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FERMENTATION AND GENETIC-engineering - PROBLEMS AND PROSPECTS

BIO-TECHNOLOGY 1983年第10期1卷 847-&页

作者： BULL, DN Daniel N. Bull Ph.D. is a consultant in fermentation technology and president of Satori Corporation P.O. Box 1730 Montclair N.J. 07042. (201) 783-9787.REFERENCES Graff G.M. Short H. and Keene J.1983. Gene-splicing methods move from lab to plant. Chem. Eng.90: 22-27.|ISI|Broda P.1979. p. 1-3. Plasmids. W. H. Freeman Oxford and San Francisco.Donoghue D.J. and Sharp P.A.1978. Construction of a hybrid bacteriophage-plasmid recombinant DNA vector. J. Bact.136: 1192-1196.|PubMed|ISI|ChemPort|Bok S.H. Hoppe D. Mueller D.C. and Lee S.E.1983. Improving the production of recombinant DNA proteins through fermentation development. Abstract from 186th ACS Natl. Mtg. Washington D.C. Sept. 1.Maniatis T. Fritsch E.F. and Sam-brook J.1982. p. 88. Molecular Cloning. Cold Spring Harbor Laboratory. Guidelines for research involving recombinant DNA molecules June 1983 Fed. Reg.48: 24556-24581. Modifications of physical containment recommendations for large-scale uses of organisms containing recombinant DNA molecules. 1983. Recomb. DNA Tech. Bull.6: 69-70.Bull D.N. Thoma R.W. and Stinnett T.E.1983. Bioreactors for submerged culture. In:Adv. in Biotechnological Proc. A. Mizrahi and A. L. van Wezel (eds.) 1: 1-30.Schmidli B.L. and Swartz R.W.1982. Design considerations for aseptic fermentation. Presentation at 184th ACS Natl. Mtg. Kanas City MO.Sittig W.1982. The present state of fermentation reactors. J. Chem. Tech. Biotechnol.32: 47-58.|ISI|Strek F.1963. Intl. Chem. Eng.3: 533.Uhl V.W. and Gray J.B.1996. Mixing Theory and Practice Vol. I. Academic Press New York.Peters M.S. and Timmerhaus K.D.1968. p. 542. Plant Design and Economics for Chemical Engineers. McGraw-Hill New York.Dickey D.S. and Hicks R.W. Fundamentals of agitation. Chem. Eng.83: 93-100.Oldshue J.Y.1983. Fluid mixing technology and practice. Chem. Eng.90: 82-108.Kipke K.D.1981. Heat transfer in aerated non-Newtonian fluids. Abstract from 2nd Eur. Cong. Biotech. Eastbourne UK April 5-10.Blakebrough N. McM

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THE EFFECT OF THERMAL FABRICATION PRACTICES ON ALUMINUM

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NAVAL ENGINEERS JOURNAL 1980年第5期92卷 37-43页

作者： HAY, RA HOLTYN, CH Mr. Robert A. Hayis currently a Welding Consultant and prior to his retirement in 1977 was the Director of Welding. Engineering & Technical Services Department. Reynolds Metals Company a position he had held since 1974. He received his formal education in Pennsylvania and New Jersey with additional studies in Welding Metallurgy at the University of California Los Angeles (UCLA). after which he spent seven years at the New York Naval Shipyard where he was a Welding Supervisor in charge of underwater welders (divers) and other specialized welding applications. Subsequent thereto he worked for the Linde Company Division Union Carbide Corporation in the R&D Laboratory on the development of the inert gas-welding processes TIG and MIG and as a Technical Sales Representative. In 1959. he joined the Engineering Services Department Reynolds Metals Company as a Welding Engineer where he specialized in cryogenic applications welder training programs and marine construction and was the Resident Welding Engineer in New Orleans. La. during the construction of the 306-foot all-aluminum Trailer shipSacal Borincano.In 1963 he accepted a position with Aero jet General Von Karman Center Azusa Calif. as a Process Engineer on the development of the aluminum and stainless steel propulsion systems for the APOLLO and ABLESTAR Space Vehicles. during which time he promoted the use of an electron beam welding system and a high strength aluminum alloy to produce the reliability required of the APOLLO Space Unit. Mr. Hay rejoined the Reynolds Metals Company as Chief Welding Engineer where he produced the first high speed technical movie “The Effect of Arc Variation on Aluminum Welds” and also developed the widely used technical comic book “MIG Welding Aluminum”with Pete and Harry which was later translated into the Parsi language for use in the Mideast. A Life Member of the American Welding Society a Past Chairman of the Welding and Joining Committee and a Past Member of SNAME. he has contributed numerous technical papers

