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Safe food for infants: An EU-China project to enhance the control of safety risks raised by microbial and chemical hazards all along the infant food chains

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Global Pediatrics 2022年 2卷

作者： Engel, Erwan Rivière, Gilles Kemmer, Diana Deusch, Oliver Fuchsbauer, Norbert Biesterveld, Steven Krystalli, Evangelia Bondoux, Marion Li, Guang Yang, Weikang Hou, Jianbo Liang, Ying Yang, Hua Fang, Weihuan Pettoello-Mantovani, Massimo Flynn, Brian Rantsiou, Kalliopi Van der Burg, Bart Bover-Cid, Sara Zwietering, Marcel H. French National Research Institute for Agriculture Food and Environment (INRAE) UR QuaPA MASS Group Saint-Genès-Champanelle France French Agency for Food Environmental and Occupational Health & Safety (ANSES) Maisons-Alfort France Fraunhofer Institute for Process Engineering and Packaging (IVV) Freising Germany Computomics GmbH Tübingen Germany HiPP-Werk Georg Hipp OHG Pfaffenhofen Germany Friesland Campina Nederland BV Amersfoort Netherlands Yiotis Anonimos Emporiki & Viomixaniki Etaireia Athens Greece INRAE Transfert Clermont-Ferrand France Beingmate (Hangzhou) Food Research Institute Co. Ltd Hangzhou China Yangzhou Fangguang Food Co. Ltd. Yangzhou China Zhejiang Academy of Science & Technology for Inspection & Quarantine (ZAIQ Hangzhou China Jiangsu Academy of Agricultural Sciences (JAAS) Nanjing China Zhejiang Academy of Agricultural Sciences (ZAAS) Hangzhou China Zhejiang University (ZJU) Hangzhou China EPA-UNEPSA Berlin Germany Creme software LTD (Creme Global) Dublin Ireland University of Turin Department of Agricultural Forest and Food Sciences Turin Italy BioDetection Systems B.V. Amsterdam Netherlands Institut de Recerca i Tecnologia Agroalimentàries (IRTA) Food Safety and Functionality Program Monells Spain Wageningen University & Research Food Microbiology Wageningen Netherlands

The EU-project SAFFI targets food for EU's 15 million and China's 45 million children under the age of three. It aims at developing an integrated approach to enhance the identification, assessment, detection and mitigation of health risks raised by microbial and chemical hazards along EU and China infant food chains. SAFFI will benchmark the main risks through an extensive hazard identification system based on multiple data sources and a risk ranking procedure. It will also develop procedures to enhance top-down and bottom-up hazard control by combining management options with a panel of technologies for the detection and mitigation of priority hazards. Furthermore, it will explore unexpected contaminants by predictive toxicology and improve risk-based food safety management of biohazards by omics and predictive microbiology. SAFFI will co-develop with and deliver to stakeholders a decision-support system (DSS) to enhance safety control all along the food chain. This DSS will integrate the databases, procedures and methods described above and will be a framework for a generic DSS dedicated to other food. This overall methodology will also be implemented in a complementary Chinese side of the project, and exemplified for each side, with four case studies that were selected to cover priority hazards, main ingredients, processes and control steps of the infant food chain. Resulting databases, tools and procedures will be shared, cross-validated, concatenated, benchmarked and finally harmonized for further use in the EU and China. This EU-China multi-actor consortium of 20 partners involves academia, food safety authorities, infant food companies, a paediatrics association and technological and data-science SMEs. © 2022

关键词： Baby food Chemical contaminants Decision support system Food safety Foodborne hazards Hazard control Hazard detection Risk assessment

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THE GOLD MEDAL AWARD FOR 1992

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NAVAL ENGINEERS JOURNAL 1993年第4期105卷 75-76页

