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Dysregulation of AR and ERα caused ovarian alterations in gerbils prenatally exposed to 17α-ethinylestradiol and pequi oil

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Histochemistry and Cell biology 2025年第1期163卷 1-13页

作者： de Campos, Amanda M. Dias, Jordana S. Lopes, Gabriel F. Pires, Thaisla M. da Silva, Daniele C. Ruiz, Thalles F. Rocha Martins, Tracy M. M. Perez, Ana P. S. Institute of Health Sciences Medicine Course Medicine Course Federal University of Jataí (UFJ) Jatobá Campus GO Jataí Brazil Institute of Agricultural Sciences Postgraduate Program in Animal Bioscience Federal University of Jataí (UFJ) Jataí Goiás Brazil Department of Structural and Functional Biology Institute of Biology University of Campinas (UNICAMP) SP Campinas Brazil Faculty of Medicine Federal University of Pará (UFPA) Pará Altamira Brazil Department of Biological Sciences Institute of Biosciences Humanities and Exact Sciences Microscopy and Microanalysis Center São Paulo State University (UNESP) SP São José do Rio Preto Brazil

This study investigated the effects of prenatal exposure to pequi oil and 17α-ethinylestradiol (EE2) on the histomorphometry and receptor expression (androgen receptor (AR) and estrogen receptor alpha (ERα) in gerbil ovaries (Meriones unguiculatus) during aging. Experimental groups included: control, vehicle (mineral oil), EE2: 15 µg/kg/day from gestational days 18–22, EE2/Pe: EE2 from days 18–22 and 300 mg/kg of pequi oil from days 18–26, and Pe: pequi oil only, via gavage. Female offspring were euthanized at 12 months, and ovaries were collected, processed histologically, and sectioned. Histological sections were stained with hematoxylin–eosin to analyze the superficial epithelium height and the tunica albuginea thickness. Immunohistochemistry for AR and ERα was performed, and the percentage of positive nuclei for these receptors was quantified in the theca interna, granulosa cells within follicles, and the interstitial gland. Data were analyzed using analysis of variance (ANOVA), Tukey’s, and Kruskal–Wallis tests. The data revealed a significant decrease (p < 0.05) in the thickness of the tunica albuginea in the EE2 group, whereas this thickness was increased in the EE2/Pe and Pe groups. Epithelial height was lower in the EE2 group and higher in the EE2/Pe group. No significant changes in AR immunoreactivity were observed. In multilaminar follicles, ERα immunostaining was elevated in granulosa cells in the Pe group and in theca cells of the EE2 group. Additionally, the interstitial gland in the Pe group showed an increase in ERα expression. Pequi oil exposure upregulated ERα more markedly than AR during folliculogenesis and in interstitial cells, suggesting endocrine-modulating potential and relevance for ovarian regulation during aging. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025.

关键词： 17α-ethinylestradiol Androgen receptor Estrogen receptor-alpha Ovary Pequi oil

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Gene expression analysis of cytokines and MMPs in melatonin and rhBMP-2 enhanced bone remodeling

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World Journal of Orthopedics 2024年第11期15卷 1075-1087页

作者： Marina Ribeiro Paulini Letícia Ferreira Montarele Dimitrius Leonardo Pitol Gisele Giannocco Bruno Fiorelini Pereira Daniela Vieira Buchaim Carlos Henrique Bertoni Reis Rogério Leone Buchaim Joao Paulo Mardegan Issa Department of Basic and Oral Biology University of São PauloRibeirao Preto 14040-904Brazil Instituto de Ciências Ambientais Químicas e FarmacêuticasFederal University of São PauloDiadema 09972-270Brazil Medical School University Center of AdamantinaAdamantina 17800-000Brazil Postgraduate Program in Structural and Functional Interactions in Rehabilitation University of MariliaMarilia 17525-902Brazil Department of Biological Sciences Bauru School of DentistryUniversity of São PauloBauru 17012-901Brazil Department of Basic and Oral Biology Ribeirão Preto School of DentistryUniversity of São PauloRibeirao Preto 14040-904Brazil

