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EGFR and Hippo signaling pathways are involved in organophosphate esters–induced proliferation and migration of triple-negative breast cancer cells

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Environmental science and Pollution Research 2024年第29期31卷 41939-41952页

作者： Xu, Ting Liu, Kaiyue Zhang, Yajie Chen, Yawen Yin, Daqiang Key Laboratory of Yangtze River Water Environment Ministry of Education College of Environmental Science and Engineering Tongji University Shanghai200092 China Shanghai Institute of Pollution Control and Ecological Security Shanghai200092 China Post-doctoral Research Station of Environmental Science and Engineering Tongji University Shanghai200092 China

The widespread application of organophosphate flame retardants has led to pervasive exposure to organophosphate esters (OPEs), prompting considerable concerns regarding their potential health risk to humans. Despite hints from previous research about OPEs’ association with breast cancer, their specific effects and underlying mechanisms of triple-negative breast cancer (TNBC) remain unclear. In this study, we investigated the effects of four representative OPEs on cell proliferation, cell cycle regulation, migration, and the expression of genes and proteins associated with the epidermal growth factor receptor (EGFR) and Hippo signaling pathways in TNBC (MDA-MB-231) cells. Our findings revealed that treatment with 1–25 μM triphenyl phosphate (TPHP) and tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) induced TNBC cell proliferation and accelerated cell cycle progression, with upregulation in MYC, CCND1, and BRCA1 mRNA. Moreover, exposure to 1–25 μM TPHP, 10–25 μM TDCIPP, and 1–10 μM tris (2-chloroethyl) phosphate (TCEP) induced MMP2/9 mRNA expression and enhanced migratory capacity, except for 2-ethylhexyl diphenyl phosphate (EHDPP). Mechanistically, four OPEs treatments activated the EGFR-ERK1/2 and EGFR-PI3K/AKT signaling pathways by increasing the transcript of EGFR, ERK1/2, PI3K, and AKT mRNA. OPEs treatment also suppressed the Hippo signaling pathway by inhibiting the expression of MST1 mRNA and phosphorylation of LATS1, leading to the overactivation of YAP1 protein, thereby promoting TNBC cell proliferation and migration. In summary, our study elucidated that activation of the EGFR signaling pathway and suppression of the Hippo signaling pathway contributed to the proliferation, cell cycle dysregulation, and migration of TNBC cells following exposure to OPEs. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.

关键词： Proteins

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Thermal reaction characteristics and microstructure evolution of aluminium nano-powder in various mixtures of oxygen and nitrogen atmosphere

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Process Safety and Environmental Protection 2023年 170卷 45-53页

作者： Qu, Jiao Deng, Jun Luo, Zhen-Min Xiao, Yang Shu, Chi-Min Post-doctoral Program Research Centre Xi'an University of Science and Technology No. 58 Yanta Mid. Rd. Shaanxi Xi'an710054 China School of Safety Science and Engineering Xi'an University of Science and Technology No. 58 Yanta Mid. Rd. Shaanxi Xi'an710054 China Shaanxi Key Laboratory of Prevention and Control of Coal Fire No. 58 Yanta Mid. Rd. Shaanxi Xi'an710054 China Department of Safety Health and Environmental Engineering National Yunlin University of Science and Technology Yunlin 64002 Taiwan

Aluminium nano-powder has a small particle size, large specific surface area, and high surface energy, therefore when using it, the risk of fires or explosions is high. In this study, synchronous thermal analyser was used to determine the thermal reaction characteristics of aluminium nano-powder for various oxygen and nitrogen mixtures. The results showed that the oxidation behaviour of aluminium nano-powder could be considered to occur in four stages, according to the characteristic temperature points and polymorphic phase changes. Under experimental heating rates of 5, 10, 15, and 20 K/min, the mass gain and thermal effects of the samples were tested, and also for different oxygen concentrations of 9, 15, and 21 vol%. Changes in the microstructure of the samples were analysed. Oxide layer thickness was found to increase as temperature increased, and this trend was the same for mass change. Surface morphology images of the aluminium particles exhibited agglomeration, melting deformation, rupture, and fragmentation at the different pretreated temperatures of 500, 650, 800, and 900 °C. The results of this study could be used as a basis for exploring oxidation kinetics, and had significance for explosion-proofing technology, particularly with respect to aluminium nano-powder. © 2022 The Institution of Chemical Engineers

