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Rapid discovery and classification of inhibitors of coronavirus infection by pseudovirus screen and amplified luminescence proximity homogeneous assay

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ANTIVIRAL RESEARCH 2023年第0期209卷 000-000页

作者： Jeong, Kwiwan Chang, JuOae Park, Sun-mi Kim, Jinhee Jeon, Sangeun Kim, Dong Hwan Kim, Young-Eui Lee, Joo Chan Im, Somyoung Jo, Yejin Min, Ji-Young Lee, Hanbyeul Yeom, Minjoo Seok, Sang-Hyuk On, Da In Noh, Hyuna Yun, Jun-Won Park, Jun Won Song, Daesub Seong, Je Kyung Kim, Kyung-Chang Lee, Joo-Yeon Park, Hyun-Ju Kim, Seungtaek Nam, Tae-gyu Lee, Wonsik Gyeonggido Business & Sci Accelerator Bioctr Suwon South Korea Sungkyunkwan Univ Sch Pharm Dept Pharm Suwon South Korea Inst Pasteur Korea Seongnam South Korea Hanyang Univ Dept Pharm Ansan South Korea Hanyang Univ Inst Pharmaceut Sci & Technol Ansan South Korea Natl Inst Infect Dis Natl Inst Hlth Ctr Emerging Virus Res Korea Dis Control & Prevention Agcy Cheongju South Korea Seoul Natl Univ Coll Vet Med Dept Vet Med Virol Lab Seoul South Korea Seoul Natl Univ Res Inst Vet Sci Dept Vet Med Virol Lab Seoul South Korea Kangwon Natl Univ Coll Biomed Sci Div Biomed Convergence Chunchon South Korea Seoul Natl Univ Coll Vet Med BK21 Program Vet Sci Res Inst Vet SciLab Dev Biol & Gen Seoul South Korea Seoul Natl Univ Korea Mouse Phenotyping Ctr KMPC Seoul South Korea Seoul Natl Univ Coll Vet Med Lab Vet Toxicol Seoul South Korea Seoul Natl Univ Program Canc Biol Interdisciplinary Program Bioinformat Seoul South Korea Seoul Natl Univ BIOMAX N Bio Inst Seoul South Korea

To identify potent antiviral compounds, we introduced a high-throughput screen platform that can rapidly classify hit compounds according to their target. In our platform, we performed a compound screen using a lentivirus-based pseudovirus presenting a spike protein of coronavirus, and we evaluated the hit compounds using an amplified luminescence proximity homogeneous assay (alpha) test with purified host receptor protein and the receptor binding domain of the viral spike. With our screen platform, we were able to identify both spike-specific compounds (class I) and broad-spectrum antiviral compounds (class II). Among the hit compounds, thiosemicarbazide was identified to be selective to the interaction between the viral spike and its host cell receptor, and we further optimized the binding potency of thiosemicarbazide through modification of the pyridine group. Among the class II compounds, we found raloxifene and amiodarone to be highly potent against human coronaviruses including Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and SARS-CoV-2. In particular, using analogs of the benzothiophene moiety, which is also present in raloxifene, we have identified benzothiophene as a novel structural scaffold for broad-spectrum antivirals. This work highlights the strong utility of our screen platform using a pseudovirus assay and an alpha test for rapid identi-fication of potential antiviral compounds and their mechanism of action, which can lead to the accelerated development of therapeutics against newly emerging viral infections.

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Reply to FJB van Duijnhoven et al

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Advances in nutrition (Bethesda, Md.) 2020年第1期11卷 179-180页

作者： James R Hébert Nitin Shivappa Michael D Wirth James R Hussey Thomas G Hurley From the Cancer Prevention and Control Program University of South Carolina Columbia SC USA. Department of Epidemiology and Biostatistics Arnold School of Public Health University of South Carolina Columbia SC USA. College of Nursing University of South Carolina Columbia SC USA.

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Comment se déroule la surveillance des décès maternels dans un district au Cameroun ? A propos du cas du district sanitaire de Deïdo, région du Littoral, 2017

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Revue d'Épidémiologie et de Santé Publique 2022年 70卷 S215-S216页

作者： M.W. Nwaha Nwaha G. Kouamen L. Esso G.A. Etoundi E. Mathieu Cameroon Field Epidemiology Training Program Cameroun Ministère de la Santé Publique Cameroun Workforce and Institution Development Branch Division of Global Health Protection Center for Global Health Centers for Disease Control and Prevention (CDC) Atlanta USA

Contexte Au Cameroun, le ratio de mortalité maternelle était estimé en 2011 à 782 décès pour 100 000 naissances vivantes. La surveillance des décès maternels (DM) a dé...