作者： KEELER, RN Dr. R. Norris Keeler has made substantial contributions to the Navy in a variety of capacities the most notable of which was as the first director of the Office of Naval Technology in 1975 in which he was responsible for managing and directing all of the Navy exploratory development programs. In more recent times Dr. Keeler has applied his extensive knowledge of physics and chemistry to make major contributions to the Navy's submarine laser communications development program. He was personally responsible for defining the baseline system “Yankee Blue” that was deployed in 1988. He also perfected the concept of using atomic resonance filters to enable the system to function effectively in day as well as night operations. Dr. Keeler continued to apply his physical optical expertise to the field of LIDAR for the purpose of locating and neutralizing antiship mines deployed by Iraq in the Persian Gulf. Since that time Dr. Keeler has designed optical command actuated underwater systems to neutralize anti-ship mines. Field trials of his concept will be conducted in the near future. Dr. Keeler has also continued to remain active in the area of high pressure physics wherein he is making significant contributions to the development of a unique high pressure high temperature process for manufacturing industrial diamonds. Dr. Keeler is now working on ways of producing large synthetic pure single crystal diamonds which would find wide application in defense programs and across the industry. Dr. Keeler embodies true scientific achievement in a myriad of areas through his role as a civilian engineer directly involved in contractor support of Navy systems engineering and research and development efforts. A distinguished scientist reserve officer and business executive Dr. Keeler blends all of these roles and his wide interests to provide innovation and technical achievement for the benefit of the Navy and the Nation. He is extremely well qualified and highly deserving of the American Society of Naval Engineers Gold Medal

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Correction: Recent trends in carbon nanotube (CNT)-based biosensors for the fast and sensitive detection of human viruses: a critical review

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Nanoscale advances 2023年第21期5卷 5983页

作者： Hicham Meskher Hussain Chaudhery Mustansar Amrit Kumar Thakur Ravishankar Sathyamurthy Iseult Lynch Punit Singh Tan Kim Han Rahman Saidur Department of Process Engineering Kasdi-Merbah University Ouargla 30000 Algeria hicham.meskher@g.enp.edu.dz. Department of Chemistry and Environmental Science New Jersey Institute of Technology Newark 07102 NJ USA. Department of Mechanical Engineering KPR Institute of Engineering and Technology Arasur Coimbatore 641407 Tamil Nadu India amritt1@***. Mechanical Engineering Department King Fahd University of Petroleum and Minerals Dhahran 31261 Saudi Arabia. Interdisciplinary Research Center for Renewable Energy and Power Systems (IRC-REPS) King Fahd University of Petroleum and Minerals Dhahran 31261 Saudi Arabia. School of Geography Earth and Environmental Sciences University of Birmingham Edgbaston Birmingham B15 2TT UK I.Lynch@bham.ac.uk. Institute of Engineering and Technology Department of Mechanical Engineering GLA University Mathura Uttar Pradesh 281406 India. Research Centre for Nano-Materials and Energy Technology (RCNMET) School of Engineering and Technology Sunway University No. 5 Jalan Universiti Bandar Sunway Petaling Jaya 47500 Malaysia saidur@sunway.edu.my.

[This corrects the article DOI: 10.1039/D2NA00236A.].

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SEAKEEPING BY DESIGN

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NAVAL ENGINEERS JOURNAL 1980年第2期92卷 157-178页

作者： COMSTOCK, EN KEANE, RG Mr. Edward N. Comstock is currently Head of the Surface Ship Hydrodynamics Section (SEA 32132) of the Hull Form Design Performance and Stability Branch Naval Sea Systems Command. He received his B.S.E. degree in Naval Architecture and Marine Engineering in 1970 and his M.S. degree in Ship Hydrodynamics in 1974 both from the University of Michigan. Mr. Comstock began his professional career with the U.S. Navy in 1974 as a Seakeeping Specialist in the Hull Form and Fluid Dynamics Branch of the former Naval Ship Engineering Center being involved in improving the design of naval ships through the integration of R&D technology advances into the ship design process. His efforts prior to 1980 were mainly aimed at developing and establishing Seakeeping Performance Assessment and Design Practices. Other responsibilities have included numerous ship performance investigations in still water and in the sea environment in support of ship design and specific Fleet problems. Prior to his employment by the Navy he worked in the Structural and Hydrodynamic Groups of General Dynamics' Electric Boat Division. There his activities spanned the areas of Submarine structural and Hydrodynamic Design and Construction. A member of ASNE since 1978. he is also a member of ASE and SNAME and has been active in supporting the efforts of the SNAME H-7 (Seakeeping) Panel the National Science Foundation (NSF). and the NATO Naval Armaments Group 6/Sub-Group 5 (Seakeeping). Mr. Robert G. Keane Jr. is presently Head of the Hull Form Design. Performance and Stability Branch (SEA 3213). Ship Design and Integration Directorate (SEA 03). Naval Sea Systems Command (NAVSEA). He received his B.E.S. degree in Mechanical Engineering from The Johns Hopkins University in 1962. his M.S. degree in Mechanical Engineering from the Stevens Institute of Technology in 1967. and his M.S.E. degree in Naval Architecture from the University of Michigan in 1970. Additionally he has done graduate work in Management Science and Operations Research at The Johns Ho

