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Study of the Hydraulic Characteristics of Slug Flow in the Microfluidic Y-shaped Junctions of Three different Cross Angles 12

Study of the Hydraulic Characteristics of Slug Flow in the M...

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2022 International Conference on Acoustics, Fluid Mechanics and Engineering, AFME 2022 and the 12th Green''s Function Seminar, GFS 2022

作者： Han, Yu R&d Institute of Fluid and Powder Engineering Dalian University of Technology Dalian116024 China

The slug flow in microchannels has been applied for microdroplet/bubble production in recent years. The comparison investigation of hydrodynamic properties of slug flow in three different Y-shaped microchannels was conducted by numerical methods. The numerical simulation results show that the VOF model can describe the velocity and pressure field in the Y-shaped microchannel. It was found that the pressure in the microchannel from upstream to downstream showed an overall decreasing trend, and the liquid phase pressure between the two gas slugs was less than the internal pressure of the adjacent gas slug. The midline pressure of the bubble generation moment is less than the rest of the state. Among the three Y-shaped junctions, the absolute value of the pressure difference at the moment of slug bubble formation is the smallest when the angle of the Y-junction is 90°. Compared to 120° and 90° Y-junctions, the pressure and velocity field of the 60° Y-junction is the most unstable when the slug flow generates. © Published under licence by IOP Publishing Ltd.

关键词： Microchannels

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Investigation on the temperature-dependent diffusion growth of intermetallic compounds in the Mg-Al-Zn system:Experiment and modeling

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Journal of Magnesium and Alloys 2024年第8期12卷 3394-3408页

作者： Kaiming Cheng Yan Zheng Jiaxing Sun Yafei Zhao Jin Wang Huan Yu dongqing Zhao Hang Li Jixue Zhou Zhenyu Ma Junmin Wang Cuiping Guo Xitao Wang Lijun Zhang Yong du Shandong Provincial Key Laboratory of High Strength Lightweight Metallic Materials Advanced Materials InstituteQilu University of Technology(Shandong Academy of Sciences)Jinan250014China Laboratory of Materials Phase Equilibria and New Materials Design School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China Technology R&D Center Shandong Qiangang Metal Technology Co.LtdJining272000China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083China

With the rapid development of Mg alloys,deeper understanding to the thermodynamic and diffusional kinetic behavior of intermetallic compounds(IMCs)is important for studying the effect of alloying elements to the microstructure ***,a systematic quantitative investigation on the diffusional growth of IMCs is of great ***,the works studying the elemental diffusion behaviors of multiple-element IMCs are rare in magnesium alloy *** current work takes the ternary Mg-Al-Zn system as research target,and combines the diffusion couple technique,phase stability diagrams,in-situ observation technique and numerical inverse method to investigate the temperature-dependent kinetic *** parabolic growth constant(PGC)and interdiffusion coefficients for Mg solid-solution phase andγ-Mg_(17)Al_(12),β-Mg_(2)Al_(3),ε-Mg_(23)Al_(30),MgZn_(2),Mg_(2)Zn_(3),τ-Mg_(32)(Zn,Al)49 andφ-Mg_(5)Zn_(2)Al_(2) IMCs in the Mg-Al-Zn alloy system are *** comparing the current experimental with calculation results,the rate-controlling factor of the temperature-dependent diffusion growth ofφ,τandεternary IMCs in the Mg-Al-Zn system is further discussed in detail.

关键词： diffusion couple Phase stability diagram Numerical inverse method(NIM) Interface migration High-temperature laser-scanning confocal microscopy(HTLSCM)

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design of Low Power Low Temperature drift reference Current Source with Startup Circuit 4

Design of Low Power Low Temperature Drift Reference Current ...

