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Functional Peptide-Loaded Gelatin Nanoparticles as Eyedrops for Cornea Neovascularization Treatment

International Journal of Nanomedicine 2023年 18卷 1413-1431页

作者： Chu, Ya-Chun Fang, Hsu-Wei Wu, Yu-Yi Tang, Yu-Jun Hsieh, Erh-Hsuan She, Yizhou Chang, Che-Yi Lin, I-Chan Chen, Yin-Ju Liu, Guei-Sheung Tseng, Ching-Li Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei City Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei City Taiwan Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Miaoli County Taiwan School of Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei City Taiwan Department of Ophthalmology Wan Fang Hospital Taipei Medical University Taipei City Taiwan Department of Ophthalmology School of Medicine College of Medicine Taipei Medical University Taipei City Taiwan Department of Radiation Oncology Taipei Medical University Hospital Taipei City Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei City Taiwan Center for Precision Medicine and Translational Cancer Research Taipei Medical University Hospital Taipei City Taiwan Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital East Melbourne VIC Australia Ophthalmology Department of Surgery University of Melbourne East Melbourne VIC Australia Menzies Institute for Medical Research University of Tasmania Hobart TAS Australia Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei City Taiwan

Background: Corneal neovascularization (NV) is a process of abnormal vessel growth into the transparent cornea from the limbus and can disturb the light passing through the cornea, resulting in vision loss or even blindness. The use of nanomedicine as an effective therapeutic formulation in ophthalmology has led to higher drug bioavailability and a slow drug release rate. In this research, we designed and explored the feasibility of a new nanomedicine, gp91 ds-tat (gp91) peptide-encapsulated gelatin nanoparticles (GNP-gp91), for inhibiting corneal angiogenesis. Methods: GNP-gp91 were prepared by a two-step desolvation method. The characterization and cytocompatibility of GNP-gp91 were analyzed. The inhibition effect of GNP-gp91 on HUVEC cell migration and tube formation was observed by an inverted microscope. The drug retention test in mouse cornea was observed by in vivo imaging system, fluorescence microscope, and DAPI/TAMRA staining. Finally, the therapeutic efficacy and evaluation of neovascularization-related factors were conducted through the in vivo corneal NV mice model via topical delivery. Results: The prepared GNP-gp91 had a nano-scale diameter (550.6 nm) with positive charge (21.7 mV) slow-release behavior (25%, 240hr). In vitro test revealed that GNP-gp91 enhanced the inhibition of cell migration and tube formation capacity via higher internalization of HUVEC. Topical administration (eyedrops) of the GNP-gp91 significantly prolongs the retention time (46%, 20 min) in the mouse cornea. In chemically burned corneal neovascularization models, corneal vessel area with a significant reduction in GNP-gp91 group (7.89%) was revealed when compared with PBS (33.99%) and gp91 (19.67%) treated groups via every two days dosing. Moreover, GNP-gp91 significantly reduced the concentration of Nox2, VEGF and MMP9 in NV’s cornea. Conclusion: The nanomedicine, GNP-gp91, was successfully synthesized for ophthalmological application. These data suggest that GNP-gp91 contain

关键词： control release corneal neovascularization eye drops gelatin gp91 peptide nanoparticles ocular retention

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Safety,dosimetry,and efficacy of an optimized long-acting somatostatin analog for peptide receptor radionuclide therapy in metastatic neuroendocrine tumors:From preclinical testing to first-in-human study

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Acta Pharmaceutica Sinica B 2025年第2期15卷 707-721页

作者： Wei Guo Xuejun Wen Yuhang Chen Tianzhi Zhao Jia Liu Yucen Tao Hao Fu Hongjian Wang Weizhi Xu Yizhen Pang Liang Zhao Jingxiong Huang Pengfei Xu Zhide Guo Weibing Miao Jingjing Zhang Xiaoyuan Chen Haojun Chen Department of Nuclear Medicine and Minnan PET Center Xiamen Key Laboratory of Radiopharmaceuticalsthe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361102China School of Clinical Medicine Fujian Medical UniversityFuzhou 350005China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen 361102China Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore 138667Singapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore 138667Singapore Nanomedicine Translational Research Program NUS Center for NanomedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore 138667Singapore Department of Nuclear Medicine the First Affiliated HospitalFujian Medical UniversityFuzhou 350005China Department of Nuclear Medicine National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhou 350212China Fujian Key Laboratory of Precision Medicine for Cancer the First Affiliated HospitalFujian Medical UniversityFuzhou 350005China

