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Green synthesis of silver nanoparticles from Cassia Auriculata: Targeting antibacterial, antioxidant activity, and evaluation of their possible effects on saltwater microcrustacean, Artemia Nauplii (non-target organism)

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The science of the total environment 2023年 861卷 160575页

作者： Chinnaperumal Kamaraj Chinnasamy Ragavendran Kumar Manimaran Sabarathinam Sarvesh Abu Reza Md Towfiqul Islam Guilherme Malafaia Interdisciplinary Institute of Indian System of Medicine (IIISM) Directorate of Research SRM Institute of Science and Technology (SRMIST) Kattankulathur 603203 Tamil Nadu India. Electronic address: kamarajc@srmist.edu.in. Department of Conservative Dentistry and Endodontics Saveetha Dental College and Hospitals Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai 600077 India. Department of Botany School of Life Sciences Periyar University Periyar Palkalai Nagar Salem 636011 Tamil Naddu India. Interdisciplinary Institute of Indian System of Medicine (IIISM) Directorate of Research SRM Institute of Science and Technology (SRMIST) Kattankulathur 603203 Tamil Nadu India. Department of Disaster Management Begum Rokeya University Rangpur 5400 Bangladesh. Electronic address: towfiq_dm@brur.ac.bd. Laboratory of Toxicology Applied to the Environment Goiano Federal Institute Urutaí GO Brazil Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute Urutaí GO Brazil Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia Uberlândia MG Brazil Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás Goiânia GO Brazil. Electronic address: guilhermeifgoiano@***.

Due to their huge surface area to volume ratio, metallic nanoparticles are becoming increasingly important in numerous spheres of life. Here, initially, we aimed to evaluate the potential use of Cassia auriculata (CA) extract to synthesize silver nanoparticles (AgNPs). Then, we evaluated its antimicrobial potential and antioxidant capacity, as well as performed in silico analysis, and investigated the possible non-toxic effect of AgNPs on Artemia nauplii. Fourier transform infrared (FTIR) spectroscopy, scanning and transmission electron microscopy (SEM/TEM), energy dispersive spectroscopy (EDX), X-ray diffraction (XRD), and dynamic light scattering (DLS) studies were used to characterize the biosynthesized AgNPs. Our data indicate that Bacillus cereus, Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus bacteria were susceptible to the biosynthesized AgNPs, whose effect was concentration-response. With a ZOI of 10 mm, the AgNPs were most efficient against gram-positive B. cereus bacteria at the highest concentration (75 μg/mL). The biosynthesized AgNPs (at 25 to 125 μg/mL) showed good antioxidant activity in the DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) and FRAP (ferric reducing antioxidant power) assays. Oleanolic acid from CA exhibited strong binding affinity and high binding energy to E. coli and B. cereus (-9.66 and - 9.74 kcal/mol) on in silico research. According to the comparative non-toxicity analysis, AgNPs, AgNO, and CA bark extract had the least toxic effects on A. nauplii, with respective mortality rates of 28.14, 32.26, and 38.42 %, respectively. In conclusion, the current work showed that AgNPs produced from CA bark could be a promising material for diverse applications.

关键词： AgNPs Antibacterial Antioxidant Cassia auriculata Green nanosynthesis In silico Non-toxic

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Bioactivity, Efficacy, and Safety of a Wound Healing Ointment With Medicinal Plant Bioactives: In Vitro and In Vivo Preclinical Evaluations

Scientific World Journal

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Scientific World Journal 2025年第1期2025卷 9466270页