BACKGROUND In the medical and dental fields,there is a need for studies of new therapeutic approaches for the treatment of bone defects that cause extensive bone *** may be an important endogenous biological factor for bone remodeling,and growth factors may enhance the repair *** To evaluate the gene expression of cytokines(IL-1β,IL-6,IL-10 and TNF-α),markers of osteoclastogenesis(RANK,RANKL and OPG)and MMPs(MMP-1,MMP-2,MMP-8 and MMP-13)from the treatment of melatonin associated with an osteogenic membrane and rhBMP-2 on the recovery of a bone *** Sixty-four rats were used and divided into 9 experimental groups and were formed according to the treatment carried out in the region of the bone lesion,which varied between the combination of 1,10 and 100μmol/L of *** Expression analysis was performed using real time-PCR by reading the concentration of total RNA and reverse *** There were differences between groups when compared with clot or scaffold control,and improvement with a higher concentration of melatonin or *** combination melatonin(1μg)with 5μg of rhBMP-2,using the guided bone regeneration technique,demonstrated some effects,albeit mild,on bone repair of critical bone *** This indicates that the approach for administering these substances needs to be reassessed,with the goal of ensuring their direct application to the affected ***,future research must be carried out,seeking to produce materials with these ideal characteristics.

关键词： Bone repair Melatonin Gene expression Rhbmp-2 Scaffold Tissue engineering Guided bone regeneration

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Acute toxicity of trypsin inhibitor from tamarind seeds in embryo and adult zebrafish (Danio rerio)

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Toxicology Reports 2024年 13卷 101766页

作者： dos Santos Melo, Yohanna Layssa Luchiari, Ana Carolina Lopes, Beatriz Silva Ferreira Rocha Silva, Maria Gabriela dos Santos Pais, Tatiana Procópio Gama Cortez, João Eduardo da Silva Camillo, Christina Bezerra de Moura, Sérgio Adriane da Silva-Maia, Juliana Kelly de Araújo Morais, Ana Heloneida Nutrition Postgraduate Program Health Sciences Center Federal University of Rio Grande do Norte RN Natal Brazil FishLab Physiology and Behavior Department Federal University of Rio Grande do Norte RN Natal Brazil Psychobiology Postgraduate Program Biosciences Center Federal University of Rio Grande do Norte Natal Brazil Biochemistry and Molecular Biology Postgraduate Program Biosciences Center Federal University of Rio Grande do Norte Natal Brazil Nutrition Course Federal University of Rio Grande do Norte RN Natal Brazil Postgraduate Program in Structural and Functional Biology Biosciences Center Federal University of Rio Grande do Norte Natal Brazil

The trypsin inhibitor isolated from tamarind seeds (TTI) is being investigated for potential applications in the treatment of noncommunicable diseases (NCD), such as hypertension, obesity, and diabetes. This study aimed to assess TTI embryotoxicity and acute toxicity in adult zebrafish (Danio rerio). TTI was extracted and isolated from tamarind seeds. Embryonic and adult zebrafish were exposed for 96 hours to three concentrations of TTI (12.5, 25, and 50 mg/L). Zebrafish embryos (n=60 per group) were evaluated for survival, hatching, malformations, and potential developmental marker alterations, in addition to cardiotoxicity and neurotoxicity tests. For acute toxicity assessment in adults (n=20 per group), survival and locomotor and anxiety-like behaviors were assessed, along with genotoxicity (micronucleus) evaluation. Embryos exposed to TTI showed no significant adverse effects, presented normal heart rates and positive reflex response in the neurotoxicity tests. In adult fish, TTI did not cause mortality or significant behavioral changes, suggesting no neurotoxicity and no genotoxicity. Histopathological analyses of the whole body showed only changes in the liver and spinal cord, similar to those observed in the control group not exposed to TTI. These findings indicate TTI's biosafety and therapeutic potential in complex organisms. Further research is required to evaluate its long-term effects and efficacy in treating non-communicable diseases. © 2024 The Authors

关键词： Cardiotoxicity Embryotoxicity Genotoxicity Neurotoxicity Preclinical model Tamarindus indica L.