“Seakeeping … is the ability of our ships to go to sea, and Successfully and safely execute their missions despite adverse environmental factors.” — VAdm. R.E. Adamson. USN In June 1975, VAdm. R.E. Adamson, USN, then Commander Naval Surface Forces, U.S. Atlantic Fleet, addressed the participants of the Seakeeping Workshop [1] and established what has come to be a most profound definition of seakeeping as it relates to the U.S. Navy. In those few words he identified the two major issues facing the operator today and provided the focus for all subsequent seakeeping efforts within the design community at the Naval Sea systems Command (NAVSEA). For it is these two hues of mission sum and safety at sea which are addressed within NAVSEA, for each new ship design and for ships in the Fleet, in terms of: SEAKEEPING PERFORMANCE — Ability to execute mission in a sea environment, and SEAWORTHINESS — Ability to survive in an extreme sea environment. In the past, the design of ships exhibiting superior seakeeping performance and seaworthiness and seaworthiness has been looked upon by many as an art or an academic exercise. The objective of this paper then is to demonstrate clearly that the ability of our ships to execute their missions successfully and safely in a sea environment is not by chance but by design.

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Abstracts from the 6th International Conference on the engineering of Sport, 10-14 July 2006, Olympic Hall, Munich, Germany Abstracts

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SPORTS engineering 2006年第4期9卷 229-249页

作者： [Anonymous] TNO Netherlands Delcam plc UK Technological Institute of Toys AIJU Spain Technische Universitaet Muenchen Germany Hochschule für Gestaltung und Kunst Zuerich Germany Otto-v.-Guericke-University Magdeburg Germany AISTS-International Academy of Sports Science and Technology Lausanne Switzerland CSEM-Swiss Center for Electronics and Microtechnology Neuchâtel Swizerland University of Illinois at Urbana-Champaign USA Delft University of Technology Netherlands Faculty of Education Art and Science Yamagata University Japan Department of Mathematical Modelling Perm State Technical University Russia Department of Theoretical Mechanics Perm State Technical University Russia Department of Computational Fluid Dynamics JSC Aviadvigatel Perm Motors Russia Mechanical and Automotive Engineering RMIT University Japan Fluent Europe Ltd Sheffield UK SportKreativWerkstatt GmbH München Germany Sports Technology Research Group Loughborough University UK Department of Mechanical Engineering University of Bath UK Instituto de Biomecánica de Valencia (IBV) Spain University Augsburg UK Sports Engineering Research Group University of Sheffield England Sports-Equipment Technology Technikum Wien Austria Fischer GmbH Germany Biocompatible Materials and Process Engineering TU Munich Germany The University of Waikato New Zealand Sandvik Materials Technology Sweden Institute for Machine Tools and Industrial Management TU Munich Germany Institut fuer Verbundwerkstoffe GmbH Canada Sports Engineering Centre for Sports and Exercise Science Sheffield Hallam University England University of Glamorgan UK Department of Information Science and Engineering Tokyo Institute of Technology Tokyo Japan Toyota Motor Co. Aichi Japan Iowa Univeristy Iowa USA Simbex Lebanon USA Japan Institute of Sports Sciences Tokyo Japan University of Vienna Austria Technische Universität München Germany Department of Econometrics University of Groningen The Netherlands Department of Physical Education and Sport

