检索结果-内蒙古大学图书馆

Positively charged patches:tonic for CAR fitness

细胞研究（英文版） 2023年第5期33卷 331-332页

作者： Meraj H.Khan Jan Joseph Melenhorst Cell Therapy & Immuno-Engineering Program Center for ImmunoTherapy & Precision Immuno-OncologyLerner Research InstituteCleveland ClinicClevelandOHUSA

Tonic signaling is a constitutive low-level activation of chimeric antigen receptors(CARs)in the absence of tumor antigen and plays an imperative role in the CAR-T *** a recent paper published in Cell Research,Chen et *** that the positively charged patches on the surface of the CAR antigen-binding domain regulate CAR tonic signaling and open a door to further optimization of improvements of CAR.

关键词： Immunology Tumour immunology

来源：评论

学校读者我要写书评

暂无评论

Detection of Alzheimer’s disease and Frontotemporal Dementia: An Explainable Machine Learning Approach Using EEG signals 13

Detection of Alzheimer’s disease and Frontotemporal Dementi...

引用

13th International Winter Conference on Brain-Computer Interface, BCI 2025

作者： Lee, Hwa-Yeon Jung, Min-Kyung Lee, Choel-Hui Kim, Hakseung Kim, Dong-Joo Department of Brain and Cognitive Engineering Interdisciplinary Program in Precision Public Health Korea University Seoul Korea Republic of Department of Brain and Cognitive Engineering Korea University Seoul Korea Republic of

ISBN: (纸本)9798331521929

Alzheimer’s disease and frontotemporal dementia are among the most prevalent neurodegenerative diseases worldwide. With the absence of definitive treatments, early detection and precise diagnosis remain crucial for alleviating patient suffering and reducing healthcare costs. This study aimed to differentiate Alzheimer’s disease, frontotemporal dementia and normal cognition using electroencephalography biomarkers. Significant power spectral density and functional connectivity features were identified via one-way analysis of variance and Scheffe’s post-hoc test. A three-class classification was performed by a support vector machine classifier and explainable artificial intelligence technique was employed to investigate feature importance. This classifier achieved an average accuracy of 84.09%, and linear shapley additive explanation model identified T5-Fp1 connectivity in alpha band as the most important feature, consistent with findings from previous studies. Further clinical research and brain network analysis using advanced deep learning models could enhance our understanding of the cognitive functions and neural mechanisms underlying these dementias. © 2025 IEEE.

关键词： Electroencephalography

来源：评论

学校读者我要写书评

暂无评论

Stratification of metastatic melanoma patients based on mutational signatures

Stratification of metastatic melanoma patients based on muta...

引用

2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023

作者： Alfano, Caterina Farina, Lorenzo Petti, Manuela Sapienza University of Rome Program in Network Oncology and Precision Medicine Rome Italy Sapienza University of Rome Program in Network Oncology and Precision Medicine Dept. of Computer Control and Management Engineering Rome Italy Sapienza University of Rome Dept. of Computer Control and Management Engineering Rome Italy

ISBN: (纸本)9798350337488

Genetic instability is one of the hallmarks of cancer, however mutations can occur for different causes and induce different effects. Mutational signatures are characteristic patterns of somatic mutations in cancer genomes, reflecting the underlying mutational processes. A mutational signature can be determined by studying the kind of mutations a patient has acquired during their life: patient stratification based on mutational signatures has become more and more useful in genomic studies, given its possible clinical implications. In this work we focused on Single Base Substitution (SBS) signatures to study a cohort of 115 metastatic melanoma patients. We inferred and identified two mutational signatures characterizing the patients. Based on these signatures we divided patients into two group: the bigger group was characterized by a signature associated with exposure to ultraviolet light, while the smaller group resulted to be mostly composed of patients which did not respond to immunotherapy (anti-PD1) and that presented a low mutational count. More importantly this second group showed a significantly worse survival outcome. The use of mutational signatures is clearly a powerful tool to identify disease sub-types that have a clinical relevance, however we believe that this topic needs further investigation focused on the characterization of patient subtypes with a multi-omics based approach. © 2023 IEEE.