Contexte Au Cameroun, le ratio de mortalité maternelle était estimé en 2011 à 782 décès pour 100 000 naissances vivantes. La surveillance des décès maternels (DM) a débuté en 2014. Cependant, elle se heurte aux problèmes de sous-notification des cas et de mauvaise qualité des données. L'objectif de cette étude était d'évaluer le système de surveillance des DM dans le DS de Deïdo. Méthodes Les directives de CDC ont été utilisées pour l'évaluation des systèmes de surveillance. L'étude s'est déroulée de janvier à décembre 2017 dans huit fosas choisis par convenance dans le DS de Deïdo. Les données étaient recueillies auprès de tous les points focaux surveillance (PFS) des DM, des formulaires hebdomadaires des fosa et des registres des salles de travail et d'accouchement, des services d'hospitalisation, de chirurgie, et d'urgence. Des « score cards » ont été élaborées pour évaluer la qualité, la sensibilité, l'acceptabilité et l'utilité des données. Les données étaient analysées via les logiciels EPI Info et Microsoft Excel. Résultats Des neuf PFS des DM interrogés, six étaient des sages-femmes et huit énonçaient exactement la définition de DM. Sur les 62 DM enregistrés dans les registres de trois des huit fosas choisis par convenance, 61 % (38/62) ont été signalés au système. Le temps pour remplir un formulaire était jugé long pour deux répondants ; 78 % (324/417) fiches de notification examinées étaient correctement remplies et 80 % (373/468) de ces fiches étaient envoyées à temps au District. La surveillance des DM faisait partie du travail quotidien des neufs PFS. Le suivi des DM a conduit le DS à sensibiliser les fosas de niveau inférieur sur la référence rapide des urgences obstétricales. Discussion/Conclusion Malgré une faible sensibilité, la surveillance des DM est réactive, utile et acceptée par le personnel. Cependant, elle doit être dynamisée par une formation continue du personnel pour améliorer la notification de ces décès. Déclaration de liens d'intérêts L

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Climate-influenced vector-borne diseases in Africa:a call to empower the next generation of African researchers for sustainable solutions

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Infectious Diseases of Poverty 2024年第2期13卷 83-92页

作者： Judicaël Obame-Nkoghe Adjoavi Esse Agossou Gerald Mboowa Basile Kamgang Cyril Caminade Dawn C.Duke Andrew Karanja Githeko Obed M.Ogega Nestor Engone Elloué Fatou Bintou Sarr DieudonnéNkoghe Pierre Kengne Nicaise T.Ndam Christophe Paupy Moses Bockarie Patricks Voua Otomo Molecular and Cellular Biology Laboratory(LabMC) Biology DepartmentUniversity of Science and Technology of MasukuBP 901FrancevilleGabon Ecology and Health Research Unit Interdisciplinary Center for Medical Research of FrancevilleBP 769FrancevilleGabon Department of Zoology and Entomology Faculty of Natural and Agricultural SciencesUniversity of the Free StatePrivate Bag x13Phuthaditjhaba 9866Republic of South Africa Laboratory of Pharmacology and Improved Traditional Medicines Department of Animal PhysiologyFaculty of Science and TechnologyUniversity of Abomey-CalaviBP 526CotonouBenin The African Center of Excellence in Bioinformatics and Data-Intensive Sciences Infectious Diseases InstituteCollege of Health SciencesMakerere UniversityP.O Box 22418KampalaUganda Africa Centers for Disease Control and Prevention African Union CommissionRoosevelt StreetP.O.Box 3243W21 K19 Addis AbabaEthiopia Centre for Research in Infectious Diseases P.O.Box 13591YaoundéCameroon Earth System Physics Department The Abdus Salam International Centre for Theoretical PhysicsTriesteItaly Africa Research Excellence Fund 99 Charterhouse StreetLondon EC1M 6HRUK Community Health Support Program P.O.Box 872Kisumu 40100Kenya The African Academy of Sciences NairobiKenya Center for Phylosophical Studies and Research(CERP) Omar Bongo University(UOB)BP 13131LibrevilleGabon UMRED Health Training and Research UnitUniversity of Iba Der Thiam of ThièsBP 967ThièsSenegal National Parasitic Diseases Control Program Ministry of HealthLibrevilleGabon MIVEGEC Univ.MontpellierCNRSIRDMontpellierFrance MERIT IRDParis CitéUniversity75006 ParisFrance Department of Parasitology Noguchi Memorial Institute for Medical ResearchUniversity of GhanaLG 54AccraGhana School of Community Health Sciences Njala UniversityBoSierra Leone