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Safety and bioactive potential of nanoparticles containing Cantaloupe melon (Cucumis melo L.) carotenoids in an experimental model of chronic inflammation

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Biotechnology Reports 2020年 28卷 e00567页

作者： Medeiros, Isaiane de Oliveira, Grazielle Louise Ribeiro de Queiroz, Jaluza Luana Carvalho de Carvalho Gomes, Camila de Carvalho, Fabiana Maria Coimbra de Souza Lima, Maíra Conceição Jerônimo Serquiz, Alexandre Coelho de Andrade Santos, Pedro Paulo da Silva Camillo, Christina Maciel, Bruna Leal Lima de Araújo Morais, Ana Heloneida Passos, Thaís Souza Postgraduate Program in Nutrition Health Sciences Center Federal University of Rio Grande do Norte Natal Brazil Postgraduate Program in Biochemistry Center for Biosciences Federal University of Rio Grande do Norte Natal Brazil Nutrition Course Potiguar University Natal Brazil Veterinary Medicine Course Potiguar University Natal Brazil Nutrition Course University Center of Rio Grande do Norte Natal Brazil Postgraduate Program in Structural and Functional Biology Center for Biosciences Federal University of Rio Grande do Norte Natal Brazil Department of Morphology Center for Biosciences Federal University of Rio Grande do Norte Natal Brazil Department of Nutrition Health Sciences Center Federal University of Rio Grande do Norte Natal Brazil

The safety and bioactive potential of crude carotenoid extract from Cantaloupe melon nanoencapsulated in porcine gelatin (EPG) were evaluated in a chronic inflammatory experimental model. Animals were fed a high glycemic index and high glycemic load (HGLI) diet for 17 weeks and treated for ten days with 1) HGLI diet, 2) standard diet, 3) HGLI diet + crude carotenoid extract (CE) (12.5 mg/kg), and 4) HGLI diet + EPG (50 mg/kg). General toxicity signals were investigated, considering body weight, food intake, hematological, biochemical parameters, relative weight, morphology, and histopathology of organs. The biochemical parameters indicated the low toxicity of EPG. Acute hepatitis was observed in animals' livers, but CE and EPG groups presented improved tissue appearance. Chronic enteritis was observed in animals, with villi and intestinal glands preservation in the EPG group. The results suggest the safety and the bioactive effect of EPG, possibly related to its anti-inflammatory potential. © 2020 The Authors

关键词： Curcubitaceae Nanotechnology Obesity Toxicity β-carotene

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Correction to: Cholesterol-functionalized carvedilol-loaded PLGA nanoparticles: anti-inflammatory, antioxidant, and antitumor effects

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Journal of Nanoparticle Research 2020年第7期22卷 1-1页

作者： de S. L. Oliveira, Ana Luiza C. dos Santos-Silva, Alaine M. da Silva-Júnior, Arnóbio A. Garcia, Vinícius B. de Araújo, Aurigena A. de Geus-Oei, Lioe-Fee Chan, Alan B. Cruz, Luis J. de Araújo Júnior, Raimundo F. Postgraduate Program in Health Science Federal University of Rio Grande do Norte (UFRN) Natal Brazil Department of Radiology Translational Nanobiomaterials and Imaging Leiden University Medical Center Leiden Netherlands Department of Pharmacy Laboratory of Pharmaceutical Technology and Biotechnology Federal University of Rio Grande do Norte (UFRN) Natal Brazil Department of Biophysics Postgraduate Programs in Public Health and Pharmaceutical Science and Pharmacology Federal University of Rio Grande do Norte (UFRN) Natal Brazil Department of Radiology Nuclear Medicine Leiden University Medical Center Leiden Netherlands Percuros B.V Leiden Netherlands Department of Morphology Postgraduate Program in Functional and Structural Biology Federal University of Rio Grande do Norte (UFRN) Natal Brazil

The original version of this article unfortunately contained a mistake on the first author name.

