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*** aureusBacteremia Treatment: Results From Pilot Surveillance in Four US States

Open Forum Infectious Diseases 2018年第SUPPL_1期5卷 S316–S317页

作者： Kabbani, Sarah Jackson, Kelly Epstein, Lauren Gellert, Anita Bernu, Carmen Overton, Rahsaan Nadle, Joelle Dumyati, Ghinwa Lynfield, Ruth Ray, Susan M Epson, Erin See, Isaac Division of Healthcare Quality Promotion Centers for Disease Control and Prevention Atlanta Georgia NY Emerging Infections Program Center for Community Health and Prevention University of Rochester Medical Center Rochester New York Minnesota Department of Health St. Paul Minnesota Georgia Emerging Infections Program Atlanta Georgia California Emerging Infections Program Oakland California University of Rochester Medical Center Rochester New York Emory University School of Medicine Atlanta Georgia Healthcare-Associated Infections Program California Department of Public Health Richmond California

BackgroundStaphylococcus aureustreatment guidelines are being revised to include proposed quality measures for evaluation of patients withS. aureusbacteremia (SAB) (e.g., infectious disease [ID] consultation, echocard...

Background Staphylococcus aureus treatment guidelines are being revised to include proposed quality measures for evaluation of patients with S. aureus bacteremia (SAB) (e.g., infectious disease [ID] consultation, echocardiogram, and documenting clearance of bacteremia). We describe current management practices of SAB to identify opportunities for quality improvement. Methods We conducted a pilot assessment of SAB cases reported to CDC’s Emerging Infections program active, laboratory- and population-based surveillance from 24 hospitals in four states during 1–2 months in 2017 or 2018. An SAB case was the isolation of S. aureus from a blood culture among adults (≥18 years) in the catchment area. We collected clinical and demographic information and performed a descriptive analysis of management of SAB cases. Results Among 109 SAB cases identified, 50 (46%) were methicillin-resistant S. aureus (MRSA). While hospitalized, 87 (80%) patients were evaluated by ID consultation, 90 (83%) underwent an echocardiogram (26 were transesophageal), and 92 (84%) had documented clearance of bacteremia. During the hospitalization, 15 (14%) died and 12 (11%) left against medical advice (AMA). Of those who survived and did not leave AMA, median duration of hospitalization after initial culture was 10.5 days (interquartile range 7–18). In total, 10 survivors (9% of cases) completed at least 2 weeks of antibiotics while hospitalized, and 65 (60% of cases) were discharged on antibiotic therapy. Among the 25 MRSA patients discharged on antibiotics, common treatments were vancomycin (64%), daptomycin (8%), ceftaroline (8%), and linezolid (4%). Among the 40 methicillin-susceptible SAB patients discharged on antibiotics, cefazolin (56%), ceftriaxone (13%), cefepime (5%), linezolid (5%), nafcillin (3%), and vancomycin (3%) were most common. The remainder of outpatient treatments included oral β-lactams, clindamycin, doxycycline, levofloxacin, and erythromycin. Conclusion Overall, the majority o

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746. Characteristics of Respiratory Syncytial Virus (RSV) Infection Among Hospitalized Adults, United States, 2014–2017

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Open Forum Infectious Diseases 2018年第SUPPL_1期5卷 S268–S268页

作者： Kim, Lindsay Cikesh, Bryanna Kirley, Pam Daily Anderson, Evan J Eckel, Seth Como-Sabetti, Kathryn Dufort, Elizabeth M Felsen, Christina B Crawford, Courtney Talbot, H Keipp Langley, Gayle E Gerber, Susan I Division of Viral Diseases Centers for Disease Control and Prevention Atlanta Georgia California Emerging Infections Program Oakland California Emerging Infections Program Atlanta Veterans Affairs Medical Center Atlanta Georgia Pediatrics and Medicine Emory University School of Medicine Atlanta Georgia Communicable Disease Division Michigan Department of Health and Human Services Lansing Michigan Minnesota Department of Health St. Paul Minnesota Division of Epidemiology New York State Department of Health Albany New York NY Emerging Infections Program Center for Community Health and Prevention University of Rochester Medical Center Rochester New York Acute and Communicable Disease Prevention Section Oregon Health Authority Portland Oregon Vanderbilt University Medical Center Nashville Tennessee Respiratory Diseases Branch Centers for Disease Control and Prevention Atlanta Georgia

BackgroundRespiratory syncytial virus (RSV) vaccines are in clinical development for older adults. We described RSV infections among adults requiring hospitalization and risk factors for severe outcomes using a popula...

