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Enhanced diabetic wound healing using platelet-derived extracellular vesicles and reduced graphene oxide in polymer-coordinated hydrogels

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Journal of Nanobiotechnology 2023年第1期21卷 1-17页

作者： Hao, Ping-Chien Burnouf, Thierry Chiang, Chih-Wei Jheng, Pei-Ru Szunerits, Sabine Yang, Jen-Chang Chuang, Er-Yuan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei10617 Taiwan Department of Orthopedics Taipei Medical University Hospital Taipei11031 Taiwan Univ. Lille CNRS Centrale Lille Univ. Polytechnique Hauts-de-France UMR 8520 IEMN LilleF- 59000 France Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei110-52 Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei11696 Taiwan Precision Medicine and Translational Cancer Research Center Taipei Medical University Hospital Taipei11031 Taiwan

Impaired wound healing is a significant complication of diabetes. Platelet-derived extracellular vesicles (pEVs), rich in growth factors and cytokines, show promise as a powerful biotherapy to modulate cellular proliferation, angiogenesis, immunomodulation, and inflammation. For practical home-based wound therapy, however, pEVs should be incorporated into wound bandages with careful attention to delivery strategies. In this work, a gelatin-alginate hydrogel (GelAlg) loaded with reduced graphene oxide (rGO) was fabricated, and its potential as a diabetic wound dressing was investigated. The GelAlg@rGO-pEV gel exhibited excellent mechanical stability and biocompatibility in vitro, with promising macrophage polarization and reactive oxygen species (ROS)-scavenging capability. In vitro cell migration experiments were complemented by in vivo investigations using a streptozotocin-induced diabetic rat wound model. When exposed to near-infrared light at 2 W cm− 2, the GelAlg@rGO-pEV hydrogel effectively decreased the expression of inflammatory biomarkers, regulated immune response, promoted angiogenesis, and enhanced diabetic wound healing. Interestingly, the GelAlg@rGO-pEV hydrogel also increased the expression of heat shock proteins involved in cellular protective pathways. These findings suggest that the engineered GelAlg@rGO-pEV hydrogel has the potential to serve as a wound dressing that can modulate immune responses, inflammation, angiogenesis, and follicle regeneration in diabetic wounds, potentially leading to accelerated healing of chronic wounds. © 2023, BioMed Central Ltd., part of Springer Nature.

关键词： Platelets

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Gamma-ray Probe Endoscope using Phoswich structure & Pulse Shape Discrimination system

Gamma-ray Probe Endoscope using Phoswich structure & Pulse S...

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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： M. Park H. Lee S. Song J. Hwang C. Park K. Lee J.-Y. Yeom Department of Bioengineering Korea University Seoul Republic of Korea Interdisciplinary Program in Precision Public Health Korea University Seoul Republic of Korea Global Health-Tech Research Center Korea University Seoul Republic of Korea School of Biomedical Engineering Korea University Seoul Republic of Korea

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

This study focuses on separation of gamma-ray signals, when a high density BGO is used in place of a light guide. The purpose of utilizing BGO instead of the light guide is to shield the GAGG scintillator from background radiation while also acting as a light guide. By using a 1.5mm BGO scintillator, over 87% of side/rear gamma rays were found to interact with BGO rather than GAGG. Gamma radiation interacting with GAGG from the front and the signals interacting with BGO from the side/rear can be separated using our pulse shape discrimination (PSD) method. In addition, unlike the conventional gamma-ray PSD method that processes with raw signals, our method can separate signals processed through CSA using rising time discrimination. By shielding side/rear gamma rays, the structural/spatial limitations of detectors such as the 3 mm diameter flexible gamma probe endoscope being developed by our research team, which limits the use shielding materials, can be overcome.

关键词： Microwave integrated circuits Scintillators Shape Endoscopes Semiconductor detectors Gamma-rays Probes

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Performance Evaluation of Cs3Cu2I5 Perovskite Scintillator Grown by Seedless SEST Method

Performance Evaluation of Cs3Cu2I5 Perovskite Scintillator G...

