Grenoble Alpes CNRS Grenoble France College of Earth Ocean and Atmospheric Sciences Oregon State University Corvallis OR USA School of Earth and Environmental Sciences Cardiff University Cardiff UK Department of Geography and Environmental Sciences Northumbria University Newcastle upon Tyne UK Department of Earth and Environmental Sciences Columbia University NY USA Department of Geosciences Université de Fribourg Fribourg Switzerland Department of Earth and Atmospheric Sciences Cornell University Ithaca NY USA Department of Atmospheric and Oceanic Sciences University of Colorado Boulder Boulder CO USA Cooperative Institute for Research in Environmental Sciences (CIRES) University of Colorado Boulder Boulder CO USA WSL Institute for Snow and Avalanche Research SLF Davos Switzerland National Centre for Polar and Ocean Research (NCPOR) Ministry of Earth Sciences Vasco da Gama Goa India Department of Geosciences University of Tübingen Tübingen Germany Center for Global Sea Level Change New York University Abu Dhabi Abu Dhabi UAE Department of Glacial Environment Research Korea Polar Research Institute Incheon Republic of Korea Geodesy and Earth Observation DTU Space Technical University of Denmark Kongens Lyngby Denmark Danish Meteorological Institute Copenhagen Denmark Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research Bremerhaven Germany Faculty of Geosciences University of Bremen Bremen Germany Observatoire de la Côte d’Azur Université Côte d’Azur CNRS Valbonne France Department of Geological Sciences and Engineering University of Nevada Reno USA Graduate Program of Hydrologic Sciences University of Nevada Reno NV USA Institute for Marine and Atmospheric Research (IMAU) Utrecht University Utrecht The Netherlands Department of Earth and Environmental Sciences KU Leuven Leuven Belgium Department of Geoscience and Remote Sensing Delft University of Technology (TUDel

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Supernova model discrimination with Hyper-Kamiokande