作者： Floriano, Juliana Ferreira Rodrigues, Daniel Ohara, Rie Almeida, Nara Lígia Martins Lara, Vanessa Soares Sartorelli, Patricia Graeff, Carlos Frederico de Oliveira Grecco, Simone dos Santos González, Alejandra Hortencia Miranda D’Alpino, Paulo Henrique Perlatti Imperial College London National Heart and Lung Institute imperial.ac.uk GBR London United Kingdom Botucatu Medical School São Paulo State University (UNESP) São Paulo unesp.br BRA Botucatu Brazil Bioengineering and Biomaterials Group School of Pharmaceutical Sciences São Paulo State University (UNESP) unesp.br BRA Araraquara São Paulo Brazil Biotechnology and Innovation in Health Program Universidade Anhanguera de São Paulo (UNIAN) São Paulo BRA Brazil Brazil Department of Health Management Fundação Nacional de Gestão de Saúde São Paulo Brazil Undergraduate Program Medical School Universidade Nove de Julho Bauru São Paulo Brazil Department of Surgery Stomatology Pathology and Radiology Bauru School of Dentistry University of São Paulo (USP) São Paulo usp.br BRA Bauru Brazil Department of Chemistry Institute of Environmental Chemical and Pharmaceutical Sciences Federal University of São Paulo São Paulo unifesp.br BRA Diadema Brazil Department of Physics School of Sciences POSMAT-Post-Graduate Program in Materials Science and Technology São Paulo State University (UNESP) São Paulo Bauru Brazil Department of Research and Development (RD) and Innovation Center Triplet Biotechnology Solutions Inc Bauru São Paulo Brazil Post-Graduate Program in Dentistry Uniderp Anhanguera University Mato Grosso do Sul Campo Grande Brazil Post-Graduate Program in Integrated Dental Sciences University of Cuiabá (UNIC) Mato Grosso do Sul Cuiabá Brazil Department of Physics School of Sciences São Paulo State University (UNESP) São Paulo unesp.br BRA Bauru Brazil

Chronic wounds have a significant impact on patients’ quality of life, necessitating the management of pain, infection, bleeding, and emotional challenges. Debridement, which involves the removal of nonviable tissue, is crucial for promoting wound healing. In addition to surgical methods, cost-effective alternatives such as local solutions and ointments with biological properties have been explored. The use of natural compounds with anti-inflammatory, antibacterial, and collagen-synthesizing abilities holds promise for wound healing. This in vitro and in vivo preclinical study aimed to assess the safety and effectiveness of a wound healing ointment containing bioactive ingredients derived from medicinal plants (extracts, essential oils, and vegetable oils). The chemical composition of the ointment was characterized using Fourier transform infrared (FTIR) spectroscopy to gain insights into its synergistic action. Preclinical tests were conducted following standardized protocols. FTIR analysis revealed similarities between the product’s spectrum and that of bioactive compounds. The in vitro tests demonstrated that all formulations of the ointment induced no cell death, DNA damage, or acute toxicity in cell cultures (p < 0.05). No lethal dose was observed, indicating the safety of the ointment at all concentrations. The ointment also stimulated a notably more organized, significantly higher collagen production compared to control groups (p < 0.05). In vivo preclinical analyses also demonstrated no adverse responses being effective in the healing process compared to the control group (silver sulfadiazine) in terms of wound contraction and ulcer re-epithelization (p < 0.05). Significantly higher means of wound contraction were observed in the groups treated with the bioactive-containing ointment when compared to both the positive control group (sulfadiazine) and the control untreated groups (p < 0.05). The regenerative ointment exhibited excellent biocompatibility and bi

关键词： biocompatibility chronic wounds natural compounds preclinical tests wound care

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Gene expression profiling in liver of zebrafish exposed to ethylhexyl methoxycinnamate and its photoproducts

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The science of the total environment 2022年 826卷 154046页

作者： Bojan Nataraj Kannan Maharajan Guilherme Malafaia Devan Hemalatha Mohamed Ahmed Ibrahim Ahmed Mathan Ramesh Unit of Toxicology Department of Zoology School of Life Sciences Bharathiar University Coimbatore 641046 India. Unit of Toxicology Department of Zoology School of Life Sciences Bharathiar University Coimbatore 641046 India Biology Institute Qilu University of Technology (Shandong Academy of Sciences) 28789 East Jingshi Road Jinan 250103 Shandong Province PR China. Post-Graduation Program in Environmental Sciences Federal University of Goiás Goiânia GO Brazil Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia Uberlândia MG Brazil Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás Goiânia GO Brazil. Department of Zoology PSG College of Arts & Science Coimbatore Tamil Nadu - 641014 India. Plant Protection Department Faculty of Agriculture Assiut University Assiut 71526 Egypt. Unit of Toxicology Department of Zoology School of Life Sciences Bharathiar University Coimbatore 641046 India. Electronic address: mathanramesh@***.