Peptide receptor radionuclide therapy(PRRT)with radiolabeled SSTR2 agonists is a treatment option that is highly effective in controlling metastatic and progressive neuroendocrine tumors(NETs).Previous studies have shown that an SSTR2 agonist combined with albumin binding moiety Evans blue(denoted as^(177)Lu-EB-TATE)is characterized by a higher tumor uptake and residence time in preclinical models and in patients with metastatic *** study aimed to enhance the in vivo stability,pharmacokinetics,and pharmacodynamics of^(177)Lu-EB-TATE by replacing the maleimide-thiol group with a polyethylene glycol chain,resulting in a novel EB conjugated SSTR2-targeting radiopharmaceutical,^(177)Lu-LNC1010,for *** preclinical studies,^(177)Lu-LNC1010 exhibited good stability and SSTR2-binding affinity in AR42J tumor cells and enhanced uptake and prolonged retention in AR42J tumor ***,we presented the first-in-human dose escalation study of^(177)Lu-LNC1010 in patients with advanced/metastatic NETs.^(177)Lu-LNC1010 was well-tolerated by all patients,with minor adverse effects,and exhibited significant uptake and prolonged retention in tumor lesions,with higher tumor radiation doses than those of^(177)*** PRRT efficacy results showed an 83%disease control rate and a 42%overall response rate after two^(177)Lu-LNC1010 treatment *** encouraging findings warrant further investigations through multicenter,prospective,and randomized controlled trials.

关键词： Radiolabeled somatostatin analog Neuroendocrine tumor Evans blue ^(177)Lu-LNC1010 Peptide receptor radionuclide therapy First-in-human dose escalation study

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High-Resolution Hydrogen Molecule Detection Utilizing a Nanocandle-Based Optical Sensor

High-Resolution Hydrogen Molecule Detection Utilizing a Nano...

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Pacific Rim Conference on Lasers and Electro-Optics (CLEO/Pacific Rim)

作者： Nu-Ri Park Min-Joong Kim Jongsu Lee Minah Seo Yong-Sang Ryu Myung-Ki Kim KU-KIST Graduate School of Converging Science and Technology Korea University Seoul Republic of Korea Sensor System Research Center Korea Institute of Science and Technology Seoul Republic of Korea Department of Electrical Engineering and Computer Science Northwestern University Evanston IL USA School of Biomedical Engineering Korea University Seoul Republic of Korea Interdisciplinary Program in Precision Public Health Korea University Seoul Republic of Korea

Our research introduces a novel method for safe hydrogen detection. We've developed an advanced nano-candle sensor, combining Pd with nano-candles, enabling accurate detection of low-concentration hydrogen (<3%... 详细信息

ISBN: (数字)9798350372076

ISBN: (纸本)9798350372083

关键词： Electric potential Accuracy Hydrogen Lasers and electrooptics Optical sensors Electro-optical waveguides

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Deep learning for Proportion Estimation of Target Radionuclides in Extreme Environment

Deep learning for Proportion Estimation of Target Radionucli...

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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： M. Park J. Hwang J.-Y. Yeom C. Kim Department of Bioengineering Korea University Seoul Republic of Korea Korea University Interdisciplinary Program in Precision Public Health Seoul Republic of Korea Global Health-Tech Research Center Korea University Seoul Republic of Korea School of Biomedical Engineering Korea University Seoul Republic of Korea Korea Atomic Energy Research Institute Daejeon Republic of Korea

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

We propose a deep learning-based approach utilizing a 1D Convolutional Neural Network to accurately estimate the proportions of target radionuclides, 137Cs and 133Ba, within mixed gamma-ray spectra, even under extreme conditions of high temperature and radiation. Our results demonstrated high precision, with Mean Absolute Error (MAE) values below 5% for each target radionuclide in standard testing conditions. Remarkably, even when 54Mn-a radionuclide not included in the training phase-was introduced as noise, the model’s performance remained robust, with error rates kept below 9%. This underscores the model’s capability to deliver accurate radionuclide quantification, despite the presence of unfamiliar spectral noise, affirming its substantial utility for nuclear safety in complex environments.