A radical change (Feenstra, Holmer, Tromans, Moos and Mieritz 2003) in manufacturing is starting to occur. The Rapid Manufacturing, which can be defined as "the use of an additive manufacturing process to construct parts that are used directly as finished products or components", is set to supersede many current uses of moulds and dies. Rapid Manufacturing (Wohlers 2003) is based on new additive manufacturing techniques that produce fully functional parts directly from a 3D CAD model without the use of tooling. The ambitious scope of the European Initiative CUSTOM-FIT, a Framework 6 Integrated Project, is to create a fully integrated system for the design, production and supply of individualized custom-products. Within the cases under study there are strong connections to sporting articles. This project is being funded by the European Commission over the next four years and a half and will become central to European research concerning Rapid Manufacturing (RM).

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Digital Twins of Business processes: A Research Manifesto

arXiv

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arXiv 2024年

作者： Fornari, Fabrizio Compagnucci, Ivan De Donato, Massimo Callisto Bertrand, Yannis Beyel, Harry H. Carrión, Emilio Franceschetti, Marco Groher, Wolfgang Grüger, Joscha Kilic, Emre Koschmider, Agnes Leotta, Francesco Li, Chiao-Yun Lugaresi, Giovanni Malburg, Lukas Mangler, Juergen Mecella, Massimo Pastor, Oscar Riss, Uwe Seiger, Ronny Serral, Estefania Torres, Victoria Valderas, Pedro University of Camerino School of Science and Technology Computer Science Department Via Madonna delle Carceri 7 Camerino62032 Italy Gran Sasso Science Institute Computer Science Department Viale Francesco Crispi 7 L’Aquila67100 Italy University of St.Gallen Institute of Computer Science Rosenbergstrasse 30 St.Gallen9000 Switzerland University of Bayreuth Business Informatics and Process Analytics Wittelsbacherring 8 Bayreuth95444 Germany Fraunhofer Institute for Applied Information Technology Schloss Birlinghoven Sankt Augustin53757 Germany RWTH Aachen University Ahornstraße 55 Aachen52074 Germany Mercadona Tech Mercadona Plaza de Amèrica 2 Valencia46004 Spain PROS Research Center - VRAIN Institute Universitat Politècnica de València Camino de Vera Valencia46022 Spain TU Dortmund University Leonhard-Euler-Str. 5 Dortmund44227 Germany KU Leuven Warmoesberg 26 Brussels1000 Belgium Sapienza Università di Roma DIAG via Ariosto 25 Rome00185 Italy KU Leuven Faculty of Engineering Technology Celestijnenlaan 300 Leuven3001 Belgium Branch Trier University Behringstraße 21 Trier54296 Germany Artificial Intelligence and Intelligent Information Systems Trier University Universitätsring 15 Trier54296 Germany OST Eastern Switzerland University of Applied Sciences Rosenbergstrasse 59 St. Gallen9001 Switzerland TUM School of Computation Information and Technology Boltzmannstraße 3 Garching bei München85748 Germany

Modern organizations necessitate continuous business processes improvement to maintain efficiency, adaptability, and competitiveness. In the last few years, the Internet of Things, via the deployment of sensors and actuators, has heavily been adopted in organizational and industrial settings to monitor and automatize physical processes influencing and enhancing how people and organizations work. Such advancements are now pushed forward by the rise of the Digital Twin paradigm applied to organizational processes. Advanced ways of managing and maintaining business processes come within reach as there is a Digital Twin of a business process - a virtual replica with real-time capabilities of a real process occurring in an organization. Combining business process models with real-time data and simulation capabilities promises to provide a new way to guide day-to-day organization activities. However, integrating Digital Twins and business processes is a non-trivial task, presenting numerous challenges and ambiguities. This manifesto paper aims to contribute to the current state of the art by clarifying the relationship between business processes and Digital Twins, identifying ongoing research and open challenges, thereby shedding light on and driving future exploration of this innovative interplay. © 2024, CC BY-NC-ND.