arXiv

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arXiv 2021年

作者： Abe, K. Adrich, P. Aihara, H. Akutsu, R. Alekseev, I. Ali, A. Ameli, F. Anghel, I. Anthony, L.H.V. Antonova, M. Araya, A. Asaoka, Y. Ashida, Y. Aushev, V. Ballester, F. Bandac, I. Barbi, M. Barker, G.J. Barr, G. Batkiewicz-Kwasniak, M. Bellato, M. Berardi, V. Bergevin, M. Bernard, L. Bernardini, E. Berns, L. Bhadra, S. Bian, J. Blanchet, A. Blaszczyk, F.D.M. Blondel, A. Boiano, A. Bolognesi, S. Bonavera, L. Booth, N. Borjabad, S. Boschi, T. Bose, D. Boyd, S.B. Bozza, C. Bravar, A. Bravo-Berguño, D. Bronner, C. Brown, L. Bubak, A. Buchowicz, A. Avanzini, M. Buizza Cafagna, F.S. Calabria, N.F. Calvo-Mozota, J.M. Cao, S. Cartwright, S.L. Carroll, A. Catanesi, M.G. Cebriàn, S. Chabera, M. Chakraborty, S. Checchia, C. Choi, J.H. Choubey, S. Cicerchia, M. Coleman, J. Collazuol, G. Cook, L. Cowan, G. Cuen-Rochin, S. Danilov, M. Lopez, G. Daz de la Fuente, E. de Perio, P. de Rosa, G. Dealtry, T. Densham, C.J. Dergacheva, A. Deshmukh, N. Devi, M.M. Di Lodovico, F. Di Meo, P. Di Palma, I. Doyle, T.A. Drakopoulou, E. Drapier, O. Dumarchez, J. Dunne, P. Dziewiecki, M. Eklund, L. El Hedri, S. Ellis, J. Emery, S. Esmaili, A. Esteve, R. Evangelisti, A. Feely, M. Fedotov, S. Feng, J. Fernandez, P. Fernández-Martinez, E. Ferrario, P. Ferrazzi, B. Feusels, T. Finch, A. Finley, C. Fiorentini, A. Fiorillo, G. Fitton, M. Frankiewicz, K. Friend, M. Fujii, Y. Fukuda, Y. Galinski, G. Gao, J. Garde, C. Garfagnini, A. Garode, S. Gialanella, L. Giganti, C. Gomez-Cadenas, J.J. Gonin, M. González-Nuevo, J. Gorin, A. Gornea, R. Gousy-Leblanc, V. Gramegna, F. Grassi, M. Grella, G. Guigue, M. Gumplinger, P. Hadley, D.R. Harada, M. Hartfiel, B. Hartz, M. Hassani, S. Hastings, N.C. Hayato, Y. Hernando-Morata, J.A. Herrero, V. Hill, J. Hiraide, K. Hirota, S. Holin, A. Horiuchi, S. Hoshina, K. Hultqvist, K. Iacob, F. Ichikawa, A.K. Ibnsalih, W. Idrissi Iijima, T. Ikeda, M. Inomoto, M. Inoue, K. Insler, J. Ioannisian, A. Ishida, T. Ishidoshiro, K. AGH University of Science and Technology Faculty of Computer Science Electronics and Telecommunications Krakow Poland Boston University Department of Physics BostonMA United States University of British Columbia Department of Physics and Astronomy VancouverBC Canada British Columbia Institute of Technology Physics Department BurnabyBC Canada Università della Campania L. Vanvitelli INFN Sezione di Napoli Napoli Italy Carleton University Department of Physics OttawaON Canada University of California Davis Department of Physics DavisCA United States University of California Irvine Department of Physics and Astronomy IrvineCA United States California State University Department of Physics CarsonCA United States Charles University IPNP FMF Prague Czech Republic Chonnam National University Department of Physics Gwangju Korea Republic of Dongshin University Laboratory for High Energy Physics Naju Korea Republic of Donostia International Physics Center Ikerbasque Foundation Basque Country Spain Ecole Polytechnique IN2P3-CNRS Laboratoire Leprince-Ringuet Palaiseau France University of Edinburgh School of Physics and Astronomy Edinburgh United Kingdom ETH Zurich Institute for Particle and Astroparticle Physics Zurich Switzerland University of Geneva Section de Physique DPNC Geneva Switzerland GIST College Gwangju Institute of Science and Technology Gwangju Korea Republic of University of Glasgow School of Physics and Astronomy Glasgow United Kingdom Universidad de Guadalajara CUCEI Departamento de Fisica Jal Guadalajara Mexico Universidad de Guadalajara CUCEA IT.Ph.D. program Jal Guadalajara Mexico H. Niewodniczá nski Institute of Nuclear Physics PAN Cracow Poland University of Hawaii Department of Physics and Astronomy HonoluluHI United States Imperial College London Department of Physics London United Kingdom Indian Institute of Technology Guwahati Guwahati India Indian Institute of Technology Jodhpur Department of Physics Raj

Core-collapse supernovae are among the most magnificent events in the observable universe. They produce many of the chemical elements necessary for life to exist and their remnants-neutron stars and black holes-are interesting astrophysical objects in their own right. However, despite millennia of observations and almost a century of astrophysical study, the explosion mechanism of core-collapse supernovae is not yet well understood. Hyper-Kamiokande is a next-generation neutrino detector that will be able to observe the neutrino flux from the next galactic core-collapse supernova in unprecedented detail. We focus on the first 500 ms of the neutrino burst, corresponding to the accretion phase, and use a newly-developed, high-precision supernova event generator to simulate Hyper-Kamiokande's response to five different supernova models. We show that Hyper-Kamiokande will be able to distinguish between these models with high accuracy for a supernova at a distance of up to 100 kpc. Once the next galactic supernova happens, this ability will be a powerful tool for guiding simulations towards a precise reproduction of the explosion mechanism observed in nature. Copyright © 2021, The Authors. All rights reserved.

关键词： Supernovae

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