Background Respiratory syncytial virus (RSV) vaccines are in clinical development for older adults. We described RSV infections among adults requiring hospitalization and risk factors for severe outcomes using a population-based platform, the Influenza Hospitalization Surveillance Network (FluSurv-NET). Methods Surveillance occurred October 1–April 30 (2014–2017) at sites located in seven states (California, Georgia, Michigan, Minnesota, New York, Oregon, and Tennessee) covering an annual catchment population of up to 13 million adults ≥18 years. Laboratory-confirmed RSV cases were identified using hospital and state public health laboratories, hospital infection preventionists, and/or reportable condition databases. Medical charts were reviewed for demographic and clinical data. International Classification of Diseases (ICD) discharge codes were abstracted. Odds ratios (Oregon) and 95% confidence intervals (CIs) were determined to assess risk factors for ICU hospitalization and deaths. Results A total of 2,326 hospitalized RSV cases were identified. Over half were ≥65 years (62%, n = 1,438/2,326), female (59%, n = 1,362/2,326), white (70%, n = 1,301/1,855), and had ≥3 underlying medical conditions (52%, n = 1,204/2,326). 20% ( n = 398/2,000) were hospitalized in the ICU (median length of stay, 3 days; interquartile range, 1–6 days), and 5% ( n = 96/2,001) died in the hospital. Congestive heart failure (CHF; OR: 1.4, 95% CI: 1.1–1.8) and chronic obstructive pulmonary disease (COPD; OR: 1.3, 95% CI: 1.1–1.7) were associated with ICU admission, while age ≥80 years (OR: 4.1, 95% CI: 1.8–12.1) and CHF (OR: 2.4, 95% CI: 1.6–3.6) were associated with in-hospital deaths. RSV-specific ICD codes were listed in the first 9 positions in only 44% (879/1,987) of cases. Conclusion To our knowledge, this is the largest US case series of RSV-infected hospitalized adults. Most cases were ≥65 years and had multiple underlying medical conditions. Older age, CHF, and COPD were associat

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Sex-Specific Effects of Prenatal Exposure to Endocrine Disrupting Chemicals on Adverse Birth Outcomes: Results from the Korean Children's Environmental Health Study (Ko-Chens)

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SSRN 2025年

作者： Oh, Jongmin Shah, Surabhi Lee, Kyung A. Park, Eunkyo Lee, Dong-Wook Hong, Yun-Chul Song, Sanghwan Kim, Sung Yeon Park, Huibyeol Ha, Eunhee Kim, Suejin Park, Choonghee Song, Sanghwan Lee, Jueun Park, Huibyeol Jo, JungHeum Jung, A-Ra Yu, Seung Do Kim, Hyun Jeong Jung, Soon-Won Hong, Sooyeon Seo, Heung Won Hwang, Namkyoung Kang, Tack Shin Jeong, Dong Jin Lee, Seungjune Kim, Hwan-Cheol Jeong, Kyoung Sook Kim, Byungmi Lee, Seulbi Kim, Hyesook Kook, Hoon Baek, Hee Jo Moon, Jai Dong Park, Won Ju Shin, Myung-Geun Ha, Mina Paik, Ki-Chung Kwon, Ho-Jang Lim, Myung-Ho Yoo, Seung Jin Bae, Sanghyuk Kim, Jin Kyung Bae, Jisuk Hong, Young-Seoub Kim, Yu-Mi Son, Hyunjin Park, Mi-Hye Lim, Dae Hyun Kim, Jeong Hee Hong, Sung-Chul Lee, Keun Hwa Kim, Su-Young Kim, Woo Jin Na, Sunghun Lim, Myoung-Nam Yoo, Young Song, Dae Jin Lee, Jue Seong Yoon, Wonsuck Choe, Seung-Ah Kim, Seunghyun Choung, Ji Tae Kim, Sukyung Kim, Jihyun Ahn, Kangmo Hong, Yun-Chul Choi, Baek-Yong Ryoo, Seung-Woo Son, Seok-Yoon Lee, Ji-Hyeon Lee, Dong-Wook Woo, KuckHyeun Yoon, Seong Yong Hur, Jongil Choi, Kyung-Hwa Park, Myung-Sook Lee, Seung-Hwa Chu, Yeonhee Kim, Jung-Ah Kim, Yangho Lee, Jiho Sim, Chang Sun Kim, A. Ram Oh, Inbo Department of Environmental Medicine School of Medicine Ewha Womans University Seoul Korea Republic of College of Medicine Ewha Womans University Seoul Korea Republic of Department of Human Systems Medicine College of Medicine Seoul National University Seoul Korea Republic of Department of Obstetrics and Gynecology Ewha Womans University College of Medicine Seoul Korea Republic of Department of Occupational and Environmental Medicine Inha University Hospital Inha University Incheon Korea Republic of Institute of Environmental Medicine Medical Research Center Seoul National University Korea Republic of Environmental Health Research Division National Institute of Environmental Research Incheon Korea Republic of Graduate Program in System Health Science and Engineering Ewha Womans University Ewha Medical Research Institute College of Medicine Seoul Korea Republic of Environmental Health Research Division Department of Environmental Health Research National Institute of Environmental Research Ministry of Environment Incheon Korea Republic of Environmental Health Policy Division Office of Environmental Health Ministry of Environment Sejong Korea Republic of Department of Occupational and Environmental Medicine Inha University School of Medicine Incheon Korea Republic of Department of Occupational and Environmental Medicine Wonju Severance Christian Hospital Wonju College of Medicine Yonsei University Wonju Korea Republic of Division of Cancer Prevention National Cancer Control Institute National Cancer Center Goyang Korea Republic of Department of Big Data Strategy National Health Insurance Service Wonju Korea Republic of Department of Food and Nutrition Wonkwang University Iksan Korea Republic of Environmental Health Center for Childhood Leukemia and Cancer Department of Pediatrics Chonnam National University Hwasun Hospital Hwasun Korea Republic of Environmental Health Center for Childhood Leukemia and Cancer Department of Occupational and