In recent decades, the ecotoxicological potential of organic ultraviolet filters (OU-VFs) has received growing attention. However, the toxicity of its photoproducts or transformation products on freshwater vertebrates has been little explored. Therefore, the aim of the present study is to evaluate the possible adverse effects of ethylhexyl methoxycinnamate (EHMC) and its photoproducts [2-ethylhexanol (2-EH) and 4-methoxybenzaldehyde (4-MBA)] on the expression of stress-responsive and antioxidant genes. For this, zebrafish (Danio rerio) adults were exposed to pollutants at an environmentally relevant concentration (3 μg/L) and evaluated after 7, 14, and 21 days of exposure. The results of the principal component analysis (PCA) and two-way repeated measures (RM) ANOVA revealed that EHMC, 2-EH, and 4-MBA exposure caused significant downregulation of the genes hsp70, nrf2, cyp1a, ahr, sod1, sod2, cat, gstp1, gpx1a, gss, and gsr (on all trial days) in the liver of the animals. On the other hand, taken together, our data did not show significant differences between the effects induced by EHMC and its photoproducts. The genes evaluated in the present study play a major role in regulating the defensive antioxidant response against EHMC and its photoproducts. Additionally, our study provides an insight into the mechanisms of those OU-VFs in freshwater fish.

关键词： Adverse effects Liver toxicity Photoproducts UV filters mRNA expression

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Managing the invisible threat of microplastics in marine ecosystems: Lessons from coast of the Bay of Bengal

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The science of the total environment 2023年 889卷 164224页

作者： Al-Nure Mubin Shahoriar Arefin Md Sonir Mia Abu Reza Md Towfiqul Islam A B M Mainul Bari Md Saiful Islam Mir Mohammad Ali Md Abu Bakar Siddique M Safiur Rahman Venkatramanan Senapathi Abubakr M Idris Guilherme Malafaia Department of Disaster Management Begum Rokeya University Rangpur 5400 Bangladesh. Department of Disaster Management Begum Rokeya University Rangpur 5400 Bangladesh Department of Development Studies Daffodil International University Dhaka 1216 Bangladesh. Electronic address: towfiq_dm@brur.ac.bd. Department of Industrial and Production Engineering Bangladesh University of Engineering and Technology Dhaka 1000 Bangladesh. Department of Soil Science Patuakhali Science and Technology University Dumki Patuakhali 8602 Bangladesh. Department of Aquaculture Sher - e - Bangla Agricultural University Dhaka 1207 Bangladesh. Institute of National Analytical Research and Service (INARS) Bangladesh Council of Scientific and Industrial Research (BCSIR) Dhanmondi Dhaka 1205 Bangladesh. Analytical Chemistry Laboratory Chemistry Division Atomic Energy Centre Dhaka (AECD) Bangladesh Atomic Energy Commission Dhaka 1000 Bangladesh. Department of Disaster Management Alagappa University Karaikudi Tamilnadu India. Department of Chemistry College of Science King Khalid University Abha 62529 Saudi Arabia Research Center for Advanced Materials Science (RCAMS) King Khalid University Abha Saudi Arabia. Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute Urutaí GO Brazil Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia Uberlândia MG Brazil Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás Goiânia GO Brazil. Electronic address: guilhermeifgoiano@***.