Various thermal practices may be used during metal fabrication. Although certain operations are routine for steel, they are not for aluminum. The properties of aluminum are different from those of steel, and the effect of high temperature on each metal is different. Aluminum does not experience any color change while being heated to the melting point. Temperature control is essential in order to prevent damage, to minimize the loss of mechanical properties, and to safeguard against reduced corrosion resistance. Hot forming and flame straightening can be used effectively to fabricate aluminum provided adjustments are made to the shipyard's routine steel practices. Even with the best procedures the post thermal properties of thick, heavy, aluminum parts may be below the published minimums. Accordingly, parts that are exposed to high temperatures for extended periods of time should be designed with reduced properties in mind. Ship structures must meet prescribed fairness tolerances. Distorted aluminum assemblies can be brought within standards through the use of a flame/quench technique. The shipyard's procedures must be approved for Navy work and scrupulously followed by trained crews in order to obtain acceptable results.

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THE NO FRAME CONCEPT - ITS IMPACT ON SHIPYARD COST

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NAVAL ENGINEERS JOURNAL 1984年第3期96卷 218-232页

作者： NAPPI, NS WALZ, RW WIERNICKI, CJ Natale S. Nappi:graduated from City College of New York in 1954 with a B.S. degree in civil engineering and received his M.S. in civil engineering from the Polytechnic Institute of Brooklyn in 1959. He began his professional career in 1954 at the New York Naval Shipyard as a naval architect (structures) performing detail structural design and fabrication studies for CVAs LPDs DDs and CGs and eventually became a supervisory naval architect (structures). From 1965 to 1973 he was a member of the staff of the Computer-Aided Design Division at the David Taylor Naval Ship Research and Development Center (DTNSRDC). As such he was involved in the development of the computer structural design tool the SSDP (in association with Frank M. Lev) and automated detail design programs (CASDOS). His current position is Senior Naval Architect Consultant in the structural integrity group of the Ship Structures Division Structures Department DTNSRDC. Mr. Nappi is the author and co-author of numerous technical papers and reports covering a wide spectrum of topics such as automated structural design process design for producibility and survivability material weight and cost trade-off studies and structural weight determination for high performance ships (i.e. SES SWATH HYSWAS). He has lectured on the subjects of design for survivability and ship structures at the Naval Post Graduate School and MIT. He is a member of ASNE ASCE U.S. Naval Institute Sigma Xi and is a registered Professional Engineer in the State of New York. Mr. Nappi was a member of the NAVSEA working commitee for the computer supported design planning effort and is currently a member of the DTNSRDC ASSET Advisory Committee. Ronald W. Walz:graduated in 1974 from Pennsylvania State University with a B.S. degree in civil engineering. He began his professional career in 1974 at the David Taylor Naval Ship Research and Development Center as a structural engineer in the structural design concepts group of the Ship Structures Division Structures Department.

A proposed cost effective alternative to current U.S. Navy structurally configured hulls is presented in this paper. This proposed design for producibility concept involves the elimination of structural stanchions and transverse web frames. The potential impact of this “no frame” concept on structural design, weight and construction and material costs for naval surface frigates and destroyers is reflected in 1) reduced costs for the installation of distributive systems and 2) a reduced number and complexity of structural details providing a more reliable and less costly structure. This study was performed in three parts: 1) Determine the most feasible length between bulkheads without frames; 2) Using this length perform detail weight studies and construction and material costs analysis comparison on a 72-foot long hull module, with and without frames, for a FFG-7, and 3) Estimate the saving in man hours of labor on the installation of distributive systems and shipfitting for an FFG-7. For the feasible length studies on the “no frame” structural configuration, thirty-seven strength, weight and vertical center of gravity studies were performed on two ship classes; twenty-two on the FFG-7 class and fifteen on the DD-963 class. The detailed weight studies and construction and material cost analyses were conducted for FFG-7 “no frame” and “as built” modules. Results indicating the “no frame” concept module was 6.8% heavier and 14.8% less costly than the “as built” module. For the impact of an FFG-7 “no frame” structurally configured hull on the cost of labor required for the installation of distributive systems and for other functional work such as ship fitting, welding, and electrical, this study indicated a reduction of 169,206 labor hours per ship, representing 7.12% of the total required man hours to fabricate an FFG-7 class ship. With the employment of the “no frame” concept, certain areas of significant concern and potential risk were addressed. These include: 1) t

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Reuse Feasibility of Electrocoagulated Metal Hydroxide Sludge of Textile Industry in the Manufacturing of Building Blocks

