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ASSOCIATION BETWEEN postURAL BALANCE AND FUNCTIONAL STATUS IN post COVID-19 CONDITION IN NON-HOSPITALIZED PATIENTS

Brazilian Journal of Physical Therapy 2024年 28卷 100781-100781页

作者： Bastos, Janice Regina Moreira Melo, Izabella Bárbara de Araújo Paz dos Anjos, Fabio Vieira Laboratory of Neurosciences in Rehabilitation Rehabilitation Sciences Post-Graduation Program Augusto Motta University Centre (UNISUAM) Rio de Janeiro Rio de Janeiro Brazil

BackgroundIndividuals with post COVID-19 conditions risk to develop short and/or mid term neuromuscular sequels that may involve changes on balance control. The post-COVID-19 Functional Scale (PCFS) has the potential to evaluate the general functional capacity, however, if the PCFS can also be used to measure the impact on the balance control over the post COVID-19 functionality, remains unclear. ObjectivesTo investigate if COVID-19 may impact the balance control and if possible, changes are associated with the functional status of the individual estimated by PCFS. Methods60 adults were spited into two groups: 30 patients on control group and 30 on post COVID-19 group. Both groups underwent clinical evaluation of balance control based on the following tests: Functional Reach Test (FRT), Berg Balance Scale (BBS), Time Up and Go (TUG), Tinetti Balance Test (TINETTI) and Mini-BESTest (MBT). Besides, the post COVID group answered the PCFS questionnaire. For data statistical analysis, it was used the Student's T Test, comparing the score found on groups’ balance tests. The Pearson's correlation test was used to correlate the balance tests and PCFS. The multiple linear regression was used to identify which balance variable may play important role on PCFS’ prevision, with significancy level of 5%. ResultsIt wasn't found significative differences (p>0,05) between groups for: BBS (average ± control standard deviation and post COVID-19: 49.200±7.863 and 49.300±8.322 points); TUG (12.500±4.925 and 11.033±5.109 seconds); TINETTI (24.467±4.890 and 25.633±3.873 points); and MBT (22.500±5.361 and 22.967±4.716 points). But, for FRT, there was significative difference (p=0,046) between groups post COVID-19 (31,333±6,563 cm) and control (28,083±5,748 cm). The balance variables showed significative correlation (p<0,05) and moderated with PCFS: TINETTI (r=0.584), FRT (r=±-0.542), MBT (r=-0.53), BBS (r=0.415) and TUG (r=0.368). TINETTI was the independent variable that significantly pla

关键词： postural balance COVID-19 post COVID-19 condition post-COVID-19 Functional Scale

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The Perception of Nursing Professionals Working in a Central Sterile Supplies Department regarding Health Conditions, Workload, Ergonomic Risks, and Functional Readaptation

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Advances in preventive medicine 2022年第1期2022卷 1023728页

作者： Rosemere Saldanha Xavier Patrícia Dos Santos Vigário Alvaro Camilo Dias Faria Patricia Maria Dusek Agnaldo José Lopes Local Development Post-Graduation Program Augusto Motta University Center (UNISUAM) Rio de Janeiro Brazil. Rehabilitation Sciences Post-Graduation Program Augusto Motta University Center (UNISUAM) Rio de Janeiro Brazil. Unesulbahia-Integrated Faculties Salvador Bahia Brazil. Medical Sciences Post-Graduation Program School of Medical Sciences State University of Rio de Janeiro (UERJ) Rio de Janeiro Brazil.