关键词： Training Semiconductor device modeling Microwave integrated circuits Semiconductor detectors Error analysis Noise Gamma-rays

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Label-Free and Liquid State Sers Detection of Multi-Scaled Bioanalytes Via Light-Induced Pinpoint Colloidal Assembly

SSRN

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SSRN 2024年

作者： Han, Seungyeon Park, Junhee Moon, Sunghyun Eom, Seonghyeon Jin, Chang Min Kim, Seungmin Ryu, Yong-Sang Choi, Yeonho Lee, Jong Bum Choi, Inhee Department of Life Science University of Seoul Seoul02504 Korea Republic of Department of Chemical Engineering University of Seoul Seoul02504 Korea Republic of Department of Biomedical Engineering Korea University Seoul02481 Korea Republic of Interdisciplinary Program in Precision Public Health Korea University Seoul02481 Korea Republic of Exopert Corporation Seoul02580 Korea Republic of Department of Applied Chemistry University of Seoul Seoul02504 Korea Republic of

Surface-enhanced Raman scattering (SERS) has been extensively applied to detect complex analytes due to its ability to enhance the fingerprint signals of molecules around nanostructured metallic surfaces. Thus, it is essential to design SERS-active nanostructures with abundant electromagnetic hotspots in a probed volume according to the dimensions of the analytes, as the analytes must be located in their hotspots for maximum signal enhancement. Herein, we demonstrate a simple method for detecting robust SERS signals from multi-scaled bioanalytes, regardless of their dimensions in the liquid state, through a photothermally driven co-assembly with colloidal plasmonic nanoparticles as signal enhancers. Under resonant light illumination, plasmonic nanoparticles and analytes in the solution quickly assemble at the focused surface area by convective movements induced by the photothermal heating of the plasmonic nanoparticles without any surface modification. Such collective assemblies of plasmonic nanoparticles and analytes were optimized by varying the optical density and surface charge of the nanoparticles, the viscosity of the solvent, and the light illumination time to maximize the SERS signals. Using these light-induced co-assemblies, the intrinsic SERS signals of small biomolecules can be detected down to nanomolar concentrations based on their fingerprint spectra. Furthermore, large-sized biomarkers, such as viruses and exosomes, were successfully detected without labels, and the complexity of the collected spectra was statistically analyzed using t-distributed stochastic neighbor embedding combined with support vector machine (t-SNE+SVM). The proposed method is expected to provide a robust and convenient method to sensitively detect biologically and environmentally relevant analytes at multiple scales in liquid samples. © 2024, The Authors. All rights reserved.

关键词： Viruses

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Silicon–metal and silicon–silicon ultrafast laser welding with domesticated filaments 17

Silicon–metal and silicon–silicon ultrafast laser welding ...

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Laser-based Micro- and Nanoprocessing XVII 2023

作者： Chambonneau, Maxime Li, Qingfeng Blothe, Markus Fedorov, Vladimir Yu. Tzortzakis, Stelios Nolte, Stefan Friedrich Schiller University Jena Institute of Applied Physics Abbe Center of Photonics Albert-Einstein-Straße 15 Jena07745 Germany Science Program Texas A&M University at Qatar P.O. Box 23874 Doha Qatar P.O. Box 1527 HeraklionGR-71110 Greece Materials Science and Technology Department University of Crete Heraklion71003 Greece Fraunhofer Institute for Applied Optics and Precision Engineering Albert-Einstein-Straße 7 Jena07745 Germany

ISBN: (纸本)9781510659230

We demonstrate for the first time ultrafast laser welding in the silicon–metal and silicon–silicon configurations, with focused infrared picosecond pulses. This achievement relies on accurate characterizations of filamentation in silicon with nonlinear propagation imaging. In the silicon–metal configuration, precompensating for the nonlinear focal shift prior to the welding yields bonding strengths > 1 MPa. By combining this filament relocation technique with metallic nanolayer deposition at the interface to exalt the energy deposition, similar bonding strength values are obtained in the silicon–silicon configuration. © 2023 SPIE.

