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Crowning Analysis of Involute Helical Pairs Shaved by CNC Gear Shaving Machine with Two Synchronous Axes

IOP Conference Series: Materials Science and engineering 2018年第1期417卷

作者： Ruei-Hung Hsu Shih-Sheng Chen Bachelor Program in Precision System Design Feng Chia University No. 100 Wenhwa Road Seatwen Taichung 407 Taiwan Department of Mechanical Engineering National Chung Hsing University No. 250 Kuo-Kuang Road Taichung 40227 Taiwan

Gear Shaving is one of the most efficient and economical ways to finish gears after gear hobbing or gear shaping. In tradition, the shaved gear can be crowning by shaving machine with the rocking mechanism. In this paper, we propose a mathematical model of a CNC shaving machine with two synchronous axes. The proposed mathematical model can be used to calculate the crowning tooth surface of the gear in parallel-shaving process.

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Synthetic BZLF1-targeted transcriptional activator for efficient lytic induction therapy against EBV-associated epithelial cancers

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Nature communications 2024年第1期15卷 3729页

作者： Man Wu Pok Man Hau Linxian Li Chi Man Tsang Yike Yang Aziz Taghbalout Grace Tin-Yun Chung Shin Yee Hui Wing Chung Tang Nathaniel Jillette Jacqueline Jufen Zhu Horace Hok Yeung Lee Ee Ling Kong Melissa Sue Ann Chan Jason Ying Kuen Chan Brigette Buig Yue Ma Mei-Ru Chen Charles Lee Ka Fai To Albert Wu Cheng Kwok-Wai Lo Department of Anatomical and Cellular Pathology Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong SAR China. State Key Laboratory of Translational Oncology Sir YK Pao Centre for Cancer The Chinese University of Hong Kong Hong Kong SAR China. Ming Wai Lau Centre for Reparative Medicine Karolinska Institutet Shatin Hong Kong SAR China. Department of Surgery Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong SAR China. Center for Neuromusculoskeletal Restorative Medicine Hong Kong Science Park Hong Kong SAR China. College of Chemistry and Green Catalysis Center Zhengzhou University Zhengzhou China. The Jackson Laboratory for Genomic Medicine Farmington CT 06032 USA. School of Biological and Health Systems Engineering Arizona State University Tempe AZ 85281 USA. Department of Otorhinolaryngology Head and Neck Surgery Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong SAR China. Department of Clinical Oncology State Key Laboratory of Translational Oncology Charlie Lee Precision Immuno-oncology program Sir Y.K. Pao Centre for Cancer The Chinese University of Hong Kong Hong Kong SAR China. Graduate Institute and Department of Microbiology College of Medicine National Taiwan University Taipei 100233 Taiwan. The Jackson Laboratory for Genomic Medicine Farmington CT 06032 USA. albert.cheng@***. School of Biological and Health Systems Engineering Arizona State University Tempe AZ 85281 USA. albert.cheng@***. Department of Genetics and Genome Sciences University of Connecticut Health Center Farmington CT 06030 USA. albert.cheng@***. Institute for Systems Genomics University of Connecticut Health Center Farmington CT 06030 USA. albert.cheng@***. The Jackson Laboratory Cancer Center Bar Harbor ME 04609 USA. albert.cheng@***. State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing China. albert.cheng@ioz.ac.cn. Key Laboratory of Organ R

The unique virus-cell interaction in Epstein-Barr virus (EBV)-associated malignancies implies targeting the viral latent-lytic switch is a promising therapeutic strategy. However, the lack of specific and efficient therapeutic agents to induce lytic cycle in these cancers is a major challenge facing clinical implementation. We develop a synthetic transcriptional activator that specifically activates endogenous BZLF1 and efficiently induces lytic reactivation in EBV-positive cancer cells. A lipid nanoparticle encapsulating nucleoside-modified mRNA which encodes a BZLF1-specific transcriptional activator (mTZ3-LNP) is synthesized for EBV-targeted therapy. Compared with conventional chemical inducers, mTZ3-LNP more efficiently activates EBV lytic gene expression in EBV-associated epithelial cancers. Here we show the potency and safety of treatment with mTZ3-LNP to suppress tumor growth in EBV-positive cancer models. The combination of mTZ3-LNP and ganciclovir yields highly selective cytotoxic effects of mRNA-based lytic induction therapy against EBV-positive tumor cells, indicating the potential of mRNA nanomedicine in the treatment of EBV-associated epithelial cancers.

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Minimizing task-specific uncertainty in CMM-Based freeform optics metrology 31

Minimizing task-specific uncertainty in CMM-Based freeform o...