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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： S. Song J. Seo M. Park J.-Y. Yeom Department of Bioengineering Korea University Seoul Republic of Korea Interdisciplinary Program in Precision Public Health Korea University Seoul Republic of Korea Department of Health and Safety Convergence Science Korea University Seoul Republic of Korea School of Biomedical Engineering Korea University Seoul Republic of Korea

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

In this study, we utilized the seedless Slow evaporation solution growth technique (SEST) method to grow Cs 3 Cu 2 I 5 , a 0-D perovskite scintillator material, at room temperature. The growth was conducted under conditions of 23°C temperature and 40% humidity for 10 days, resulting in obtaining multiple crystals of 5 mm in size. Using single crystal Cs 3 Cu 2 I 5 detectors grown in our lab, we evaluated its performance using radioactive isotopes ${ }^{137} \mathrm{Cs},{ }^{241} \mathrm{Am},{ }^{54} \mathrm{Mn},{ }^{60} \mathrm{Co},{ }^{22} \mathrm{Na}$, and ${}^{57}\mathrm{Co}$, and acquired energy resolutions of 8.55%, 23.35%, 7.59%, 6.49%, 9.38%, and 16.8%, respectively. In comparison with polycrystalline counterparts, single crystal Cs 3 Cu 2 I 5 exhibited superior performance, although both demonstrated excellent characteristics. By comparison, measurement using GAGG:Ce as a reference scintillator with the same setup showed an energy resolution of 10.00 %.

关键词： Temperature measurement Performance evaluation Semiconductor device measurement Microwave integrated circuits Scintillators Temperature Semiconductor detectors

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Opto-thermoelectric pulling of light-absorbing particles

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Light(Science & Applications) 2020年第1期9卷 1686-1696页

作者： Linhan Lin Pavana Siddhartha Kollipara Abhay Kotnala Taizhi Jiang Yaoran Liu Xiaolei Peng Brian A.Korgel Yuebing Zheng Walker Department of Mechanical Engineering The University of Texas at AustinAustinTX 78712USA Materials Science&Engineering Program and Texas Materials Institute The University of Texas at AustinAustinTX 78712USA State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084People’s Republic of China McKetta Department of Chemical Engineering The University of Texas at AustinAustinTX 78712USA Department of Electrical and Computer Engineering The University of Texas at AustinAustinTX 78712USA

Optomechanics arises from the photon momentum and its exchange with low-dimensional *** is well known that optical radiation exerts pressure on objects,pushing them along the light ***,optical pulling of an object against the light path is still a counter-intuitive ***,we present a general concept of optical pulling-opto-thermoelectric pulling(OTEP)—where the optical heating of a light-absorbing particle using a simple plane wave can pull the particle itself against the light *** irradiation orientation-directed pulling force imparts self-restoring behaviour to the particles,and three-dimensional(3D)trapping of single particles is achieved at an extremely low optical intensity of 10^(−2)mWμm^(−2).Moreover,the OTEP force can overcome the short trapping range of conventional optical tweezers and optically drive the particle flow up to a macroscopic *** concept of selfinduced opto-thermomechanical coupling is paving the way towards freeform optofluidic technology and lab-on-achip devices.

关键词： absorbing light trapping

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Intelligent Phase Contrast Meta-Microscope System

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Nano Letters 2023年第24期23卷 11630-11637页

