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Plant-based meat analogues aggravated lipid accumulation by regulating lipid metabolism homeostasis in mice

Food Science and Human Wellness 2024年第2期13卷 946-960页

作者： Yunting Xie Linlin Cai Zhiji Huang Kai Shan Xinglian Xu Guanghong Zhou Chunbao Li Key Laboratory of Meat Processing and Quality Control MOEKey Laboratory of Meat ProcessingMARAJiangsu Innovative Center of Meat ProductionProcessing and Quality ControlCollege of Food Science and TechnologyNanjing Agricultural UniversityNanjing 210095China

To determine the effects of plant-based meat analogues on the metabolic health and the possible mechanisms,mice were fed with a real pork diet(AP),a real beef diet(AB),a plant-based pork analogue diet(PP)and plant-based beef analogue diet(PB)for 68 *** with real meat,the plant-based meat analogues increased food and energy intake,body weight,white fat and liver weight and caused adipocyte hypertrophy,hepatic lipid droplet accumulation,and inflammatory responses in *** revealed that plantbased meat analogues altered the composition of serum metabolites,which regulated lipid metabolism *** PB diet upregulated gene expression related to lipid synthesis,lipolysis and adipocyte differentiation while the PP diet upregulated expression of lipolysis-related genes but downregulated expression of adipocyte differentiation-related genes in white adipose ***,both PP and PB diets upregulated lipid influx-and synthesis-related genes but downregulated lipid oxidation-related genes in *** specific metabolite biomarkers may affect fat accumulation mainly by direct lipid metabolism pathways or indirect amino acid metabolism,protein digestion and absorption,bile secretion,aminoacyl-tRNA biosynthesis,neuroactive ligand-receptor interaction and ABC transporters *** findings provide a new insight into understanding the differences in nutritional functions of meat and plant-based meat analogues.

关键词： Meat analogues Metabolomics Lipid metabolism Adipose tissue dysfunction Ectopic fat deposition

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Decentralized fault diagnosis of discrete-event systems with unreliable sensors using linear temporal logic

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Science China(Information Sciences) 2025年第1期68卷 322-341页

作者： Weijie DONG Shaoyuan LI Xiang YIN Key Laboratory of System Control and Information Processing Ministry of EducationDepartment of Automation Shanghai Jiao Tong University

In this paper,we investigate a decentralized diagnosis problem of a discrete-evnt system(DES) subject to unreliable sensors,where the sensor observations of local diagnosers may be non-deterministic as a result of possible *** studies on decentralized robust diagnosis can only deal with different types of sensor failures separately,e.g.,all sensors suffer from the same type of sensor failures such as intermittent sensor failures or permanent sensor ***,since sensors of different local diagnosers may face different external environments and have different internal characteristics,sensors corresponding to different local diagnosers may also have their own fault *** this paper,we propose a flexible framework of decentralized diagnosis for DES subject to unreliable sensors such that sensors of different local diagnosers are permitted to have different types of sensor *** this end,we extend the existing decentralized diagnosis framework to the case where there exist common sensors broadcasting their observations to all local *** apply linear temporal logic(LTL) to constrain infinite behaviors of private sensors of local diagnosers and common ***,a new notion of φ-codiagnosability is proposed as the necessary and sufficient condition for the existence of a decentralized diagnoser that works correctly under sensors,satisfying LTL-based sensor ***,we provide an effective approach to verify the φ-codiagnosability.

关键词： discrete event systems decentralized diagnosis codiagnosability automata

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Evolution of free amino acids, biogenic amines and volatile compounds in fermented sausages inoculated with Lactiplantibacillus plantarum and Staphylococcus simulans

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Food Science and Human Wellness 2024年第6期13卷 3642-3651页

作者： Xuefei Shao Huhu Wang Xiangyu Song Mingyuan Huang Jian Sun Xinglian Xu Key Laboratory of Meat Processing and Quality Control Ministry of EducationNational Center of Meat Quality and Safety ControlJiangsu Collaborative Innovation Center of Meat Production and ProcessingQuality and Safety ControlCollege of Food Science and technologyNanjing Agricultural UniversityNanjing 210095China

Lactic acid bacteria and coagulase-negative staphylococci play an important role in the production of fermented sausages,such as inhibiting the growth of undesirable bacteria and *** this study,the effects of inoculation with different starter cultures(Lactiplantibacillus plantarum HN108 and Staphylococcus simulans NJ209)on the free amino acids(FAAs),biogenic amines(BAs)and volatile compounds of fermented sausages were investigated using an amino acid analyzer,ultra performance liquid chromatography and gas chromatography-ion mobility spectrometry,*** pH and carbonyl content of the inoculated group was significantly lower than those in the control group(P<0.05).*** HN108 significantly reduced the content of FAAs and BAs in fermented sausage production(P<0.05),while *** NJ209 promoted the formation of FAAs(especially bitter amino acids)and exhibited slight BAs-reducing *** addition,*** HN108 promoted the formation of volatile compounds such as ketones,alcohols and alkenes in *** conclusion,*** HN108 could contribute to reducing the content of putrescine and tyramine and forming the desirable flavor compounds in fermented ***,*** HN108 is expected to be a starter culture that can improve the safety and flavor of fermented sausages.