We look at the link between climate change and vector-borne diseases in low-and middle-income countries in *** large endemicity and escalating threat of diseases such as malaria and arboviral diseases,intensified by climate change,disproportionately affects vulnerable communities *** highlight the urgency of prioritizing research and development,advocating for robust scientific inquiry to promote adaptation strategies,and the vital role that the next generation of African research leaders will play in addressing these *** significant challenges such as funding shortages within countries,various pan-African-oriented funding bodies such as the African Academy of Sciences,the Africa Research Excellence Fund,the Wellcome Trust,the *** Institutes of Health,and the Bill and Melinda Gates Foundation as well as initiatives such as the African Research Initiative for Scientific Excellence and the Pan-African Mosquito control Association,have empowered(or are empowering)these researchers by supporting capacity building activities,including continental and global networking,skill development,mentoring,and African-led *** article underscores the urgency of increased national investment in research,proposing the establishment of research government agencies to drive evidence-based *** between governments and scientific communities,sustained by pan-African funding bodies,is *** these efforts,African nations are likely to enhance the resilience and adaptive capacity of their systems and communities by navigating these challenges effectively,fostering scientific excellence and implementing transformative solutions against climate-sensitive vector-borne diseases.

关键词： Climate change Vector-borne diseases Africa Environmental justice Research and development Pan-African funding initiatives

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2456. Methicillin-Resistant Staphylococcus aureus Bacteremia 30-Day Mortality During 2020 Compared to 2016-2019: Assessing the Impact of COVID-19

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Open Forum Infectious Diseases 2023年第SUPPLEMENT_2期10卷

作者： Holly Biggs Kelly A Jackson Joelle Nadle Susan Petit Susan M Ray Ghinwa Dumyati Marissa Tracy Tiffanie M Markus William Schaffner Isaac See CDC Atlanta Georgia U.S. Centers for Disease Control and Prevention Atlanta Georgia California Emerging Infections Program Oakland California Connecticut Department of Public Health Hartford Connecticut Emory University School of Medicine Atlanta Georgia New York Emerging Infections Program and University of Rochester Medical Center Rochester New York University of Rochester Medical Center Rochester New York Vanderbilt University Medical Center Nashville Tennessee

BackgroundMethicillin-resistantStaphylococcus aureus(MRSA) bacteremia is associated with substantial mortality, but the effect of the COVID-19 pandemic on MRSA mortality has not been fully explored.

Background Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is associated with substantial mortality, but the effect of the COVID-19 pandemic on MRSA mortality has not been fully explored.

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1038. Assessment of risk factors for coronavirus disease 2019 in healthcare workers: a nested case-control study, Bishkek, Kyrgyzstan, June 2020-May 2021

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Open Forum Infectious Diseases 2022年第SUPPLEMENT_2期9卷

作者： Venera Alymkulova Dilyara Nabirova Nasyat Kemelbek kyzy Dinara Otorbaeva Chynar Zhumalieva Nazgul Abamuslimova Central Asia Field Epidemiology Training Program Bishkek Kyrgyzstan Bishkek Bishkek Kyrgyzstan US Centers for Disease Control and Prevention Regional Office of Central Asia Almaty Kazakhstan Almaty Almaty Kazakhstan Department of Disease Prevention and State Sanitary and Epidemiological Supervision Bishkek Kyrgyzstan Bishkek Bishkek Kyrgyzstan Republican Scientific and Practical Center for Infectious Control of Scientific and Production Association &quot Preventive Medicine&quot Bishkek Kyrgyzstan Bishkek Bishkek Kyrgyzstan

Background Despite infection control and mitigation measures against coronavirus disease (COVID-19) in Kyrgyzstan hospitals, 3173 healthcare workers (HCW) had been diagnosed with COVID-19 by September 2020 (22 COVID-19 cases/100 HCW). We aimed to identify risks for COVID-19 among HCW exposed to COVID-19 patients in Bishkek.