关键词： computational medicine genomics metastatic melanoma mutational signatures patient stratification precision oncology

来源：评论

学校读者我要写书评

暂无评论

Evaluating cooling tube effects on defect formation and distribution in Czochralski crystal growth

引用

Journal of Materials Science: Materials in Electronics 2024年第19期35卷 1315页

作者： Huang, Yi-Jen Dezfoli, Amir Reza Ansari Department of Chemical and Materials Engineering National Chin-Yi University of Technology Taichung41170 Taiwan Department of Intelligent Automation Engineering National Chin-Yi University of Technology Taichung Taiwan Ph.D. Program at Graduate Institute of Precision Manufacturing National Chin-Yi University of Technology Taichung Taiwan

The quality of silicon ingots is paramount in semiconductor manufacturing as defects profoundly influence the crystal integrity and device performance. This study investigates the impact of cooling-tube configurations on defect formation during the Czochralski process. Comprehensive modeling and simulation elucidated the intricate relationship between the presence of a cooling tube and the evaluation of point defects within silicon ingots. The results show that cooling tubes augment the axial temperature gradient and shift the point-defect behavior from vacancy-rich to interstitial-dominated regions with an increase in the axial temperature gradient of up to 1.6 times. Additionally, cooling tubes impede the formation of agglomerated defects by reducing point-defect mobility and propagation time, resulting in a reduction of the agglomerated defect count by up to 30% compared to processes without cooling tubes. Experiments validated the simulation findings, demonstrating a notable decrease in agglomerated defect counts. These insights underscore the potential of optimized cooling-tube designs for enhancing semiconductor device performance and manufacturing yield, thereby driving progress in electronics and beyond. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.

关键词： Agglomeration

来源：评论

学校读者我要写书评

暂无评论

Dual modifications of sensitizers and lanthanide ions on a two-dimensional zirconium-based metal-organic framework for photoluminescent detection

引用

CrystEngComm 2024年第22期26卷 2852-2861页

作者： Chang, Jhe-Wei Lin, Tzu-Chi Chen, You-Liang Han, Po-Chun Yang, Shang-Cheng Tsai, Meng-Dian Wu, Kevin C.-W. Kung, Chung-Wei Department of Chemical Engineering National Cheng Kung University Tainan City70101 Taiwan Department of Chemical Engineering National Taiwan University Taipei10617 Taiwan Ph. D. Program of Green Materials and Precision Devices College of Engineering National Taiwan University Taipei10617 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Chung-Li Taoyuan320 Taiwan

A two-dimensional (2D) zirconium-based metal-organic framework (Zr-MOF) with abundant terminal -OH/-OH2 groups on its nodes, ZrBTB (BTB = 1,3,5-tris(4-carboxyphenyl)benzene), is utilized as a platform for dual post-synthetic modifications (PSM) to immobilize both the benzophenone-based photosensitizer (benzophenone-4,4′-dicarboxylate, bzpdc) and terbium ions onto the 2D Zr-MOF molecular sheets. Terbium ions are installed on the 2D Zr-MOF at various temperatures to adjust the loading of terbium ions on the 2D Zr-MOF while preserving the loading of the photosensitizer. The crystallinity, morphology, porosity, and loadings of both bzpdc ligands and terbium ions are characterized for each material, and the coordinating locations of terbium ions in the Zr-MOF structure are investigated. The photoluminescence (PL) properties of these materials are then examined. Since the installed bzpdc ligand can induce a highly efficient energy transfer to the neighbouring terbium ion upon excitation, the obtained material after dual PSM (ZrBTB-bzpdc-Tb-120) can show strong PL emissions of terbium ions upon the excitation of the bzpdc ligand at 355 nm, with a PL quantum yield of 5.04%. It is more advantageous than the 2D Zr-MOF solely functionalized with terbium ions, which can only exhibit similar emissions upon the excitation of the BTB linker at a less friendly wavelength of 310 nm, with a lower PL quantum yield of 2.94%. Owing to the high chemical stability as well as good dispersity of the luminescent ZrBTB-bzpdc-Tb-120 in water, its performances in selective PL sensing of Fe(iii) ions present in aqueous solutions are investigated. © 2024 The Royal Society of Chemistry.

关键词： Carboxylation

来源：评论

学校读者我要写书评

暂无评论

Scalable electrochemical grafting of anthraquinone for fabrication of multifunctional carbon fibers

引用

Journal of Materials Science & Technology 2024年第33期200卷 162-175页

作者： Piers Coia Bhagya Dharmasiri Filip Stojcevski David J.Hayne Elmer Austria Jr. Behnam Akhavan Joselito M.Razal Ken Aldren S.Usman Melissa K.Stanfield Luke C.Henderson Institute for Frontier Materials Deakin UniversityWaurn PondsVictoria 3216Australia DSTG Victoria 3168Australia School of Biomedical Engineering Faculty of EngineeringUniversity of SydneySydneyNSW 2006Australia School of Engineering University of NewcastleCallaghanNSW 2308Australia Hunter Medical Research Institute(HMRI) Precision Medicine ProgramNew Lambton Heights NSW 2305Australia School of Natural Sciences–Chemistry University of TasmaniaHobartTasmania 7005Australia