关键词： Virtual corporation

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New Zwitterion Schiff Base Ligand Derived from Pyran-2-One: Synthesis, Xrd/Has, Docking, Spectral, Dft and Catecholase Study

SSRN

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SSRN 2024年

作者： Tabti, Salima Louaileche, Tinhinane Djedouani, Amel Maouche, Chaima Shalalin, Khalil Alobaid, Abeer Chafai, Nadjib Amamra, Samra Djukic, Jean-Pierre Bailly, Corinne Warad, Ismail Faculty of sciences and technology Department of sciences and maters Mohamed El Bachir El Ibrahimi University El Anasser Bordj Bou Arreridj34000 Algeria Laboratory of Electronic Materials and Systems Mohamed El Bachir El Ibrahimi University El Anasser Bordj Bou Arreridj34000 Algeria Department of ecology and environment Faculty of Life and Natural Sciences of Earth and Universe Sciences University Mohamed El Bachir El Ibrahimi Bordj Bou Arreridj34000 Algeria Laboratory of Electrochemistry and environment University Mohamed El Bachir El Ibrahimi Bordj Bou Arreridj34000 Algeria Ecole Normale Supérieure de Constantine Université Constantine 3 25000 Algeria Department of Dentistry and Dental Surgery Faculty of Medicine and Health Sciences An-Najah National University P.O. Box 7 Nablus Palestine Department of Chemistry College of Science King Saud University P.O. Box 2455 Riyadh11451 Saudi Arabia Department of Process Engineering Faculty of Technology University of Ferhat ABBAS Setif-1 El-Mabouda Campus Setif19000 Algeria Laboratoire de Chimie et Systémique organométalliques UMR 7177 CNRS Université de Strasbourg 4 rue Blaise Pascal Strasbourg67000 France Service de Radiocristallographie Fédération de Chimie Le Bel UAR 2042 CNRS Université de Strasbourg 1 rue Blaise Pascal BP 296/R8 Strasbourg67008 cedex France King Saud University Saudi Arabia

A new chelate zwitterion was synthesized and designated as Schiff base derived from pyran-2-one. The synthesis entailed the condensation of 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one with 5-amino-2-methoxyphenol in refluxing ethanol, leading to the creation of the Schiff base (SB). A thorough examination of the SB ligand was conducted utilizing a variety of physicochemical methods, such as NMR, XRD, UV-vis, and FT-IR. The presence of a zwitterionic salt form was verified using XRD analysis, which revealed the occurrence of intra-H-bond interactions between [N+—H...-O] groups. To mimic the activity of catechol oxidase, in situ copper (II) complexes of SB ligand were investigated against catechol into the corresponding o-quinone using different metal salts in different solvents. The molecular docking of this ligand was performed against two enzymes responsible for the production of reactive oxygen species (ROS): NADPH oxidase and xanthin oxidoreductase (XOR), with PDB IDs: 5O0X and 3B9J respectively. Hirschfield surface analysis (HSA) and HOMO/LUMO/DOS techniques were employed to gain a deeper understanding of the electron transfer in molecule. The progress of the SB dehydration reaction was monitored using UV-Vis spectroscopy by examining the characteristics of the reactants prior to and during their combination. In addition, TD-DFT of the SB derived from pyran-2-one. © 2024, The Authors. All rights reserved.

关键词： Surface analysis

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THE STRUCTURAL SYNTHESIS DESIGN PROGRAM - ITS IMPACT ON THE FLEET

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NAVAL ENGINEERS JOURNAL 1983年第3期95卷 87-99页

