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652. Foodborne outbreak investigation at a wedding event – Batken, Kyrgyzstan, June 2022

Open Forum Infectious Diseases 2023年第SUPPLEMENT_2期10卷

作者： Timur Dautov Nasyat Kemelbek Marina Malisheva Dinagul Otorbaeva Roberta Horth Dilyara Nabirova Central Asia Field Epidemiology Training Program Gulcha Osh Kyrgyzstan US Centers for Disease Control and Prevention Dulles Virginia CDC Central Asia office Almaty Almaty Kazakhstan

Background On August 2nd, 2022, local health departments were informed that over a hundred people had sought care or reported gastrointestinal illness after attending the same wedding event in Batken, Kyrgyzstan, on July 30th. We investigated to identify the source and associated risk factors to stop transmission.

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2463. Bacterial Infections in Intensive Care Unit patients in a large general hospital, Kazakhstan, 2022

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Open Forum Infectious Diseases 2023年第SUPPLEMENT_2期10卷

作者： Ademi Yergaliyeva Saya Gazezova Gulzhan Ayapova Elvira Ibragimova Dilyara Nabirova Roberta Horth Central Asia Field Epidemiology Training Program Almaty Almaty Kazakhstan CDC Central Asia office Almaty Almaty Kazakhstan US Centers for Disease Control and Prevention Dulles Virginia

Background Between January and April 2022, an audit of surveillance data revealed five cases of bloodstream Acinetobacter baumannii infection in intensive care unit (ICU) patients in a large general hospital. Bacterial infections such as Acinetobacter baumannii contribute to significant mortality and complications of treatment in ICU patients. We aimed to describe bacterial pathogens and their resistance profile among ICU patients to inform infection prevention and control programs.

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Engagement of TLR and Dectin-1/Syk Signaling Is Required for Activation of Notch Targets in Dendritic Cells

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Infectious Microbes & Diseases 2021年第2期3卷 101-108页

作者： Yuna Zhao Chanyang Ju Karmen Au Jimmy Zhu Baohong Zhao Yingli Shang Xiaoyu Hu Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention College of Veterinary MedicineShandong Agricultural UniversityTaianShandongChina Arthritis and Tissue Degeneration Program Hospital for Special SurgeryNew YorkNYUSA Department of Medicine Weill Cornell MedicineNew YorkNYUSA Institute for Immunology and School of Medicine Tsinghua UniversityBeijingChina Tsinghua-Peking Centre for Life Sciences BeijingChina Beijing Key Laboratory for Immunological Research on Chronic Diseases BeijingChina

Pattern-recognition receptors,such as toll-like receptors(TLRs),detect a wide range of microbial products and initiate innate immune responses leading to the production of inflammatory *** addition,TLR signaling also activates expression of Notch target genes that play crucial roles in suppression of TLR-triggered inflammatory ***,whether TLR signaling pathways engaged by other classes of pattern-recognition receptors induce expression of Notch target genes remains *** we demonstrate that zymosan,a stimulus for TLR2 and dectin-1,strongly induces expression of multiple Notch target genes in both human and murine dendritic ***,induction of Notch targets by zymosan is both TLR2-and Syk-dependent through activation of mitogen-activated protein kinases and the transcription factor ***,our data reveals a novel mechanism that efficient induction of Notch target genes requires engagement of TLR and dectin-1/Syk signaling pathways.

关键词： dectin-1 dendritic cell Notch targets toll-like receptor zymosan Introduction

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Hair product use and urinary biomarker concentrations of non-persistent endocrine disrupting chemicals among reproductive-aged Black women

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Chemosphere 2024年 361卷 142442页

作者： Schildroth, Samantha Geller, Ruth J. Wesselink, Amelia K. Lovett, Sharonda M. Bethea, Traci N. Claus Henn, Birgit Harmon, Quaker E. Taylor, Kyla M. Calafat, Antonia M. Wegienka, Ganesa Gaston, Symielle A. Baird, Donna D. Wise, Lauren A. Department of Epidemiology Boston University School of Public Health BostonMA United States Office of Minority Health & Health Disparities Research Georgetown Lombardi Comprehensive Cancer Institute Washington DC United States Department of Environmental Health Boston University School of Public Health BostonMA United States National Institute of Environmental Health Sciences DurhamNC United States National Toxicology Program National Institute of Environmental Health Sciences NC United States Division of Laboratory Sciences Centers for Disease Control and Prevention AtlantaGA United States Henry Ford Health System Detroit MI United States