Journal of Waste Management

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Journal of Waste Management 2013年第1期2013卷

作者： Tanveer Mehedi Adyel Syed Hafizur Rahman Mohammad Moniruz Zaman Hossain Md. Sayem Mala Khan Md. Abdul Gafur S. M. Nazrul Islam School of Environmental Systems Engineering The University of Western Australia 35 Stirling Highway Crawley WA 6009 Australiauwa.edu.au Department of Environmental Science Z. H. Sikder University of Science & Technology Modhupur Bhedergonj Shariatpur Dhaka 8024 *** Department of Environmental Sciences Jahangirnagar University Savar Dhaka 1342 Bangladeshjuniv.edu Institute of Glass and Ceramic Research and Testing Bangladesh Council of Scientific and Industrial Research Dhaka 1205 Bangladeshbcsir.gov.bd Department of Geological Sciences Jahangirnagar University Dhaka 1342 Bangladeshjuniv.edu Instrumentation and Calibration Service Laboratory Bangladesh Council of Scientific and Industrial Research Dhaka 1205 Bangladeshbcsir.gov.bd Pilot Plant and Process Development Center Bangladesh Council of Scientific and Industrial Research Dhaka 1205 Bangladeshbcsir.gov.bd Department of Environmental Science and Engineering School of Natural Resources and Environmental Studies University of Northern British Columbia 3333 University Way Prince George BC Canada V2N 4Z9unbc.ca

During the last decade, the growing load of sludge from textile industries, the top foreign exchange earning sector of Bangladesh, is a common nuisance to environmental system and community health. The present study was aimed to minimize the environmental impact from the disposal of Electrocoagulated Metal Hydroxide Sludge (EMHS) by using it as a partial substitute of clay in the manufacturing of construction material like building blocks (BBs). Different batches of normal and pressurized building blocks (NBBs and PBBs, resp.) were prepared using up to 50% EMHS with clay and then fired at a particular temperature. EMHS proportion in the mixture and firing temperature were two key factors determining the quality of BB. BB did not show any deformation or uneven surfaces at any of the examined firing temperature. At higher firing temperature and EMHS proportion, more weight loss and shrinkage of BB were noticed. Higher compressive strength and lower water adsorption were found at lower EMHS content and higher firing temperature. It was explored that NBB and PBB with 20 and 30% EMHS in clay, respectively, and fired at 1050 °C would be usable for nonloading applications; namely, ornamental bricks, decoration purposes, and fence of garden.

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Combination Cancer Immunotherapy with Dendritic Cell Vaccine and Nanoparticles Loaded with Interleukin-15 and Anti-beta-catenin siRNA Significantly Inhibits Cancer Growth and Induces Anti-Tumor Immune Response

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Pharmaceutical research 2022年第2期39卷 353-367页

作者： Armin Mahmoud Salehi Kheshti Farnaz Hajizadeh Asal Barshidi Bentolhoda Rashidi Farbod Ebrahimi Simin Bahmanpour Vahid Karpisheh Fatemeh Karimian Noukabadi Fariba Karoon Kiani Hadi Hassannia Fatemeh Atyabi Seyed Hossein Kiaie Fatah Kashanchi Jamshid Gholizadeh Navashenaq Hamed Mohammadi Rafieh Bagherifar Reza Jafari Naime Majidi Zolbanin Farhad Jadidi-Niaragh Immunology Research Center Tabriz University of Medical Sciences Tabriz Iran. Student Research Committee Tabriz University of Medical Sciences Tabriz Iran. Nanoparticle Process Technology Faculty of Engineering University of Duisburg-Essen Duisburg Germany. Department of Biotechnology Falavarjan Branch Islamic Azad University Isfahan Iran. Immunogenetic Research Center Faculty of Medicine and Amol Faculty of Paramedical Sciences Mazandaran University of Medical Sciences Sari Iran. Nanotechnology Research Centre Department of Pharmaceutics Faculty of Pharmacy Tehran University of Medical Sciences Tehran Iran. Nano Drug Delivery Research Center Kermanshah University of Medical Sciences Kermanshah *** Iran. Laboratory of Molecular Virology School of Systems Biology George Mason University Manassas Virginia USA. Noncommunicable Diseases Research Center Bam University of Medical Sciences Bam Iran. Non-communicable Diseases Research Center Alborz University of Medical Sciences Karaj Iran. Nephrology and Kidney Transplant Research Center Clinical Research Institute Urmia University of Medical Sciences Urmia Iran. Hematology Immune Cell Therapy and Stem Cell Transplantation Research Center Clinical Research Institute Urmia University of Medical Sciences Urmia Iran. Hematology Immune Cell Therapy and Stem Cell Transplantation Research Center Clinical Research Institute Urmia University of Medical Sciences Urmia Iran. majidiz.n@umsu.ac.ir. Experimental and Applied Pharmaceutical Research Center Urmia University of Medical Sciences Urmia Iran. majidiz.n@umsu.ac.ir. Department of Pharmacology and Toxicology Faculty of Pharmacy Urmia University of Medical Sciences Urmia Iran. majidiz.n@umsu.ac.ir. Immunology Research Center Tabriz University of Medical Sciences Tabriz Iran. jadidif@tbzmed.ac.ir. Department of Immunology Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran. jadidif@tbzmed.ac.ir. Research Center for Integrative Medicine in Agin