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31st Annual Meeting of the American Society for precision engineering, ASPE 2016

作者： Uwakwe, Michael U. Evans, Christopher J. Optical Science and Engineering Program University of North Carolina at Charlotte NC28223 United States Center for Precision Metrology University of North Carolina at Charlotte NC28223 United States

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Cell migration guided by a groove with branches

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Journal of Biomechanical Science and engineering 2017年第1期12卷 16-00613-16-00613页

作者： Miyoshi, Hiromi Nishimura, Miki Yamagata, Yutaka Liu, Hao Watanabe, Yasuyoshi Sugawara, Michiko Pathophysiological and Health Science Team RIKEN Center for Life Science Technologies 6-7-3 Minatojima-minamimachi Chuo Kobe Hyogo650-0047 Japan Health Metrics Development Team RIKEN Compass to Healthy Life Research Complex Program 6-7-1 Minatojima-minamimachi Chuo Kobe Hyogo650-0047 Japan PRIME AMED 6-7-3 Minatojima-minamimachi Chuo Kobe Hyogo650-0047 Japan Graduate School of Engineering Chiba University Chiba 1-33 Yayoicho Inage Chiba263-8522 Japan Ultrahigh Precision Optics Technology Team RIKEN Center for Advanced Photonics 2-1 Hirosawa Wako Saitama Japan

Cell migration is an important process both in physiological and pathological conditions. Migrating cells in vivo respond to various extracellular environmental factors and change their migratory behavior. Thus, it is important to take into account extracellular environmental factors in studies on cell migration. This study specifically focused on fibroblast migration in a three-dimensional microenvironment. We fabricated a polydimethylsiloxane cell culture substrate with intersecting grooves as a model to mimic a feature of the complex porous microenvironment experienced by fibroblasts in vivo. The sizes of the grooves allowed fibroblasts to penetrate into the grooves. The effects of branched grooved structures on cell migration, and on cellular organization of the actin filaments and phosphorylated myosin light chain, were analyzed. Fibroblasts migrated along intersecting lattice grooves that were 5 μm wide, 13 μm deep, and spaced 10 μm apart. Analysis of the cellular distribution of actin filaments and phosphorylated myosin light chain demonstrated two effects of the intersecting grooved structure on actin cytoskeletal organization in the fibroblast. One was the enhancement of filopodia protrusions into the branched groove at the junction, and the other was the formation of stress fibers to cross the opening of the junction. These results suggest that the filopodia protrusions are guided by the groove and are followed by the cytoplasmic protrusion, then the rear of the cell retracts due to stress fiber contraction, leading to fibroblast guided migration in the branched intersecting groove. © 2017 The Japan Society of Mechanical Engineers.

关键词： Fibroblasts

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Patterns of somatic structural variation in human cancer genomes (vol 578, pg 112, 2020)

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NATURE 2023年第7948期614卷 E38-E38页

作者： Li, Yilong Roberts, Nicola D. Wala, Jeremiah A. Shapira, Ofer Schumacher, Steven E. Kumar, Kiran Khurana, Ekta Waszak, Sebastian Korbel, Jan O. Haber, James E. Imielinski, Marcin Weischenfeldt, Joachim Beroukhim, Rameen Campbell, Peter J. Cancer Genome Project Wellcome Trust Sanger Institute Hinxton UK Totient Inc Cambridge MA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Haematology University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Korea Advanced Institute of Science and Technology Daejeon South Korea Department of Zoology Genetics and Physical Anthropology University of Santiago de Compostela Santiago de Compostela Spain Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS) University of Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) University of Vigo Vigo Spain Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain Department of Zoology Genetics and Physical Anthropology (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) Universidade de Vigo Vigo Spain The Broad Institute of Harvard and MIT Cambridge MA USA Bioinformatics and Integrative Genomics Harvard University Cambridge MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Harvard Medical School Boston MA USA Massachusetts General Hospital Center for Cancer Research Charlestown MA USA Dana-Farber Cancer Institute Boston MA USA Department of Biostatistics and Computational Biology Dana-Farber Cancer Institute and Harvard Medical School Boston MA USA Weill Cornell Medical College New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine Ne

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Corrigendum to "Monastrol suppresses invasion and metastasis in human colorectal cancer cells by targeting fascin independent of kinesin-Eg5 pathway" [Biomed. Pharmacother. 175 (2024) 116785]