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4th International Conference on Electronic Information Engineering and Computer technology, EIECT 2024

作者： Song, Kuixin Xu, Kaifeng Kong, Ying Zeng, Qiyu Xu, Xiaojun Liu, Lingyun Beijing Microelectronics Technology Institute Analog Circuit R&d Laboratory Beijing China

ISBN: (纸本)9798331528850

This article addresses the issues of complex and high power consumption in low-temperature drift reference current source circuits, and designs a reference current source with low power consumption, low-temperature drift, and a wide power supply voltage range. The reference current source adopts the temperature characteristics of the V_BE and V_BE of the transistor, exhibiting a near zero temperature characteristic. In order to eliminate the two non ideal operating degeneracy points in the circuit, a starting circuit is designed to ensure that the reference current source starts up to normal working state after the power is turned on, while improving the stability of the circuit. The circuit is designed based on 0.18um BCd technology and applied in a soft start circuit of a step-down dC-dC converter. The results show that the circuit proposed in this article outputs a reference current of 2.92uA, a temperature drift coefficient of 182.2ppm/°C, and an overall current consumption of 7.5uA at an input voltage of 2.1-5.5V power supply voltage and a temperature range of -25125 °C. © 2024 IEEE.

关键词： Power supply circuits

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Screening and identification of functional bacterial attachment genes in aerobic granular sludge

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Journal of Environmental Sciences 2024年第7期141卷 205-214页

作者： Kai Qiao Tingting Zhao LeiWang Wei Zhang WeiMeng Fan Liu Xu Gao Jianrong Zhu School of Environment Beijing Normal UniversityBeijing 100875China State Key Laboratory of Water Simulation Beijing 100875China R&D Centre of Aerobic Granule Technology Beijing 100875China

The screening and identification of attachment genes is important to exploring the formation mechanism of biofilms at the gene *** is helpful to the development of key culture technologies for aerobic granular sludge(AGS).In this study,genome-wide sequencing and gene editing were employed for the first time to investigate the effects and functions of attachment genes in *** the help of whole-genome analysis,ten attachment genes were screened from thirteen genes,and the efficiency of gene screening was greatly ***,two attachment genes were selected as examples to further confirm the gene functions by constructing gene-knockout recombinant mutants of Stenotrophomonas maltophilia;when the two attachment genes were knocked out,the attachment potential was reduced by 50.67%and 43.93%,*** results provide a new theoretical principle and efficient method for the development of AGS from the perspective of attachment genes.

关键词： Attachment gene Genome-wide sequence Gene-knockout Attachment potential Aerobic granular sludge biofilm

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Improving lipid production by rhodotorula glutinis for renewable fuel production based on machine learning

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Frontiers of Chemical Science and Engineering 2024年第5期18卷 23-35页

作者： Lihe Zhang Changwei Zhang Xi Zhao Changliu He Xu Zhang National Energy R&D Center for Biorefinery Beijing University of Chemical TechnologyBeijing 100029China Collage of Life Science and Technology Beijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Bioprocess Beijing University of Chemical TechnologyBeijing 10029China

Microbial lipid fermentation encompasses intricate complex cell growth processes and heavily relies on expert experience for optimal *** modeling of the fermentation process assists researchers in making intelligent decisions,employing logical reasoning and strategic planning to optimize lipid *** this study,the effects of medium components and concen-trations on lipid fermentation were investigated,*** then,leveraging the collated data,a variety of machine learning algorithms were used to model and optimize the lipid fermentation *** models,based on artificial neural networks and support vector machines,achieved r?values all higher than 0.93,ensuring accurate predictions of the fermentation *** linear regression was used to evaluate the respective target parameter,which were affected by the medium components of lipid ***,single and multi-objective optimiza-tion were conducted for lipid fermentation using the genetic *** results demonstrated the maximum biomass of 50.3 g·L^(-1) and maximum lipid concentration of 14.1 g:L^(-1) with the error between the experimental and predicted values less than 5%.The results of the multi-objective optimization reveal the synergistic and competitive relationship between biomass,lipid concentration,and conversion rate,which lay a basis for in-depth optimization and amplification.