PURPOSE:The invention and application of new immunotherapeutic methods can compensate for the inefficiency of conventional cancer treatment approaches, partly due to the inhibitory microenvironment of the tumor. In this study, we tried to inhibit the growth of cancer cells and induce anti-tumor immune responses by silencing the expression of the β-catenin in the tumor microenvironment and transmitting interleukin (IL)-15 cytokine to provide optimal conditions for the dendritic cell (DC) vaccine. METHODS:For this purpose, we used folic acid (FA)-conjugated SPION-carboxymethyl dextran (CMD) chitosan (C) nanoparticles (NPs) to deliver anti-β-catenin siRNA and IL-15 to cancer cells. RESULTS:The results showed that the codelivery of β-catenin siRNA and IL-15 significantly reduced the growth of cancer cells and increased the immune response. The treatment also considerably stimulated the performance of the DC vaccine in triggering anti-tumor immunity, which inhibited tumor development and increased survival in mice in two different cancer models. CONCLUSIONS:These findings suggest that the use of new nanocarriers such as SPION-C-CMD-FA could be an effective way to use as a novel combination therapy consisting of β-catenin siRNA, IL-15, and DC vaccine to treat cancer.

关键词： cancer cancer immunotherapy dendritic cell vaccine interleukin-15 nanoparticle β-catenin

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Nanowire Transistors: Manipulating III–V Nanowire Transistor Performance via Surface Decoration of Metal‐Oxide Nanoparticles (Adv. Mater. Interfaces 12/2017)

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Advanced Materials Interfaces 2017年第12期4卷

作者： Fengyun Wang SenPo Yip Guofa Dong Fei Xiu Longfei Song Zaixing Yang Dapan Li Tak Fu Hung Ning Han Johnny C. Ho College of Physics and Cultivation Base for State Key Laboratory Qingdao University Qingdao 266071 P. R. China Department of Physics and Materials Science City University of Hong Kong 83 Tat Chee Avenue Kowloon Hong Kong State Key Laboratory of Millimeter Waves City University of Hong Kong 83 Tat Chee Avenue Kowloon Hong Kong Shenzhen Research Institute City University of Hong Kong Shenzhen 518057 P. R. China Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University (NanjingTech) Nanjing 211816 P. R. China School of Microelectronics and Center of Nanoelectronics Shandong University Jinan 250100 P. R. China State Key Laboratory of Multiphase Complex Systems Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 P. R. China

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Cover Picture: Atomically Precise Nanometer-Sized Pt Catalysts with an Additional Photothermy Functionality (Angew. Chem. Int. Ed. 25/2024)

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Angewandte Chemie International Edition 2024年第25期63卷

作者： Runguo Wang Dr. Dong Chen Dr. Liang Fang Dr. Wentao Fan Dr. Qing You Guoqing Bian Yue Zhou Dr. Wanmiao Gu Dr. Chengming Wang Dr. Licheng Bai Prof. Dr. Jin Li Prof. Dr. Haiteng Deng Dr. Lingwen Liao Prof. Dr. Jun Yang Prof. Dr. Zhikun Wu Key Laboratory of Materials Physics Anhui Key Laboratory of Nanomaterials and Nanotechnology CAS Center for Excellence in Nanoscience Institute of Solid State Physics HFIPS Chinese Academy of Sciences Hefei 230031 China Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of China Hefei 230026 P. R. China Institute of Physical Science and Information Technology Anhui University Hefei 230601 P.R. China State Key Laboratory of Multiphase Complex Systems Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 P. R. China Instruments' Center for Physical Science University of Science and Technology of China Hefei 230026 P. R. China Shenzhen Engineering Center for the Fabrication of Two-Dimensional Atomic Crystals Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 P. R. China Tsinghua University-Peking University Joint Center for Life Sciences School of Life Sciences Tsinghua University Beijing 100084 P.R.China MOE Key Laboratory of Bioinformatics School of Life Sciences Tsinghua University Beijing 100084 P.R.China