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024年 179卷 117411页

作者： Begoña Alburquerque-González Silvia Montoro-García Ángel Bernabé-García Manuel Bernabé-García Priscila Campioni-Rodrigues Alejandro Rodríguez-Martínez Irene Luque Tuula Salo Alfonso Pérez-Garrido Horacio Pérez-Sánchez María Luisa Cayuela Ginés Luengo-Gil Enrico Luchinat Fatima Postigo-Corrales Tommaso Staderini Francisco José Nicolás Pablo Conesa-Zamora Health Sciences Faculty Universidad Católica de Murcia (UCAM) Guadalupe Spain. Regeneración Oncología Molecular y TGF-ß. IMIB-Arrixaca Carretera Madrid-Cartagena El Palmar 30120 Spain. Research group "Telomerasa Envejecimiento y Cáncer" CIBERER Hospital Clínico Universitario Virgen de la Arrixaca IMIB-Arrixaca Murcia Spain. ECM and Hypoxia research unit Faculty of Biochemistry and Molecular Medicine University of Oulu Aapistie 7C Oulu FI-90014 Finland Microelectronic Research Unit Faculty of Information Technology and Electrical Engineering University of Oulu Oulu FI-90570 Finland. Department of Physical Chemistry Institute of Biotechnology and Excellence Unit in Chemistry Applied to Biomedicine and Environment School of Sciences University of Granada Granada 18071 Spain Structural Bioinformatics and High-Performance Computing (BIO-HPC) Research Group Universidad Católica de Murcia (UCAM) Guadalupe Spain. Department of Physical Chemistry Institute of Biotechnology and Excellence Unit in Chemistry Applied to Biomedicine and Environment School of Sciences University of Granada Granada 18071 Spain. Oral Medicine and Pathology Research Unit of Population Health University of Oulu Finland Medical Research Center and Oulu University Hospital Aapistie 3 Oulu FI-90220 Finland Department of Oral and Maxillofacial Diseases University of Helsinki Haartmaninkatu 8 Helsinki FI-0014 Finland Translational Immunology Research Program (TRIMM) and iCAN Digital Precision Cancer Medicine Flagship University of Helsinki Finland Department of Pathology Helsinki University Hospital Helsinki Finland. Health Sciences Faculty Universidad Católica de Murcia (UCAM) Guadalupe Spain Pathology and Clinical Analysis Department Group of Molecular Pathology and Pharmacogenetics Instituto Murciano de Investigación Biosanitaria (IMIB) Hospital Universitario Santa Lucía Cartagena Spain. CERM - Magnetic Resonance Center and Dipartimento di Chimica Università degli Studi di Firenze Via Luigi

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Author Correction: The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer

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Nature immunology 2025年第4期26卷 635页

作者： Jiacheng He Xiaolei Chai Qiansen Zhang Yang Wang Yijie Wang Xinyu Yang Jingbo Wu Bo Feng Jing Sun Weiwei Rui Shuyin Ze Yuanyuan Fu Yumiao Zhao Ying Zhang Yao Zhang Meizhen Liu Chuang Liu Meifu She Xiangfei Hu Xueyun Ma Huaiyu Yang Dawei Li Senlin Zhao Guichao Li Zhen Zhang Zhonghui Tian Yanlin Ma Lingyan Cao Bo Yi Dali Li Ruth Nussinov Charis Eng Timothy A Chan Eytan Ruppin J Silvio Gutkind Feixiong Cheng Mingyao Liu Weiqiang Lu Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences East China Normal University Shanghai China. Department of Urology and Department of Pathology The Fifth People's Hospital of Shanghai Fudan University Shanghai China. Department of General Surgery and Department of Pathology Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China. Research Center for Complexity Sciences Hangzhou Normal University Hangzhou China. Department of Colorectal Surgery Department of Radiation Oncology Fudan University Shanghai Cancer Center Shanghai China. School of Life Sciences Fudan University Shanghai China. Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research Hainan Provincial Clinical Research Center for Thalassemia Department of Reproductive Medicine Key Laboratory of Reproductive Health Diseases Research and Translation (Hainan Medical University) Ministry of Education The First Affiliated Hospital of Hainan Medical University Haikou China. Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine College of Stomatology Shanghai Jiao Tong University Shanghai China. Department of Gastrointestinal Surgery The Third Xiangya Hospital Central South University Changsha China. Computational Structural Biology Section Basic Science Program Frederick National Laboratory for Cancer Research National Cancer Institute at Frederick Frederick MD USA. Department of Human Molecular Genetics and Biochemistry Sackler School of Medicine Tel Aviv University Tel Aviv Israel. Genomic Medicine Institute Lerner Research Institute Cleveland Clinic Cleveland OH USA. Department of Molecular Medicine Cleveland Clinic Lerner College of Medicine Case Western Reserve University Cleveland OH USA. Case Comprehensive Cancer Center Case Western Reserve University School of Medicine Cleveland OH USA. Center for Immunotherapy and Precision Immuno-Oncology Cleveland Clini