Background: Studies have shown an association between hair product use and adverse health outcomes. Scientists have hypothesized that exposure to endocrine-disrupting chemicals (EDCs) drives these associations, but few studies have directly evaluated associations between hair product use and biomarkers of EDCs. Even more limited are studies of Black women, who frequently use EDC-containing products (e.g., hair relaxers). Objective: We estimated associations between hair product use and EDC biomarker concentrations. Methods: We leveraged cross-sectional data from the Study of Environment, Lifestyle, and Fibroids, a cohort of females aged 23–34 years who self-identified as Black/African American from the Detroit-metropolitan area (USA;n = 425). On structured questionnaires, participants reported their past 24-h and past 12-month use of hair products, including relaxers/straighteners/perms, styling products, moisturizers, oils, and hair food. We quantified urinary concentrations of 19 phthalate/phthalate alternative metabolites, 7 phenols, and 4 parabens using high performance liquid chromatography isotope dilution tandem mass spectrometry. EDC biomarker concentrations were creatinine-adjusted and natural log-transformed. We used multivariable linear regression to estimate mean percent differences in EDC biomarker concentrations and 95% confidence intervals (CIs) associated with hair product use, adjusting for sociodemographic confounders. Results: Hair product use was associated with greater concentrations of multiple EDC biomarkers. Notably, use of hair products in the previous 24 h (compared with non-use) was associated with 16.2% (95% CI = 0.7%, 35.9%), 35.0% (95% CI = 2.6%, 77.6%), and 32.3% (95% CI = 8.8%, 92.0%) higher concentrations of mono-isobutyl phthalate, methyl paraben, and ethyl paraben, respectively. Use of hair relaxers/straighteners/perms, styling products, moisturizers, oils, and hair food in the past 12 months was also associated with higher concent

关键词： Phenols

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Characteristics of survivors enrolled in the World Trade Center Health program

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Archives of Environmental Health: An International Journal 2024年第5-6期79卷

作者： Ruiling Liu Albeliz Santiago-Colón Emma Butturini Travis L. Kubale Joan Reibman a World Trade Center Health Program National Institute for Occupational Safety and Health (NIOSH) Centers for Disease Control and Prevention (CDC) Atlanta GA USA b New York University Langone Medical Center New York NY USA

The World Trade Center (WTC) Health program is a limited federal health care program that provides medical monitoring and treatment for WTC-related health conditions to responders and survivors impacted by the terrorist attacks on September 11, *** study described the characteristics of the program survivor members (who lived, worked, went to school, daycare or adult daycare or present in the New York City Disaster Area of 9/11/2001) to stimulate innovative ideas for improving healthcare services, generate new research interest, and serve as a reference for future research on this population. Administrative and medical claims data collected from the program start date (07/01/2011) through 2022 were used. As of 12/31/2022, there were 37,384 enrolled survivors: 5.0% were aged ≤21 years on 9/11/2001, 45.9% females, and 31.2% non-Hispanic Whites. A total of 24,148 (64.6%) were certified for at least one WTC-related condition, including neoplasms (36.0%), aerodigestive disorders (35.6%) and mental health conditions (18.6%); 22.9% were certified for more than one category. Certification rates of some WTC-related conditions differed by sex, age and race/ethnicity. WTC survivor population is diverse in sex, age and race/ethnicity, with a high proportion certified for certain WTC-related health conditions, providing great opportunities for research in various areas.