关键词： Fermented sausages Starter cultures Free amino acids Biogenic amines Volatile compounds

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Investigation of conformational changes of cathepsin B as a feasibility assessment for NaCl reduction in Jinhua ham

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Food Science and Human Wellness 2025年第2期14卷 429-438页

作者： Shiqi Hu Guanghong Zhou Xinglian Xu Wangang Zhang Chunbao Li Key Laboratory of Meat Processing and Quality Control Ministry of EducationKey Laboratory of Meat ProcessingMinistry of Agriculture and Rural AffairsJiangsu Synergetic Innovation Center of Meat Processing and Quality ControlCollege of Food Science and TechnologyNanjing Agricultural UniversityNanjing 210095China School of Life Science and Food Engineering Huaiyin Institute of TechnologyHuai’an 223003China

To regulate the sodium chloride content in Jinhua ham,the impact of NaCl on the activity and conformation of cathepsin B was investigated using spectroscopy and computational *** results showed that the activity of cathepsin B decreased with an increase in Na^(+)cation content and ***,decreasedα-helix content and increasedβ-sheet content were *** increase in sulfhydryl group content was attributed to the breaking of original disulfide bonds in the molecular structure or the release of embedded ***,the surface hydrophobicity gradually declined,which was consistent with the analysis of endogenous fluorescence *** the molecular level,the number of hydrogen bonds formed in NaCl-treated samples decreased,and the interactions between the hydrogen bonding were less powerful,which caused instability in the binding of the protein and *** conformation of cathepsin B accurately characterized its activity,and the structural changes had a macroscopic effect on the decrease in protease activity.

关键词： Protein conformation Cathepsin B activity Jinhua ham Molecular docking Molecular dynamics

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The efficiency and safety evaluation of hemoglobin hydrolysate as a non-heme iron fortifier

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Food Science and Human Wellness 2024年第2期13卷 999-1010页

作者： Dejiang Xue Shuai Jiang Miao Zhang Kai Shan RenéLametsch Chunbao Li Key Laboratory of Meat Processing and Quality Control Ministry of EducationKey Laboratory of Meat ProcessingMinistry of Agriculture and Rural AffairsJiangsu Collaborative Innovation Center of Meat ProductionProcessing and Quality ControlCollege of Food Science and TechnologyNanjing Agricultural UniversityNanjing 210095China Department of Food Science University of CopenhagenFrederiksberg C DK-1958Denmark

Hemoglobin hydrolysate is derived from the enzymatic degradation of *** work aimed to evaluate whether hemoglobin hydrolysate promotes the absorption of non-heme iron and the safety of absorbed iron in mice by analyzing the iron binding content,iron circulation,and liver *** found that hemoglobin hydrolysate promoted the absorption of non-heme iron with high efficiency in duodenum by spontaneously binding non-heme iron during digestion,and increased hepatic iron content by up-regulating divalent metal transporter 1,zinc transporter 14,but hepatic iron content only increased at 3 *** iron entered the blood through ferroportin without restriction at 3 weeks,and excessive iron entered the liver and then affected the hepatocyte membranes permeability and lipid synthesis through oxidative *** the prolongation of dietary intervention,the up-regulated hepcidin acted on the ferroportin to restrict excess iron from entering the blood,and then the hepatic homeostasis *** addition,hemoglobin hydrolysate enhanced the hepatic antioxidant *** together,hemoglobin hydrolysate has a strong ability to promote the absorption of non-heme iron in vivo,and the absorbed iron is relatively safe due to the regulation of hepcidin.

关键词： Hemoglo bin hydrolysate Non-heme iron Absorption Liver homeostasis Hepcidin

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Connectivity-maintaining Consensus of Multi-agent Systems With Communication Management Based on Predictive control Strategy

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IEEE/CAA Journal of Automatica Sinica 2023年第3期10卷 700-710页

作者： Jie Wang Shaoyuan Li Yuanyuan Zou Key Laboratory of System Control and Information Processing Shanghai Jiao Tong UniversityShanghai 200240China IEEE

This paper studies the connectivity-maintaining consensus of multi-agent *** the impact of the sensing ranges of agents for connectivity and communication energy consumption,a novel communication management strategy is proposed for multi-agent systems so that the connectivity of the system can be maintained and the communication energy can be *** this paper,communication management means a strategy about how the sensing ranges of agents are adjusted in the process of reaching *** proposed communication management in this paper is not coupled with controller but only imposes a constraint for controller,so there is more freedom to develop an appropriate control strategy for achieving *** the multi-agent systems with this novel communication management,a predictive control based strategy is developed for achieving *** results indicate the effectiveness and advantages of our scheme.

关键词： Consensus energy-saving multi-agent system predictive control

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Scenario Analysis of Protest Potential Based on Simulation Modeling 12

Scenario Analysis of Protest Potential Based on Simulation M...