Background:The central sterile supply department (CSSD) is wrongly seen as a place in the hospital environment that does not require skills and physical effort, being commonly a hospital sector for the relocation of functionally-readapted professionals. However, CSSD is a work environment that demands professional experience and presents itself as a sector that does not have a healthy work environment. This study aims to evaluate the frequency of comorbidities and functionally-readapted people among nursing professionals allocated to a CSSD and, also, to seek the perception of these professionals about the ergonomic risks and the degree of difficulty to perform activities within a CSSD. Methods:This is a cross-sectional study that analyzed the opinions of nursing professionals who work in the CSSD of public hospitals in Rio de Janeiro, Brazil. Nurses, nursing technicians and nursing assistants aged ≥18 years were included. Results:Seventy-two nursing professionals were consecutively evaluated. It was observed that 43 of them (59.7%) had never worked in a CSSD. The most prevalent comorbidity in the present study was chronic rhinosinusitis, observed in more than half of the sample, although it is interesting to note the high frequency of participants with work-related musculoskeletal disorders (WMSD) and repetitive strain injuries (RSI). There is a relationship between previous work in a CSSD and the ability to identify surgical tweezers by visual recognition (=0.031). There is a relationship between the time the participant had previously worked in the hospital and the skill regarding the information contained in the conference folders for preparing the tray surgical procedures ( = -0.34, =0.001). Conclusion:Almost a third of nursing professionals working in a CSSD are rehabilitated, with a high prevalence of WMSD and RSI. The commitment of managers to an internal health policy aimed at workers is necessary for health promotion.

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Overall survival analyses of female malignancies in Southern Brazil during 2008–2017: A closer look at breast, cervical and ovarian cancer

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Dialogues in Health 2022年 1卷 100010-100010页

作者： Schneider, Ione Jayce Ceola Schmidt, Tauana Prestes dos Santos, Ana Maria Martins Correa, Vanessa Pereira Garcia, Leandro Pereira de Oliveira, Cesar Franzoi, Maria Alice Department of Epidemiology & Public Health University College London United Kingdom Federal University of Santa Catarina (UFSC) Health Sciences Department Araranguá Brazil Federal University of Santa Catarina (UFSC) Rehabilitation Sciences Post-Graduation Program Araranguá Brazil Municipality Health Secretary of Florianópolis Brazil Institut Jules Bordet Université Libre de Bruxelles (U.L.B) Belgium Latin America Cooperative Oncology Group Brazil

Background: The aim of this study was to report the overall survival and baseline factors associated with OS for breast, cervical and ovarian cancer in Florianópolis, Southern Brazil, a region with quality-of-life indicators comparable to high-income countries. Methods: Cohort study was performed from probabilistic record linkage of the Mortality Information System and the Population-based cancer registry of Florianópolis. It was included breasts, cervical and ovarian cancer diagnosis during the period of 2008–2012 with a follow up of 60 months. Cox regression and Kaplan-Meier method were used for associations with overall survival and risk factors. Findings: 1857 cases of the three malignancies were included in the analysis. We identified 202 deaths in breast cancer subjects, 53 for cervical cancer and 51 for ovarian cancer. Metastatic disease at diagnosis was present in 31%, 9.6%, and 55% of the cases, respectively. Overall survival was statistically correlated with age, educational level and stage for breast cancer;age and stage for cervical cancer;age and stage for ovarian cancer. Interpretation: Metastatic disease and age are the main prognostic factors for the malignancies studied, as they were associated with both overall survival and risk of death. Better screening and preventive tests for early diagnosis are needed. Funding: Support of Research and Innovation in the State of Santa Catarina, Research program for the Unified Health System (FAPESC/MS-DECIT/CNPQ/SES-SC-PPSUS);the Brazilian National Research Council (CNPq);and the Coordination for the Improvement of Higher Education Personnel (CAPES). © 2022 The Authors

关键词： Brazil Breast cancer Ccancer mortality Cervical cancer Epidemiology Female malignancies Incidence Ovarian cancer Overall survival

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Balance as an Additional Effect of Strength and Flexibility Aquatic Training in Sedentary Lifestyle Elderly Women

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Current Gerontology and Geriatrics Research 2020年第1期2020卷 1895473-1895473页

作者： Vale, Fernando Alves Voos, Mariana Callil Brumini, Christine Suda, Eneida Yuri Silva, Ronaldo Luis Da Caromano, Fátima Aparecida Rehabilitation Sciences Post Graduation Program Medical School University of São Paulo Laboratory of Physical Therapy and Behavior São Paulo Brazil Ibirapuera University Physical Therapy Course São Paulo Brazil Rehabilitation Sciences Post Graduation Program Medical School University of São Paulo Laboratory of Physical Therapy and Behavior São Paulo Brazil Rheumatology Sciences Federal University of São Paulo São Paulo Brazil Faculté des Sciences Université du Québec À Montréal QC Canada University Center São Camilo São Paulo Brazil