作者： WIERNICKI, CJ GOODING, TG NAPPI, NS Mr. Christopher J. Wiernicki:graduated from Vanderbilt University in 1980 with a B.E. degree in Structural Engineering. Upon graduation he began his professional career at the David Taylor Naval Ship Research and Development Center. As a structural engineer in the Surface Ship Structures Division Mr. Wiernicki was responsible for developing improved methods and procedures for designing and evaluating structural systems for surf ace combatants. Specific projects included design for producibility development and evaluation of automated ship structural design methods and participation in the structural design of the CG 49 Cruiser and the current DDG 51 Destroyer. In 1982 Mr. Wiernicki received his M.S. degree in Ocean Engineering from George Washington University. Mr. Wiernicki is a recipient of the SNAME 1982-82 Graduate Scholarship and is currently doing post graduate work in Naval Architecture at Massachusetts Institute of Technology he is a member of ASNE SNAME ASCE and Chi Epsilon. Mr. Thomas G. Gooding:graduated in 1975 from the University of Michigan with B.S. degrees in Oceanography and Naval Architecture. After graduation he began his professional career at the Naval Ship Engineering Center (NA VSEC) as a structural engineer. From 1975 till 1978 Mr. Gooding worked in the area of ship dry docking and was the structural task leader on the complex overhaul ofUSS Long Beach (CGN-9). Mr. Gooding returned to the University of Michigan to receive a M.S. in Naval Architecture in 1979. Currently Mr. Gooding is the structural task leader on the DDGX/DDG 51 program at the Naval Sea Systems Command (NAVSEA). Mr. Gooding is a member of SNAME and the Naval Institute. Mr. Natale S. Nappi:graduated from City College of New York in 1954 with a Bachelor of Civil Engineering and received his M.S. in Civil Engineering from Polytechnic Institute of Brooklyn in 1959. He began his professional career in 1964 at the New York Naval Shipyard as a Naval Architect (Structure) performing detail structural design and fabrication s

The structural design of a ship's section is a complicated, repetitive and time consuming task. With the advent of new technology, high speed computers have enabled the ship designer to accomplish in a matter of seconds what would formerly take days to accomplish by hand. The Structural Synthesis Design Program (SSDP) is a N avy developed computer-aided design tool which is used to design (or to analyze) the longitudinal scantlings for a variety of ship cross sections, consisting of any practical combinations of decks, platforms, bulkheads and materials, i.e., various steel and aluminum alloys. The final hull section design will have the lowest practical weight for the chosen geometric configuration, structural arrangements, and imposed loadings. The scantling developed by the program will satisfy all U.S. N avy ship structural design criteria. An explanation of the objective and design elements of N avy ship structures is included. The rationale behind the SSDP design philosophy is developed along with the significant program capabilities. In an attempt to highlight the influence of automated design procedures on the current naval ship design process, the effect of the SSDP on the DDG 51 destroyer structural development is addressed.

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嗜热古菌GTP结合蛋白的X射线晶体结构揭示了一类新的GTP酶

嗜热古菌GTP结合蛋白的X射线晶体结构揭示了一类新的GTP酶

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第十次中国生物物理学术大会

作者：吴豪孙蕾 Stan J.J.Brouns Thijs J.G.Ettema 傅晟 Bram Snijders Mark Bartlam John van der Oost 饶子和 Laboratory of Microbiology Department of Agrotechnology and Food Sciences Wageningen University Hesselink van Suchtelenweg 4 6703 CT Wageningen The Netherlands 中国科学院生物物理所 Laboratory of Microbiology Department of Agrotechnology and Food Sciences Wageningen University Hesselink van Suchtelenweg 4 6703 CT Wageningen The Netherlands Laboratory of Microbiology Department of Agrotechnology and Food Sciences Wageningen University Hesselink van Suchtelenweg 4 6703 CT Wageningen The Netherlands 中国科学院生物物理所 Biological and Environmental Systems Group Department of Chemical and Process Engineering University of Sheffield Mappin Street Sheffield S1 3JD United Kingdom 中国科学院生物物理所 Laboratory of Microbiology Department of Agrotechnology and Food Sciences Wageningen University Hesselink van Suchtelenweg 4 6703 CT Wageningen The Netherlands 中国科学院生物物理所

GTP结合蛋白广泛存在于真核生物,古菌及细菌中。它们在不同的细胞生命过程中扮演着极其重要的角色,如蛋白质的合成,信号传导及膜的运输等。这里,我们率先报导了一从嗜热古菌中提取出来全长的GTP结合蛋白酶。其晶体结构分辨率为2．0A(1)... 详细信息