作者： Chu, Cheng Hung Chia, Yu-Hsin Hsu, Hung-Chuan Vyas, Sunil Tsai, Chen-Ming Yamaguchi, Takeshi Tanaka, Takuo Chen, Huei-Wen Luo, Yuan Yang, Pan-Chyr Tsai, Din Ping YongLin Institute of Health National Taiwan University Taipei10672 Taiwan Institute of Medical Device and Imaging National Taiwan University Taipei10051 Taiwan Department of Biomedical Engineering National Taiwan University Taipei10051 Taiwan Department of Mechanical Engineering National Taiwan University Taipei10617 Taiwan Innovative Photon Manipulation Research Team RIKEN Center for Advanced Photonics Saitama351-0198 Japan Graduate Institute of Toxicology College of Medicine National Taiwan University Taipei100 Taiwan Genome and Systems Biology Degree Program National Taiwan University and Academia Sinica Taipei100 Taiwan Program for Precision Health and Intelligent Medicine National Taiwan University Taipei106319 Taiwan Department of Internal Medicine National Taiwan University Hospital National Taiwan University Taipei10002 Taiwan Institute of Biomedical Sciences Academia Sinica Taipei11529 Taiwan Department of Electrical Engineering City University of Hong Kong Kowloon999077 Hong Kong Centre for Biosystems Neuroscience and Nanotechnology City University of Hong Kong Kowloon999077 Hong Kong The State Key Laboratory of Terahertz and Millimeter Waves City University of Hong Kong Kowloon99907 Hong Kong

Phase contrast imaging techniques enable the visualization of disparities in the refractive index among various materials. However, these techniques usually come with a cost: the need for bulky, inflexible, and complicated configurations. Here, we propose and experimentally demonstrate an ultracompact meta-microscope, a novel imaging platform designed to accomplish both optical and digital phase contrast imaging. The optical phase contrast imaging system is composed of a pair of metalenses and an intermediate spiral phase metasurface located at the Fourier plane. The performance of the system in generating edge-enhanced images is validated by imaging a variety of human cells, including lung cell lines BEAS-2B, CLY1, and H1299 and other types. Additionally, we integrate the ResNet deep learning model into the meta-microscope to transform bright-field images into edge-enhanced images with high contrast accuracy. This technology promises to aid in the development of innovative miniature optical systems for biomedical and clinical applications. © 2023 American Chemical Society.

关键词： Microscopes

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TiCu-CMC/PDA coatings with long-term antimicrobial activity and cytocompatibility for surface engineering of implants

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Surface and Coatings Technology 2025年 509卷

作者： Zheng, Xiaosong Jiang, Yehao Zheng, Fazhan Xiang, Long Zhou, Lili Liang, Wenlang Huang, Nan Leng, Yongxiang Akhavan, Behnam Jing, Fengjuan Institute of Biomedical Engineering College of Medicine Southwest Jiaotong University Sichuan Chengdu610031 China Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University Chengdu610031 China School of Engineering University of Newcastle CallaghanNSW2308 Australia Precision Medicine Program New Lambton HeightsNSW2305 Australia School of Biomedical Engineering University of Sydney SydneyNSW2006 Australia School of Physics University of Sydney SydneyNSW2006 Australia Sydney Nano Institute University of Sydney SydneyNSW2006 Australia

Long-term antibacterial effects and favourable biocompatibility are crucial to sustaining the long-term application of medical devices such as cardiac implantable devices, orthopedic devices, hernia meshes, and catheters. This study reports the development of sodium carboxymethyl cellulose/polydopamine films on Ti[sbnd]Cu coatings (TiCu-CMC/PDA) with long-term antimicrobial effects and cytocompatibility for surface engineering of implants. The TiCu-CMC/PDA coatings demonstrate sustained antimicrobial efficacy, maintaining bacterial inhibition rates above 99.6 % after aging in simulated body fluid (SBF) at 37 °C for 60 days. This remarkable antibacterial performance is primarily driven by the controlled release of copper ions during aging, complemented by surface copper's contribution to antimicrobial effects. Further, the TiCu-CMC/PDA coatings exhibit high cell viability and proliferation with negligible cytotoxicity, attributed to the regulated copper ion release. However, the endothelial cell viability on TiCu-CMC/PDA coatings decreased with aging due to the formation of copper ion complexes and CuO/Cu(OH)2, as well as increased surface roughness and hydrophilicity over time. The technology offers a simple and controllable approach to fabricating TiCu-CMC/PDA coatings, providing a pathway for the design of long-term antibacterial biomedical devices, including cardiovascular and orthopedic implants. © 2024

关键词： Antibiotics

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Effect of sputtering power and thickness ratios on the materials properties of Cu-W and Cu-Cr bilayer thin films using high power impulse magnetron and DC magnetron sputtering