Context. Physiological changes due to the aging process cause balance deficit and increased risk of falls, more frequently in women. Exercises improve balance and prevent falls;and aquatic exercises are recommended as an alternative strategy to improve muscle strength, flexibility, and balance, in a safer environment for older persons. Objective. To evaluate the additional effects of on balance an aquatic muscle strengthening and flexibility training program in healthy sedentary lifestyle elderly women. Method. This controlled clinical trial included 56 healthy sedentary women, aged from 65 to 70 years, divided into two groups. The aquatic group (AG) underwent aquatic training (45 minutes/session, 32 sessions), and the control group (CG) received no intervention. Data were collected pre- and post-intervention, during a one-week period. Lower limb muscle strength was measured by a force sensor (myometer). Flexibility was measured by biophotogrammetry. Functional balance was evaluated by the Performance Oriented Mobility Assessment (POMA) and the Berg Balance Scale (BBS). Results. Muscle strength, flexibility, and balance improved in AG (p < 0.001), but not in CG. Conclusion. The aquatic exercises program, which was originally developed to promote muscle strength and flexibility, also improved functional balance. Aquatic training is an option for physical health promotion for sedentary lifestyle elderly women. © 2020 Fernando Alves Vale et al.

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Author Correction: A possible association between fructose consumption and pulmonary emphysema

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Scientific reports 2020年第1期10卷 16158页

作者： Camila Liyoko Suehiro Alessandra Choqueta de Toledo-Arruda Rodolfo de Paula Vieira Francine Maria de Almeida Clarice Rosa Olivo Milton de Arruda Martins Chin Jia Lin Laboratory of Molecular Pathology (LIM-22) Department of Pathology School of Medicine University of Sao Paulo Sao Paulo Brazil. Department of Medicine (LIM-20) School of Medicine University of Sao Paulo Sao Paulo Brazil. Federal University of Sao Paulo (UNIFESP) Post-Graduation Program in Sciences of Human Movement and Rehabilitation Santos - SP Brazil. Universidade Brasil Post-Graduation Program in Bioengineering and in Biomedical Engineering Sao Paulo - SP Brazil. Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (LABPEI) Sao Jose dos Campos - SP Brazil. Anhembi Morumbi University School of Medicine Sao Jose dos Campos - SP Brazil. Laboratory of Molecular Pathology (LIM-22) Department of Pathology School of Medicine University of Sao Paulo Sao Paulo Brazil. cjlin@usp.br.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Montelukast, Leukotriene Inhibitor, Reduces LPS-Induced Acute Lung Inflammation and Human Neutrophil Activation

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Archivos de Bronconeumología (English Edition) 2019年第11期55卷 573-580页

作者： Jaime Eduardo Davino-Chiovatto Manoel Carneiro Oliveira-Junior BreAnne MacKenzie Alana Santos-Dias Ana Roberta Almeida-Oliveira Jefferson Comin Jonco Aquino-Junior Auriléia Aparecida Brito Nicole Cristine Rigonato-Oliveira Nilsa Regina Damaceno-Rodrigues Ana Paula Ligeiro Oliveira Alessandro Pereira Silva Fernanda Marciano Consolim-Colombo Flavio Aimbire Hugo Caire Castro-Faria-Neto Rodolfo Paula Vieira Nove de Julho University (UNINOVE) São Paulo SP Brazil Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE) São José dos Campos SP Brazil University of São Paulo School of Medicine Department of Pathology (LIM 59) São Paulo SP Brazil Post-graduation Program in Biomedical Engineering University of Mogi das Cruzes Mogi das Cruzes SP Brazil Federal University of Sao Paulo (UNIFESP) São José dos Campos SP Brazil Laboratory of Immunopharmacology Osvaldo Cruz Institute (IOC) Osvaldo Cruz Foundation Rio de Janeiro RJ Brazil Universidade Brasil Post-graduation Program in Bioengineering and in Biomedical Engineering São Paulo SP Brazil Federal University of Sao Paulo (UNIFESP) Post-graduation Program in Sciences of Human Movement and Rehabilitation Santos SP Brazil Anhembi Morumbi University School of Medicine Avenida Deputado Benedito Matarazzo 4050 São José dos Campos SP Brazil

