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SSRN 2022年

作者： de Souza, Cristiane Gimenes dos Santos, Rafael Cavalcante Bertolino, Luiz Carlos de Andrade, Débora França Spinelli, Luciana d'Avila, Luiz Antonio Graduate Program in Nanotechnology Engineering COPPE Federal University of Rio de Janeiro Cidade Universitária Rio de JaneiroCEP 21941-909 Brazil Program in Chemical and Biochemical Process Engineering School of Chemistry Federal University of Rio de Janeiro Cidade Universitária Rio de JaneiroCEP 21941-909 Brazil Mineral Technology Center CETEM Cidade Universitária Rio de JaneiroCEP 21941-908 Brazil Institute of Chemistry Federal University of Rio de Janeiro Cidade Universitária Rio de JaneiroCEP 21941-908 Brazil

This study presents the results of a novel method developed for quantitative determination of water in ethanol fuel based on a colorimetric device composed of the solvatochromic dye methylene blue adsorbed on palygorskite, with filter paper as a support. The quantitative analysis was based on digital images taken of the prepared support, in which hydrous ethanol interacted with the colorimetric devices, giving different colors according to the level of water in the fuel. The digital images were acquired using a novel system consisting of a photo chamber and compartments for liquid or solid samples coupled to a smartphone. The digital images were processed by image processing software (ImageJ v.1.52n) installed on an external laptop, which enabled analyses using RGB and/or HSB. The method was partially validated and compared to the reference method ( Karl Fischer ASTM E203/16 ) for determining water in ethanol fuel. The proposed method showed good linearity, with coefficients of determination 0.9613, 0.9431, and 0.8835 for R, G, and S, respectively. The limits of detection of the channels R, G, and S were 0.329%, 0.306%, and 0.557% m/m, respectively;the limits of quantification for the same channels were 0.998%, 0.927%, and 1.688% m/m, respectively. The accuracy of the method (recovery) was between 98% and 110%. Precision, assessed by relative standard deviation, was 0.56%, 0.92%, and 2.05%, respectively, for R, G, and S. The paired t-test showed that there was no significant difference (with 95% confidence) between the proposed and reference methods. R was selected as the best channel for analyzing water in ethanol fuel as it had the best validation parameters. The proposed method, based on a novel colorimetric device, was found to be a good alternative to the reference method for the determination of water in ethanol fuel as it is quick, simple, effective, and could be used in the field for quality control. © 2022, The Authors. All rights reserved.

关键词： Ethanol

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Comparative study of mixing liquids and powders in a continuous medium using CFD

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Journal of engineering Science and Technology Review 2018年第5期11卷 134-138页

作者： Enamorado, Alberto Mario Fuentes Betancourt, Juan Bernardo Restrepo Obregon, Luis Guillermo Research Group in Process Simulation and Coal Transformation Chemical Engineering Program Universidad del Atlántico Barranquilla Colombia Research Group on Sustainable Chemical and Biochemical Processes Chemical Engineering Program Universidad del Atlántico Barranquilla Colombia

Prediction of flow and mixing of powders is a difficult challenge that has not been solved yet. Different numerical methods have been used to find the solution to the mathematical models proposed, but there are no experiments to compare and validate the results. The method with the best approximation is the discrete element method (DEM). However, this method requires a high computational power. In this article, it was made a comparison between the experimental results obtained when mixing two powders in an oscillatory low shear mixing device, and the 3D simulation of the same equipment using liquids with the help of a commercial software of computational fluids dynamics, CFD. Experiments at different wall velocities and wall displacements were run. Results reveal that the mixing in solids and liquids present lots of similarities when working at low velocity. This velocity lets solids to stay in frictional regime and liquids in the laminar regime. A zone of no mixing at the bottom of the mixing cavity is presented in liquids which is similar to the triangular pattern of no mixing found in solids. The height of the no mixing zone depends on the time of mixing, and the displacement and velocity of the walls. Under laminar regime conditions, the Navier Stokes equations can be applied to the powders because the velocity profiles obtained are similar. © 2018 Eastern Macedonia and Thrace Institute of Technology.