关键词： microbial lipid machine learning artificial neural network support vector machine genetic algorithm

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Microstructure evolution and phase transformation of the mushy zone in a quenchedβ-solidifying TiAl alloy

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Journal of Materials Science & technology 2024年第2期169卷 28-41页

作者： Fuqiang Zhang Xianfei ding Leming Xu Xin Feng Hai Nan Jianping He Yongfeng Liang Junpin Lin State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Cast Titanium Alloy R&D Center Beijing Institute of Aeronautical MaterialsBeijing 100095China

This study investigates the phase constitutions and transformations that occur in the mushy zone and in the adjacent phase fields of a directionally solidified Ti-44Al-8Nb-1Cr alloy via quenching *** results indicate that the mushy zone consists of unmeltedβdendrites and interdendritic liquid,whose formation can be attributed to the difference in melting point aroused by local heterogeneity in ***βdendrite is composed of numerous subgrains with various *** quenching,theβdendrite transforms into Widmanstättenαvia a precipitation reaction,owing to the decreasing cooling rate caused by heat transfer from the surrounding ***,after quenching,the interdendritic liquid is transformed intoγ*** the singleβphase field and the lower part of the mushy zone,a massive transformation ofβtoγ***,in theβ+αphase field,bothβandαphases are retained to ambient *** the heating process,the transformation ofα→βgives rise to the formation ofβvariants,which affects the orientation ofβdendrites in the mushy *** growth kinematics of theα→βtransformation was elucidated,revealing the preferential growth directions of111and112forβ***,this study presents an illustration of the formation process of the mushy zone and the microstructural evolution during the heating and quenching process.

关键词： Titanium aluminides Mushy zone Quenching Electron backscattering diffraction Phase transformation

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Halophobic Prussian blue analogue electrodes for saturated saline water electrolysis

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Nano research 2025年第3期18卷 90-97页

作者： Wei Liu Jiage Yu Boyu ding Tianshui Li Shihang Li Xinlong Guo Linlin Zhou Benqiang Tian Yixin Zhang Yizhe Li Mengze Ma Kairui Wang Huijun Xin daojin Zhou Yun Kuang Xiaoming Sun State Key Laboratory of Chemical Resource Engineering College of ChemistryBeijing University of Chemical TechnologyBeijing 100029China Ocean Hydrogen Energy R&D Center Research Institute of Tsinghua University in ShenzhenShenzhen 518057China

Continuous seawater electrolysis is efficient for green hydrogen production,but some key issues have been *** example,the accumulated to saturated NaCl in electrolyte is poison to cathode by covering its surface and available active *** we demonstrate Pt/NiFe Prussian blue analogue(Pt/NiFePBA)electrode can continuously catalyze hydrogen evolution effectively at−500 mA·cm^(−2)in a 6 M NaOH electrolyte containing saturated NaCl,without being impeded by the formation of NaCl crystals on the electrode surface,which is in distinct contrast to commercial *** results indicate that Fe(CN)_(6)^(4−)spontaneously released by Pt/NiFePBA blocks the traditionally preferred basal plane growth of NaCl along{100}facets,but favors its growth along{110}basal *** alteration leads to an increased crystallization difficulty of NaCl near the electrode,rendering it halophobic(anti-NaCl precipitation)*** investigation should shed light on general salt involving process besides the practical implementation of seawater electrolysis.

关键词： seawater electrolysis saturate saline water hydrogen evolution reaction halophobic electrode Prussian blue analogue

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development of Practical Manufacturing Process of Ensitrelvir‚ a SArS–CoV–2 3CL Protease Inhibitor for Oral Treating COVId–19

Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Che...

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Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry 2025年第1期83卷 15-24页

作者： Tsuritani, Takayuki Kijima, Akihito Fukui, Nobuaki Yanagisawa, Shuichi Agura, Kazushi Kasamatsu, Koji API R&D Laboratory Pharmaceutical Technology Research Division Shionogi & Co. Ltd. 1–3 Kuise Terajima 2–chome Amagasaki660–0813 Japan

Ensitrelvir, SArS–CoV–2 3CL protease inhibitor, has been discovered for the treatment of the coronavirus disease 2019 (COVId–19). Ensitrelvir is structurally composed from three main units, which are indazole unit, triazole unit and triazinone unit. Synthetic strategies where these three units are employed at latter steps in the synthesis made it possible to construct a highly productive convergent route. In addition, the lean manufacturing process was also established through process optimization based on SELECT perspectives. These achievements contributed for the rapid commercial manufacturing of Ensitrelvir with less than one year. In this report, we describe r&d activities for route scouting and process optimization. In addition, a few trouble shootings which occurred during the manufacturing are also introduced. Lastly, additional study for further investigations to improve productivity and flexibility are briefly explained. © 2025 Society of Synthetic Organic Chemistry. All rights reserved.