Objectives Some pro-inflammatory lipids derived from 1 lipooxygenase enzyme are potent neutrophil chemoattractant, a cell centrally involved in acute respiratory distress syndrome (ARDS); a syndrome lacking effective treatment. Considering the beneficial effects of the leukotriene receptor inhibitor, montelukast, on other lung diseases, whether montelukast attenuates inflammation in a mouse model of ARDS, and whether it reduces LPS stimulated activation of human neutrophils was investigated. Methods Thirty-five C57Bl/6 mice were distributed into control (PBS) + 24 h, LPS + 24 h (10 μg/mouse), control + 48 h, LPS + 48 h, and LPS 48 h + Montelukast (10 mg/kg). In addition, human neutrophils were incubated with LPS (1 μg/mL) and treated with montelukast (10 μM). Results Oral-tracheal administration of montelukast significantly attenuated total cells ( P < .05), macrophages ( P < .05), neutrophils ( P < .01), lymphocytes ( P < .001) and total protein levels in BAL ( P < .05), as well as IL-6 ( P < .05), CXCL1/KC ( P < .05), IL-17 ( P < .05) and TNF-α ( P < .05). Furthermore, montelukast reduced neutrophils ( P < .001), lymphocytes ( P < .01) and macrophages ( P < .01) in the lung parenchyma. In addition, montelukast restored BAL VEGF levels ( P < .05). LTB4 receptor expression ( P < .001) as well as NF-κB ( P < .001), a downstream target of LPS, were also reduced in lung parenchymal leukocytes. Furthermore, montelukast reduced IL-8 ( P < .001) production by LPS-treated human neutrophils. Conclusion In conclusion, montelukast efficiently attenuated both LPS-induced lung inflammation in a mouse model of ARDS and in LPS challenged human neutrophils. Objetivos Algunos lípidos proinflamatorios derivados de la enzima lipooxigenasa 1 son potentes quimioatrayentes de neutrófilos, un tipo celular con una implicación principal en el síndrome de distrés respiratorio agudo (SDRA),

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Reduced Fat Oxidation During Exercise in post-Menopausal Overweight-Obese Women with Higher Lipid Accumulation Product Index

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Experimental and Clinical Endocrinology & Diabetes 2018年第8期128卷 556-562页

作者： Elana Stein Igor Martins Silva Gilson P. Dorneles Fabio Santos Lira Pedro Romão Alessandra Peres Graduate Program in Nutrition Sciences Laboratory of Cellular and Molecular Immunology Federal University of Health Sciences of Porto Alegre Porto Alegre RS Brazil Graduate Program in Health Sciences Laboratory of Cellular and Molecular Immunology Federal University of Health Sciences of Porto Alegre Porto Alegre RS Brazil Exercise and Immunometabolism Research Group Post-Graduation Program in Movement Sciences Department of Physical Education State University of São Paulo – UNESP. School of Technology and Sciences Presidente Prudente Sao Paulo Brazil Graduate Program in Rehabilitation Sciences Laboratory of Cellular and Molecular Immunology Federal University of Health Sciences of Porto Alegre Porto Alegre RS Brazil Research Center Graduate Program in Bioscience and Rehabilitation Methodist University Center IPA Porto Alegre RS Brazil

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Psychometric properties of the Alcohol Use Disorders Identification Test (AUDIT) across cross-cultural subgroups, genders, and sexual orientations: Findings from the International Sex Survey (ISS)

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Comprehensive Psychiatry 2023年 127卷 152427页