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Publisher Correction: A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans

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NPJ Regenerative medicine 2023年第1期8卷 47页

作者： Wencheng Zhang Xicheng Wang Giacomo Lanzoni Eliane Wauthier Sean Simpson Jennifer Ashley Ezzell Amanda Allen Carolyn Suitt Jonah Krolik Alexander Jhirad Juan Dominguez-Bendala Vincenzo Cardinale Domenico Alvaro Diletta Overi Eugenio Gaudio Praveen Sethupathy Guido Carpino Christopher Adin Jorge A Piedrahita Kyle Mathews Zhiying He Lola McAdams Reid Department of Cell Biology and Physiology University of North Carolina (UNC) School of Medicine Chapel Hill NC 27599 USA. Institute for Regenerative Medicine Shanghai East Hospital School of Life Sciences and Technology Tongji University School of Medicine 200123 Shanghai China. Shanghai Engineering Research Center of Stem Cells Translational Medicine 200335 Shanghai China. Shanghai Institute of Stem Cell Research and Clinical Translation 200120 Shanghai China. Diabetes Research Institute Leonard Miller School of Medicine 1450 N.W. 10th Avenue Miami FL 33136 USA. Department of Molecular Biomedical Sciences North Carolina State University (NCSU) College of Veterinary Medicine Raleigh NC 27606 USA. Comparative Medicine Institute NCSU Raleigh NC 27606 USA. Center for Gastrointestinal Biology and Disease (CGIBD) UNC School of Medicine Chapel Hill NC 27599 USA. Department of Medico-Surgical Sciences and Biotechnologies Sapienza University Rome Latina 04100 Italy. Department of Translational and Precision Medicine Sapienza University Rome 00185 Italy. Department of Anatomical Histological Forensic Medicine and Orthopedics Sciences Sapienza University Rome 00161 Italy. Department of Biomedical Sciences Cornell University College of Veterinary Medicine Ithaca NY 14853 USA. pr46@cornell.edu. Department of Anatomical Histological Forensic Medicine and Orthopedics Sciences Sapienza University Rome 00161 Italy. guido.carpino@uniroma1.it. Department of Clinical Sciences Soft Tissue and Oncologic Surgery Service College of Veterinary Medicine NCSU Raleigh NC 27606 USA. adinc@ufl.edu. Department of Small Animal Clinical Sciences University of Florida College of Veterinary Medicine Gainesville FL 32608 USA. adinc@ufl.edu. Department of Molecular Biomedical Sciences North Carolina State University (NCSU) College of Veterinary Medicine Raleigh NC 27606 USA. japiedra@ncsu.edu. Comparative Medicine Institute NCSU Raleigh NC 27606 USA. japiedra@ncsu

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Genomic basis for RNA alterations in cancer (vol 578, pg 129, 2020)

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NATURE 2023年第7948期614卷 E37-E37页

作者： Calabrese, Claudia Davidson, Natalie R. Demircioglu, Deniz Fonseca, Nuno A. He, Yao Lehmann, Kjong-Van Liu, Fenglin Shiraishi, Yuichi Soulette, Cameron M. Urban, Lara Greger, Liliana Li, Siliang Liu, Dongbing Perry, Marc D. Xiang, Qian Zhang, Fan Zhang, Junjun Bailey, Peter Erkek, Serap Hoadley, Katherine A. Hou, Yong Huska, Matthew R. Kilpinen, Helena Korbel, Jan O. Marin, Maximillian G. Markowski, Julia Nandi, Tannistha Pan-Hammarstrom, Qiang Pedamallu, Chandra Sekhar Siebert, Reiner Stark, Stefan G. Su, Hong Tan, Patrick Waszak, Sebastian M. Yung, Christina Zhu, Shida Awadalla, Philip Creighton, Chad J. Meyerson, Matthew Ouellette, B. F. Francis Wu, Kui Yang, Huanming Brazma, Alvis Brooks, Angela N. Goke, Jonathan Ratsch, Gunnar Schwarz, Roland F. Stegle, Oliver Zhang, Zemin European Molecular Biology Laboratory European Bioinformatics Institute Hinxton UK European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany CIBIO/InBIO - Research Center in Biodiversity and Genetic Resources Universidade do Porto Vairão Portugal Berlin Institute for Medical Systems Biology Max Delbruck Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) partner site Berlin Germany German Cancer Research Center (DKFZ) Heidelberg Germany Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) Partner site Berlin Berlin Germany European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Division of Computational Genomics and Systems Genetics German Cancer Research Center (DKFZ) Heidelberg Germany ETH Zurich Zurich Switzerland Memorial Sloan Kettering Cancer Center New York NY USA Weill Cornell Medical College New York NY USA SIB Swiss Institute of Bioinformatics Lausanne Switzerland University Hospital Zurich Zurich Switzerland Computational Biology Center Memorial Sloan Kettering Cancer Center New York NY USA Department of Biology ETH Zurich Zürich Switzerland Department of Computer Science ETH Zurich Zurich Switzerland Korea University Seoul South Korea Computational and Systems Biology Program Memorial Sloan Kettering Cancer Center New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine New York NY USA National University of Singapore Singapore Singapore Genome Institute of Singapore Singapore Singapore Computational and Systems Biology Genome Institute of Singap