Carbon fiber electrodes were prepared by grafting anthraquinone molecules via a scalable electrochemical approach which simultaneously increased interfacial and electrochemical capacitance *** this work,anthraquinone diazonium salts were synthesized and grafted onto carbon fiber tows at various *** modified fibers were subsequently evaluated mechanically and electrochemically to analyze their suitability in structural *** to control fibers,the grafted anthraquinone groups resulted in a 30%increase in interfacial shear strength(IFSS)and 6.6×increase in specific *** application was also a focus thus carbon fibers were also modified with insitu generated diazonium salts to determine the applicability to an in-line industrial ***,potentiostatic functionalization of fibers with in-situ generated diazonium salts AQ-1 and AQ-2,showed 3×and 4.3×increase in specific capacitance,respectively,relative to unmodified carbon fiber(CF).We expect that implementing a scalable method to introduce a conductive and electrochemically active covalently bound surface chemistry layer onto carbon fiber exhibits a higher specific capacitance than carbon fiber grafted with most other small molecules reported in *** will open new avenues for manufacturing multifunctional and high-performance fibers with tailored properties for specific/targeted applications.

关键词： Carbon fiber Energy storage Interface Surface modification

来源：评论

学校读者我要写书评

暂无评论

Polyetheretherketone (PEEK) Implant Functionalization with Magnetron-Sputtered SrTiO3 for Regenerative Medicine

引用

Plasma Medicine 2023年第3期13卷 53-67页

作者： Harumningtyas, Anjar Anggraini Ito, Tomoko Ikuta, Masato Kaito, Takashi Hamaguchi, Satoshi International Priority Graduate Program on Applied and Engineering Physics Division of Precision Engineering and Applied Physics Osaka University Osaka Japan Yogyakarta Indonesia Division of Materials and Manufacturing Science Graduate School of Engineering Osaka University Osaka Japan Department of Orthopaedic Surgery Osaka University Graduate School of Medicine Osaka Japan

Polyetheretherketone (PEEK) is a polymer widely used for artificial bone implants but exhibits a low affinity for bone tissue and lacks osteoconductivity and osseointegration. Because strontium (Sr) is known to enhance bone growth, PEEK implants coated with strontium titanate [SrTiO3 (STO)] are expected to improve the bone growth around them. In this study, STO was deposited on model PEEK implants by magnetron sputtering deposition and its ability to release Sr2+ ions to a surrounding phosphate-buffered saline (PBS) solution was examined. It was found that, in the early stage of the deposition process, STO on a PEEK surface exhibits irregular surface structures with many holes. The amount of Sr stored in the STO film increases with the increasing film thickness but the release rate of Sr2+ ions from the STO film to the surrounding PBS also increases with the film thickness, limiting the duration of effectiveness of the STO-coated PEEK films. It was found, however, that a three-layer titanium (Ti)-STO-Ti film deposited on PEEK allows a steady release of Sr2+ ions to the surrounding PBS for an extended period. © 2023 by Begell House, Inc. ***.

关键词： Titanium compounds

来源：评论

学校读者我要写书评

暂无评论

Application of Recurrence Plots and VGG Deep Learning Model to the Study of Condition Monitoring of Robotic Grinding

引用

International Journal of precision engineering and Manufacturing 2023年第9期24卷 1675-1683页

作者： Chung, Kuan-Jung Dai, Cheng-Han Chiang, Tung-Chun Xie, June-Jia Lin, Ming-Tzer Department of Mechatronics Engineering National Changhua University of Education Changhua500 Taiwan Graduate Institute of Precision Engineering National Chung Hsing University Taichung402 Taiwan Doctoral Program in Industrial and Smart Technology Academy of Circular Economy National Chung Hsing University Nantou540 Taiwan

This study adopted AI to identify the normal and abnormal vibration signals generated during robotic grinding. This study classified four fundamental factors affecting grinding into three levels to obtain a widely used result and designed an L9(3 4) orthogonal array for the grinding experiment. During experimentation, part of the grinding wheels was added weight to produce abnormal vibration signals, which an accelerometer would measure. The study transformed the collected vibration signals into recurrence plots and conducted model training with VGG16 CNN architecture. Finally, this study tested a model with 89.6% training accuracy. The results showed the model could identify whether the recurrence plots stand for normal or abnormal vibrations, with an accuracy of 85%. This means it could predict normal and abnormal grinding conditions and help avoid problems caused by abnormal vibrations. © 2023, The Author(s), under exclusive licence to Korean Society for precision engineering.