作者： Horváth, Zsolt Nagy, Léna Koós, Mónika Kraus, Shane W. Demetrovics, Zsolt Potenza, Marc N. Ballester-Arnal, Rafael Batthyány, Dominik Bergeron, Sophie Billieux, Joël Briken, Peer Burkauskas, Julius Cárdenas-López, Georgina Carvalho, Joana Castro-Calvo, Jesús Chen, Lijun Ciocca, Giacomo Corazza, Ornella Csako, Rita Fernandez, David P. Fujiwara, Hironobu Fernandez, Elaine F. Fuss, Johannes Gabrhelík, Roman Gewirtz-Meydan, Ateret Gjoneska, Biljana Gola, Mateusz Grubbs, Joshua B. Hashim, Hashim T. Islam, Md. Saiful Ismail, Mustafa Jiménez-Martínez, Martha C. Jurin, Tanja Kalina, Ondrej Klein, Verena Költő, András Lee, Sang-Kyu Lewczuk, Karol Lin, Chung-Ying Lochner, Christine López-Alvarado, Silvia Lukavská, Kateřina Mayta-Tristán, Percy Miller, Dan J. Orosová, Oľga Orosz, Gábor Ponce, Fernando P. Quintana, Gonzalo R. Quintero Garzola, Gabriel C. Ramos-Diaz, Jano Rigaud, Kévin Rousseau, Ann Scanavino, Marco De Tubino Schulmeyer, Marion K. Sharan, Pratap Shibata, Mami Shoib, Sheikh Sigre-Leirós, Vera Sniewski, Luke Spasovski, Ognen Steibliene, Vesta Stein, Dan J. Strizek, Julian Tsai, Meng-Che Ünsal, Berk C. Vaillancourt-Morel, Marie-Pier Van Hout, Marie Claire Bőthe, Beáta Institute of Psychology ELTE Eötvös Loránd University Budapest Hungary Centre of Excellence in Responsible Gaming University of Gibraltar Gibraltar Gibraltar Doctoral School of Psychology ELTE Eötvös Loránd University Budapest Hungary Department of Psychology University of Nevada Las Vegas Las Vegas NV United States Yale University School of Medicine New Haven CT United States Connecticut Council on Problem Gambling Wethersfield CT United States Connecticut Mental Health Center New Haven CT United States Departmento de Psicología Básica Clínica y Psicobiología University Jaume I of Castellón Spain Institute for Behavioural Addictions Sigmund Freud University Vienna Austria Département de psychologie Université de Montréal Montréal Canada Institute of Psychology University of Lausanne Lausanne Switzerland Center for Excessive Gambling Addiction Medicine Lausanne University Hospitals (CHUV) Lausanne Switzerland Institute for Sex Research Sexual Medicine and Forensic Psychiatry University Medical Centre Hamburg-Eppendorf Hamburg Germany Laboratory of Behavioral Medicine Neuroscience Institute Lithuanian University of Health Sciences Palanga Lithuania Virtual Teaching and Cyberpsychology Laboratory School of Psychology National Autonomous University of Mexico Mexico William James Center for Research Departamento de Educação e Psicologia Universidade de Aveiro Aveiro Portugal Department of Personality Assessment and Psychological Treatments University of Valencia Spain Department of Psychology College of Humanity and Social Science Fuzhou University China Section of Sexual Psychopathology Department of Dynamic and Clinical Psychology and Health Studies Sapienza University of Rome Rome Italy Department of Clinical Pharmaceutical and Biological Sciences University of Hertfordshire United Kingdom Department of Psychocology and Cognitive Science University of Trento Italy Department of Psychology and Neuroscience Auckland University of Technology Auc

Introduction: Despite being a widely used screening questionnaire, there is no consensus on the most appropriate measurement model for the Alcohol Use Disorders Identification Test (AUDIT). Furthermore, there have been limited studies on its measurement invariance across cross-cultural subgroups, genders, and sexual orientations. Aims: The present study aimed to examine the fit of different measurement models for the AUDIT and its measurement invariance across a wide range of subgroups by country, language, gender, and sexual orientation. Methods: Responses concerning past-year alcohol use from the participants of the cross-sectional International Sex Survey were considered (N = 62,943;M_age: 32.73;SD = 12.59). Confirmatory factor analysis, as well as measurement invariance tests were performed for 21 countries, 14 languages, three genders, and four sexual-orientation subgroups that met the minimum sample size requirement for inclusion in these analyses. Results: A two-factor model with factors describing ‘alcohol use’ (items 1–3) and ‘alcohol problems’ (items 4–10) showed the best model fit across countries, languages, genders, and sexual orientations. For the former two, scalar and latent mean levels of invariance were reached considering different criteria. For gender and sexual orientation, a latent mean level of invariance was reached. Conclusions: In line with the two-factor model, the calculation of separate alcohol-use and alcohol-problem scores is recommended when using the AUDIT. The high levels of measurement invariance achieved for the AUDIT support its use in cross-cultural research, capable also of meaningful comparisons among genders and sexual orientations. © 2023