关键词： Coronavirus

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Spherical modification of tungsten powder by particle composite system

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rare Metals 2022年第6期41卷 1972-1976页

作者： Cong-Cong Wang Cheng-Chang Jia Peng Gao Guo-Sheng Gai Yu-Fen Yang School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Powder Technology R&D Group Department of Material Science and EngineeringTsinghua UniversityBeijing 100084China

Owing to contradiction between increasing demand of spherical tungsten powder and limitation of traditional manufacturing technology,a novel preparation method was developed to sphericize the polygonal tungsten powder by means of modification of particle composite *** powder particles were modified by par-ticle composite system,and detailed characterization by scanning electron microscopy(SEM)was *** size distribution and function mechanism were analyzed,and the internal relationship between average diameter and processing time was *** results show that the spherical tungsten powder with an average diameter of 6.41μm is obtained from polyhedral tungsten powder with an average diameter of 7.50μ*** spherical effect could be achieved(sharp edge angles of particles are rounded off and reshaped)when the processing time is over 30 *** relationship between average diameter(d)and pro-cessing time can be described by the exponential decay model,which provides a good interpretation for the process of *** relationship between them can be expressed by the equation d=1.87406exp(-x/8.92718)+*** proposed method could readily enable large-scale production of spherical tungsten powder.

关键词： Tungsten powder Modification Average diameter powder metallurgy

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Built-in electric field induced by defected carbons adjacent to graphitic nitrogen valley for efficient oxygen reduction reaction and zinc-air batteries

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Journal of Energy Chemistry 2025年第4期103卷 813-825页

作者： Na Li Tingting Ma Huihui Wang Jiayi Li dingrong Qiu Zhen Meng Jiangdu Huang Lijun Sui Faming Han Huidan Lu Yongping Liu Sundaram Chandrasekaran Guangxi Key Laboratory of Electrochemical and Magneto-Chemical Functional Materials College of Chemistry and Bioengineering Guilin University of Technology Guangxi Colleges and Universities Key Laboratory of Surface and Interface Electrochemistry College of Chemistry and Bioengineering Guilin University of Technology Shanghai Key Laboratory for R&D and Application of Metallic Functional Materials Institute of New Energy for Vehicles School of Materials Science and Engineering Tongji University

rational design of defected carbons adjacent to nitrogen（N） dopants is a fascinating but challenging approach for enhancing the catalytic performance of N-doped ***,the combined effect of heteroatom doping and defect engineering can efficiently increase the oxygen reduction reaction（Orr） ability of inactive carbons through charge ***,we report that an enhanced built-in electric field caused by the combined effect of N-doping and carbon defects in the twodimensional（2d） mesoporous N-doped carbon nano flakes（NCNF） is a promising technique for improving Orr *** a result,the NCNF exhibits more promising Orr activity than Pt/C and similar performance with reported robust *** experimental and theoretical investigations suggest that topologically defected carbon adjacent to the graphitic valley nitrogen is a real active site,rendering optimal energy for the adsorption of Orr intermediates and lowering the total energy barrier for ***,NCNF-based Zn-air batteries exhibited an excellent power density and specific capacity of ～121.10 mW cm-2and ～679.86 mA h gZn-1,*** study not only offers new insights into defected carbons with graphitic valley N for Orr but also proposes novel catalyst design principles and provides a solid grasp of the built-in electric field effect on the Orr performance of defective catalysts.

关键词： Built-in electric field defective carbon Graphitic valley nitrogen-doped carbon defects Oxygen reduction reaction Zn-air batteries

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