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Atomically Precise Nanometer-Sized Pt Catalysts with an Additional Photothermy Functionality

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Angewandte Chemie 2024年第25期136卷

Atomically precise ~1-nm Pt nanoparticles (nanoclusters, NCs) with ambient stability are important in fundamental research and exhibit diverse practical applications (catalysis, biomedicine, etc.). However, synthesizing such materials is challenging. Herein, by employing the mixture ligand protecting strategy, we successfully synthesized the largest organic-ligand-protected (~1-nm) Pt 23 NCs precisely characterized with mass spectrometry and single-crystal X-ray diffraction analyses. Interestingly, natural population analysis and Bader charge calculation indicate an alternate, varying charge -layer distribution in the sandwich-like Pt 23 NC kernel. Pt 23 NCs can catalyze the oxygen reduction reaction under acidic conditions without requiring calcination and other treatments, and the resulting specific and mass activities without further treatment are sevenfold and eightfold higher than those observed for commercial Pt/C catalysts, respectively. Density functional theory and d -band center calculations interpret the high activity. Furthermore, Pt 23 NCs exhibit a photothermal conversion efficiency of 68.4 % under 532-nm laser irradiation and can be used at least for six cycles, thus demonstrating great potential for practical applications.

关键词： Pt nanocluster atomically precise ambient stability ORR photothermy

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Titelbild: Atomically Precise Nanometer-Sized Pt Catalysts with an Additional Photothermy Functionality (Angew. Chem. 25/2024)

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Angewandte Chemie 2024年第25期136卷

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Deposition of thin layers of CZTS by sol-gel route via spin-coating

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Materials Today: Proceedings 2024年

作者： Marius Armand Amou Bouchaib Hartiti Ahmed Ziti Fransisco Kouadio Konan Abdelkrim Batan Hicham Labrim Laazizi Abdellah Boko Aka Philippe thevenin Laboratoire de Virologie Oncologie Biosciences Environnement et Energies Nouvelles (LVOBEEN) Groupe Matériaux Energie Eau Modélisation et Développement Durable (GMEEM & DD) FSTM Hassan II University of Casablanca (UH2C) BP 146 Mohammedia 20650 Morocco Laboratoire d’Energie Solaire et de Nanotechnologie (LESN) – IREN (Institut de Recherches sur les Energies Nouvelles) Université Nangui Abrogoua 02 BP 801 Abidjan 02 Ivory Coast West Africa Ecole Normale Superieure (ENS) d’Abidjan Laboratoire des Sciences Physiques Fondamentales et Appliquées 08 BP I0 Ivory Coast West Africa FST Errachidia Equipe Sciences des Materiaux University Moulay Ismail of Meknes BP 509 Boutalamine 52000 Errachidia Morocco Advanced Systems Engineering Laboratory National School of Applied Sciences Ibn Tofaîl University Kenitra Morocco Laboratory of Materials Metallurgy and Process Engineering ENSAM Meknes Morocco MOPS Laboratory University of Lorraine Centrale Supelec – 2 rue E. Belin B.P. 57070 Metz France

This work focuses on the development of Cu 2 ZnSnS 4 (CZTS) thin films by chemical sol gel via spin-coating for photovoltaic applications. CZTS thin films were developed using metal salts of copper II chloride dihydrate (CuCl 2 , 2H 2 O), zinc(II) chloride (ZnCl 2 ), tin II chloride dihydrate (SnCl 2 , 2H 2 O), and thiourea (CS(NH 2 ) 2 ) respectively as precursors of copper, zinc, tin and sulphur dissolved in a solvent consisting of a mixture of ethanol and distilled water (30 % ethanol and 70% water). Monoethanolamine (MEA) was used as a stabilising agent. The characterisation techniques used were X-ray diffraction (XRD), Raman spectroscopy and UV–visible spectroscopy (UV–vis). DRX analysis shows that the samples possess the CZTS kesterite phase with a preferential orientation in the (1 1 2) direction. This result is confirmed by the Raman spectrum of the samples. Optical characterisation indicates that the layers have a relatively high absorption coefficient (greater than 10 4 cm −1 ) in the visible spectrum with a gap energy equal to or close to the optimum value of 1.5 eV. These kesterite-type CZTS samples with good structural and optical properties are likely to fulfil sought-after functionalities as absorber layers for photovoltaic applications.

关键词： CZTS kesterite Sol-gel Spin-coating DRX UV–visible Raman

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