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The nanotoxicity assessment of cube-like iron nitride magnetic nanoparticles at the organismal level of nematode Caenorhabditis elegans

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Nanotoxicology 2022年第4期16卷 472-483页

作者： Gubert, Greici Gubert, Priscila Sandes, Jana Messias Bornhorst, Julia Alves, Luiz Carlos Quines, Caroline Brandão Mosca, Dante Homero Departamento de Física Universidade Federal do Paraná Curitiba Brazil Instituto Federal Catarinense Rio do Sul Brazil Graduate Program in Pure and Applied Chemistry POSQUIPA. Federal University of Western Bahia Barreiras Brazil Immunopathology Laboratory Keizo Asami LIKA. Federal University of Pernambuco Recife Brazil Department of Food Chemistry Institute of Nutritional Science University of Potsdam Nuthetal Germany Food Chemistry Faculty of Mathematics and Natural Sciences University of Wuppertal Wuppertal Germany Oswaldo Cruz Foundation Aggeu Magalhães Institute Department of Virology and Experimental Therapy Recife Brazil Postgraduating Program in Biochemistry Federal University of Pampa (UNIPAMPA) Uruguaiana Brazil

Magnetic nanoparticles (NPs) are suitable candidates for various medical and biological applications, despite some concerns that they may have negative impacts on human health. In this study, the toxicity effects of magnetic NPs consisting of α”-Fe₁₆N₂ captured and bioaccumulated by the nematode Caenorhabditis elegans (C. elegans) in the early larval stage are evaluated. The choice of α”-Fe₁₆N₂ NPs is based on their good structural stability when stored in saline solution and high magnetic performance. The uptake and bioaccumulation of α”-Fe₁₆N₂ NPs in intestinal cells of C. elegans was evidenced by transmission electron microscopy. After exposure to NPs up to 40 mg mL⁻¹, C. elegans larval development, survival, feeding behavior, defecation cycles, movement and reproduction were monitored. C. elegans survival and other monitored behavioral evolutions do not show significant changes, except for a slight statistical reduction in the reproductive profile. Therefore, the present results are promising and very encouraging for investigations of applications of α”-Fe₁₆N₂ NPs in the biomedical area. © 2022 Informa UK Limited, trading as Taylor & Francis Group.

关键词： C. elegans iron nitride Nanoparticles Nanotoxicology α”-Fe16N2

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