Invisible microplastics (MP) have become a significant problem worldwide in recent years. Although many studies have highlighted the sources, effects, and fate of MPs pollution on various ecosystems in developed countries, there is limited information on MPs in the marine ecosystem along the northeastern coast of the Bay of Bengal (BoB). Coastal ecosystems along the BoB coasts are critical to a biodiverse ecology that supports human survival and resource extraction. However, the multi-environmental hotspots, ecotoxicity effects, transport mechanisms, fates, and intervention measures to control MP pollution initiatives along the BoB coasts have received little attention. Therefore, this review aims to highlight the multi-environmental hotspots, ecotoxicity effects, sources, fates, and intervention measures of MP in the northeastern BoB to understand how MP spreads in the nearshore marine ecosystem. This study critically evaluates the hotspots and ecotoxic effects of pollution from MP on the coastal multi-environment, e.g., soil, sediment, salt, water, and fish, as well as current intervention measures and additional mitigation recommendations. This study identified the northeastern part of the BoB as a hotspot for MP. In addition, the transport mechanisms and fate of MP in different environmental compartments are highlighted, as are research gaps and potential future research areas. Research on the ecotoxic effects of MP on BoB marine ecosystems must be a top priority, given the increasing use of plastics and the presence of significant marine products worldwide. The knowledge gained from this study would inform decision-makers and stakeholders in a way that could reduce the impact of the legacy of micro- and nanoplastics in the area. This study also proposes structural and non-structural measures to mitigate the effects of MPs and promote sustainable management.

关键词： Bay of Bengal coast Marine ecosystem Marine pollution Microplastic Sustainable management

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Understanding the Energy-Water-Land Flow Nexus in Transnational Trade of the Belt and Road Countries

SSRN

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SSRN 2020年

作者： Nawab, Asim Liu, Gengyuan Meng, Fanxin Zhang, Lixiao Hao, Yan Giannetti, Biagio F. Agostinho, Feni Almeida, Cecília M.V.B. Xue, Jingyan Casazza, Marco State Key Joint Laboratory of Environment Simulation and Pollution Control School of Environment Beijing Normal University Beijing100875 China Beijing Engineering Research Center for Watershed Environmental Restoration & Integrated Ecological Regulation Beijing100875 China School of Forestry & Environmental Studies Yale University New HavenCT06511 United States Post-graduation Program in Production Engineering Paulista University Brazil University of Naples ‘Parthenope’ Department of Science and Technology Centro Direzionale Isola C4 Naples80143 Italy

Economic globalization and population growth have greatly challenged energy, water and land resources to meet demand at national and supra-national level. A growing share of this demand is met through trade. The Belt and Road, a major global initiative of China, with trade as one of its core fields is of particular importance due to greater potential of economic growth, substantial population size and varying degree of resource availability. The initiative reflects a new phase of globalization yet resources management with nexus thinking has received little attention. The increasing economic interdependence of national economies have contributed to rise in production and trade of goods and services, these activities require the input of energy-water-land and generate disturbances in the environment. The multi-regional input-output approach is utilized, to assess resources use by production as well as consumption (for the year 2010). A nexus strength indicator was developed to show the simultaneous use of multiple resources in economic system, conceived as resource nexus. The ternary diagrams were used for screening resources combinations along with *** revealed that China has strong nexus strength that indicates large usage of the three resources together. Besides China, the East European countries were also positioned mostly at the center of ternary plot suggesting somewhat equal contributions of energy, water and land to the resource nexus. On the contrary, countries that appeared at the margins of the plot indicated one or two stronger nexus components in the three resources system. For instance, Russia largely used land, South Korea was entirely driven by energy while India mostly used water in the ternary mix. Due to differences in industrial structure, trade policy priorities and technology use, the resource nexus matters are not the same among countries. The nexus strength indicator established that strong nexus caused by intensive use of e

关键词： Roads and streets

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Investigation of thermal parameters in numerical modeling of the laser powder bed fusion process for maraging 300 steel

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Materials science and Engineering: B 2025年 321卷