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Retraction notice to "Toxicity of spike fragments SARS-CoV-2 S protein for zebrafish: A tool to study its hazardous for human health?" [Sci. Total Environ. 813 (2022) / 152345]

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The Science of the total environment 2024年 957卷 177653页

作者： Bianca H Ventura Fernandes Natália Martins Feitosa Ana Paula Barbosa Camila Gasque Bomfim Anali M B Garnique Ivana F Rosa Maira S Rodrigues Lucas B Doretto Daniel F Costa Bruno Camargo-Dos-Santos Gabrielli A Franco João Favero Neto Juliana Sartori Lunardi Marina Sanson Bellot Nina Pacheco Capelini Alves Camila C Costa Mayumi F Aracati Letícia F Rodrigues Rafaela Hemily Cirilo Raul Marcelino Colagrande Francisco I F Gomes Rafael T Nakajima Marco A A Belo Percília Cardoso Giaquinto Susana Luporini de Oliveira Silas Fernandes Eto Dayanne Carla Fernandes Wilson G Manrique Gabriel Conde Roberta R C Rosales Iris Todeschini Ilo Rivero Edgar Llontop Germán G Sgro Gabriel Umaji Oka Natalia Fernanda Bueno Fausto K Ferraris Mariana T Q de Magalhães Renata J Medeiros Juliana M Mendonça-Gomes Mara Souza Junqueira Kátia Conceição Leticia Gomes de Pontes Antonio Condino-Neto Andrea C Perez Leonardo J G Barcellos José Dias Correa Júnior Erick Gustavo Dorlass Niels O S Camara Edison Luiz Durigon Fernando Q Cunha Rafael H Nóbrega Glaucia M Machado-Santelli Chuck S Farah Flavio P Veras Jorge Galindo-Villegas Letícia V Costa-Lotufo Thiago M Cunha Roger Chammas Luciani R Carvalho Cristiane R Guzzo Guilherme Malafaia Ives Charlie-Silva Laboratório de Controle Genético e Sanitário Diretoria Técnica de Apoio ao Ensino e Pesquisa Faculdade de Medicina da Universidade de São Paulo Brazil. Laboratório Integrado de Biociências Translacionais (LIBT) Instituto de Biodiversidade e Sustentabilidade (NUPEM) Universidade Federal do Rio de Janeiro (UFRJ) Macaé RJ Brazil. Department of Microbiology Institute of Biomedical Sciences University of Sao Paulo Sao Paulo Brazil. Department of Cell Biology Institute of Biomedical Sciences University of São Paulo Brazil. Reproductive and Molecular Biology Group Department of Morphology Institute of Biosciences Sao Paulo State University Botucatu São Paulo Brazil. Department of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University SP Brazil. Department of Preventive Veterinary Medicine São Paulo State University (UNESP) Jaboticabal Brazil. Department of Pharmacology Center of Research in Inflammatory Diseases Ribeirao Preto Medical School University of São Paulo Brazil. Brasil University Descalvado São Paulo Brazil. Universidade Estadual Paulista Júlio de Mesquita Filho Instituto de Biociências - Departamento de Fisiologia São Paulo Brazil. Universidade Estadual Paulista Júlio de Mesquita Filho São Paulo Brazil. Postgraduate Program in Health Sciences PROCISA Federal University of Roraima Brazil. Immunochemistry Laboratory Butantan Institute São Paulo Brazil. Aquaculture Health Research and Extension Group GRUPESA Aquaculture Health Laboratory LABSA Department of Veterinary Medicine Federal University of Rondônia Rolim de Moura Campus Rondônia Brazil. Department of Preventive Veterinary Medicine São Paulo State University Jaboticabal Brazil. Department of Cell and Molecular Biology Ribeirao Preto Medical School University of São Paulo Ribeirão Preto Brazil. Departamento de Bioquímica Instituto de Química Universidade de São Paulo Brazil. Pontifícia Universidade Católica de Minas Gerais Brazil. Departamento de B

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Toxicity of spike fragments SARS-CoV-2 S protein for zebrafish: A tool to study its hazardous for human health?