关键词： Surface morphology

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Natural antimicrobial properties of liquid smoke derived from cocoa pod shells in meatball preservation

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South African Journal of Chemical engineering 2023年 46卷 106-111页

作者： Desvita, Hera Faisal, M. Mahidin, Mahidin Suhendrayatna Doctoral Program Post Graduate Program Universitas Syiah Kuala Indonesia Research Center for Chemistry National Research and Innovation Agency B.J. Habibie Science and Techno Park Serpong Banten South Tangerang 15314 Indonesia Chemical Engineering Department Faculty of Engineering Universitas Syiah Kuala Indonesia Halal Research Center Universitas Syiah Kuala Indonesia

The liquid smoke, which is produced by pyrolyzing wood materials containing cellulose, hemicellulose, and lignin, can be used to preserve food. Phenolic, acetic, and carbonyl compounds found in liquid smoke can serve as a natural preservative. This study aimed to determine meatball preservation ability of liquid smoke from cocoa pod shells. Specifically, cocoa pod shells were converted to liquid smoke using slow pyrolysis at three different temperatures, 300 °C, 340 °C and 380 °C. Prior to its use, liquid smoke was purified using distillation at 190 °C. Liquid smoke at concentrations of 0.5%–3.0% was then used to preserve meatballs using an immersion method. Total volatile base-nitrogen (TVB-N), total plate count (TPC), and most probable number (MPN) analyses were used to evaluate preservation performance of liquid smoke. The statistical methods for MPN using one-way ANOVA followed by Tukey's tests. The SNI (Standar Nasional Indonesia) threshold to test whether meatballs remained fresh (TVB-N <20 mg N/g). TPC test results indicated that beef meatballs stay fresh at room temperature for 42 h or 48 h of storage using 0.5% or 1%–3% liquid smoke concentrations, respectively. Based on MPN tests showed meatballs could last for 48 h for all samples. Liquid smoke produced from cocoa pod shells can be used as a natural preservative for beef meatballs;however, liquid smoke concentrations influence the maximum preservation period for meatballs. © 2023 The Author(s)

关键词： Cocoa pod shells Liquid smoke MPN Pyrolysis Total plate count Total volatile base-nitrogen

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Immunomolecular response of CD4^(+),CD8^(+),TNF-α and IFN-γ in Myxobolus-infected koi(Cyprinus carpio)treated with probiotics

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Aquaculture and Fisheries 2023年第5期8卷 514-527页

作者： Uun Yanuhar Nico Rahman Caesar Nur Sakinah Junirahma Rachmat Noer Soelistyoadi Department of Aquatic Resources Management Faculty of Fisheries and Marine SciencesBrawijaya UniversityJalan VeteranMalangEast Java65145Indonesia Doctoral Program of Environment Science Post Graduate ProgramBrawijaya UniversityJalan VeteranMalangEast Java65145Indonesia Fish Quarantine Center for Quality Control and Safety of Fishery Products Surabaya I Ministry of Marine Affairs and FisheriesSurabayaEast Java60115Indonesia

A poor environment increases fish’s susceptibility to myxosporean infection that can cause the death of larval fish,especially for koi fish(Cyprinus carpio).This study aimed to determine the effect of probiotics,local anti-parasitic drugs(kutuklin),and the chemical compound diflubenzuron treatments on the koi immune *** study used PCR with specific primer 18S SSU rDNA and DNA sequencing to detect Myxobulus *** treatments were divided into 5 groups:Treatment(A)(healthy koi without treatment),(B)(infected koi without treatment),(C)(infected koi with 0.55 mL/30 L probiotics),(D)(infected koi with 1μL/g of feed kutuklin),and(E)(infected koi with 0.02 mg/5 L dimilin).Myxospore has observed with Scanning Electron Microscopy(SEM)and 4′,6-diamidino-2-phenylindole(DAPI)fluorescence *** histological analysis using semi-quantitative scoring methods,and flow cytometry was conducted to analyse the immune response of Cluster of differentiation 4(CD4^(+)),Cluster of differentiation 8(CD8^(+)),Tumor Necrosis Factor-alpha(TNF-α),Interferon gamma(IFN-γ)cells in the *** show that the histological analysis indicated edema,hyperplasia,lamella fusion,congestion,and hypertrophy lesions in infected *** with probiotics shows the lowest damage(30.6%).The immune responses of CD4^(+)and CD8^(+)cells to dimilin treatment were 10.54%and 16.86%,*** largest TNF-αand IFN-γresponse were for the kutuklin treatment(29.26%)and probiotics treatment(8.23%).