关键词： World Trade Center Health program WTC-related health conditions WTC survivors WTC youth

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2389. Surveillance evaluation of COVID-19 pharmacovigilance—Karakalpakstan, Uzbekistan, 2022

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Open Forum Infectious Diseases 2023年第SUPPLEMENT_2期10卷

作者： Yunis Tursinov Botirjon Kurbanov Alfiya Denebayeva Roberta Horth Dilyara Nabirova Central Asia Field Epidemiology Training Program Нукус Qoraqalpoghiston Uzbekistan Sanitary-Epidemiological Tranquility and Public Health Committee Tashkent Uzbekistan Tashkent Toshkent Uzbekistan Almaty City Center for Prevention and Control of AIDS HIV Center Kazakhstan Almaty Almaty Kazakhstan US Centers for Disease Control and Prevention Dulles Virginia CDC Central Asia office Almaty Almaty Kazakhstan

Background COVID-19 vaccines are safe and effective. Rapid rollout of vaccines reduced COVID-19 morbidity and mortality globally. Pharmacovigilance systems have ensured safety of these vaccines. Well-functioning vaccine safety surveillance builds public confidence in vaccine programs, but these systems may be lacking in limited-resource settings. To identify gaps in pharmacovigilance surveillance, we conducted an evaluation in Khojaly District, Uzbekistan, with population of 120 thousand people.

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The World Trade Center Health program: Cancer screening and cancer care best practices

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Archives of Environmental Health: An International Journal 2023年第4期78卷

作者： Geoffrey M. Calvert Gerald Lilly John Cochran a World Trade Center Health Program National Institute for Occupational Safety and Health (NIOSH) Centers for Disease Control and Prevention (CDC) Cincinnati OH USA b Optum Serve LaCrosse WI USA

The events of September 11, 2001 (9/11) exposed nearly a half million persons to many carcinogenic chemicals and dusts, as well as psychological and physical stressors. Subsequent epidemiologic studies of 9/11-exposed persons have suggested elevated risks for some cancers, e.g., prostate cancer, thyroid cancer, and melanoma. To detect cancer at an early stage, the US Preventive Services Task Force recommends screening certain asymptomatic persons for lung, colorectal, cervical and breast cancer, but not for other cancers. High quality cancer diagnosis and treatment guidelines are available from the National Comprehensive Cancer Network and the National Cancer Institute. For enrolled members, the WTC Health program provides coverage for cancer screening and diagnosis, and covers medically necessary treatment costs for all types of cancer, assuming 9/11-exposure and minimum latency requirements are met, and a program-affiliated physician attests that 9/11 exposures were substantially likely to have been a significant factor in aggravating, contributing to, or causing the enrolled WTC member’s cancer.

关键词： 9/11 breast cancer cancer cancer screening cervical cancer colorectal cancer latency lung cancer pulmonary nodule World Trade Center

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Clinical Validation of a Personalized NHL-TME Model System: One-on-One Comparison between Modeled Drug Responses and Patients' Clinical Responses

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Blood 2024年 144卷 2214-2214页

作者： Shazia K. Nakhoda Pin Lu Tingwei Guo Denise Connelly Marcus Messmer Zachary AK Frosch Henry C. Fung Asya Varshavsky Yanovsky Y. Lynn Wang Fox Chase Cancer Center Philadelphia PA Department of Hematology/Oncology； Cancer Prevention and Control Research Program Fox Chase Cancer Center Philadelphia PA Fox Chase Cancer Center Temple University Health System Philadelphia PA