Objectives Although previous epidemiological studies have reported the effects of fetal exposure to phthalates and phenols on birth outcomes, evidence is limited. The objective of this study was to investigate whether... 详细信息

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LB9. Rising High Rate of Invasive Group AStreptococcusInfections Among Persons Experiencing Homelessness in San Francisco, 2010–2017

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Open Forum Infectious Diseases 2018年第SUPPL_1期5卷 S762–S762页

作者： Scheuer, Tara Libby, Tanya Van Beneden, Chris Watt, James Reingold, Arthur Apostol, Mirasol Vugia, Duc California Emerging Infections Program Oakland California Respiratory Diseases Branch Centers for Disease Control and Prevention Atlanta Georgia California Department of Public Health Richmond California School of Public Health University of California at Berkeley Berkeley California

BackgroundRates of invasive group AStreptococcus(iGAS) disease in the United States have risen since 2014; reasons remain unclear. Outbreaks of iGAS infection among persons experiencing homelessness (PEH) and persons ...

Background Rates of invasive group A Streptococcus (iGAS) disease in the United States have risen since 2014; reasons remain unclear. Outbreaks of iGAS infection among persons experiencing homelessness (PEH) and persons who inject drugs in Europe, Canada, and the United States have been described. Using active, population-based surveillance data from California’s Emerging Infections program, we describe incidence trends and characteristics of iGAS infection among PEH and persons not experiencing homelessness (PNEH) in San Francisco (SF) County during 2010–2017. Methods We defined an iGAS case as infection with GAS isolated from a normally sterile site (e.g., blood) in an SF resident. We calculated annual iGAS disease incidence rates (cases per 100,000 population) for PEH and PNEH using denominators from SF’s Department of Homelessness and Supportive Housing and the State of California Department of Finance. Demographic, clinical, and exposure characteristics of PEH and PNEH were compared by chi-square or t-test. Results We identified 673 iGAS cases in SF during 2010–2017. Among these, 34% (229/673) were among PEH. Annual iGAS incidence among PEH rose from ~300 (2010–2014) to 547 (95% CI: 379–714) per 100,000 in 2017 ( P < 0.001, Cochran-Armitage trend test); rates peaked at 758 (95% CI: 561–955) in 2016. Annual iGAS incidence in PNEH rose from a mean of 5 in 2010–2013 to 9.3 (95% CI: 7.3–11.4) per 100,000 in 2017 ( P < 0.001). Annual iGAS incidence in PEH was 42–72 times that in PNEH. PEH with iGAS infections were significantly younger and more likely to be male, white, and uninsured or enrolled in Medicaid ( P < 0.05 for each) compared with PNEH with iGAS disease. Case fatality ratios, ICU admission, infection type, and length of hospital stay did not differ significantly. Smoking, current injection drug use, current alcohol abuse, and AIDS diagnosis were significantly more common among PEH with iGAS. Obesity, diabetes, and cancer were significantly more common amo