关键词： Addictive behaviors Alcohol Use Disorders Identification Test (AUDIT) Cross-cultural comparison Gender LGBTQ Measurement invariance Sexual orientation

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Determination of functional prognosis in hospitalized patients following an intensive care admission

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World Journal of Critical Care Medicine 2016年第4期5卷 219-227页

作者： Natália A Ferreira Agnaldo José Lopes Arthur S Ferreira George Ntoumenopoulos Jerffesson Dias Fernando S Guimaraes Rehabilitation Sciences Post-Gradua-tion Program Augusto Motta University Centre Physical Therapy Department Barra D’Or Hospital Post-Graduation Program in Medical Sciences State University of Rio de Janeiro Graduate School of Health Sciences University of Technology Sydney Physical Therapy Department Federal University of Rio de Janeiro

AIM To investigate the factors associated with the functional progress of hospitalized patients following an intensive care *** Retrospective study including data from a cohort of 198 hospitalized patients following an intensive care admission and not requiring mechanical ventilation in a single tertiary referral hospital. A generalized linear model was used to identify the main effects of clinical and demographic variables on the outcomes of functionality(KATZ Index of Independence in Activities of Daily Living) and muscle strength(MRC Scale). The covariates identified as independent predictors were analysed using the receiver operating characteristic curves. The analysis differentiated the periods in the intensive care unit(ICU), in the Ward(WARD) and the total time of hospital stay(TOT).RESULTS Considering the functional outcome(ΔKATZ), the variables that significantly contributed to the model(P < 0.05) were the KATZ and MRC on admission, age, sepsis(no), and total length of stay(TLS). Regarding the muscle strength outcome model(ΔMRC), the predictors were MRC on admission, Simplified Acute Physiology Score III, previous stroke, TLS, and sex(female). The variable age(AUC = 0.664) discriminated the ΔKATZICU. The variables age(AUC = 0.712), KATZ in ICU(AUC = 0.590) and on ward admission(AUC = 0.746), and MRC on ward admission(AUC = 0.721) were discriminative for ΔKATZWARD. For ΔKATZTOT the variables KATZ on ICU admission(AUC = 0.621) and TLS(AUC = 0.617) were discriminative. For ΔMRCICU the variables SAPSIII(AUC = 0.661) and MRC on ICU admission(AUC = 0.653) were discriminative. MRC on ICU(AUC = 0.681) and ward admission(AUC = 0.553) were discriminative for ΔMRCWARD. TLS(AUC = 0.649) and MRC on ward admission(AUC = 0.696) discriminative for the Δ*** Specific functional, clinical and demographical variables at ICU admission are associated with the functional prognosis during the hospitalization period.

关键词： Muscle strength Intensive care units Activities of daily living rehabilitation Early mobilization post-intensive care unit syndrome

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Stroke genetics informs drug discovery and risk prediction across ancestries (vol 611, pg 115, 2022)

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NATURE 2022年第7938期612卷 E7-E7页