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The Science of the total environment 2022年 813卷 152345页

作者： Bianca H Ventura Fernandes Natália Martins Feitosa Ana Paula Barbosa Camila Gasque Bomfim Anali M B Garnique Ivana F Rosa Maira S Rodrigues Lucas B Doretto Daniel F Costa Bruno Camargo-Dos-Santos Gabrielli A Franco João Favero Neto Juliana Sartori Lunardi Marina Sanson Bellot Nina Pacheco Capelini Alves Camila C Costa Mayumi F Aracati Letícia F Rodrigues Rafaela Hemily Cirilo Raul Marcelino Colagrande Francisco I F Gomes Rafael T Nakajima Marco A A Belo Percília Cardoso Giaquinto Susana Luporini de Oliveira Silas Fernandes Eto Dayanne Carla Fernandes Wilson G Manrique Gabriel Conde Roberta R C Rosales Iris Todeschini Ilo Rivero Edgar Llontop Germán G Sgro Gabriel Umaji Oka Natalia Fernanda Bueno Fausto K Ferraris Mariana T Q de Magalhães Renata J Medeiros Juliana M Mendonça-Gomes Mara Souza Junqueira Kátia Conceição Leticia Gomes de Pontes Antonio Condino-Neto Andrea C Perez Leonardo J G Barcellos José Dias Correa Júnior Erick Gustavo Dorlass Niels O S Camara Edison Luiz Durigon Fernando Q Cunha Rafael H Nóbrega Glaucia M Machado-Santelli Chuck S Farah Flavio P Veras Jorge Galindo-Villegas Letícia V Costa-Lotufo Thiago M Cunha Roger Chammas Luciani R Carvalho Cristiane R Guzzo Guilherme Malafaia Ives Charlie-Silva Laboratório de Controle Genético e Sanitário Diretoria Técnica de Apoio ao Ensino e Pesquisa Faculdade de Medicina da Universidade de São Paulo Brazil. Laboratório Integrado de Biociências Translacionais (LIBT) Instituto de Biodiversidade e Sustentabilidade (NUPEM) Universidade Federal do Rio de Janeiro (UFRJ) Macaé RJ Brazil. Department of Microbiology Institute of Biomedical Sciences University of Sao Paulo Sao Paulo Brazil. Department of Cell Biology Institute of Biomedical Sciences University of São Paulo Brazil. Reproductive and Molecular Biology Group Department of Morphology Institute of Biosciences Sao Paulo State University Botucatu São Paulo Brazil. Department of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University SP Brazil. Department of Preventive Veterinary Medicine São Paulo State University (UNESP) Jaboticabal Brazil. Department of Pharmacology Center of Research in Inflammatory Diseases Ribeirao Preto Medical School University of São Paulo Brazil. Brasil University Descalvado São Paulo Brazil. Universidade Estadual Paulista Júlio de Mesquita Filho Instituto de Biociências - Departamento de Fisiologia São Paulo Brazil. Universidade Estadual Paulista Júlio de Mesquita Filho São Paulo Brazil. Postgraduate Program in Health Sciences PROCISA Federal University of Roraima Brazil. Immunochemistry Laboratory Butantan Institute São Paulo Brazil. Aquaculture Health Research and Extension Group GRUPESA Aquaculture Health Laboratory LABSA Department of Veterinary Medicine Federal University of Rondônia Rolim de Moura campus Rondônia Brazil. Department of Preventive Veterinary Medicine São Paulo State University Jaboticabal Brazil. Department of Cell and Molecular Biology Ribeirao Preto Medical School University of São Paulo Ribeirão Preto Brazil. Departamento de Bioquímica Instituto de Química Universidade de São Paulo Brazil. Pontifícia Universidade Católica de Minas Gerais Brazil. Departamento de B