关键词： Cyprinus carpio Flowcytometry Immune responses Myxobolus koi Probiotic

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Semi-enclosed experimental system for coal spontaneous combustion for determining regional distribution of high-temperature zone of coal fire

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International Journal of Coal science & Technology 2022年第5期9卷 124-137页

作者： Jingyu Zhao Hanqi Ming Tao Guo Yuxuan Zhang Jun Deng Jiajia Song Qiang Zeng Chi‑Min Shu School of Safety Science and Engineering Xi’an University of Science&TechnologyXi’an 710054China Shaanxi Key Laboratory of Prevention and Control of Coal Fire Xi’an University of Science&TechnologyXi’an 710054China Post-Doctoral Research Centre for Ecology Institute for Arid Ecology and EnvironmentXinjiang UniversityUrumqi 830046China Xi’an High-Tech Zone Emergency Management Bureau Xi’an 710065China Shaanxi Coal Chemical Industry Technology Research Institute Co.Ltd. Xi’an 710065China Department of Safety Healthand Environmental EngineeringNational Yunlin University of Science and TechnologyDouliou 64002YunlinTaiwanChina

Temperature variation and gas generation at diferent depths and positions in the coal combustion process were studied to determine the propagation and evolution of high temperature regions in the process of coal spontaneous *** study selected coal samples from Mengcun,Shaanxi Province,People’s Republic of China,and developed a semi-enclosed experimental system(furnace)for simulating coal *** thermal mass loss of coal samples under various heating rates(5,10,and 15℃/min)was analyzed through thermogravimetric analysis,and the dynamic characteristics of the coal samples were analyzed;the reliability of the semi-enclosed experimental system was verifed through the equal proportional method of fuzzy *** results reveal that the high-temperature zone is distributed nonlinearly from the middle to the front end of the furnace,and the temperatures of points in this zone decreased gradually as the layer depth *** apparent activation energy of the coal samples during combustion frst increased and then decreased as the conversion degree ***,the proportion of mass loss and the mass loss rate in the coal samples observed in the thermogravimetric experiment is consistent with that observed in the frst and second stages of the experiment conducted using the semi-enclosed *** research fndings can provide a theoretical basis for the prevention and control of hightemperature zones in coal combustion.

关键词： Coalfeld fre area Fuzzy migration path Semi-enclosed experimental system Thermogravimetric analysis Dynamic characteristics

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Research on splitting damage characteristics of concrete after different thermal cycles

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Construction and Building Materials 2025年 485卷

作者： Fan, Chaotao Li, Yingming Dong, Chunliang Zhao, Guangming Meng, Xiangrui Wang, Xiangjun State Key Laboratory of Deep Coal Mine Mining Response and Disaster Prevention and Control Anhui University of Science and Technology Huainan232001 China School of Mining Engineering Anhui University of Science and Technology Huainan232001 China School of Mechanics and Optoelectronics Physics Anhui University of Science and Technology Huainan232001 China Mining Engineering Post-Doctoral Flow Station Anhui University of Science and Technology Huainan232000 China

Effects of thermal cycles on the mechanical properties and damage characteristics of concrete under splitting tests were investigated by using digital image correlation (DIC) and acoustic emission (AE) techniques. The quantitative investigation was conducted on damage changes in concrete after thermal cycles. A damage constitutive model based on AE parameters was established. Results show that an appropriate increase in thermal cycles strengthened the tensile strength and tensile modulus of concrete, but the strength decreased and the deformation increased with continuously increased thermal cycles. As thermal cycles increased, ringing counts became more numerous and intensive, accompanied by a greater concentration of damage inside concrete. Concrete specimens underwent the failure evolution process of tensile failure predominantly → mixed failure → shear failure predominantly by analyzing RA (rise time/amplitude)-AF (average frequency) characteristic parameters and macroscopic fracture characteristics. More thermal cycles accelerated the formation of the non-uniform principal strain field and local strain concentration zone on the concrete surface during the loading process. Besides, a continuum damage model using the AE ringing count as a variable was proposed in this paper, which was able to describe the evolution characteristics of various mechanical parameters of concrete treated with different thermal cycles during the deformation and failure process. © 2025 Elsevier Ltd

关键词： Tensile strength

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Interferometry Among Strongly Driven Quasiparticles with Distinct Dynamical and Geometrical Phases

Interferometry Among Strongly Driven Quasiparticles with Dis...