作者： Mishra, Aniket Malik, Rainer Hachiya, Tsuyoshi Jurgenson, Tuuli Namba, Shinichi Posner, Daniel C. Kamanu, Frederick K. Koido, Masaru Le Grand, Quentin Shi, Mingyang He, Yunye Georgakis, Marios K. Caro, Ilana Krebs, Kristi Liaw, Yi-Ching Vaura, Felix C. Lin, Kuang Winsvold, Bendik Slagsvold Srinivasasainagendra, Vinodh Parodi, Livia Bae, Hee-Joon Chauhan, Ganesh Chong, Michael R. Tomppo, Liisa Akinyemi, Rufus Roshchupkin, Gennady V. Habib, Naomi Jee, Yon Ho Thomassen, Jesper Qvist Abedi, Vida Carcel-Marquez, Jara Nygaard, Marianne Leonard, Hampton L. Yang, Chaojie Yonova-Doing, Ekaterina Knol, Maria J. Lewis, Adam J. Judy, Renae L. Ago, Tetsuro Amouyel, Philippe Armstrong, Nicole D. Bakker, Mark K. Bartz, Traci M. Bennett, David A. Bis, Joshua C. Bordes, Constance Borte, Sigrid Cain, Anael Ridker, Paul M. Cho, Kelly Chen, Zhengming Cruchaga, Carlos Cole, John W. de Jager, Phil L. de Cid, Rafael Endres, Matthias Ferreira, Leslie E. Geerlings, Mirjam I. Gasca, Natalie C. Gudnason, Vilmundur Hata, Jun He, Jing Heath, Alicia K. Ho, Yuk-Lam Havulinna, Aki S. Hopewell, Jemma C. Hyacinth, I. Hyacinth Inouye, Michael Jacob, Mina A. Jeon, Christina E. Jern, Christina Kamouchi, Masahiro Keene, Keith L. Kitazono, Takanari Kittner, Steven J. Konuma, Takahiro Kumar, Amit Lacaze, Paul Launer, Lenore J. Lee, Keon-Joo Lepik, Kaido Li, Jiang Li, Liming Manichaikul, Ani Markus, Hugh S. Marston, Nicholas A. Meitinger, Thomas Mitchell, Braxton D. Montellano, Felipe A. Morisaki, Takayuki Mosley, Thomas H. Nalls, Mike A. Nordestgaard, Borge G. O'Donnell, Martin J. Okada, Yukinori Onland-Moret, N. Charlotte Ovbiagele, Bruce Peters, Annette Psaty, Bruce M. Rich, Stephen S. Rosand, Jonathan Sabatine, Marc S. Sacco, Ralph L. Saleheen, Danish Sandset, Else Charlotte Salomaa, Veikko Sargurupremraj, Muralidharan Sasaki, Makoto Satizabal, Claudia L. Schmidt, Carsten O. Shimizu, Atsushi Smith, Nicholas L. Sloane, Kelly L. Sutoh, Yoichi Sun, Yan V. Tanno, Kozo Tiedt, Steffen Tatlisumak, Turgut Torres-Aguila, Nuria P. Tiwari, Hemant K. Tregouet, Bordeaux Population Health Research Center University of Bordeaux Inserm UMR 1219 Bordeaux France Department of Public Health Bordeaux University Hospital Bordeaux France Department of Neurology Memory Clinic Bordeaux University Hospital Bordeaux France Department of Neurology Institute for Neurodegenerative Diseases CHU de Bordeaux Bordeaux France Institute for Stroke and Dementia Research (ISD) University Hospital LMU Munich Munich Germany Center for Genomic Medicine Massachusetts General Hospital Boston MA USA Program in Medical and Population Genetics Broad Institute of Harvard and the Massachusetts Institute of Technology Cambridge MA USA Munich Cluster for Systems Neurology Munich Germany German Center for Neurodegenerative Diseases (DZNE) Munich Germany Iwate Tohoku Medical Megabank Organization Iwate Medical University Iwate Japan Estonian Genome Centre Institute of Genomics University of Tartu Tartu Estonia Institute of Mathematics and Statistics University of Tartu Tartu Estonia Department of Computational Biology University of Lausanne Lausanne Switzerland Swiss Institute of Bioinformatics Lausanne Switzerland University Center for Primary Care and Public Health Lausanne Switzerland Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan Department of Genome Informatics Graduate School of Medicine The University of Tokyo Tokyo Japan Laboratory for Systems Genetics RIKEN Center for Integrative Medical Sciences Yokohama Japan Laboratory of Statistical Immunology Immunology Frontier Research Center (WPI-IFReC) Osaka University Suita Japan Integrated Frontier Research for Medical Science Division Institute for Open and Transdisciplinary Research Initiatives Osaka University Suita Japan Center for Infectious Disease Education and Research (CiDER) Osaka University Suita Japan Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC) VA Boston Healthcare System Boston MA USA TIMI S

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