作者： Bruno Caetano dos Santos Silva Lucas de Figueiredo Soares Luã Fonseca Seixas J.P. Oliveira Jiajia Shen Rodrigo Santiago Coelho Gilmar Ferreira Batalha SENAI CIMATEC SENAI Innovation Institute for Forming and Joining of Materials Av. Orlando Gomes 1845 Piata 41650-010 Salvador-BA Brazil Department of Mechatronics and Mechanical Systems Engineering Polytechnic School of Engineering University of Sao Paulo Av. Prof. Mello Moraes 2231 Butantã Sao Paulo 05508-030 SP Brazil SENAI CIMATEC University Post-Graduation Program MPDS/GETEC/MCTI Av. Orlando Gomes 1845 Piata 41650-010 Salvador-BA Brazil CENIMAT | i3N Department of Materials Science School of Science and Technology NOVA University Lisbon Caparica Portugal

The development of numerical simulations for metal additive manufacturing (AM) processes to predict distortion and residual stress is considered a strategic tool for supporting the industrialization of AM. However, the complexity of these analyses, due to the intricacies of thermal cycles, demands substantial computational resources and a deep understanding of the key process variables to achieve accurate models. This study aims to evaluate the influence of thermal parameters on the results of thermomechanical simulations using the Inherent Strain Method (ISM). Specifically, the analysis investigates the effects of estimated peak temperatures on thermal analyses, distortion, equivalent stress, and microstructure volume fraction in maraging 300 steel (MS300) parts simulated via finite elements. The results indicate that varying the peak temperature of the models causes a linear change in the thermal simulation output, referred to as the exposed energy fraction (EEF) in the Simufact Additive software, which determines the thermal history of the process in fabricated geometry. However, the distortion behavior—by the mechanical analyses that used the EEF as input—deviated from this linearity across specific regions, emphasizing the need for localized accuracy assessment within complex geometries. Equivalent stress decreased with lower peak temperatures, highlighting a correlation between these factors, while the microstructure volume fraction remained unchanged across different peak temperatures. The simulation results were validated by comparing the simulated measurements with experimental data of the same geometry manufactured via laser powder bed fusion (LPBF). Displacement in the simulation was assessed by comparing the diameters of the front and back faces, as well as through surface deviation analysis, which highlighted variations between the scanned experimental geometry and the simulated part. Additionally, the microstructure of the experimental part was examine

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A re-evaluation of the Chaetothyriales using criteria of comparative biology

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Fungal Diversity 2020年第4期103卷 47-85页

作者： Yu Quan Lucia Muggia Leandro F.Moreno Meizhu Wang Abdullah M.S.Al-Hatmi Nickolas da Silva Menezes Dongmei Shi Shuwen Deng Sarah Ahmed Kevin D.Hyde Vania A.Vicente Yingqian Kang JBenjamin Stielow Sybren de Hoog Centre of Expertise in Mycology of Radboud University Medical Centre/Canisius Wilhelmina Hospital NijmegenThe Netherlands Key Laboratory of Environmental Pollution Monitoring and Disease Control Ministry of Education of Guizhou&Key Laboratory of Medical Microbiology and ParasitologySchool of Basic Medical SciencesGuizhou Medical UniversityGuiyangChina College of Food and Pharmaceutical Engineering Guizhou Institute of TechnologyGuiyangChina Department of Life Sciences University of TriesteTriesteItaly Amsterdam Medical Center AmsterdamThe Netherlands Foundation Atlas of Clinical Fungi HilversumThe Netherlands Ministry of Health Directorate General of Health ServicesIbriOman Postgraduate Program in Microbiology Parasitology and PathologyBiological SciencesDepartment of Basic PathologyFederal University of ParanaCuritibaBrazil Department of Dermatology&Laboratory of Medical Mycology Jining No.1 People’s HospitalJiningShandongChina Department of Medical Microbiology People’s Hospital of Suzhou National New&Hi-Tech Industrial Development ZoneSuzhouChina Center of Excellence in Fungal Diversity Mae Fah Luang UniversityChiang RaiThailand Thermo Fisher Diagnostics Specialty Diagnostics GroupLandsmeerThe Netherlands Guizhou Academy of Tobacco Science GuiyangChina Engineering Bioprocess and Biotechnology Post-graduation Program Department of Bioprocess Engineering and BiotechnologyFederal University of ParanaCuritibaBrazil