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2024 Conference on Lasers and Electro-Optics, CLEO 2024

作者： O'Hara, Seamus Costello, Joe Tian, Qi Wu, Qile West, Ken Pfeiffer, Loren Sherwin, Mark Wu, Liang Department of Physics Institute of Terahertz Science and Technology University of California Santa Barbara Santa BarbaraCA93106 United States Intelligence Community Post-Doctoral Research Fellowship Program PhiladelphiaPA19104 United States Department of Physics University of Pennsylvania PhiladelphiaPA19104 United States Department of Electrical and Computer Engineering Princeton University PrincetonNJ08542 United States

ISBN: (纸本)9781957171395

In this proceeding, we present polarization data of sidebands emitted from strongly driven quasiparticles, demonstrate the dependence of these data on various parameters of the external driving field, and describe the data using an analytical expression, dependent on driving field parameters and the effective Hamiltonian of the system. We propose using this method on spin-momentum locked systems, such as altermagnets, to observe and reconstruct sidebands which are influenced by the topology of individual bands. © Optica Publishing Group 2024 © 2024 The Author(s)

关键词： Topology

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Interferometry Among Strongly Driven Quasiparticles with Distinct Dynamical and Geometrical Phases

Interferometry Among Strongly Driven Quasiparticles with Dis...

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CLEO: Fundamental science, CLEO:FS 2024 - Part of Conference on Lasers and Electro-Optics, CLEO 2024

ISBN: (纸本)9781957171395

关键词： Hamiltonians

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Key technologies and engineering practices for soft-rock protective seam mining

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International Journal of Mining science and Technology 2020年第6期30卷 889-899页

作者： Xiang Cheng Guangming Zhao Yingming Li Xiangrui Meng Qingyi Tu State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China Geological Resources and Geological Engineering Post-Doctoral Flow Station Anhui University of Science and TechnologyHuainan 232001China Post-Doctoral Research Station Huaibei Mining Corporation LimitedHuaibei 235006China

Severe gas disasters in deep mining areas are increasing,and traditional protective coal seam mining is facing significant *** paper proposes an innovative technology using soft rock as the protective seam in the absence of an appropriate coal *** on the geological engineering conditions of the new horizontal first mining area of Luling Coal Mine in Huaibei,China,the impacts of different mining parameters of the soft-rock protective seam on the pressure-relief effect of the protected coal seam were analyzed through numerical *** unit stress of the protected coal seam,which was less than half of the primary rock stress,was used as the mining stress pressure-relief *** optimized interlayer space was found to be 59 m for the first soft-rock working face,with a 2 m mining thickness and 105 m face *** physicochemical characteristics of the orebody were analyzed,and a device selection framework for the soft-rock protective seam was *** equipment for the working face was selected,including the fully-mechanized hydraulic support and coal cutter.A production technology that combined fully-mechanized and blasting-assisted soft-rock mining was *** practices demonstrated that normal circulation operation can be achieved on the working face of the soft-rock protective seam,with an average advancement rate of 1.64 m/*** maximum residual gas pressure and content,which were measured at the cut hole position of the protected coal seams(Nos.8 and 9),decreased to 0.35 MPa and 4.87 m^3/t,*** results suggested that soft-rock protective seam mining can produce a significant gas-control effect.

关键词： Gas outburst hazard Soft-rock protective seam Pressure-relief Three-machine optimization Blasting-assisted mining Gas extraction

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Interferometry Among Strongly Driven Quasiparticles with Distinct Dynamical and Geometrical Phases

Interferometry Among Strongly Driven Quasiparticles with Dis...

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Conference on Lasers and Electro-Optics (CLEO)

作者： Seamus O'Hara Joe Costello Qi Tian Qile Wu Ken West Loren Pfeiffer Mark Sherwin Liang Wu Department of Physics and Institute of Terahertz Science and Technology University of California Santa Barbara Santa Barbara CA Intelligence Community Post-Doctoral Research Fellowship Program Philadelphia PA Department of Physics University of Pennsylvania Philadelphia PA Department of Electrical and Computer Engineering Princeton University Princeton NJ

ISBN: (纸本)9798350369311

关键词： Electro-optic effects Amplitude modulation Topology Interferometry

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