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Morphological analysis for feature extraction and classification of breast calcifications

Morphological analysis for feature extraction and classifica...

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2012 Pan American Health Care Exchanges, PAHCE 2012 - Conference, Workshops, and Exhibits. Cooperation / Linkages: An Independent Forum for Patient Aare and Technology Support

作者： Elpídio, F.G.G. Brasil, L.M. Lamas, J.M. Miosso, C.J. Lemos, L.A. Post-Graduation Program of Biomedical Engineering Gama Brazil Janice Lamas Clinical Radiology Brasília Brazil

ISBN: (纸本)9781467311328

Calcifications (calcium build-ups) in breast regions are frequently found in breast screening examinations. It is estimated that 90% of nonpalpable intraductal breast cancers are detectable morphologically by the presence of calcifications. This work performs a morphological analysis of regions of interest related to breast calcifications by extraction of a set of features that help the health care provider in the automatic classification of these calcifications. The results are being validated in a controlled test that simulates calcifications in order to consider morphological information that characterizes the geometrical characteristics. This allows one to assign an object signature and hence to approximate the test conditions to real calcifications. © 2012 IEEE.

关键词： Extraction

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Computer games with therapeutic potential for maintaining cognitive abilities of elderly people

Computer games with therapeutic potential for maintaining co...

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2012 Pan American Health Care Exchanges, PAHCE 2012 - Conference, Workshops, and Exhibits. Cooperation / Linkages: An Independent Forum for Patient Aare and Technology Support

作者： Santos, L.I.B. Calixto, M.F. Da Silva, J.P.L. Peron, G.C. Brasil, L.M. De Meneses, K.V.P. University of Brasília at Ceilândia Ceilândia Brazil Graduation Course in Engineering University of Brasília Gama Brazil Post-Graduation Program in Biomedical Engineering University of Brasília Gama Brazil

The use computer games in cognitive rehabilitation programs is a new trend by health professionals. In this perspective, nine computer games were developed for cognitive stimulation of the elderly people with cognitiv... 详细信息

ISBN: (纸本)9781467311328

关键词： Patient rehabilitation

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Analysis of tumor morphology and vasculature in an animal model of colorectal cancer using in vivo contrast-enhanced endoluminal ultrasound biomicroscopy

Analysis of tumor morphology and vasculature in an animal mo...

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IEEE International Ultrasonics Symposium

作者： Rossana Soletti Marcelo A. P. de Britto Helena L. Borges Joao C. Machado Biomedical Engineering Program COPPE Federal University of Rio de Janeiro Rio de Janeiro Brazil Post-Graduation Program in Surgical Sciences Biomedical Science Institute Federal University of Rio de Janeiro Rio de Janeiro Brazil Biomedical Engineering Program and Post-Graduation Program in Surgical Sciences School of Medicine Federal University of Rio de Janeiro Rio de Janeiro Brazil

ISBN: (纸本)9781467345613

Colorectal cancer (CRC) has a high incidence in the world, being the third leading cause of cancer-related mortality in the United States. Ninety percent of the malignant tumors can be cured if diagnosed in the early stages of localized disease and this motivates a great interest in the development and design of experimental models for CRC detection, staging and monitoring. The aim of this work was to use VEGFR2 (vascular endothelial growth factor receptor 2)-targeted ultrasound contrast agent (UCA) coupled to an endoluminal ultrasound biomicroscopy (eUBM) system to diagnose colon tumors and to analyze tumor vasculature. Colon tumors were induced in mice by using azoxymethane/dextran sulfate sodium and according to histopathology, 55% of colon tumors were adenomas and 45% were adenocarcinomas. Images of the lesion were obtained before and 2-15 minutes after VEGFR2-targeted UCA injection into the mice tail. Compared to post-mortem histopathology, all colonic lesions (lymphoid hyperplasias, ulcerations, thickened mucosa and tumors) were correctly diagnosed by eUBM. In addition, when coupled to a VEGFR2-targeted UCA, the eUBM system provided hyperechoic image areas compatible with intense VEGFR2 staining by immunohistochemical diagnosis. The results suggest that eUBM associated to UCA is a promising tool for histopathologycal and molecular imaging, and could be used to diagnose, stage and monitor colon tumor morphology and vasculature.

关键词： Ultrasound biomicroscopy Ultrasound contrast Agent Mice Colon Cancer VEGFR2

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Morphological analysis for feature extraction and classification of breast calcifications

Morphological analysis for feature extraction and classifica...

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Pan American Health Care Exchanges, PAHCE

作者： F. G. G. Elpídio L. M. Brasil J. M. Lamas C. J. Miosso L. A. Lemos Post-Graduation Program of Biomedical Engineering University of Brasília Gama Gama Brazil Janice Lamas Clinical Radiology Brasilia Brazil

关键词： Breast cancer Shape Radiology Feature extraction

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Computer games with therapeutic potential for maintaining cognitive abilities of elderly people

Computer games with therapeutic potential for maintaining co...

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Pan American Health Care Exchanges, PAHCE

作者： L. I. B. Santos M. F. Calixto J.P.L da Silva G.C. Peron L.M. Brasil K.V. P. de Meneses University of Brasília at Ceilândia Ceilandia Brazil Graduation Course in Engineering University of Brasília Gama Brazil Post-Graduation Program in Biomedical Engineering University of Brasília Gama Gama Brazil

关键词： Games Computers Senior citizens Educational institutions Conferences Couplings

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In vivo endoluminal ultrasound biomicroscopic imaging of colon lesions in mouse models of cancer and inflammation

In vivo endoluminal ultrasound biomicroscopic imaging of col...