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Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population

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Science advances 2025年第23期11卷 eadt0539页

作者： Ting-Yuan Liu Hsing-Fang Lu Yu-Chia Chen Chi-Chou Liao Ying-Ju Lin Jai-Sing Yang Wen-Ling Liao Wei-De Lin Shih-Yin Chen Yu-Chuen Huang Wei-Yong Lin Yu-Huei Liu Kai-Cheng Hsu Shih-Sheng Chang Hong-Da Chen Yu-Pao Chou Jan-Gowth Chang Chung-Hsing Wang Chwen-Tzuei Chang Chung-Ming Huang Kai-Jieh Yeo Tzu-Yuan Wang Chin-Chung Yeh Jiunn-Horng Chen Chi-Ping Huang Hsueh-Chou Lai Rong-Hsing Chen Hui-Ju Lin Po-Yuan Wu Jiu-Yao Wang Chin-Chi Kuo Der-Yang Cho Chang-Hai Tsai Fuu-Jen Tsai Million-person precision medicine initiative Department of Medical Research China Medical University Hospital Taichung 40402 Taiwan. Master Program for Digital Health Innovation China Medical University Taichung 406040 Taiwan. Department of Medical Research China Medical University Hospital Taichung 40402 Taiwan. Genetic Center Department of Medical Research China Medical University Hospital Taichung 40402 Taiwan. School of Post Baccalaureate Chinese Medicine China Medical University Taichung 404333 Taiwan. Graduate Institute of Integrated Medicine College of Chinese Medicine China Medical University Taichung 406040 Taiwan. Center for Personalized Medicine Department of Medical Research China Medical University Hospital Taichung 406040 Taiwan. School of Chinese Medicine China Medical University Taichung 406040 Taiwan. Drug Development Center China Medical University Taichung 406040 Taiwan. Artificial Intelligence Center China Medical University Hospital Taichung 40402 Taiwan. Department of Neurology China Medical University Hospital Taichung 40402 Taiwan. Department of Medicine China Medical University Taichung 406040 Taiwan. Department of Laboratory Medicine China Medical University Hospital Taichung 40402 Taiwan. Department of Bioinformatics and Medical Engineering Asia University Taichung 41300 Taiwan. Department of Medical Laboratory Science and Biotechnology China Medical University Taichung Taiwan. Division of Genetics and Metabolism Children's Hospital of China Medical University Taichung 404447 Taiwan. Intelligent Diabetes Metabolism and Exercise Center Department of Internal Medicine China Medical University Hospital Taichung 40402 Taiwan. Division of Immunology and Rheumatology Department of Internal Medicine China Medical University Hospital Taichung 40402 Taiwan. Division of Endocrine and Metabolism China Medical University Hospital Taichung 40402 Taiwan. Department of Urology China Medical University Hospital Taichung 40402 Taiwan. Cen

We addressed the underrepresentation of non-European populations in genome-wide association studies (GWASs) by building HiGenome, a large-scale genetic resource for the Taiwanese Han population. Using a custom genotyping array, we integrated deidentified electronic medical records (2003 to 2021) with genomic data to enable GWASs, phenome-wide association studies, and polygenic risk score (PRS) analysis. Among 413,000 participants, 323,397 passed ancestry and quality control filtering. GWASs covered 1085 traits, focusing on diseases prevalent in Taiwan such as type 2 diabetes, chronic kidney disease, gout, and alcoholic liver damage. PRSs were calculated for 238 traits, with the strongest associations observed in musculoskeletal disorders. Incorporating PRS into clinical practice supports early risk prediction and personalized prevention. To further expand translational value, we also conducted pharmacogenomic analysis and human leukocyte antigen typing. HiGenome offers a large-scale genetic and clinical dataset from the Taiwanese Han population, supporting population-specific analyses and precision medicine development in East Asia. The hospital-based design enables continuous follow-up and longitudinal data expansion.

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