关键词： Silicon

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Materials’ properties of low temperature deposited Cu/W and Cu/Cr multilayer thin films using high power impulse magnetron sputtering

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Journal of Vacuum Science and Technology A: Vacuum, Surfaces and Films 2024年第3期42卷

作者： Huang, Yu Nguyen, Tra Anh Khoa Dang, Nhat Minh Wang, Hao-Yu Lin, Ming-Tzer Graduate Institute of Precision Engineering National Chung Hsing University Taichung402 Taiwan REMElab Faculty of Mechanical Engineering Ho Chi Minh City University of Technology and Education Ho Chi Minh70000 Viet Nam Taiwan ASML Technology Taiwan Ltd. Hsinchu City300 Taiwan Industrial and Smart Technology Program Academy of Circular Economy National Chung Hsing University Nantou540 Taiwan

In this study, copper/tungsten (Cu/W) and copper/chromium (Cu/Cr) multilayers were created by stacking bilayer films in a 3:1 ratio, with layer thicknesses ranging from 400 to 800 nm, deposited on Si (100) substrates using high power impulse magnetron sputtering (HiPIMS). The microstructural and surface properties of these films were examined through x-ray diffraction, atomic force microscopy, and scanning electron microscopy. Electrical properties were assessed using a four-point probe, while mechanical properties were measured via nanoindentation. Both multilayer systems showed a decrease in the hardness accompanied by an increase in the elastic modulus with each stacking bilayer. The Cu/W system experienced a gradual hardness reduction (down to 19%), compared to the Cu/Cr system, which exhibited a similar decrease (14.5%). The Cu/W and Cu/Cr multilayer film samples consistently demonstrate a softer nature compared to their bilayer counterparts due to the influence of the underlying Cu soft layers. A distinctive surface smoothness in these multilayer systems correlates with the elastic modulus in a manner unlike that with hardness. These multilayer films also demonstrated altered electrical resistivity, enhancing our understanding and capabilities in fabricating films with an increased number of layers. © 2024 Author(s).

关键词： Multilayer films

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Smart Residential Parking

Smart Residential Parking

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International Conference on Informatics and Computational Sciences (ICICoS)

作者： Suhartono Jung-Lung Chiang Maria Mahardini Sakanti C. Bambang Dwi Kuncoro Ph.D. Program Prospective Technology of Electrical Engineering and Computer Science National Chin-Yi University of Technology Taichung Taiwan R.O.C Graduate Institute of Precision Manufacturing National Chin-Yi University of Technology Taichung Taiwan R.O.C Department of Refrigeration Air Conditioning and Energy Engineering National Chin-Yi University of Technology Taichung Taiwan R.O.C

ISBN: (数字)9798350375886

ISBN: (纸本)9798350375893

This research aims to create a smart residential system that will improve parking management in residential areas using mini-server technology. Another aim is to provide a safe and effective smart parking solution for residential areas with limited capacity. This research method uses mini-server technology and control to create smart system ideas. Apart from that, this research also uses servo motor technology, proximity sensors, cameras, and IoT applications for smart parking management. The result is the creation of intelligent residential parking management, which uses a Raspberry Pi 5 Model B as a server and control to improve the parking management system in residential areas, and the use of number plate recognition technology to be applied to Smart City. This further research offers a new perspective on creating intelligent parking solutions using two input validation parameters simultaneously, namely facial and license plate recognition

关键词： Smart cities Automated parking Servers Security Internet of Things Usability Servomotors

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FIB-DIC ring-core measurement of the residual stress on HiPIMS W/Cu and Cr/Cu multilayer thin films

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Surface and Coatings Technology 2024年 483卷

作者： Zeng, Zhen-Yi Nguyen, Tra Anh Khoa Dang, Nhat Minh Wu, Xiu-Wei Chen, Terry Yuan-Feng Lin, Ming-Tzer Graduate Institute of Precision Engineering National Chung Hsing University Taichung402 Taiwan REMElab Faculty of Mechanical Engineering Ho Chi Minh City University of Technology and Education Ho Chi Minh70000 Viet Nam Taiwan Semiconductor Manufacturing Co. Ltd. HsinChu300 Taiwan Department of Mechanical Engineering National Cheng Kung University Tainan70101 Taiwan Industrial and Smart Technology Program Academy of Circular Economy National Chung Hsing University Nantou 540 Taiwan