GTP结合蛋白广泛存在于真核生物,古菌及细菌中。它们在不同的细胞生命过程中扮演着极其重要的角色,如蛋白质的合成,信号传导及膜的运输等。这里,我们率先报导了一从嗜热古菌中提取出来全长的GTP结合蛋白酶。其晶体结构分辨率为2．0A(1)。该GTP结合蛋白酶包括两个结构域。其C端是与GTP结合蛋白家族保守的G结构域负

关键词：嗜热古菌结构域结合蛋白晶体结构 GTP

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Environmental considerations and current status of grouping and regulation of engineered nanomaterials

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Environmental Nanotechnology, Monitoring and Management 2022年 18卷

作者： Tschiche, Harald R. Bierkandt, Frank S. Creutzenberg, Otto Fessard, Valerie Franz, Roland Giese, Bernd Greiner, Ralf Haas, Karl‑Heinz Haase, Andrea Hartwig, Andrea Hund‑Rinke, Kerstin Iden, Pauline Kromer, Charlotte Loeschner, Katrin Mutz, Diana Rakow, Anastasia Rasmussen, Kirsten Rauscher, Hubert Richter, Hannes Schoon, Janosch Schmid, Otmar Som, Claudia M.Tovar, Günter E. Westerhoff, Paul Wohlleben, Wendel Luch, Andreas Laux, Peter German Federal Institute for Risk Assessment (BfR) Department of Chemical and Product Safety Berlin Germany Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM) Hannover Germany French Agency for Food Environmental and Occupational Health & Safety (ANSES) Fougères Laboratory Toxicology of contaminants Unit Fougères France Fraunhofer Institute for Process Engineering and Packaging (IVV) Freising Germany University of Natural Resources and Life Sciences (BOKU) Institute of Safety and Risk Sciences (ISR) Vienna Austria Max Rubner-Institut Department of Food Technology and Bioprocess Engineering Karlsruhe Germany Fraunhofer Institute for Silicate Research (ISC) Würzburg Germany Karlsruhe Institute of Technology (KIT) Institute of Applied Biosciences (IAB) Food Chemistry and Toxicology Germany Fraunhofer Institute for Molecular Biology and Applied Ecology (IME) Schmallenberg Germany Nanid Scientific Consulting Germany National Food Institute Technical University of Denmark Lyngby Denmark German Federal Institute for Risk Assessment (BfR) Research Strategy and Coordination Berlin Germany Charité - Universitätsmedizin Berlin Center for Musculoskeletal Surgery Berlin Germany University Medicine Greifswald Center for Orthopaedics Trauma Surgery and Rehabilitation Medicine Greifswald Germany European Commission Joint Research Centre (JRC) Ispra Italy Fraunhofer IKTS - Institute for Ceramic Technologies and Systems Hermsdorf Germany Berlin Institute of Health at Charité - Universitätsmedizin Berlin Julius Wolff Institute Berlin Germany Comprehensive Pneumology Center (CPC-M) Member of the German Center for Lung Research (DZL) Munich Germany Institute of Lung Health and Immunity Helmholtz Zentrum München – German Research Center for Environmental Health Neuherberg Germany Swiss Federal Laboratories for Materials Science and Technology (Empa) Technology and Society Laboratory St. Gallen Switzerland Fraunhofer Institute for Interfacial Engineering and Biot

This article reviews the current status of nanotechnology with emphasis on application and related environmental considerations as well as legislation. Application and analysis of nanomaterials in infrastructure (construction, building coatings, and water treatment) is discussed, and in particular nanomaterial release during the lifecycle of these applications. Moreover, possible grouping approaches with regard to ecotoxicological and toxicological properties, and the fate of nanomaterials in the environment are evaluated. In terms of potential exposure, the opportunities that arise from leveraging advances in several key areas, such as water treatment and construction are addressed. Additionally, this review describes challenges with regard to the European Commission's definition of ‘nanomaterial’. The revised REACH information requirements, intended to enable a comprehensive risk assessment of nanomaterials, are outlined. © 2022 The Author(s)

关键词： Engineered Nanomaterials Environmental Nanotechnology Grouping Regulation

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