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12th International Conference on Mathematical Modeling in Physical Sciences, IC-MSQUARE 2023

作者： Chernov, Igor Feyzov, Vadim Institute of Control Sciences RAS Laboratory of Modular Data Processing and Control Systems Russia

In this study, we present a scenario-based approach to investigate the protest potential in society using mathematical tools from graph theory and simulation modeling. The research aims to construct a cognitive map that reflects key factors, such as population deprivation levels, overall well-being, social fears, trust in authority, social expectations, and stability of social structures. We report the results of a scenario analysis of the developed model, obtaining forecasted scenarios of the dynamics of society's protest potential under various conditions and influences. At the core of this research is the examination of a complex system's possible response to external destructive impacts, and we propose a set of measures to counteract these influences on societal dynamics. The scenario methodology combines graph theory for representing complex relationships between key factors and simulation modeling for predicting potential developmental scenarios. Conducting this study required modifying the traditional mathematical apparatus of cognitive modeling. We developed methods and algorithms for scenario-event identification of the model's significant factors' behavior and utilizing the results of such identification when forming complex functional relationships in the scenario model. In generating scenarios, the range of events is significantly expanded compared to traditional cognitive modeling approaches, which could have been overlooked but may be crucial for situational analysis. © 2024 Institute of Physics Publishing. All rights reserved.

关键词： Graph theory

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Optimal Deceptive Strategy Synthesis for Autonomous Systems under Asymmetric Information

IEEE Transactions on Intelligent Vehicles

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IEEE Transactions on Intelligent Vehicles 2024年第10期9卷 1-14页

作者： Lv, Peng Li, Shaoyuan Yin, Xiang Department of Automation and Key Laboratory of System Control and Information Processing Shanghai Jiao Tong University Shanghai China

High-level task planning under adversarial environments is one of the central problems in the development of autonomous systems such as unmanned ground vehicles (UGV). Existing works commonly assume that the decision-maker such as UAV shares the same information with the environment. However, in many scenarios, the UGV, as an integral part of the system, generally has more information than the external adversary. For such a scenario, the decision-maker with more information may achieve better performance by using deceptive strategies. In this paper, we investigate the problem of optimal deceptive strategy synthesis for autonomous systems under asymmetric information between the internal decision-maker and the external adversary. Specifically, we model the dynamic system as a weighted two-player graph game and the objective is to optimize the mean payoff value per task. To capture the asymmetric information between two parties, we assume that the UGV has complete knowledge of the system, whereas the adversary may have misconceptions regarding the task as well as the cost. To synthesize an optimal deceptive strategy, we propose a synthesis algorithm based on hyper-games. The correctness as well as the complexity of the algorithm are analyzed. We illustrate the proposed algorithm by running examples as well as a simulation case study. Finally, we conduct an empirical experiment using real-world scenarios to verify the practical applicability of our algorithm. IEEE

关键词： Intelligent vehicle highway systems

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Strip width spread prediction in rough rolling process based on mechanism modeling and optimization

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Journal of Iron and Steel Research International 2023年第12期30卷 2416-2424页

作者： Yan-jiu Zhong Jing-cheng Wang Jia-hui Xu Jun Rao Department of Automation Key Laboratory of System Control and Information ProcessingShanghai Jiao Tong UniversityShanghai 200240China

Aiming at the problems of low accuracy and poor robustness that existed in the current hot rolling strip width spread model,an improved strip spread prediction model based on a material forming mechanism and Bayesian optimized adaptive differential evolution algorithm(BADE)was *** first,we improved the original spread mechanism model by adding the weight and bias term to enhance the model robustness based on rolling ***,the BADE algorithm was proposed to optimize the improved spread mechanism *** optimization algorithm is based on a novel adaptive differential evolution algorithm,which can effectively achieve the global optimal ***,the prediction performances of five machine learning algorithms were compared in *** results show that the prediction accuracy of the improved spread model is obviously better than that of the machine learning algorithms,which proves the effectiveness of the proposed method.

关键词： Hot rolling Width spread prediction Bayesian optimization:Adaptive differential evolution Parameter optimization

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Value Iteration-Based Cooperative Adaptive Optimal control for Multi-Player Differential Games With Incomplete Information

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 690-697页

作者： Yun Zhang Lulu Zhang Yunze Cai the Department of Automation Shanghai Jiao Tong UniversityShanghai 200240 the Key Laboratory of System Control and Information Processing Ministry of Education of ChinaShanghai 200240China

This paper presents a novel cooperative value iteration(VI)-based adaptive dynamic programming method for multi-player differential game models with a convergence *** players are divided into two groups in the learning process and adapt their policies *** method removes the dependence of admissible initial policies,which is one of the main drawbacks of the PI-based ***,this algorithm enables the players to adapt their control policies without full knowledge of others’ system parameters or control *** efficacy of our method is illustrated by three examples.

关键词： Adaptive dynamic programming incomplete information multi-player differential game value iteration

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