关键词： Grinding (machining)

来源：评论

学校读者我要写书评

暂无评论

Modelling the development of biological structures displaying longitudinal geometries in vitro:culturing pluripotent stem cells on plasma-treated,growth factor-coupled polycaprolactone fibres

引用

Engineered Regeneration 2024年第1期5卷 124-138页

作者： Badwi B.Boumelhem Stuart T.Fraser Syamak Farajikhah Rachel A.Shparberg Michael B.Morris Marcela M.M.Bilek Anyu Zhang Behnam Akhavan Simon Fleming Maryanne Large School of Physics Faculty of ScienceUniversity of SydneyAustralia Sydney Nano Institute University of SydneyAustralia School of Chemical and Biomolecular Engineering University of SydneyAustralia School of Medical Sciences Faculty of Medicine and HealthUniversity of SydneyAustralia School of Biomedical Engineering Faculty of EngineeringUniversity of SydneyAustralia School of Engineering University of NewcastleCallaghanNSW 2308Australia Hunter Medical Research Institute(HMRI) Precision Medicine ProgramNew Lambton Heights NSW 2305Australia

Many biological structures such as nerves,blood and lymphatic vessels,and muscle fibres exhibit longitudinal ge-ometries with distinct cell types extending along both the length and width of internal linear *** these three-dimensional structures in vitro is challenging:the best-defined stem-cell differentiation systems are mono-layer cultures or organoids using pluripotent stem *** stem cells can differentiate into functionally mature cells depending on the signals received,holding great promise for regenerative ***,the integration of in vitro differentiated cell types into diseased tissue remains a *** scaffolds can bridge this gap if the appropriate signalling systems are incorporated into the ***,we have taken a biomimicry approach to generate longitudinal structures in *** this approach,mouse embryonic stem cells are directed to differentiate to specific cell types on the surface of polycaprolactone(PCL)fibres treated by plasma-immersion ion implantation and to which with lineage-specifying molecules have been covalently *** demonstrate the simplicity and utility of our method for efficiently generating high yields of the following cell types from these pluripotent stem cells:neurons,vascular endothelial cells,osteoclasts,adipocytes,and cells of the erythroid,myeloid,and lymphoid *** arranged plasma-treated scaffolds with differentiated cell types could ultimately serve as a means for the repair or treatment of diseased or damaged tissue.

关键词： Pluripotent stem cells Lineage commitment Growth factors Biomaterial engineering Plasma-immersion ion implantation Covalent biomolecule attachment Polycaprolactone

来源：评论

学校读者我要写书评

暂无评论

Retaining spatial resolution multifocal confocal fluorescence microscopy with deep learning

引用

Optics Express 2025年第6期33卷 12288-12303页

作者： Suresh, Surag Athippillil Vyas, Sunil Yeh, J. Andrew Luo, Yuan Institute of Nano Engineering and Microsystems National Tsing Hua University Hsinchu30013 Taiwan Institute of Medical Device and Imaging National Taiwan University Taipei10051 Taiwan Program for Precision Health and Intelligent Medicine National Taiwan University Taipei106319 Taiwan Department of Biomedical Engineering National Taiwan University Taipei10051 Taiwan YongLin Institute of Health National Taiwan University Taipei10087 Taiwan

Confocal microscopy is a standard modality for volumetric imaging of biological samples due to its high spatial resolution and signal-to-noise ratio (SNR). However, the slow point-by-point scanning process limits its image acquisition speed. Multifocal illumination allows for faster acquisition but compromises spatial resolution. Here, we introduce a deep learning approach for multifocal confocal microscopy that achieves faster acquisition while preserving high resolution. The proposed model is based on image-to-image translation, implemented using modified U-Net, ResU-Net, and Attention U-Net architectures. The model is trained and tested on paired experimental datasets, with conventional confocal images as groundtruth and multifocal confocal images as input from various biological samples. The modified Attention U-Net significantly improves image quality and retains structural details, with higher peak SNR (32.83 dB) and structural similarity index measure (0.935) values. Additionally, spatial frequency analysis and Fourier ring correlation confirm that the Attention U-Net outperforms other models in preserving both low-frequency (>0.92 accuracy) and high-frequency information (0.90 vs. 0.83 for U-Net). Performance metrics demonstrate that our models match the quality of traditional confocal imaging, increasing imaging speed and addressing the trade-off between speed and resolution in multifocal confocal microscopy. These findings underscore the potential of combining deep learning with various confocal imaging applications. © 2025 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.

关键词： Fluorescence microscopy

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：