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1654. Analysis of Prescribing Patterns for Respiratory Tract Illnesses Following the Conclusion of an Education and Feedback Intervention

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Open Forum Infectious Diseases 2022年第SUPPLEMENT_2期9卷

作者： James J Harrigan Keith W Hamilton Leigh Cressman Warren B Bilker Kathleen Degnan David Tran Michael Z David David A Pegues Lauren Dutcher University of the Hospital of Pennsylvania Philadelphia Pennsylvania University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania University of Pennsylvania Philadelphia Pennsylvania Independent Contractor Philadelphia Pennsylvania Hospital of the University of Pennsylvania Philadelphia Pennsylvania for the Centers for Disease Control and Prevention (CDC) Epicenters Program

Background We previously conducted a study in primary care practices assessing the impact of an educational session paired with peer comparison feedback on antibiotic prescribing, demonstrating a reduction in overall prescribing for respiratory tract diseases (RTDs). However, the lasting effects of this intervention on antibiotic prescribing patterns without ongoing feedback are unknown.

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The World Trade Center Health program: Obstructive sleep apnea best practices

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Archives of Environmental Health: An International Journal 2023年第4期78卷

作者： Iris G. Udasin Jag Sunderram Geoffrey Calvert a World Trade Center Health Program Clinical Center of Excellence Environmental and Occupational Health Sciences Institute Rutgers Biomedical and Health Sciences Piscataway NJ USA b Division of Pulmonary and Critical Care Medicine Department of Medicine Rutgers Robert Wood Johnson Medical School New Brunswick NJ USA c World Trade Center Health Program National Institute for Occupational Safety and Health (NIOSH) Centers for Disease Control and Prevention (CDC) Cincinnati OH USA

The events of September 11, 2001 exposed nearly half a million community residents and workers engaged in rescue and recovery and clean-up to dust, debris and toxic chemicals, as well as psychologic and physical stressors. Early studies showed an excess of aerodigestive diseases including rhinosinusitis and gastroesophageal reflux. Several studies of World Trade Center (WTC) responders report an excess of obstructive sleep apnea among patients who developed new onset or worsening chronic rhinosinusitis. High quality clinical diagnostic and treatment guidelines are available from The American Academy of Sleep Medicine and the Department of Veterans Affairs/Department of Defense. For enrolled members, the WTC program covers diagnostic evaluation and treatment for sleep apnea in members diagnosed with WTC-related upper and lower respiratory disease and gastroesophageal reflux.

关键词： Occupational diseases adults respiratory diseases workers

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THE EFFECT OF AN ANTI-INFLAMMATORY DIET FOR KNEE OSTEOARTHRITIS (FEAST) TRIAL: BASELINE CHARACTERISTICS AND RELATIONSHIPS WITH DIETARY INFLAMMATORY INDEX

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Osteoarthritis and Cartilage 2025年 33卷 S500-S501页

作者： Lynette Law Josh Heerey Brooke L. Devlin Peter Brukner Alysha De Livera Amanda Attanayake Indiana Cooper Amy Donato James Hebert Sherry Price Nathan White Adam Culvenor La Trobe Sport and Exercise Medicine Research Centre School of Allied Health Human Services and Sport La Trobe University Melbourne Victoria Australia School of Human Movement and Nutrition Sciences University of Queensland Brisbane Queensland Australia Cancer Prevention and Control Program Department of Epidemiology and Biostatistics Arnold School of Public Health University of South Carolina Columbia South Carolina United States Melbourne Knee Centre Melbourne Victoria Australia

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2314. Hospitalizations and Antibiotic Use in the Year Prior to an Incident C. difficile Infection for Medicare Beneficiaries in Four States, 2016–2018

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Open Forum Infectious Diseases 2022年第SUPPLEMENT_2期9卷

作者： Kelly M Hatfield James Baggs Sujan Reddy Rasaki Aranmolate James Meek Scott Fridkin Jill Szydlowski Trupti T Hatwar Ghinwa Dumyati Jasmine Watkins Christopher Wilson L Clifford McDonald John A Jernigan Alice Guh Centers for Disease Control and Prevention Atlanta Georgia CDC Atlanta GA Connecticut Emerging Infections Program New Haven Connecticut Emory University School of Medicine Atlanta GA University of Rochester Medical Center Pittsford New York Tennessee Department of Health Nashville Tennessee

Background Studies describing risk factors for Clostridioides difficile infection (CDI) are often limited in their ability to identify potentially important exposures occurring long before diagnosis. We describe hospitalizations and antibiotic use (AU) occurring up to one year prior to CDI diagnosis among Medicare beneficiaries.

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