关键词： Shear stress

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Simulation of a compressible powder flow under oscillatory shear stress modeled as a non-linear fluid by using an explicit solution method

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Journal of engineering Science and Technology Review 2018年第4期11卷 84-90页

作者： Robledo, Mauricio E. Obregón, Luis G. Velázquez, Carlos Research Group on Process Simulation and Coal Transformation Chemical Engineering Program Universidad del Atlántico Carrera 30 Número 8- 49 Puerto Colombia - Atlántico081007 Colombia Research Group on Sustainable Chemical and Biochemical Processes Chemical Engineering Program Universidad del Atlántico Carrera 30 Número 8- 49 Puerto Colombia - Atlántico081007 Colombia Chemical Engineering Department University of Puerto Rico Mayagüez Campus PO Box 9000 Mayagüez00681 Puerto Rico

The purpose of this research is to develop the modeling and simulation of a frictional and compressible powder flow subjected to oscillatory shear stress in a device that consists of a rectangular shaped cavity with a free surface, two oscillatory moving walls, and three non-moving walls. The finite differences method under the explicit scheme is used to approximate the real solution to the resulting equations from the mathematical modeling of the studied system. The simulation results were compared qualitatively with experimental results, and the solution method was verified by comparing the simulation results of a viscous glycerin flow with the results of the software STAR-CCM+ under the same conditions of the powder flow. The results showed that the powder velocity profiles were coherent with the experimental results. Furthermore, the solution method was validated finding that the 83.5% of the compared data presented absolute errors less than 0.5 cm/s. The complete velocity profiles obtained from the simulation help to have a deep understanding of the granular material behavior subjected to oscillatory shear stress. © 2018 Eastern Macedonia and Thrace Institute of Technology.

关键词： Shear stress

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Synergistic Glutathione Depletion and STING Activation to Potentiate Dendritic Cell Maturation and Cancer Vaccine Efficacy

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Angewandte Chemie 2024年第10期136卷

作者： Dr. Jianping Liu Dr. Ye Zhang Bowei Yang Dr. Yingbo Jia Prof. Rui-Tian Liu Dr. Lingwen Ding Prof. Zheyu Shen Prof. Xiaoyuan Chen Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore Singapore 119074 Singapore Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore School of Biomedical Engineering Southern Medical of University Guangzhou Guangdong 510515 P. R. China CAS Key Laboratory of Nano-Bio Interface Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Suzhou Jiangsu 215123 P. R. China State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 P. R. China Department of Pathology Yong Loo Lin School of Medicine National University of Singapore Singapore 119074 Singapore Clinical Imaging Research Center Center for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore Institute of Molecular and Cell Biology Agency for Science Technology and Research (A*STAR) 61 Biopolis Drive Proteos Singapore 138673 Singapore

Dendritic cell (DC) maturation and antigen presentation are key factors for successful vaccine-based cancer immunotherapy. This study developed manganese-based layered double hydroxide (Mn-LDH) nanoparticles as a self-adjuvanted vaccine carrier that not only promoted DC maturation through synergistically depleting endogenous glutathione (GSH) and activating STING signaling pathway, but also facilitated the delivery of model antigen ovalbumin (OVA) into lymph nodes and subsequent antigen presentation in DCs. Significant therapeutic-prophylactic efficacy of the OVA-loaded Mn-LDH (OVA/Mn-LDH) nanovaccine was determined by the tumor growth inhibition in the mice bearing B16-OVA tumor. Our results showed that the OVA/Mn-LDH nanoparticles could be a potent delivery system for cancer vaccine development without the need of adjuvant. Therefore, the combination of GSH exhaustion and STING pathway activation might be an advisable approach for promoting DC maturation and antigen presentation, finally improving cancer vaccine efficacy.