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IEEE Symposium (IUS) Ultrasonics

作者： Kelly Z. Alves Rossana C. Soletti Marcelo A. P. Britto Dyanna G. Matos Helena L. Borges Mônica Soldan João C. Machado Biomedical Engineering Program at COPPE Federal University of Rio de Janeiro Rio de Janeiro Rio de Janeiro Brazil Post-Graduation Program in Surgical Sciences Department of Surgery from School of Medicine Federal University of Rio de Janeiro Rio de Janeiro Rio de Janeiro Brazil Biomedical Science Institute Federal University of Rio de Janeiro Rio de Janeiro Rio de Janeiro Brazil Division of Gastroenterology Endoscopy Unit Clementino Fraga Filho University Hospital Federal University of Rio de Janeiro Rio de Janeiro Brazil Biomedical Engineering Program at COPPE and Post-Graduation Program in Surgical Sciences Department of Surgery from School of Medicine Federal University of Rio de Janeiro Rio de Janeiro Rio de Janeiro Brazil

ISBN: (纸本)9781457712531

Colorectal cancer (CRC) is the third most common cancer in the world and the third leading cause of cancer-related mortality in United States. Most malignant tumors are cured if diagnosed and properly treated during the disease early stage. CRC risk increases in patients with inflammatory bowel disease (IBD), a chronic inflammatory condition affecting about five million people worldwide. Mice models of CRC and IBD are used to understand the pathogenic mechanisms, to establish therapeutic and preventive measures and to evaluate diagnostic tools. The development of minimally invasive tools to detect and monitor colon diseases could improve the studies in mice models for IBD and CRC. This has motivated the use endoluminal ultrasound biomicroscopy (eUBM) to image colon lesions in mice models for CRC and IBD, in vivo. An eUBM system was employed using a 40 MHz transducer attached to a microcomputer controlled front-end electronics. The transducer rotates inside a catheter and ultrasound cross-sectional colon images were obtained with the catheter inserted into the working channel of flexible bronchofiberscope. Water, injected through the catheter, was the ultrasound coupling medium. All colonic tissue layers in control mice (mucosa, muscularis mucosae, submucosa and muscularis externa) were detected by eUBM. Small adenomas and invasive adenocarcinomas were well visualized in eUBM images of CRC and IBD mouse models. All eUBM images correlated well with the post-mortem colon histology sections.

关键词： Ultrasonic imaging Mice Colon Imaging Lesions Cancer Catheters

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Human gait classification after lower limb fracture using Artificial Neural Networks and principal component analysis

Human gait classification after lower limb fracture using Ar...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Carlos A. Lozano-Ortiz Adriane M. S. Muniz Jurandir Nadal Biomedical Engineering Program Federal University of Rio de Janeiro Rio de Janeiro Brazil Post graduation Department Army Physical Education School Rio de Janeiro Brazil

Vertical ground reaction force (vGRF) has been commonly used in human gait analysis making possible the study of mechanical overloads in the locomotor system. This study aimed at applying the principal component (PC) analysis and two Artificial Neural Networks (ANN), multi-layer feed forward (FF) and self organized maps (SOM), for classifying and clustering gait patterns from normal subjects (CG) and patients with lower limb fractures (FG). The vGRF from a group of 51 subjects, including 38 in CG and 13 in FG were used for PC analysis and classification. It was also tested the classification of vGRF from five subjects in a treatment group (TG) that were submitted to a physiotherapeutic treatment. Better results were obtained using four PC as inputs of the ANN, with 96% accuracy, 100% specificity and 85% sensitivity using SOM, against 92% accuracy, 100% specificity and 69% sensitivity for FF classification. After treatment, three of five subjects were classified as presenting normal vGRF.

关键词： Artificial neural networks Principal component analysis Accuracy Neurons Force Training Classification algorithms

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Gait initiation evaluation after deep brain stimulation for Parkinson's disease: A 7-year follow-up

Gait initiation evaluation after deep brain stimulation for ...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： A. M. S. Muniz W. Liu H. Liu K. E. Lyons R. Pahwa J. Nadal Department of Post-graduation Physical Education College of Brazilian Army Rio de Janeiro Brazil Department of Physical Therapy and Rehabilitation Sciences University of Kansas Medical Center KS USA Parkinsons Disease and Movemengt Disorder Center Department of Neurology University of Kansas Medical Center Kanas KS USA Biomedical Engineering Program Federal University of Rio de Janeiro Rio de Janeiro Brazil

This study evaluated the long-term effects of deep brain stimulation of the subthalamic nucleus (DBS-STN) on gait initiation. Six Parkinson's disease (PD) patients who had undergone DBS-STN and 31 control subjects were evaluated. PD subjects were assessed at two different time periods: 11.3 ± 10.3 (P1) and 78.9 ± 10.6 (P2) months after surgery. Subjects under stimulation were tested in two conditions: without medication and with medication. Principal components (PC) analysis was separately applied on vertical, anterior-posterior and medial-lateral ground reaction force (GRF) from gait initiation, during the anticipatory postural adjustment (APA) phase. Three PC scores were chosen by the scree test for each GRF component. The higher loading factors pointed to major differences between controls and PD patients on maximum APA amplitude for vertical and anterior-posterior GRF. Friedman test showed a significant difference in standard distance among conditions (P = 0.006), with the post-hoc test recognizing differences only between P1 and P2 in the medication-on condition. All distances increased in the follow-up evaluation (P2), when considering the same medication condition, indicating a worsening in gait initiation after 7 years of follow-up.

关键词： Parkinson's disease Loading Foot PD control Force Principal component analysis Medical diagnostic imaging

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