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Journal of Vacuum Science and Technology A: Vacuum, Surfaces and Films 2024年第5期42卷

作者： Nguyen, Tra Anh Khoa Huang, Yu Dang, Nhat Minh Lin, Chi-Han Chen, Wei-Chieh Wang, Zhao-Ying Lin, Ming-Tzer Graduate Institute of Precision Engineering National Chung Hsing University Taichung402 Taiwan Faculty of Mechanical Engineering Ho Chi Minh City University of Technology and Education Ho Chi Minh71307 Viet Nam ASML Technology Taiwan Ltd HsinChu300 Taiwan Industrial and Smart Technology Program Academy of Circular Economy National Chung Hsing University Nantou540 Taiwan

This study investigates the influence of Cu thickness ratios on the structural, morphological, and mechanical properties of sputtered Cu-W and Cu-Cr bilayer thin films. Employing high power impulse magnetron sputtering (HiPIMS), five distinct thickness ratios of 1:3, 3:5, 1:1, 5:3, and 3:1 were analyzed and compared to bilayer films developed using direct current magnetron sputtering (DCMS). The microstructural and surface characteristics of these films were evaluated using x-ray diffraction (XRD), atomic force microscopy, and scanning electron microscopy. Electrical properties were measured using a four-point probe, while mechanical properties were assessed through nanoindentation. Results reveal that increasing Cu thickness in Cu-W and Cu-Cr bilayers inversely affects hardness, grain size, and roughness, highlighting the influence of thickness ratios on film properties. Films with a higher Cu thickness ratio in both Cu-W and Cu-Cr bilayer systems deposited by HiPIMS exhibited lower hardness, smaller grain size, and reduced average roughness. Cross-sectional analysis and XRD confirmed the impact of thickness ratio on crystal phase and microstructure, indicating smoother columnar structures. Specifically, the HiPIMS-deposited Cu-Cr 3-1 film exhibited the lowest resistivity, at 4.77 μΩ cm, and hardness, measuring 8.26 GPa. Moreover, the 1:1 ratio films of Cu-W and Cu-Cr demonstrated hardness values of 13.81 and 11.37 GPa, respectively, which were 1.39 times higher than the films grown by DCMS. Additionally, variations in the bilayer thickness ratio significantly affected the electrical properties of the films. The enhanced properties of HiPIMS films are attributed to the higher peak power density of the target, leading to increased ion energy and deposition of dense grain structures. © 2024 Author(s).

关键词： Thin films

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MIRROR: miRNA regulation-level differential network to study sex and ethnic disparities in cancer

MIRROR: miRNA regulation-level differential network to study...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Caterina Alfano Marco Filetti Lorenzo Farina Manuela Petti Dept. of Experimental Medicine Sapienza University of Rome Rome Italy Phase 1 Unit Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Dept. of Computer Control and Management Engineering PhD Program in Network Oncology and Precision Medicine Sapienza University of Rome Rome Italy Dept. of Computer Control and Management Engineering Sapienza University of Rome Rome Italy

ISBN: (数字)9798350371499

ISBN: (纸本)9798350371505

Cancer disparities are adverse differences in cancer measures that exist among certain population groups. Given that the role they play not only in the disease prognosis but also in therapy response, there is an urgent need to understand what causes them. Most studies investigate these disparities by analyzing transcriptomic data and in particular miRNAs for their regulatory role, but only focusing on expression levels. To face this challenge we propose MIRROR, a new method which analyzes a differential co-expression network of miRNAs between patients’ cohorts, to study the role they play at the target genes’ level. Doing so, we can study the altered molecular mechanism that are linked to cancer disparities. The application of MIRROR to two different cases of cancer disparities has demonstrated its efficacy in identifying molecular players involved in the considered disparity, presenting itself as a viable option to approach this challenge.