Residual stress in multilayer coatings is a complex phenomenon influenced by layer number and thickness, layer and substrate materials, deposition technique, process parameters, and working pressure. It is crucial to realize these stresses because they have a significant impact on the performance and reliability of multilayer structures in their applications. The measurement of the residual stress on multilayer thin films locally and globally is crucial. This study employed ring-core milling residual stress measurement on the High-Power Impulse Magnetron Sputtering (HiPIMS) fabricated Tungsten/Copper (W/Cu) Chromium/Copper (Cr/Cu) multilayer thin films. The displacement transformation strain was analyzed using Focused Ion Beam (FIB) ring-core milling combined with Digital Image Correlation (DIC), and the strain stress transformation calibration coefficients were analyzed through Finite Element Method (FEM) to investigate the residual stress of the thin films layer by layer. The study results indicated that the hard thin films (W, Cr) were the main source of residual stress in the multilayer thin film structure, while the soft thin film (Cu) had a lower residual stress. Having Cu as the intermediate layer was found to be effective for controlling the residual stress of thin films. The hard thin films encapsulated by the soft thin films had smaller stress values than those with hard films on the surface. In addition, the study observes the stress gradient and distribution at different depths and locations on the sample to reveal process parameters to balance between the soft and hard thin films and could help to predict the location of the damage on the multilayer thin films caused by higher stress. © 2024 Elsevier B.V.

关键词： Multilayers

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A Study on the Application Design of Soil Moisture Diffusion and Crop Roots According to Subsurface Irrigation Method

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Journal of Biosystems engineering 2021年第3期46卷 197-205页

作者： Kim, Jin Hyun Kim, Tae Wook Kim, Seol Ha Lee, Hwang Gyu Eum, Duk Ho Lee, Sang Hun Department of Precision Mechanical Engineering Kyungpook National University Sangju37224 Korea Republic of Young Engineering Education Program for Multidisciplinary Smart Disaster Management Kyungpook National University Sangju37224 Korea Republic of Nam Kyung Co. Ltd. 497-48 Chorok-Ro Yanggam-Myeon Gyeonggido 445-932 Hwaseong18626 Korea Republic of Department of Southern Area Crop Science National Institute of Crop Science Rural Development Administration Miryang50424 Korea Republic of

Purpose: Global climate change has increased drought frequency and caused significant damage to agricultural industries worldwide;for example, soybean yield has decreased by 30% on small-scale farms. Therefore, the development of subsurface irrigation methods, which conserve both water and labor, is urgently needed for open-field cropping systems. Although water and nutrient supply through subsurface irrigation shows clear advantages, the specific design of these irrigation systems relies on empirical data rather than systematic research and practical optimization. Because of irregularities and uncertainties in field soil conditions, the theoretical approach for water diffusion in soil frequently could give a wrong range of data to an irrigation system. In this study, the water diffusion by means of a commercial subsurface irrigation system has been experimentally tested in several soil types to get practical application and understand the water diffusion performance. Methods: In the present study, to better understand the shape of the subsurface diffusion plume in an open-field soybean crop during irrigation, we supplied 4 L of water through 3 mm vertical tubes using three types of dripper, at transfer rates of 2, 4, and 8 L/h. A map of the wetted soil near the dripper showed that the optimal water supply depends on the growth stage of the soybeans. Results: Subsurface irrigation testing was conducted on well-graded sand containing clay (SWC: sand well + sand clay) and poorly graded sand (SP: sand plastic). As both SWC and SP showed that the wetted area rises well upward to the ground surface from the dripping point with 2 L/h supply, it is considered that 2 L/h case is effective for water absorption by the roots of the crops. Besides, the size of the grown root of 30 days showed 450 mm of width and 300 mm of depth, so it was estimated that 150 mm wide and 100 mm deep after 10 days, and 300 mm wide and 200 mm deep after 20 days. Judging from the results of the root

关键词： Soil moisture

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