关键词： Antigen Delivery DC Maturation GSH Depletion ROS Upregulation STING Activation

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Transient heat transfer in a packed-bed elliptic cylindrical reactor: A finite-volume approach

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Defect and Diffusion Forum 2017年第1期380卷 79-85页

作者： Moura da Silva, R. Barbosa de Lima, A.G. Gomes de Oliveira, L. Vasconcellos Araújo, M. Sousa Santos, R. Federal University of Campina Grande Center of Science and Technology Process Engineering Postgraduate Program Campina Grande Paraíba58429-900 Brazil Federal Institute of Education Science and Technology of Paraíba Princesa Isabel Paraíba58755-000 Brazil Federal University of Campina Grande Center of Science and Technology Mechanical Engineering Department Campina Grande Paraíba58429-900 Brazil Federal University of Campina Grande Center of Science and Technology Chemical Engineering Department Campina Grande Paraíba58429-900 Brazil

This work aims to develop a transient three-dimensional mathematical model using the elliptic cylindrical coordinate system, to predict heat transfer in a elliptic cylindrical packed fixed bed reactor. The model considers variable thermo physical properties and a parabolic temperature profile at the fluid inlet. The governing equation is solved using the finite volume method. Results of temperature profile along the reactor are presented and discussed at different *** was verified that the maximum heat transfer rate inside the reactor occurs near the extreme region close to minor semi-axis of the ellipse;the higher temperatures at the reactor surface are also in this region, along the entire height of the bed;the steady-state regime is reached at t = 4.5 s of process, presenting after this time interval,small axial temperature gradients and high radial gradients along of the reactor bed;the parabolic temperature profile give to the bed a predominance of radial temperature gradients, and the radial porosity profile favours a higher heat transfer rate at reactor surface. © 2017 Trans Tech Publications, Switzerland

关键词： Heat transfer

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Effect of the electrostatic potential on the internalization mechanism of cell penetrating peptides

Effect of the electrostatic potential on the internalization...

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2011 AIChE Annual Meeting, 11AIChE

作者： Flores, Karen A. Salgado, J. Cristian Zapata-Torres, Gerald Gerdtzen, Ziomara P. Gonzalez, María-Julieta Hermoso, Marcela A. Laboratory of Process Modeling and Distributed Computing Department of Chemical Engineering and Biotechnology University of Chile Santiago Chile Millennium Institute for Cell Dynamics and Biotechnology Centre for Systems Biology University of Chile Santiago Chile Department of Inorganic and Analytical Chemistry Faculty of Chemical and Pharmaceutical Sciences University of Chile Santiago Chile Centre for Biochemical Engineering and Biotechnology Department of Chemical Engineering and Biotechnology University of Chile Santiago Chile Laboratory of Cell Biology Cell and Molecular Program Faculty of Medicine University of Chile Santiago Chile Laboratory of Innate Immunology Institute of Biomedical Sciences University of Chile Santiago Chile

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Improvement of heterologous protein productivity using recombinantYarrowia lipolyticaand cyclic fed‐batch process strategy

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Biotechnology and Bioengineering 2000年第3期59卷

作者： Ching Chuan Chang Dewey D. Y. Ryu Cheon Seok Park Jeong‐Yoon Kim Process Development Division Development Center for Biotechnology 81 Chang‐Hsing Street Taipei Taiwan Republic of China Biochemical Engineering Program Department of Chemical Engineering and Material Science University of California Davis California 95616 Department of Microbiology Chungnam National University Taejon Korea

A cyclic fed‐batch bioprocess is designed and a significant improvement of rice α‐amylase productivity of recombinant Yarrowia lipolytica is illustrated. A bioprocess control strategy developed and reported here entails use of a genetically stable recombinant cloned for heterologous protein, use of optimized media for cell growth and enzyme production phases, and process control strategy enabling high cell‐density culture and high α‐amylase productivity. This process control can be achieved through maintaining a constant optimal specific cell growth rate at a predetermined value (i.e., 0.1 h −1 ), controlling medium feed rate commensurate with the cell growth rate, and maintaining a high cell‐density culture (i.e., 60–70 g/L) for high productivity of cloned heterologous protein. The volumetric enzyme productivity (1,960 units/L · h) achieved from the cyclic fed‐batch process was about 3‐fold higher than that of the fed‐batch culture process (630 units/L · h). © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng 59:379–385, 1998.

关键词： recombinant Yarrowia lipolytica heterologous protein expression improvement of rice α‐amylase productivity cyclic fed‐batch culture bioprocess control strategy

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