关键词： Proteins Technological innovation Transcriptomics Medical treatment Focusing Mirrors Prostate cancer Prognostics and health management Faces Cancer

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Review Integration of smartphone technology and artificial intelligence for advanced ophthalmic care:A systematic review

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Advances in Ophthalmology Practice and Research 2024年第3期4卷 120-127页

作者： Kai Jin Yingyu Li Hongkang Wu Yih Chung Tham Victor Koh Yitian Zhao Ryo Kawasaki Andrzej Grzybowski Juan Ye Eye Center The Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang Provincial Key Laboratory of OphthalmologyZhejiang Provincial Clinical Research Center for Eye DiseasesZhejiang Provincial Engineering Institute on Eye DiseasesHangzhouChina Centre for Innovation and Precision Eye Health National University of SingaporeSingapore Department of Ophthalmology National University of SingaporeSingapore Singapore Eye Research Institute Singapore National Eye CentreSingapore Ophthalmology and Visual Science Academic Clinical Program Duke-NUS Medical SchoolSingapore Cixi Institute of Biomedical Engineering Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboChina Ningbo Eye Hospital NingboChina Zhejiang International Scientific and Technological Cooperative Base of Biomedical Materials and Technology Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboChina Zhejiang Engineering Research Center for Biomedical Materials Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboChina Division of Public Health Department of Social MedicineGraduate School of MedicineOsaka UniversityOsakaJapan Artificial Intelligence Center for Medical Research and Application Osaka University HospitalOsakaJapan Institute for Research in Ophthalmology Foundation for Ophthalmology DevelopmentPoznanPoland

Background:The convergence of smartphone technology and artificial intelligence(AI)has revolutionized the landscape of ophthalmic care,offering unprecedented opportunities for diagnosis,monitoring,and management of ocular ***,there is a lack of systematic studies on discussing the integration of smart-phone and AI in this *** text:This review includes 52 studies,and explores the integration of smartphones and AI in ophthalmology,delineating its collective impact on screening methodologies,disease detection,telemedicine initiatives,and patient *** collective findings from the curated studies indicate promising performance of the smartphone-based AI screening for various ocular diseases which encompass major retinal diseases,glaucoma,cataract,visual impairment in children and ocular surface ***,the utilization of smartphone-based imaging modalities,coupled with AI algorithms,is able to provide timely,efficient and cost-effective screening for ocular *** modality can also facilitate patient self-monitoring,remote patient monitoring and enhancing accessibility to eye care services,particularly in underserved *** involving data pri-vacy,algorithm validation,regulatory frameworks and issues of trust are still need to be ***,evaluation on real-world implementation is imperative as well,and real-world prospective studies are currently ***:Smartphone ocular imaging merged with AI enables earlier,precise diagnoses,personalized treat-ments,and enhanced service accessibility in eye *** is crucial to navigate ethical and data security challenges while responsibly leveraging these innovations,promising a potential revolution in care access and global eye health equity.

关键词： Artificial intelligence Smartphone imaging Ophthalmology Telemedicine Ocular disease management

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Highly efficient mRNA transfection with droplet cell squeezing for cellular engineering

Highly efficient mRNA transfection with droplet cell squeezi...

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IEEE International Conference on Nano/Molecular Medicine and engineering (NANOMED)

作者： Ju-Hee Lee Aram Chung Department of Bioengineering Korea University 02841 Seoul Republic of Korea Interdisciplinary Program in Precision Public Health (PPH) Korea University 02841 Seoul Republic of Korea School of Biomedical Engineering Korea University 02841 Seoul Republic of Korea MxT Biotech 04785 Seoul Republic of Korea

We present a novel droplet-based intracellular delivery platform for mRNA transfection. The platform leverages the use of two immiscible fluids to encapsulate a cell and external cargos within a single droplet. The formed droplets travel a narrow z-axis stepwise constriction, smaller than the cell diameter, exerting a physical opening of the cell membrane. Consequently, the platform enables highly effective internalization of cargo into the cell through a combination of diffusive and convective flow. The presented microfluidic approach offers high mRNA transfection efficiency (>98%) with nearly clog-free operation. These results highlight the platform’s potential as a next-generation microfluidics-based intracellular delivery system, showcasing its capacity to achieve both exceptional delivery efficiency and high-throughput capabilities for cell therapy applications.

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