Chaetothyriales is an ascomycetous order within *** order is particularly known through the black yeasts and filamentous relatives that cause opportunistic infections in *** species in the order are consistently *** and habitats of species are highly diverse,and often rather extreme in terms of exposition and *** are defined on the basis of evolutionary history,which is reconstructed by time of divergence and concepts of comparative biology using stochastical character mapping and a multi-rate Brownian motion model to reconstruct ecological ancestral character *** is hypothesized to be with a rock-inhabiting life *** disparity increased significantly in late Jurassic,probably due to expansion of cytochromes followed by colonization of vacant *** diversification took place subsequently,but at a low level of innovation resulting in strong niche conservatism for extant *** are ecologically different in degrees of *** of the clades has adapted ant domatia,which are rich in *** derived families,similar processes have enabled survival in domesticated environments rich in creosote and toxic hydrocarbons,and this ability might also explain the pronounced infectious ability of vertebrate hosts observed in these *** systems of morphological classification poorly correspond with recent phylogenetic *** are hypothesized to have low competitive ability against neighboring microbes,which interferes with their laboratory isolation on routine *** dataset is unbalanced in that a large part of the extant biodiversity has not been analyzed by molecular methods,novel taxonomic entities being introduced at a regular *** study comprises all available species sequenced to date for LSU and ITS,and a nomenclatural overview is provided.A limited number of species could not be assigned to any extant family.

关键词： Black yeasts Phylogeny Ecology Ancestral reconstruction Evolution Nomenclature

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Physical characteristics of modified cassava flour wastewater at room temperature

Physical characteristics of modified cassava flour wastewate...

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International Conference on Food science and technology 2018, ICFST 2018

作者： Yaqin, N. Al-Baarri, A.N. Legowo, A.M. Widayat Budihardjo, M.A. Program of Environmental Science School of Post-Graduate Studies Diponegoro University Semarang Indonesia Food Technology Department Faculty of Animal and Agricultural Sciences Diponegoro University Semarang Indonesia Chemical Engineering Department Faculty of Engineering Diponegoro University Semarang Indonesia Center of Research and Services Diponegoro University Semarang Indonesia Department of Environmental Engineering Faculty of Engineering Diponegoro University Indonesia

Cassava is an agricultural material that is considered as important raw resources in the industrial sector. The benefits are even greater after being modified using lactic acid bacteria. However, the mocaf industry often causes water and air pollution. environmental problems arise after the fermentation process. Determination problems with lightness, TDS (Total Dissolved Solid), conductivity and pH analysis are required to measure the impact to the environment. This research was used waste water from mocaf during 3 days fermentation. The wastewater had the highest color level (Lightness) on initial day of fermentation at 83.7±3.73 and then decrease along the day of fermentation at the averages of 65.2±2.0. The highest TDS was resulted from the mocaf wastewater at a value of 1218 ± 4.6 ppm which continued to decline until day 4. The conductivity and pH showed a decrease along the day of fermentation. As conclusion, physical characteristic of wastewater from mocaf production could be analyzed specifically and determined through color, TDS, conductivity, and pH. © 2019 Published under licence by IOP Publishing Ltd.

关键词： Fermentation

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Growing Food on Green Roofs:The First Step of an Interdisciplinary Approach

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Journal of Civil Engineering and Architecture 2019年第11期13卷 694-703页

作者： Eduardo Grala da Cunha Celina Maria Britto Correa Viviane Ritter Daniela Hohn Roberta Marins Nogueira Peil Helayne Aparecida Maieves Lisandra Fachinello Krebs Mariana Estima Silva Laboratory of Comfort and Energy Efficiency Federal University of PelotasPelotas 96010-020Brazil CNPq(National Council for Scientific and Technological Development) Brasilia71605-170Brazil Post-graduation Program in Familiar Agriculture Production Systems Crop Production DepartmentCollege of AgronomyFederal University of PelotasPelotas 96010-020Brazil Post-graduation Program in Science and Food Technology College of NutritionFederal University of PelotasPelotas 96010-020Brazil College of Architecture and Urbanism Federal University of PelotasPelotas 96010-020Brazil