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Corrigendum to: Environmental Sampling for Severe Acute Respiratory Syndrome Coronavirus 2 During a COVID-19 Outbreak on the Diamond Princess Cruise Ship

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The Journal of infectious diseases 2021年第3期223卷 540页

作者： Takuya Yamagishi Makoto Ohnishi Nobuaki Matsunaga Kensaku Kakimoto Hajime Kamiya Kiyoko Okamoto Motoi Suzuki Yoshiaki Gu Mikiyo Sakaguchi Taichi Tajima Saho Takaya Norio Ohmagari Makoto Takeda Shutoku Matsuyama Kazuya Shirato Naganori Nao Hideki Hasegawa Tsutomu Kageyama Ikuyo Takayama Shinji Saito Koji Wada Retsu Fujita Hiroki Saito Keiji Okinaka Mathew Griffith Amy Elizabeth Parry Brenda Barnetson James Leonard Takaji Wakita Infectious Disease Surveillance Center National Institute of Infectious Diseases Tokyo Japan. National Institute of Infectious Diseases Tokyo Japan. Antimicrobial Resistance Clinical Research Center National Center for Global Health and Medicine Tokyo Japan. Field Epidemiology Training Program National Institute of Infectious Diseases Tokyo Japan. Disease Control and Prevention Center National Center for Global Health and Medicine Tokyo Japan. Department of Virology III National Institute of Infectious Diseases Tokyo Japan. Influenza Virus Research Center National Institute of Infectious Diseases Tokyo Japan. Graduate School of Public Health International University of Health and Welfare Chiba Japan. Innovation & Research Support Center International University of Health and Welfare Chiba Japan. Department of Emergency and Critical Care Medicine Yokohama City Seibu Hospital St. Marianna University School of Medicine Yokohama Japan. Division of General Internal Medicine National Cancer Center Hospital East Chiba Japan. Health Emergency Programme World Health Organization Western Pacific Regional Office Manila Philippines. Department of Health Services Princess Cruises USA.

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480. Reduction inClostridium difficileInfection Rates Following a prevention Collaborative in Orange County, California, 2014–2017

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Open Forum Infectious Diseases 2018年第SUPPL_1期5卷 S178–S178页

作者： Rizzo, Kyle Garcia, Erin Zahn, Matthew Yi, Sarah H Epson, Erin Healthcare-Associated Infections Program California Department of Public Health Richmond California Epidemiology and Assessment Orange County Health Care Agency Santa Ana California Division of Healthcare Quality Promotion Centers for Disease Control and Prevention Atlanta Georgia

BackgroundThe California Department of Public Health (CDPH) Healthcare-Associated Infections (HAI) program and Orange County Health Care Agency convened aClostridium difficileinfection (CDI) prevention collaborative w...

Background The California Department of Public Health (CDPH) Healthcare-Associated Infections (HAI) program and Orange County Health Care Agency convened a Clostridium difficile infection (CDI) prevention collaborative with health care facilities in Orange County (OC) to reduce CDI incidence in the region. Methods We invited all 34 hospitals and 76 skilled nursing facilities (SNF) in OC to participate from June 2015 to June 2016. Participants received onsite infection control and antimicrobial stewardship assessments, trainings, and an interfacility transfer communication improvement initiative. We used an interrupted time-series design and segmented regression analysis to evaluate monthly hospital-onset (HO) and community-onset (CO) CDI rates for acute care hospitals (ACH) reporting HAI data to CDPH via the National Healthcare Safety Network. The baseline period included 17 months (January 2014–June 2015) and the collaborative period 28 months (September 2015–December 2017). All OC acute care hospitals were included in the CO-CDI model to account for direct and indirect effects of the collaborative. We included only participating ACH in the HO-CDI model. For informal comparisons, we assessed changes in CO-CDI for ACH in three San Francisco Bay Area counties and HO-CDI rates in nonparticipant OC acute care hospitals. Results Collaborative participants comprised 15 ACH, three long-term acute care hospitals, one children’s hospital, and 20 SNF; all but two SNF received an onsite assessment. Unadjusted, baseline pooled mean HO-CDI rates were 8.5 cases per 10,000 patient days for participant ACH, and CO-CDI rates were 4.9 cases per 1,000 admissions in OC acute care hospitals. During the collaborative period, HO-CDI rates in OC participant ACH decreased 2% per month (incidence rate ratio [IRR]: 0.98, 95% CI: 0.96, 0.99; P < 0.001). HO-CDI rates among OC nonparticipant ACH ( N = 10) did not change during the same timeframe (IRR: 0.99, 0.96, 1.02; P = 0.37). During the col