Despite the significant increase in the generation of SARS-CoV-2 contaminated domestic and hospital wastewater, little is known about the ecotoxicological effects of the virus or its structural components in freshwater vertebrates. In this context, this study evaluated the deleterious effects caused by SARS-CoV-2 Spike protein on the health of Danio rerio, zebrafish. We demonstrated, for the first time, that zebrafish injected with fragment 16 to 165 (rSpike), which corresponds to the N-terminal portion of the protein, presented mortalities and adverse effects on liver, kidney, ovary and brain tissues. The conserved genetic homology between zebrafish and humans might be one of the reasons for the intense toxic effects followed inflammatory reaction from the immune system of zebrafish to rSpike which provoked damage to organs in a similar pattern as happen in severe cases of COVID-19 in humans, and, resulted in 78,6% of survival rate in female adults during the first seven days. The application of spike protein in zebrafish was highly toxic that is suitable for future studies to gather valuable information about ecotoxicological impacts, as well as vaccine responses and therapeutic approaches in human medicine. Therefore, besides representing an important tool to assess the harmful effects of SARS-CoV-2 in the aquatic environment, we present the zebrafish as an animal model for translational COVID-19 research.

关键词： Acute respiratory syndrome Coronavirus Danio rerio Environmental impacts Infection diseases

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Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019

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eClinicalMedicine 2023年 64卷 102193-102193页

作者： Wu, Dongze Jin, Yingzhao Xing, Yuhan Abate, Melsew Dagne Abbasian, Mohammadreza Abbasi-Kangevari, Mohsen Abbasi-Kangevari, Zeinab Abd-Allah, Foad Abdelmasseh, Michael Abdollahifar, Mohammad-Amin Abdulah, Deldar Morad Abedi, Aidin Abedi, Vida Abidi, Hassan Aboagye, Richard Gyan Abolhassani, Hassan Abuabara, Katrina Abyadeh, Morteza Addo, Isaac Yeboah Adeniji, Kayode Nelson Adepoju, Abiola Victor Adesina, Miracle Ayomikun Adnani, Qorinah Estiningtyas Sakilah Afarideh, Mohsen Aghamiri, Shahin Agodi, Antonella Agrawal, Anurag Arriagada, Constanza Elizabeth Aguilera Ahmad, Aqeel Ahmad, Danish Ahmad, Sohail Ahmadi, Ali Ahmed, Ayman Aithala, Janardhana P. Ajadi, Abdullateef Abiodun Ajami, Marjan Akbarzadeh-Khiavi, Mostafa Alahdab, Fares AlBataineh, Mohammad T. Alemi, Sharifullah Al-Gheethi, Adel Ali Saeed Ali, Liaqat Alif, Sheikh Mohammad Almazan, Joseph Uy Almustanyir, Sami Alqahtani, Jaber S. Alqasmi, Ibrahim Altaf, Ihsan Ullah Khan Alvis-Guzman, Nelson Alvis-Zakzuk, Nelson J. Al-Worafi, Yaser Mohammed Aly, Hany Amani, Reza Amu, Hubert Amusa, Ganiyu Adeniyi Andrei, Catalina Liliana Ansar, Adnan Ansariniya, Hossein Anyasodor, Anayochukwu Edward Arabloo, Jalal Arefnezhad, Reza Arulappan, Judie Asghari-Jafarabadi, Mohammad Ashraf, Tahira Atata, Jamila Abdulhamid Athari, Seyyed Shamsadin Atlaw, Daniel Atout, Maha Moh'd Wahbi Aujayeb, Avinash Awan, Asma Tahir Ayatollahi, Haleh Azadnajafabad, Sina Azzam, Ahmed Y. Badawi, Alaa Badiye, Ashish D. Bagherieh, Sara Baig, Atif Amin Bantie, Berihun Bantie Barchitta, Martina Bardhan, Mainak Barker-Collo, Suzanne Lyn Barone-Adesi, Francesco Batra, Kavita Bayileyegn, Nebiyou Simegnew Behnoush, Amir Hossein Belgaumi, Uzma Iqbal Bemanalizadeh, Maryam Bensenor, Isabela M. Beyene, Kebede A. Bhagavathula, Akshaya Srikanth Bhardwaj, Pankaj Bhaskar, Sonu Bhat, Ajay Nagesh Bitaraf, Saeid Bitra, Veera R. Boloor, Archith Bora, Kaustubh Botelho, João Silva Buchbinder, Rachelle Calina, Daniela Cámera, Luis Alberto Carvalho, Andre F. Chan, Jeffrey Shi Kai Chattu, Vijay Kumar Abebe, Endeshaw Chekol Department of Rheumatology and Immunology Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China China Department of Medicine & Therapeutics The Chinese University of Hong Kong Hong Kong Department of Paediatrics The Chinese University of Hong Kong Hong Kong School of Pharmacy The Chinese University of Hong Kong Hong Kong Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong Hong Kong Department of Nursing Woldia University Woldia Ethiopia Department of Orthopedic Surgery Harvard University Boston MA United States Postgraduate Medical Education Harvard University Boston MA United States Maternal Fetal Care Center Harvard University Boston MA United States Department of Health Policy and Oral Epidemiology Harvard University Boston MA United States Division of General Internal Medicine Harvard University Boston MA United States Department of Orthopaedic Surgery Shahid Beheshti University of Medical Sciences Tehran Iran Social Determinants of Health Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Department of Biotechnology Shahid Beheshti University of Medical Sciences Tehran Iran Department of Epidemiology Shahid Beheshti University of Medical Sciences Tehran Iran National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences Tehran Iran Department of Immunology Shahid Beheshti University of Medical Sciences Tehran Iran Department of Neurology Shahid Beheshti University of Medical Sciences Tehran Iran Department of Medical Genetics Shahid Beheshti University of Medical Sciences Tehran Iran Center for Comprehensive Genetic Services Shahid Beheshti University of Medical Sciences Tehran Iran Cancer Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Department of Health Economics and Statistics Shahid Beheshti University of Medical Sciences Tehran Iran Functional Neuro