Under the many available strategies for the adoption of sustainable practices,the urban agriculture emerges as a relevant *** naturation is the vegetative treatment of built surfaces,using plants adapted to the local environmental *** vegetation is a highly relevant element to the regulation and balance of extreme climatic *** also affects buildings thermal comfort and energy use,when assuming functions of control regarding solar radiation,air relative humidity and air *** the role of climate control,the vegetation can also play a role in food *** growing of vegetable crops,spices and medicinal herbs has gained the urban spaces of Brazilian *** growth of plants at home or in the urban environment,described as productive landscape,becomes one of the few ways of contact with the elements of ***,the urban agriculture can create natural spaces in the urban centers,thus,promoting the comfort into two scales:the urban scale and the building *** the other hand,the addition of vegetation for food production on built surfaces assumes a multidisciplinary *** is needed to technically respond to the suitable choice of substrate and plant species,to the nutrition values of the cultivated foods and,therefore,to the building physics that supports the food *** aims of this investigation project are:(i)to increase international partnerships in the subject(the Federal University of Pelotas,in Brazil;the Lund and the ALNARP Universities,in Sweden;the Polytechnic University of Madrid,in Spain;and the Arizona State University,in the United States);(ii)to bring information on both the building energy efficiency and the outdoor microclimate as a consequence of the green roof establishment;(iii)to generate a cultivation guide for food production on ***,this paper presents the first step of the research interdisciplinary approach,which deals with the construction of the Cultivation

关键词： Rooftop farming substrate urban microclimate buildings thermal performance modeling

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Risk of Hypothyroidism in Females Who Received Chinese Herbal Medicine for Treatment of Rheumatoid Arthritis: A Matched Nested Case-Control Study

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Journal of Herbal Medicine 2025年 49卷

作者： Liao, Hou-Hsun Livneh, Hanoch Huang, Hui-Ju Lu, Ming-Chi Lai, Ning-Shen Tsai, Tzung-Yi Department of Chinese Medicine Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Dalin Township 62247 Taiwan School of Post-Baccalaureate Chinese Medicine Tzu Chi University Hualien 97004 Taiwan Department of Biochemical Science and Technology National Chiayi University Chiayi City 60004 Taiwan Rehabilitation Counseling Program Portland State University Portland 97207-0751 OR United States Department of Nursing Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Dalin Township 62247 Taiwan School of Medicine Tzu Chi University Hualien 97004 Taiwan Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Dalin Township 62247 Taiwan Department of Environmental and Occupational Health College of Medicine National Cheng Kung University Tainan 70428 Taiwan Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Dalin Township 62247 Taiwan

Introduction: Thyroid dysfunction is a frequently observed clinical manifestation in females with rheumatoid arthritis (RA). Emerging evidence demonstrates that Chinese herbal medicine (CHM) can safely manage chronic diseases and treatment-related symptoms, but the association between CHM use and hypothyroidism risk in RA females has yet to be fully described. We put forward this population-level nested case-control study to explore the risk of hypothyroidism among them with and without integrating CHM into routine care. Methods: Firstly, 8 685 females aged 20–80 years, diagnosed with RA between 2002 and 2010, were extracted from a nationwide health claims database. Among them, 192 cases developed hypothyroidism after RA by the end of 2013, and all of the enrollees were randomly matched to 960 controls without hypothyroidism at a 1:5 ratio. Results: After fitting the conditional logistic regression, we found those ever receiving routine care plus CHM indeed exhibited a lower hypothyroidism risk, with an adjusted odds ratio of 0.60 (95% confidence intervals: 0.44–0.81). Of particular importance was that initiating CHM within the first 3 years after RA onset and having a prolonged usage for more than 365 days were markedly correlated with a lower hypothyroidism chance. Conclusions: This study implicated that timely integrating CHM into conventional care may substantially reduce hypothyroidism risk among RA females. A further well-designed randomised controlled trial to specify the possible mechanism is needed. © 2024 Elsevier GmbH

关键词： Chinese herbal medicine Females Hypothyroidism Nested case-control study Rheumatoid arthritis

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