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Correction: Salutary effects of moderate but not high intensity aerobic exercise training on the frequency of peripheral T-cells associated with immunosenescence in older women at high risk of breast cancer: a randomized controlled trial

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Immunity & ageing : I & A 2022年第1期19卷 30页

作者： Grace M Niemiro Adriana M Coletta Nadia H Agha Preteesh Leo Mylabathula Forrest L Baker Abenaa M Brewster Therese B Bevers Enrique Fuentes-Mattei Karen Basen-Engquist Emmanuel Katsanis Susan C Gilchrist Richard J Simpson Department of Pediatrics The University of Arizona Tucson Arizona USA. The University of Arizona Cancer Center Tucson Arizona USA. Department of Health and Kinesiology The University of Utah Salt Lake City Utah USA. Cancer Control and Population Sciences Program Huntsman Cancer Institute Salt Lake City Utah USA. Department of Health and Human Performance University of Houston Houston Texas USA. School of Nutritional Sciences and Wellness The University of Arizona Tucson Arizona USA. Department of Clinical Cancer Prevention The University of Texas MD Anderson Cancer Center Houston Texas USA. Department of Radiation Oncology Clinical Research The University of Texas MD Anderson Cancer Center Houston Texas USA. Department of Behavioral Science The University of Texas MD Anderson Cancer Center Houston Texas USA. Department of Immunobiology The University of Arizona Tucson Arizona USA. Department of Cardiology The University of Texas MD Anderson Cancer Center Houston Texas USA. Department of Pediatrics The University of Arizona Tucson Arizona USA. rjsimpson@arizona.edu. The University of Arizona Cancer Center Tucson Arizona USA. rjsimpson@arizona.edu. Department of Health and Human Performance University of Houston Houston Texas USA. rjsimpson@arizona.edu. School of Nutritional Sciences and Wellness The University of Arizona Tucson Arizona USA. rjsimpson@arizona.edu. Department of Behavioral Science The University of Texas MD Anderson Cancer Center Houston Texas USA. rjsimpson@arizona.edu. Department of Immunobiology The University of Arizona Tucson Arizona USA. rjsimpson@arizona.edu.

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Erratum to "IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045" [Diabetes Res. Clin. Pract. 183 (2022) 109119]

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Diabetes research and clinical practice 2023年 204卷 110945页

作者： Hong Sun Pouya Saeedi Suvi Karuranga Moritz Pinkepank Katherine Ogurtsova Bruce B Duncan Caroline Stein Abdul Basit Juliana C N Chan Jean Claude Mbanya Meda E Pavkov Ambady Ramachandaran Sarah H Wild Steven James William H Herman Ping Zhang Christian Bommer Shihchen Kuo Edward J Boyko Dianna J Magliano International Diabetes Federation Brussels Belgium. Institute for Health Services Research and Health Economics German Diabetes Center Leibniz Center for Diabetes Research at the Heinrich-Heine-University Düsseldorf Düsseldorf Germany. Postgraduate Program in Epidemiology Universidade Federal do Rio Grande do Sul Porto Alegre Brazil. Baqai Institute of Diabetology and Endocrinology Baqai Medical University Karachi Pakistan. Department of Medicine and Therapeutics Li Ka Shing Institute of Health Sciences and Hong Kong Institute of Diabetes and Obesity The Chinese University of Hong Kong Prince of Wales Hospital Hong Kong Special Administrative Region China. Department of Internal Medicine and Specialties Faculty of Medicine and Biomedical Sciences and Biotechnology Center The University of Yaounde I Yaounde Cameroon. Division of Diabetes Translation Centers for Diseases Control and Prevention Atlanta GA United States. India Diabetes Research Foundation & Dr. A. Ramachandran's Diabetes Hospital Chennai India. Usher Institute University of Edinburgh Teviot Place EH8 9AG Scotland. School of Nursing Midwifery and Paramedicine University of the Sunshine Coast Petrie Queensland Australia. Division of Metabolism Endocrinology and Diabetes Department of Internal Medicine University of Michigan Ann Arbor MI United States Department of Epidemiology School of Public Health University of Michigan Ann Arbor MI United States. Centre for Modern Indian Studies University of Goettingen Goettingen Germany Heidelberg Institute of Global Health University of Heidelberg Heidelberg Germany. Division of Metabolism Endocrinology and Diabetes Department of Internal Medicine University of Michigan Ann Arbor MI United States. Seattle Epidemiologic Research and Information Center VA Puget Sound Health Care System Seattle United States. Department of Diabetes and Population Health Baker Heart and Diabetes Institute Melbourne Australia School of Public Health and Preventive Medic