Background Clinical outcomes for patients with non-Hodgkin lymphoma (NHL) are highly variable depending on patient characteristics, pathologic features, and genomic abnormalities. Despite efforts to personalize treatment decisions using next-generation sequencing, success has been limited due to the substantial genomic heterogeneity observed even among tumors of the same histologic subtype. To address the unmet needs of personalized treatment of NHL, we established ex vivo tumor microenvironment (TME) models by co-culturing bone marrow fibroblasts (BMF) plus B-cell growth factors with tumor cells from individual CLL patients (Lu et al. Blood Cancer J 2021 ). Proliferation centers in the lymph nodes are the major histological sites for CLL pathogenesis, progression, and transformation (Soma et al. Hum Pathol, 2006 ). Our ex vivo TME models, with their ability to promote CLL proliferation, recapitulate this most salient cell behavior observed in vivo. In our initial validation with a cohort of 31 CLL patients, ex vivo drug responses ( EVR ) demonstrated strong correlation with individual patients' clinical responses to ibrutinib. Sensitive patients' cells exhibited sensitivity in the system, while resistant patients' cells behaved resistant. In our current study, we present additional validations of this model system, incorporating genomic and cytogenetic analyses, along with clinical correlations in patients with other NHL histologies, including Richter-transformed CLL and MCL. Methods & Results We found in our previous study (Lu et al) that the co-cultured CLL cells show characteristics typical of lymph node-resident CLL cells, including larger cell size and decreased cell surface CXCR4. Single cell RNA sequencing technology confirmed the downregulation of CXCR4 at the mRNA level. In addition, the co-cultured CLL cells exhibited increased MYC and E2F gene signatures, further supporting the fidelity of the ex vivo system in mimicking the lymph node TME. Additionally,

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Cancer screening information-seeking before and during the COVID-19 pandemic

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Preventive Oncology & Epidemiology 2024年第1期2卷

作者： Heather Platter Adaora Ezeani Travis Hyams Grace C. Huang William M.P. Klein Robin C. Vanderpool a Cancer Prevention Fellowship Program Division of Cancer Prevention National Cancer Institute National Institutes of Health Rockville MD USAb Office of the Associate Director Behavioral Research Program Division of Cancer Control and Population Sciences National Cancer Institute National Institutes of Health Rockville MD USA c Health Behaviors Research Branch Behavioral Research Program Division of Cancer Control and Population Sciences National Cancer Institute National Institutes of Health Rockville MD USA d Office of the Director Division of Cancer Control and Population Sciences National Cancer Institute National Institutes of Health Rockville MD USA e Public Health and Epidemiology Westat Rockville MD USA b Office of the Associate Director Behavioral Research Program Division of Cancer Control and Population Sciences National Cancer Institute National Institutes of Health Rockville MD USA f Health Communication and Informatics Research Branch Behavioral Research Program Division of Cancer Control and Population Sciences National Cancer Institute National Institutes of Health Rockville MD USA

BackgroundThe COVID-19 pandemic disrupted routine cancer screening; however, it is unclear whether the public’s cancer screening information-seeking behaviors changed. Our study examined cancer screening information-seeking before and after pandemic onset using data from the National Cancer Institute’s Cancer Information *** analyzed screening inquiries from general public users before (3/27/19–3/26/20) and after (3/27/20–3/26/21) pandemic onset. We examined point of access, subjects of interaction, and *** were more general public cancer screening inquiries made post-pandemic onset (n= 1069; 56.1%) compared to before (n= 837, 43.9%). Although the proportion of breast cancer screening inquiries increased after pandemic onset, inquiries for cervical, colorectal, and other cancers decreased. Telephone inquiries increased, whereas email and instant chat inquiries decreased. Inquiries regarding finding healthcare services and managing costs increased, whereas screening tests and other subjects decreased. Referrals increased for the National Breast and Cervical Cancer Early Detection program and other national/community organizations. All differences were significant atp≤ .*** found potentially important changes in cancer screening information-seeking after pandemic onset, including increasing interest in breast cancer screening, yet decreasing interest in other cancer screening tests. Future work should evaluate how public health crises affect information seeking and influence intentions to screen for cancer.

关键词： Health information-seeking cancer screening COVID-19 pandemic

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Development and Feasibility testing of a Highly Anti-Inflammatory Indian-Adapted Mediterranean Diet for Coronary Artery Disease Patients

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Indian Heart Journal 2024年 76卷 S25-S26页

作者： Ambuj Roy Archna Singh Megha Suresh Anudeep P. P Sherry Price Sabiha Khan Kamar Ali Neha Bakshi James R. Hebert Suparna Ghosh Jerath Department of Cardiology AIIMS New Delhi India Department of Biochemistry AIIMS New Delhi India Connecting Health Innovations LLC Columbia SC USA Cancer Prevention and Control Program Arnold School of Public Health University of South Carolina

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