Background: The causes for immune-mediated inflammatory diseases (IMIDs) are diverse and the incidence trends of IMIDs from specific causes are rarely studied. The study aims to investigate the pattern and trend of IMIDs from 1990 to 2019. Methods: We collected detailed information on six major causes of IMIDs, including asthma, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, psoriasis, and atopic dermatitis, between 1990 and 2019, derived from the Global Burden of Disease study in 2019. The average annual percent change (AAPC) in number of incidents and age standardized incidence rate (ASR) on IMIDs, by sex, age, region, and causes, were calculated to quantify the temporal trends. Findings: In 2019, rheumatoid arthritis, atopic dermatitis, asthma, multiple sclerosis, psoriasis, inflammatory bowel disease accounted 1.59%, 36.17%, 54.71%, 0.09%, 6.84%, 0.60% of overall new IMIDs cases, respectively. The ASR of IMIDs showed substantial regional and global variation with the highest in High SDI region, High-income North America, and United States of America. Throughout human lifespan, the age distribution of incident cases from six IMIDs was quite different. Globally, incident cases of IMIDs increased with an AAPC of 0.68 and the ASR decreased with an AAPC of −0.34 from 1990 to 2019. The incident cases increased across six IMIDs, the ASR of rheumatoid arthritis increased (0.21, 95% CI 0.18, 0.25), while the ASR of asthma (AAPC = −0.41), inflammatory bowel disease (AAPC = −0.72), multiple sclerosis (AAPC = −0.26), psoriasis (AAPC = −0.77), and atopic dermatitis (AAPC = −0.15) decreased. The ASR of overall and six individual IMID increased with SDI at regional and global level. Countries with higher ASR in 1990 experienced a more rapid decrease in ASR. Interpretation: The incidence patterns of IMIDs varied considerably across the world. Innovative prevention and integrative management strategy are urgently needed to mitigate the increasing ASR of rh

关键词： Global burden of disease study Immune-mediated inflammatory disease Incidence Trend

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