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Healthcare-Associated Clostridium difficile Infection Solution Guide

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American Journal of Infection control 2017年第6期45卷 S103-S103页

作者： Rosie Kim Janette Biorn Sr Data Consultant None Infection Prevention & Control Program Manager APIC

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492. Long-Term Outcomes ofClostridium difficileInfection Among Medicare Beneficiaries

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Open Forum Infectious Diseases 2018年第SUPPL_1期5卷 S182–S182页

作者： Hatfield, Kelly M Baggs, James Winston, Lisa G Parker, Erin Martin, Brittany Meek, James I Olson, Danyel Farley, Monica M Revis, Andrew Holzbauer, Stacy Bye, Maria Wilson, Lucy Perlmutter, Rebecca Phipps, Erin C Pierce, Rebecca Ocampo, Valerie L S Kainer, Marion A Smith, Miranda McDonald, L Clifford Jernigan, John A Guh, Alice Division of Healthcare Quality Promotion Centers for Disease Control and Prevention Atlanta Georgia Medicine University of California San Francisco and Zuckerberg San Francisco General Hospital and Trauma Center San Francisco California California Emerging Infections Program Oakland California Connecticut Emerging Infections Program Yale School of Public Health New Haven Connecticut Department of Medicine Emory University School of Medicine and Atlanta VA Medical Center Atlanta Georgia Georgia Emerging Infections Program Atlanta Georgia Minnesota Department of Health Saint Paul Minnesota Division of State and Local Readiness Office of Public Health Preparedness and Response Centers for Disease Control and Prevention Atlanta Georgia Maryland Department of Health Baltimore Maryland New Mexico Emerging Infections Program University of New Mexico Albuquerque New Mexico Acute and Communicable Disease Prevention Oregon Health Authority Portland Oregon Tennessee Department of Health Nashville Tennessee

BackgroundClostridium difficileinfection (CDI) is a common healthcare-associated infection, particularly among older adults. We used laboratory-confirmed CDI surveillance data from 8 states participating in the Center...

Background Clostridium difficile infection (CDI) is a common healthcare-associated infection, particularly among older adults. We used laboratory-confirmed CDI surveillance data from 8 states participating in the Centers for Disease control and prevention’s Emerging Infections program linked to claims data for Centers for Medicare and Medicaid Services (CMS) beneficiaries to measure variation in 1-year outcomes associated with CDI. Methods A CDI case was defined as a positive C. difficile stool test in 2014 in a person without a positive test in the prior 8 weeks. Cases aged ≥65 years were linked to their CMS beneficiary ID using unique combinations of date of birth, sex, and zip code. Each case was matched to five control beneficiaries who did not link to any case and were residents of the same catchment area. Inclusion criteria were continuous fee-for-service Medicare for the entire study period (1 year before and after event date), and no hospitalization or skilled nursing facility stay with an ICD-9-CM code for CDI in the year prior to their match date. Multivariable logistic regression models were used to compare mortality and hospitalization for 1 year following the event date between beneficiaries with and without CDI, adjusting for age, sex, race, catchment area, chronic conditions, number of hospitalizations in the prior year, and hospitalization status at the time of and 7 days preceding the event date. Results Of 5,097 cases aged ≥65, 3,082 (60%) were linked to a CMS ID, and 1,832 (59%) met inclusion criteria. In crude analysis, 34% of beneficiaries with CDI died within 1 year, compared with 5% of beneficiaries without CDI. Beneficiaries with CDI were also more likely to be hospitalized in the subsequent year (54% vs. 17%). Beneficiaries with CDI had a higher adjusted odds of death (adjusted OR 3.01, 95% CI: 2.46, 3.69) and hospitalization within 1 year (adjusted OR 1.93, 95% CI: 1.65, 2.25) than those without CDI. Conclusion Older adults with CDI were th

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